WO2002102445A1 - Systeme d'inhalation de poudre seche pour une administration transpulmonaire - Google Patents

Systeme d'inhalation de poudre seche pour une administration transpulmonaire Download PDF

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Publication number
WO2002102445A1
WO2002102445A1 PCT/JP2002/005955 JP0205955W WO02102445A1 WO 2002102445 A1 WO2002102445 A1 WO 2002102445A1 JP 0205955 W JP0205955 W JP 0205955W WO 02102445 A1 WO02102445 A1 WO 02102445A1
Authority
WO
WIPO (PCT)
Prior art keywords
dry powder
inhalation system
transpulmonary administration
powder inhalation
freeze
Prior art date
Application number
PCT/JP2002/005955
Other languages
English (en)
French (fr)
Inventor
Chikamasa Yamashita
Shigeru Ibaragi
Yuichiro Fukunaga
Akitsuna Akagi
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0400217A priority Critical patent/HU227300B1/hu
Priority to MXPA03011541A priority patent/MXPA03011541A/es
Priority to IL15908002A priority patent/IL159080A0/xx
Priority to APAP/P/2003/002945A priority patent/AP1861A/en
Priority to AU2002311213A priority patent/AU2002311213B2/en
Priority to NZ530044A priority patent/NZ530044A/en
Priority to BRPI0210425-3A priority patent/BR0210425B1/pt
Priority to KR1020037016433A priority patent/KR100815216B1/ko
Priority to JP2003505028A priority patent/JP3635353B2/ja
Priority to EA200400045A priority patent/EA005025B1/ru
Priority to EEP200400011A priority patent/EE04956B1/xx
Priority to SI200230430T priority patent/SI1402913T1/sl
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Priority to AP2008004396A priority patent/AP2008004396A0/xx
Priority to DE60214184T priority patent/DE60214184T2/de
Priority to CA2449954A priority patent/CA2449954C/en
Priority to EP02736105A priority patent/EP1402913B1/en
Publication of WO2002102445A1 publication Critical patent/WO2002102445A1/ja
Priority to IL159080A priority patent/IL159080A/en
Priority to ZA2003/09550A priority patent/ZA200309550B/en
Priority to NO20035554A priority patent/NO334652B1/no
Priority to HR20040033A priority patent/HRP20040033B8/xx
Priority to HK04109711.5A priority patent/HK1066748A1/xx
Priority to CY20061101585T priority patent/CY1105755T1/el
Priority to AU2008200583A priority patent/AU2008200583B2/en
Priority to NO20131597A priority patent/NO20131597L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/004—Details of the piercing or cutting means with fixed piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/JP2002/005955 2001-06-15 2002-06-14 Systeme d'inhalation de poudre seche pour une administration transpulmonaire WO2002102445A1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
AP2008004396A AP2008004396A0 (en) 2001-06-15 2002-06-14 Dry Powder inhalation system for transpulmonary administration
MXPA03011541A MXPA03011541A (es) 2001-06-15 2002-06-14 Sistema de inhalacion de polvo seco para administrar transpulmonar.
DE60214184T DE60214184T2 (de) 2001-06-15 2002-06-14 Trockenpulver-inhalationssystem für die transpulmonale verabreichung, herstellungsverfahren für eine trockenpulver-zusammensetzung, und verwendung einer gefriertrockneten zusammensetzung
AU2002311213A AU2002311213B2 (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration
NZ530044A NZ530044A (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration
BRPI0210425-3A BR0210425B1 (pt) 2001-06-15 2002-06-14 sistema de inalação com pó seco para administração transpulmonar e método de fabricação de uma preparação em pó seco para administração transpulmonar.
KR1020037016433A KR100815216B1 (ko) 2001-06-15 2002-06-14 경폐 투여용 건조 분말 흡입 시스템
JP2003505028A JP3635353B2 (ja) 2001-06-15 2002-06-14 経肺投与用乾燥粉末吸入システム
EA200400045A EA005025B1 (ru) 2001-06-15 2002-06-14 Система для ингаляции сухим порошком для транспульмонарного применения
EEP200400011A EE04956B1 (et) 2001-06-15 2002-06-14 Kuivpulberinhalatsiooniseade kuivpulberpreparaaditranspulmonaalseks manustamiseks, meetod kuivpulberpreparaadi valmistamiseks ja klmkuivatatud kompositsiooni kasutamine
SI200230430T SI1402913T1 (sl) 2001-06-15 2002-06-14 Suhoprasni inhalacijski sistem za transpulmonalno dajanje, postopek izdelave suhoprasnega pripravka in uporaba liofiliziranega sestavka
HU0400217A HU227300B1 (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration
IL15908002A IL159080A0 (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration
APAP/P/2003/002945A AP1861A (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration
CA2449954A CA2449954C (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration
EP02736105A EP1402913B1 (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration, method of manufacturing a dry powdered preparation, and use of a freeze dried composition
IL159080A IL159080A (en) 2001-06-15 2003-11-27 Dry powder inhalation system for transpulmonary administration
ZA2003/09550A ZA200309550B (en) 2001-06-15 2003-12-09 Dry powder inhalation system for transpulmonary administration
NO20035554A NO334652B1 (no) 2001-06-15 2003-12-12 Tørr-pulverinhaleringssytem for transpulmonal administrering og metode for fremstilling av slike samt anvendelse av slike ved inhalering
HR20040033A HRP20040033B8 (en) 2001-06-15 2004-01-14 Dry powder inhalation system for transpulmonary administration
HK04109711.5A HK1066748A1 (en) 2001-06-15 2004-12-08 Dry powder inhalation system for transpulmonary administration
CY20061101585T CY1105755T1 (el) 2001-06-15 2006-11-02 Συστημα εισπνοης ξηρας σκονης για διαπνευμονικη χορηγηση, μεθοδος βιομηχανοποιησης ενος παρασκευασματος ξηρας σκονης και χρηση μιας λυοφιλιωμενης συνθεσης
AU2008200583A AU2008200583B2 (en) 2001-06-15 2008-02-07 Dry powder inhalation system for transpulmonary administration
NO20131597A NO20131597L (no) 2001-06-15 2013-12-03 Tørr-pulver inhaleringssystem for transpulmonal administrering

