ES8607318A1 - Un procedimiento para la preparacion de nuevos derivados de cefalosporina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de cefalosporina.Info
- Publication number
- ES8607318A1 ES8607318A1 ES542013A ES542013A ES8607318A1 ES 8607318 A1 ES8607318 A1 ES 8607318A1 ES 542013 A ES542013 A ES 542013A ES 542013 A ES542013 A ES 542013A ES 8607318 A1 ES8607318 A1 ES 8607318A1
- Authority
- ES
- Spain
- Prior art keywords
- chemical compounds
- processes
- image
- quaternaryammonio
- iminoacetamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE CEFALOSPORINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA AMINA TERCIARIA QFN (O SUCESIVAMENTE CON UNA AMINA SECUNDARIA RRKNH Y UN COMPUESTO DE FORMULA RLZ) Y, SI M ES 1, REDUCIR EL SULFOXIDO POR MEDIOS CONVENCIONALES Y POSTERIORMENTE, SEPARAR TODOS LOS GRUPOS BLOQUEANTES POR MEDIOS CONVENCIONALES PARA PRODUCIR NUEVOS DERIVADOS DE CEFALOSPORINA DE FORMULA (I), DONDE R1 ES H O UN GRUPO CONVENCIONAL PROTECTOR DEL AMINO; R2 ES H, UN GRUPO ALQUILO CON C 1 A 4 Y OTROS; Y MCNFQ ES UN GRUPO AMINO CUATERNARIO. SE UTILIZAN COMO AGENTES ANTIBACTERIANOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59794184A | 1984-04-09 | 1984-04-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES542013A0 ES542013A0 (es) | 1986-06-16 |
ES8607318A1 true ES8607318A1 (es) | 1986-06-16 |
Family
ID=24393575
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542013A Expired ES8607318A1 (es) | 1984-04-09 | 1985-04-08 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina. |
ES551551A Expired ES8706694A1 (es) | 1984-04-09 | 1986-01-31 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina |
ES551550A Expired ES8706155A1 (es) | 1984-04-09 | 1986-01-31 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina |
ES557060A Expired ES8800949A1 (es) | 1984-04-09 | 1986-09-10 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES551551A Expired ES8706694A1 (es) | 1984-04-09 | 1986-01-31 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina |
ES551550A Expired ES8706155A1 (es) | 1984-04-09 | 1986-01-31 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina |
ES557060A Expired ES8800949A1 (es) | 1984-04-09 | 1986-09-10 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina |
Country Status (31)
Country | Link |
---|---|
JP (4) | JPS615084A (es) |
KR (1) | KR870002166B1 (es) |
AR (1) | AR244694A1 (es) |
AT (1) | AT388735B (es) |
AU (2) | AU580990B2 (es) |
BE (1) | BE902148A (es) |
CA (3) | CA1276929C (es) |
CH (1) | CH669197A5 (es) |
DD (3) | DD249024A5 (es) |
DE (1) | DE3512225A1 (es) |
DK (1) | DK155985A (es) |
ES (4) | ES8607318A1 (es) |
FI (1) | FI84830C (es) |
FR (1) | FR2563832B1 (es) |
GB (3) | GB2157293B (es) |
GR (1) | GR850883B (es) |
HU (2) | HU193750B (es) |
IE (2) | IE58408B1 (es) |
IL (1) | IL74826A (es) |
IT (1) | IT1190353B (es) |
LU (1) | LU85840A1 (es) |
MY (1) | MY101940A (es) |
NL (1) | NL192925C (es) |
NZ (1) | NZ211659A (es) |
OA (1) | OA07985A (es) |
PT (1) | PT80246B (es) |
RU (1) | RU2056425C1 (es) |
SE (4) | SE466205B (es) |
SU (4) | SU1375140A3 (es) |
YU (2) | YU46151B (es) |
