WO2000078322A2 - Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions - Google Patents

Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions Download PDF

Info

Publication number
WO2000078322A2
WO2000078322A2 PCT/IT2000/000251 IT0000251W WO0078322A2 WO 2000078322 A2 WO2000078322 A2 WO 2000078322A2 IT 0000251 W IT0000251 W IT 0000251W WO 0078322 A2 WO0078322 A2 WO 0078322A2
Authority
WO
WIPO (PCT)
Prior art keywords
lactobacillus
lactic acid
acid bacteria
component
bacteria
Prior art date
Application number
PCT/IT2000/000251
Other languages
English (en)
French (fr)
Other versions
WO2000078322A3 (en
Inventor
Claudio De Simone
Original Assignee
Vsl Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EA200200059A priority Critical patent/EA006037B1/ru
Priority to EEP200100682A priority patent/EE04620B1/xx
Application filed by Vsl Pharma Limited filed Critical Vsl Pharma Limited
Priority to BRPI0011799A priority patent/BRPI0011799B1/pt
Priority to SK1717-2001A priority patent/SK17172001A3/sk
Priority to JP2001504385A priority patent/JP4949580B2/ja
Priority to SI200030866T priority patent/SI1194525T1/sl
Priority to MXPA01013239 priority patent/MX236443B/es
Priority to IL14688900A priority patent/IL146889A0/xx
Priority to BRPI0017622A priority patent/BRPI0017622B1/pt
Priority to CA2373375A priority patent/CA2373375C/en
Priority to PL00352805A priority patent/PL352805A1/xx
Priority to HU0202051A priority patent/HUP0202051A3/hu
Priority to DZ003167A priority patent/DZ3167A1/xx
Priority to AU55660/00A priority patent/AU775452B2/en
Priority to NZ516022A priority patent/NZ516022A/en
Priority to DE60027894T priority patent/DE60027894T2/de
Priority to EP00940762A priority patent/EP1194525B1/en
Priority to UA2002010459A priority patent/UA76696C2/uk
Priority to KR1020017016367A priority patent/KR100712286B1/ko
Publication of WO2000078322A2 publication Critical patent/WO2000078322A2/en
Publication of WO2000078322A3 publication Critical patent/WO2000078322A3/en
Priority to IS6177A priority patent/IS6177A/is
Priority to IL146889A priority patent/IL146889A/en
Priority to NO20016291A priority patent/NO329324B1/no
Priority to US10/024,199 priority patent/US7052688B2/en
Priority to HK02108628.1A priority patent/HK1047132B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/853—Lactobacillus
    • Y10S435/855—Lactobacillus brevis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/853—Lactobacillus
    • Y10S435/856—Lactobacillus casei