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2001182504 2001-06-15
JP2001-182504 2001-06-15
JP2001400871 2001-12-28
JP2001-400871 2001-12-28
JP2002111131 2002-04-12
JP2002-111131 2002-04-12
JP2002363158 2002-12-13

Publications (1)

Publication Number Publication Date
WO2002102445A1 true WO2002102445A1 (fr) 2002-12-27

Family

ID=32931499

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2002/005955 WO2002102445A1 (fr) 2001-06-15 2002-06-14 Systeme d'inhalation de poudre seche pour une administration transpulmonaire
PCT/JP2003/015931 WO2004054555A1 (ja) 2001-06-15 2003-12-12 新しい経肺投与用乾燥粉末吸入システム

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/015931 WO2004054555A1 (ja) 2001-06-15 2003-12-12 新しい経肺投与用乾燥粉末吸入システム

Country Status (33)

Country Link
US (4) US7448379B2 (ja)
EP (4) EP1688133A1 (ja)
JP (1) JP3635353B2 (ja)
KR (3) KR100907333B1 (ja)
CN (2) CN100427077C (ja)
AP (1) AP1861A (ja)
AT (1) ATE336989T1 (ja)
AU (3) AU2002311213B2 (ja)
BG (1) BG108517A (ja)
BR (2) BR0210425B1 (ja)
CA (2) CA2449954C (ja)
CY (1) CY1105755T1 (ja)
CZ (1) CZ200470A3 (ja)
DE (1) DE60214184T2 (ja)
DK (1) DK1402913T3 (ja)
EA (1) EA005025B1 (ja)
EE (1) EE04956B1 (ja)
EG (2) EG24184A (ja)
ES (1) ES2271266T3 (ja)
HK (1) HK1082403A1 (ja)
HR (2) HRP20040033B8 (ja)
HU (1) HU227300B1 (ja)
IL (1) IL159080A0 (ja)
MA (1) MA27131A1 (ja)
MX (1) MXPA05006322A (ja)
NO (2) NO334652B1 (ja)
NZ (2) NZ530044A (ja)
PL (2) PL205104B1 (ja)
PT (1) PT1402913E (ja)
SI (1) SI1402913T1 (ja)
TW (1) TW570819B (ja)
UA (1) UA81280C2 (ja)
WO (2) WO2002102445A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054555A1 (ja) 2001-06-15 2004-07-01 Otsuka Pharmaceutical Co., Ltd. 新しい経肺投与用乾燥粉末吸入システム
WO2004054647A1 (en) * 2002-12-13 2004-07-01 Otsuka Pharmaceutical Co., Ltd. Inhalation device for transpulmonary administration
EP1464355A2 (en) * 2003-03-31 2004-10-06 Nathaniel Hughes Medicinal powder delivery system
JP2008519628A (ja) * 2004-11-10 2008-06-12 シプラ・リミテッド 吸入器
JP2008520262A (ja) * 2004-11-16 2008-06-19 バルワー エス．アー．エス． 流体投与装置
JP2012527974A (ja) * 2009-05-29 2012-11-12 クック メディカル テクノロジーズ エルエルシー 治療薬を送達するためのシステム及び方法
US10806770B2 (en) 2014-10-31 2020-10-20 Monash University Powder formulation

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* Cited by examiner, † Cited by third party
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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
GB2380410B (en) * 2001-10-05 2003-11-19 Alchemy Healthcare Ltd Apparatus for the nasal or oral delivery of a medicament
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
WO2004054605A1 (en) * 2002-12-13 2004-07-01 Otsuka Pharmaceutical Co., Ltd. Freeze-dried interferon-ϝ composition for transpulmonary administration and inhalation system therefor
GB0313604D0 (en) * 2003-06-12 2003-07-16 Britannia Pharmaceuticals Ltd Delivery device for powdered medicament
WO2005061088A1 (en) * 2003-12-22 2005-07-07 Finlay Warren H Powder formation by atmospheric spray-freeze drying
EP1593376A1 (en) * 2004-05-04 2005-11-09 Warner-Lambert Company LLC Improved pullulan capsules
US20060021613A1 (en) * 2004-08-02 2006-02-02 Robert Overlander Accessory for nebulizer inhaler system
CA2575692C (en) 2004-08-20 2014-10-14 Mannkind Corporation Catalysis of diketopiperazine synthesis
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
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IL159080A0 (en) 2004-05-12
UA81280C2 (uk) 2007-12-25
PL377554A1 (pl) 2006-02-06
JPWO2002102445A1 (ja) 2004-09-30
HUP0400217A2 (en) 2004-09-28
KR100906754B1 (ko) 2009-07-09
US20090126732A1 (en) 2009-05-21
NO334652B1 (no) 2014-05-05
US7735485B2 (en) 2010-06-15
CA2449954A1 (en) 2002-12-27
EP1688134A2 (en) 2006-08-09
JP3635353B2 (ja) 2005-04-06
PL367161A1 (en) 2005-02-21
HRP20040033A2 (en) 2004-08-31
NZ540935A (en) 2007-06-29
KR20050084272A (ko) 2005-08-26
AU2003289051B2 (en) 2008-06-26
KR100907333B1 (ko) 2009-07-13
EA200400045A1 (ru) 2004-06-24
CN1516606A (zh) 2004-07-28

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