ZA (1) | ZA852236B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61145186A (ja) * | 1984-12-20 | 1986-07-02 | Meiji Seika Kaisha Ltd | 新規セフエム化合物及びその製造法 |
US4708955A (en) * | 1985-06-24 | 1987-11-24 | Bristol-Myers Company | 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof |
DE3650157T2 (de) * | 1985-12-26 | 1995-05-04 | Eisai Co Ltd | Cephalosporin-verbindungen. |
AU614723B2 (en) * | 1986-10-13 | 1991-09-12 | Eisai Co. Ltd. | 3-propenylcephem derivative |
IL84128A (en) * | 1986-10-13 | 1992-12-01 | Eisai Co Ltd | 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them |
JPH085897B2 (ja) * | 1986-11-06 | 1996-01-24 | エーザイ株式会社 | 3−プロペニルセフェム誘導体 |
FR2622585B1 (fr) * | 1987-11-03 | 1991-04-19 | Roussel Uclaf | Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
JPH0699449B2 (ja) * | 1988-03-16 | 1994-12-07 | エーザイ株式会社 | セフェム誘導体の合成中間体 |
EP0612751A3 (en) * | 1988-03-16 | 1994-09-21 | Eisai Co Ltd | Compounds for the preparation of cephem derivatives. |
FR2655042B1 (fr) * | 1989-11-29 | 1994-01-21 | Adir Cie | Nouvelles benzothiazolinones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2663332B1 (fr) * | 1990-06-15 | 1997-11-07 | Roussel Uclaf | Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus. |
US5126336A (en) * | 1990-08-23 | 1992-06-30 | Bristol-Myers Squibb Company | Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof |
AT396108B (de) * | 1991-08-21 | 1993-06-25 | Biochemie Gmbh | Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten |
JPH0741484A (ja) * | 1993-07-29 | 1995-02-10 | Katayama Seiyakushiyo:Kk | セフェム化合物及び抗菌剤 |
US5661144A (en) * | 1994-08-16 | 1997-08-26 | Meiji Seika Kabushiki Kaisha | Cephem derivatives with 3-substituted bis heterocycles |
PL345266A1 (en) | 1998-06-22 | 2001-12-03 | Hoffmann La Roche | Propenyl cephalosporin derivatives |
EP1666483B1 (en) | 2003-09-09 | 2011-08-17 | Nippon Chemical Industrial Company Limited | Process for producing 3-chloromethyl-3-cephem derivative |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1342241A (en) * | 1970-01-23 | 1974-01-03 | Glaxo Lab Ltd | Cephalosporin compounds |
US4390534A (en) * | 1978-12-29 | 1983-06-28 | Fujisawa Pharmaceutical Co., Ltd. | Cephem and cepham compounds |
EP0025017A1 (de) * | 1979-08-28 | 1981-03-11 | Ciba-Geigy Ag | Polyazathiaverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend solche Verbindungen und Verwendung von letzteren |
US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
GR75644B (es) * | 1980-06-18 | 1984-08-02 | Fujisawa Pharmaceutical Co | |
GR78245B (es) * | 1980-09-12 | 1984-09-26 | Ciba Geigy Ag | |
US4521413A (en) * | 1981-09-14 | 1985-06-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4486586A (en) * | 1983-02-10 | 1984-12-04 | Bristol-Myers Company | Cephalosporin derivatives |
-
1985
- 1985-02-14 CA CA000474260A patent/CA1276929C/en not_active Expired - Lifetime
- 1985-03-25 ZA ZA852236A patent/ZA852236B/xx unknown
- 1985-04-02 NZ NZ211659A patent/NZ211659A/xx unknown
- 1985-04-02 AR AR85299945A patent/AR244694A1/es active
- 1985-04-03 SE SE8501680A patent/SE466205B/sv not_active IP Right Cessation
- 1985-04-03 DK DK155985A patent/DK155985A/da not_active Application Discontinuation