Definitions

  • the present invention relates to a combination of lactic acid bacteria and its use for making a food supplement, a hygiene product or a pharmaceutical preparation for the prevention and/or treatment of infections and inflammatory conditions caused by bacteria, viruses or fungi , especially in the mouth, vagina, urethra , nose , eyes and ears .
  • Lactic acid bacteria are Gram-posit ive bacteria that produce lactic acid by the fermentation of glucose .
  • Streptococcus thermophilus is al so included in this definition by convention .
  • H 2 0 2 -producing lactic acid bacteria can antagonize E. coli, N. gonorrhoea , G. vaginalis, C. trachoma tis, U. urealyticum and B. bivius .
  • these bacteria are only of limited benefit when used in medical practice . This can be seen from the fact that preparations based on lactic acid bacteria ( e . g . vaginal pessaries ) intended for the treatment of infections by the above microorganisms (e . g . vaginitis ) are not held in high regard by doctors , who prefer to treat their patients with antibiotics or chemotherapeutic agents.
  • H 2 0 2 -producing lactic acid bacteria is considerably potentiated by the addition of one or more strains of lactic acid bacteria that are capable of utilizing arginine.
  • Arginine forms part of various small peptides found in biological fluids and it also occurs as free arginine. Many bacterial species utilize it for their own nutrition and growth. Arginine-utilizing lactic acid bacteria can therefore deprive other, pathogenic or potentially pathogenic bacteria of a certain quantity of arginine, which - though not enough to terminate their growth - makes them more susceptible to the action of the H 2 0 2 produced by the lactic acid bacteria.
  • the present invention therefore provides a combination of lactic acid bacteria comprising:
  • the strain of lactic acid bacteria in component (a) is preferably chosen from a group made up of the strains of the species Lactobacillus crispatus , Lactobacillus salivarius and Lactobacillus casei, while the strain of lactic acid bacteria in component (b) is chosen from a group made up of the strains of the species Lactobacillus brevis, Lactobacillus gasseri and Lactobacillus fermentum. More especially, the strain of lactic acid bacteria in component (b) is the Lactobacillus brevis CD2 strain deposited in the DSM - Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany, on February 6, 1998 with access number DSM 11988 under the Budapest Treaty, or mutants or derivatives thereof.
  • the ratio of the number of bacteria in component (a) to the number of bacteria in component (b) is preferably from 1 : 100 to 100 : 1, and more especially from 1 : 5 to 5 : 1, the most preferred ratio being 1 : 1.
  • the combination can be administered in the unit dosage form comprising from 1 x 10 to
  • the combination can also be administered in the form of tablets, sucking tablets, sweets, chewing gum, gelatin capsules, pessaries, suppositories and micro-enemas, as well as pellets, dental creams and gels, denture powders, mouthwashes, dentifrices, sprays, suspensions and ointments.
  • the combination additionally comprises at least one other strain of lactic acid bacteria chosen from a group made up of : Lactoba cillus acidophilus , Lactobacillus buchneri , Lactobacillus casei , Lactobacillus ca tenaforme , Lactobacillus cellobiosus , Lactobacillus cri spa tus, Lactobacillus curva tus, Lactobacillus delbrueckii , Lactobacillus jensenii , Lactobacillus leichmannii , Lactoba cillus minutus , Lactobacillus plantarum , Lactobacillus salivarius , Lactobacillus brevis, Lactobacillus gasseri , Lactobacillus fermentum, Bifidobacterium adolescentis , Bifidobacterium angulatum, Bifidobacterium bifidum, Bifido
  • the combination can also comprise vitamins, quaternary ammonium bases , mineral salts, antioxidants and anti-plaque agents .
  • the invention also relates to the use of a combination of lactic acid bacteria comprising :
  • a second component consisting of at least one strain of arginine-util i zing lactic acid bacteria , for making a food supplement , a hygiene product or a pharmaceutical preparation for the prevention and/or treatment of infections and inflammatory conditions caused by bacteria, viruses or fungi, especially in the mouth, vagina, urethra, nose, eyes and ears.
  • infections and inflammatory conditions include gingivitis, periodontitis, mucositis and stomatitis caused by drugs and/or physical agents, Behcet ' s syndrome, diakeratosis of the oral cavity, glossitis, sore throat, sialadenitis, sialolithiasis, pemphigus, Lichen planus, Sj ⁇ gren's syndrome, vaginosis, vaginitis, urethritis, prostatitis, proctitis, otitis, conjunctivitis, rhinitis, sinusitis, leucoplakia, aphthae, herpes, and infections with Helicoba cter pilori in the oral cavity.
  • the combination can also be used to advantage for the treatment of the oral cavity as an oral deodorant, antiinflammatory, anti-caries and/or anti- plaque agent.
  • Example 1 The inhibitory effect of: H 2 0 2 -producing lactic acid bacteria (Component A) ; arginine-utilizing lactic acid bacteria (Component B) ; and the combination of the two strains, specifically in the ratio 1 : 1 (Combination AB) ; on the growth of potentially pathogenic bacteria was evaluated. Briefly, the culture of lactic acid bacteria to be tested was first adjusted to a neutral pH, because an acidic pH itself inhibits bacterial growth. The suspension was subjected to sterile filtration, and the filtrate was used to impregnate a number of discs of absorbent paper (30 ⁇ l of filtrate per disc) .
  • the discs were placed on a plate of selective growth medium that had been inoculated with 0.1 ml of Gardnerella vaginalis (a strain which causes vaginosis and which was isolated in a laboratory) together with a control disc that was impregnated only with 30 ⁇ l of distilled water. After incubation for 24 h at 37°C, the inhibition of the growth of the pathogens was evaluated by measuring the diameter of the halo around the disc in millimetres.
  • the lactic acid bacteria were obtained from the American Type Culture Collection (ATCC) , Rockville, USA. Bacterial strain Halo of inh ibition
  • Lactobacillus crispatus (ATCC 39197) 75 Lactobacillus salivarius (ATCC 11741; 60 Lactobacillus crispatus + Lactobacillus salivarius 63
  • Lactobacillus brevis (ATCC 14869) 0 Lactobacillus fermentum (ATCC 14931) 2 Lactobacillus brevis + Lactobacillus fermentum 0
  • Lactobacillus crispatus (ATCC 39197) 98 Lactobacillus salivarius (ATCC 11741) 102 Lactobacillus crispatus + Lactobacillus salivarius 99
  • Lactobacillus brevis (ATCC 14869) 0 Lactobacillus fermentum (ATCC 14931) 1 Lactobacillus brevis + Lactobacillus fermentum
  • Example 2 Sucking tablets with the following unit composition were prepared :
  • Lactobacillus brevis, ra tio 1 : 1 Lactobacillus brevis, ra tio 1 : 1 )
  • Example 3 Four subj ects with a clinical and histological diagnosis of recurrent aphthous ulcers were treated for ten days with six sucking tablets a day, whose composition is given in Example 2 .
  • suitable colouring agents and sweeteners such as saccharin, mint oil and xylitol can be added, as is customary and well known to those skilled in the art .
  • the combination AB can be administered in the form of pellets , sweets , chewing gum, gelatin capsules , dental creams and gels , denture powders , mouthwashes, denti frices , tablets , pessaries , suppositories , sprays , suspensions and micro-enemas .
  • Example 4 Preparation of a toothpaste
  • Toothpaste base Percentage composition :
  • the glycerol was added to the calcium phosphate dihydrate, which had been ground and passed through a 50-mesh screen. The mixture was allowed to undergo hydration, giving a dense homogeneous paste. The flavour (1% of peppermint oil) was added at this point .
  • the sodium carboxymethylcellulose was hydrated in water overnight (concentration of 4.6% in purified water) .
  • the polymer gel was poured into a mortar already containing the calcium phosphate that had been hydrated with glycerol, and the components were vigorously mixed.
  • the resulting thick homogeneous paste which had good rheological properties, was mixed for a few minutes and then refined by passing it through a refiner with rollers. This gave a snow-white homogeneous paste with a pleasant mint aroma .