- 1985-04-03 DD DD85287524A patent/DD249024A5/de unknown
- 1985-04-03 DE DE19853512225 patent/DE3512225A1/de active Granted
- 1985-04-03 DD DD85274832A patent/DD236735A5/de unknown
- 1985-04-04 FI FI851379A patent/FI84830C/fi not_active IP Right Cessation
- 1985-04-04 GB GB08508846A patent/GB2157293B/en not_active Expired
- 1985-04-04 CH CH1498/85A patent/CH669197A5/de not_active IP Right Cessation
- 1985-04-04 AU AU40862/85A patent/AU580990B2/en not_active Expired
- 1985-04-04 PT PT80246A patent/PT80246B/pt unknown
- 1985-04-04 OA OA58561A patent/OA07985A/xx unknown
- 1985-04-04 IE IE86685A patent/IE58408B1/en not_active IP Right Cessation
- 1985-04-04 NL NL8501002A patent/NL192925C/nl not_active IP Right Cessation
- 1985-04-05 IT IT20267/85A patent/IT1190353B/it active
- 1985-04-05 FR FR8505281A patent/FR2563832B1/fr not_active Expired
- 1985-04-05 LU LU85840A patent/LU85840A1/fr unknown
- 1985-04-05 AT AT0103985A patent/AT388735B/de not_active IP Right Cessation
- 1985-04-05 IL IL74826A patent/IL74826A/xx not_active IP Right Cessation
- 1985-04-08 RU SU853878102A patent/RU2056425C1/ru active
- 1985-04-08 ES ES542013A patent/ES8607318A1/es not_active Expired
- 1985-04-08 GR GR850883A patent/GR850883B/el not_active IP Right Cessation
- 1985-04-09 BE BE0/214810A patent/BE902148A/fr not_active IP Right Cessation
- 1985-04-09 HU HU851299A patent/HU193750B/hu unknown
- 1985-04-09 YU YU60085A patent/YU46151B/sh unknown
- 1985-04-09 KR KR1019850002383A patent/KR870002166B1/ko not_active IP Right Cessation
- 1985-04-09 JP JP60075233A patent/JPS615084A/ja active Granted
- 1985-04-09 HU HU87151A patent/HU204277B/hu unknown
- 1985-11-12 JP JP60252138A patent/JPS61143390A/ja active Granted
- 1985-11-12 JP JP60252139A patent/JPS61143391A/ja active Granted
- 1985-11-12 JP JP60252140A patent/JPS61143387A/ja active Granted
-
1986
- 1986-01-31 ES ES551551A patent/ES8706694A1/es not_active Expired
- 1986-01-31 ES ES551550A patent/ES8706155A1/es not_active Expired
- 1986-02-06 SU SU864018257A patent/SU1375140A3/ru active
- 1986-02-06 SU SU864023036A patent/SU1367858A3/ru active
- 1986-02-06 SU SU864019975A patent/SU1487814A3/ru active
- 1986-02-06 SU SU864020682A patent/SU1436882A3/ru active
- 1986-03-03 DD DD86287525A patent/DD251752A5/de unknown
- 1986-09-10 ES ES557060A patent/ES8800949A1/es not_active Expired
-
1987
- 1987-06-25 YU YU118987A patent/YU46213B/sh unknown
- 1987-09-10 GB GB08721347A patent/GB2194790B/en not_active Expired
- 1987-09-10 GB GB08721346A patent/GB2194789B/en not_active Expired
- 1987-10-01 MY MYPI87002761A patent/MY101940A/en unknown
-
1988
- 1988-11-11 AU AU25041/88A patent/AU610278B2/en not_active Expired
-
1989
- 1989-04-04 IE IE121089A patent/IE58403B1/en not_active IP Right Cessation
- 1989-04-06 SE SE8901226A patent/SE470260B/sv not_active IP Right Cessation
- 1989-04-06 SE SE8901225A patent/SE505256C2/sv not_active IP Right Cessation
- 1989-04-06 SE SE8901224A patent/SE470259B/sv not_active IP Right Cessation
-
1991
- 1991-08-12 CA CA000616143A patent/CA1340638C/en not_active Expired - Fee Related
- 1991-08-21 CA CA000616144A patent/CA1340672C/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20060410 |