  • Vaginal tablets coated with an effervescent layer were prepared by wet granulation. The tablets weighed 2100 mg each and contained 100 mg of the combination of lactic acid bacteria as the active substance .
  • Each vaginal tablet had the following composition : Lyophilized and screened lactic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
PCT/IT2000/000251 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions WO2000078322A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
KR1020017016367A KR100712286B1 (ko) 1999-06-21 2000-06-16 젖산균 복합제, 및 감염 및 염증 증상의 예방 및/또는치료를 위한 그의 용도
HU0202051A HUP0202051A3 (en) 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions
BRPI0011799A BRPI0011799B1 (pt) 1999-06-21 2000-06-16 composição de bactéria de ácido láctico e seu uso para a prevenção e/ou tratamento de infecções e condições inflamatórias
SK1717-2001A SK17172001A3 (sk) 1999-06-21 2000-06-16 Kompozícia baktérií mliečneho kvasenia a jej použitie na prevenciu a/alebo liečenie infekcií a zápalových stavov
JP2001504385A JP4949580B2 (ja) 1999-06-21 2000-06-16 乳酸菌の配合物並びに感染症および炎症の予防および／または処置のためのその使用
SI200030866T SI1194525T1 (sl) 1999-06-21 2000-06-16 Kombinacija mlecnokislinskih bakterij in njena uporaba za preprecevanje in/ali zdravljenje infekcijin vnetnih stanj
MXPA01013239 MX236443B (es) 1999-06-21 2000-06-16 Combinacion de bacterias de acido lactico y su uso para la prevencion y/o tratamiento de infecciones y condiciones inflamatorias.
IL14688900A IL146889A0 (en) 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions
BRPI0017622A BRPI0017622B1 (pt) 1999-06-21 2000-06-16 composição de bactéria de ácido láctico e uso da combinação de bactéria de ácido láctico para a prevenção e/ou tratamento de infecções e condições inflamatórias
CA2373375A CA2373375C (en) 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions
PL00352805A PL352805A1 (en) 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions
EA200200059A EA006037B1 (ru) 1999-06-21 2000-06-16 Комбинация молочно-кислых бактерий и ее применение для профилактики и/или лечения инфекций и воспалительных состояний
DZ003167A DZ3167A1 (fr) 1999-06-21 2000-06-16 Combinaison de bactéries d'acide lactique et son utilisation pour prevenir et/ou traiter les infections et les états inflammatoires.
AU55660/00A AU775452B2 (en) 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions
NZ516022A NZ516022A (en) 1999-06-21 2000-06-16 Combination of Lactobacillus and their use for the prevention and/or treatment of infections and inflammatory conditions
DE60027894T DE60027894T2 (de) 1999-06-21 2000-06-16 Milchsäurebakterienkombination und deren verwendung zur behandlung und prävention von infektionen und entzündungen
EP00940762A EP1194525B1 (en) 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions
UA2002010459A UA76696C2 (uk) 1999-06-21 2000-06-16 Комбінація молочнокислих бактерій і її застосування для профілактики і/або лікування інфекцій і запальних станів
EEP200100682A EE04620B1 (et) 1999-06-21 2000-06-16 Piimhappebakterite kombinatsioon ning selle kasutamine nakkuste ja/või põletikuliste seisundite ennetamiseks ja/või raviks
IS6177A IS6177A (is) 1999-06-21 2001-11-27 Samsetning af mjólkursýrugerlum og notkun hennar til að fyrirbyggja og/eða meðhöndla sýkingar og bólguástand
IL146889A IL146889A (en) 1999-06-21 2001-12-03 Combination of lactic acid bacteria and its use for the prevention and / or treatment of infections and inflammatory conditions
NO20016291A NO329324B1 (no) 1999-06-21 2001-12-20 Kombinasjon av melkesyrebakterier og anvendelse derav for fremstilling av et næringstilskudd, hygieneprodukt eller et farmasøytisk preparat for forebyggelse og/eller behandling av infeksjoner og inflammatoriske lidelser.
US10/024,199 US7052688B2 (en) 1999-06-21 2001-12-21 Method for prevention and/or treatment of infections and inflammatory conditions using a combination of lactic acid bacteria
HK02108628.1A HK1047132B (zh) 1999-06-21 2002-11-29 乳酸細菌的組合及其用於預防和/或治療感染和炎症的用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM99A000400 1999-06-21
IT1999RM000400A IT1306716B1 (it) 1999-06-21 1999-06-21 Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori.

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/024,199 Continuation US7052688B2 (en) 1999-06-21 2001-12-21 Method for prevention and/or treatment of infections and inflammatory conditions using a combination of lactic acid bacteria

Publications (2)

Publication Number Publication Date
WO2000078322A2 true WO2000078322A2 (en) 2000-12-28
WO2000078322A3 WO2000078322A3 (en) 2001-06-28

Family

ID=11406844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2000/000251 WO2000078322A2 (en) 1999-06-21 2000-06-16 Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions

Country Status (35)

Country Link
US (1) US7052688B2 (uk)
EP (1) EP1194525B1 (uk)
JP (3) JP4949580B2 (uk)
KR (1) KR100712286B1 (uk)
CN (1) CN1227354C (uk)
AR (2) AR024579A1 (uk)
AT (1) ATE325614T1 (uk)
AU (1) AU775452B2 (uk)
BR (2) BRPI0011799B1 (uk)
CA (1) CA2373375C (uk)
CZ (1) CZ298682B6 (uk)
DE (1) DE60027894T2 (uk)
DK (1) DK1194525T3 (uk)
DZ (1) DZ3167A1 (uk)
EA (1) EA006037B1 (uk)
EE (1) EE04620B1 (uk)
ES (1) ES2262522T3 (uk)
HK (1) HK1047132B (uk)
HU (1) HUP0202051A3 (uk)
IL (2) IL146889A0 (uk)
IN (1) IN2001KO01233A (uk)
IS (1) IS6177A (uk)
IT (1) IT1306716B1 (uk)
MA (1) MA25775A1 (uk)
MX (1) MX236443B (uk)
NO (1) NO329324B1 (uk)
NZ (1) NZ516022A (uk)
PL (1) PL352805A1 (uk)
PT (1) PT1194525E (uk)
SI (1) SI1194525T1 (uk)
SK (1) SK17172001A3 (uk)
TR (1) TR200103606T2 (uk)
UA (1) UA76696C2 (uk)
WO (1) WO2000078322A2 (uk)
ZA (1) ZA200200461B (uk)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037862A2 (en) * 1999-11-25 2001-05-31 Vakcina Kft A vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
EP1287745A1 (en) 2001-08-24 2003-03-05 The Procter & Gamble Company Chewable compositions with probiotic agents
WO2003022255A2 (en) * 2001-09-05 2003-03-20 Vsl Pharmaceuticals, Inc. Lactic acid bacteria comprising unmethylated cytosine-guanine dinucleotides for use in therapy
JP2003171292A (ja) * 2001-11-29 2003-06-17 Biofuerumin Seiyaku Kk 歯周病の予防または治療剤
WO2004035072A2 (en) * 2002-10-15 2004-04-29 Actial Farmaceutica, Lda. Identifying and treating vaginal infections
EP1481681A1 (en) * 2003-05-30 2004-12-01 Claudio De Simone Lactic acid bacteria combination and compositions thereof
KR100484480B1 (ko) * 2001-05-04 2005-04-20 정 호 김 표면 막처리된 락토바실러스 퍼멘텀 yl-3 캡슐
WO2006080035A1 (en) * 2004-12-23 2006-08-03 Actial Farmacêutica Lda. Device and method for identifying and treating vaginal affections
WO2007040444A1 (en) * 2005-10-06 2007-04-12 Probi Ab Method, device and computer program product for diagnosing of at least one exhaust emission control unit
WO2007044666A2 (en) * 2005-10-06 2007-04-19 E. I. Du Pont De Nemours And Company Enzymatic production of peracids using lactobacilli having perhydrolysis activity
WO2009021585A1 (en) * 2007-08-13 2009-02-19 Dsm Ip Assets B.V. Probiotic bacteria for rducing the occurence of symptoms of winter infections
EP2315569A1 (en) * 2008-06-13 2011-05-04 Oragenics, Inc. Use of hydrogen peroxide-producing bacteria for tooth whitening
EP1934327B1 (en) * 2005-09-13 2013-01-09 Basf Se Microorganisms inhibiting the formation of axillary malodor
EP2548563A1 (en) * 2010-03-19 2013-01-23 Kitii Co., Ltd. Anti-allergic composition
FR2981273A1 (fr) * 2011-10-14 2013-04-19 Gilles Andre Yves Bhat Nouvelle composition pour les muqueuses: tocopherol, macerat huileux de fleurs de calendula dans de l'huile de rose musquee, palmitate de retinol, ubiquinone, ascorbyl palmitate et lactobacillus
US8506953B2 (en) 2008-06-11 2013-08-13 Basf Se Use and methods for preventing and/or treating oral malodour
RU2494724C2 (ru) * 2012-01-13 2013-10-10 Владимир Николаевич Иванов Зубная паста, содержащая лиофилизированную массу живых бифидобактерий
WO2013155370A1 (en) * 2012-04-13 2013-10-17 The Regents Of The University Of California Sinusitis diagnostics and treatments
EP2740482A4 (en) * 2011-08-05 2015-03-04 Yakult Honsha Kk PROPHYLACTIC OR THERAPEUTIC FOR DISEASES OF THE MOUTH VALVE
CN104694414A (zh) * 2014-11-21 2015-06-10 北京百益恒源科技有限公司 一株詹氏乳酸杆菌(Lactobacillus jensenii)及其制药用途
KR20160030956A (ko) * 2013-07-05 2016-03-21 인테그라 메디컬 인코포레이티드 구강 조성물
RU2584610C2 (ru) * 2010-08-18 2016-05-20 Аб-Биотикс С.А. Пробиотическая композиция для здоровья полости рта
CN109554435A (zh) * 2011-07-21 2019-04-02 生命大地女神有限公司 细菌组胺的产生和应用
EP3517119A1 (en) * 2018-01-26 2019-07-31 Probisearch, S.L.U. Composition comprising new lactobacillus salivarius strain and method for the prevention and treatment of otitis and upper respiratory infections
US10893695B2 (en) 2016-01-19 2021-01-19 Probi Ab Probiotic bacterial strain of Lactobacillus plantarum and compositions and uses thereof in the treatment of inflammation
US11020441B2 (en) 2016-01-19 2021-06-01 Symrise Ag Probiotics for use as anti-inflammatory agents in the oral cavity
US11198848B2 (en) 2016-01-19 2021-12-14 Symrise Ag Probiotics for altering the composition of oral biofilms
EP3798299A4 (en) * 2018-05-23 2022-03-30 Ko Biolabs, Inc. LACTOBACILLUS CRISPATUS KBL693 STRAIN AND USE THEREOF
US11338001B2 (en) 2017-01-18 2022-05-24 Symrise Ag Probiotics for aggregation with disease-associated species in the oral cavity
US12128129B2 (en) 2019-06-26 2024-10-29 Symrise Ag Lactobacillus plantarum for skin care

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8697051B2 (en) * 1999-06-09 2014-04-15 Vsl Pharmaceuticals Inc. Composition comprising alkaline sphingomyelinase for use as a dietetic preparation, food supplement or pharmaceutical product
IT1306716B1 (it) * 1999-06-21 2001-10-02 Mendes S U R L Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori.
JP4603116B2 (ja) * 1999-12-02 2010-12-22 わかもと製薬株式会社 乳酸菌含有組成物、医薬及び食品
SE518097C2 (sv) * 2000-10-03 2002-08-27 Ellen Ab Förfarande för framställning av en absorberande sanitetsartikel som innefattar mjölksyraproducerande bakterier samt sådant alster
KR100458008B1 (ko) * 2002-12-02 2004-11-18 대한민국 가축 생산성 향상 유산균
US6872565B2 (en) * 2003-01-29 2005-03-29 Biogaia Ab Product containing Lactobacillus reuteri strain ATTC PTA-4965 or PTA-4964 for inhibiting bacteria causing dental caries
WO2005000034A2 (en) * 2003-06-23 2005-01-06 Agtech Products, Inc. Lactic bacteria and its use in direct-fed microbials
CA2535764C (en) * 2003-08-11 2012-01-24 Oragenics, Inc. Compositions and methods for the maintenance of oral health
ATE289514T1 (de) * 2003-11-03 2005-03-15 Peter-Hansen Volkmann Vaginalpflegezusammensetzung
US20050158294A1 (en) 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
WO2005085287A1 (en) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
SE528382C2 (sv) * 2004-10-05 2006-10-31 Probi Ab Probiotiska lactobacillusstammar för förbättrad vaginal hälsa
JP4938006B2 (ja) 2005-05-31 2012-05-23 ザ・アイムス・カンパニー ネコ科動物プロバイオティク・ビフィドバクテリア
JP4938005B2 (ja) 2005-05-31 2012-05-23 ザ・アイムス・カンパニー ネコ科動物プロバイオティックであるラクトバシラス
JP5020245B2 (ja) * 2005-09-19 2012-09-05 ビーエーエスエフ ソシエタス・ヨーロピア 足臭の形成を阻害する微生物
CN100556414C (zh) * 2005-10-14 2009-11-04 德阳创新生物工程有限公司 一种具免疫调节功能的多菌组合物及其制备方法与用途
CA2671507A1 (en) * 2006-12-19 2008-06-26 Basf Se Uses and methods for preventing and/or treating caries caused by mutans streptococci
KR20100014523A (ko) * 2007-02-22 2010-02-10 위르겐 슈레첸메이르 인간의 알레르기 반응을 예방, 억제 또는 제거하는 프로바이오틱 그램-양성 박테리아
KR100898491B1 (ko) * 2007-10-10 2009-05-19 주식회사한국야쿠르트 사람의 구강 충치균에 저해능이 있는 스트렙토코커스써머필러스 에이취와이9012 및 이를 이용한 식품
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
KR101100043B1 (ko) 2009-06-29 2011-12-29 주식회사한국야쿠르트 항염증 효능을 갖는 락토바실러스 플란타룸 에이취와이7711 및 이를 유효성분으로 함유하는 제품
WO2011003062A2 (en) * 2009-07-03 2011-01-06 James Madison University Probiotic compositions and processes thereof
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
DE202009011379U1 (de) * 2009-08-24 2010-12-30 Khalifa, Samir Orale Präparate zur Mund- und Zahnpflege und Bekämpfung von Mundgeruch
KR101062779B1 (ko) 2010-04-28 2011-09-06 삼육대학교산학협력단 충치 유발 세균의 성장 억제 활성을 나타내는 비피도박테리움 아돌레센티스 ｓｐｍ1005 균주 및 상기 비피도박테리움 아돌레센티스 ｓｐｍ1005 균주 또는 이의 배양물을 유효 성분으로 하는 충치 예방용 식품 및 약제학 조성물
KR101068079B1 (ko) * 2010-07-12 2011-09-28 삼육대학교산학협력단 단순포진바이러스에 대한 항바이러스 활성을 갖는 비피도박테리움 아돌레센티스 ｓｐｍ 0214 및 상기 비피도박테리움 아돌레센티스 ｓｐｍ 0214 균주 또는 이의 배양물을 유효 성분으로 함유하는 단순 포진 바이러스 감염의 예방 또는 치료용 조성물
WO2013079992A1 (en) * 2011-11-30 2013-06-06 Compagnie Gervais Danone Reuterin-producing lactobacillus brevis
KR101506995B1 (ko) * 2012-05-25 2015-03-30 (주)비타바이오 오리나무 수피 추출물 및 유산균을 포함하는 항우식성 조성물
CN102690768B (zh) * 2012-05-31 2014-07-30 江南大学 一株短乳杆菌及其应用
FR2992973B1 (fr) * 2012-07-09 2015-12-18 S P M D Nouvelle souche de lactobacillus crispatus
CN102727531A (zh) * 2012-07-23 2012-10-17 郑州金森生物科技工程有限公司 一种对阴道炎具有治疗和预防作用的活性乳酸菌胶囊
RU2504580C1 (ru) * 2012-08-01 2014-01-20 Вячеслав Михайлович Абрамов ПРОБИОТИЧЕСКИЕ ШТАММЫ Lactobacillus И ИХ КОНСОРЦИУМ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ УРОГЕНИТАЛЬНЫХ ИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙ У ЖЕНЩИН
WO2014064488A1 (en) * 2012-10-25 2014-05-01 Compagnie Gervais Danone Streptococcus thermophilus strains for treating helicobacter pylori infection
CN103409334B (zh) * 2013-01-16 2018-07-20 生合生物科技股份有限公司 抑制阴道炎病原菌之乳酸杆菌及其用途
CN105007911A (zh) 2013-02-14 2015-10-28 佛罗里达大学研究基金会公司 益生精氨酸分解口服组合物以及制备和使用益生精氨酸分解口服组合物的方法
US10206959B2 (en) 2013-02-14 2019-02-19 University Of Florida Research Foundation, Inc. Probiotic arginolytic oral compositions and methods of making and using probiotic arginolytic oral compositions
ITMI20130794A1 (it) * 2013-05-14 2014-11-15 Probiotical Spa Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle vaginosi batteriche.
JP6121057B2 (ja) 2013-06-27 2017-04-26 スターバックス・コーポレイション 飲料および他の食品のための生物的保存法
CN104957260B (zh) * 2014-03-07 2018-07-24 内蒙古伊利实业集团股份有限公司 具有缓解咽喉部炎症功效的益生菌食品组合物及食品
CN104232537B (zh) * 2014-09-03 2017-04-12 中国科学院微生物研究所 一株弯曲乳杆菌及其应用
CN104293718B (zh) * 2014-10-11 2017-01-18 中国科学院微生物研究所 一株詹氏乳杆菌及其应用
CN104622914A (zh) * 2015-01-06 2015-05-20 占美华 阴道益生菌栓
KR101980252B1 (ko) 2015-05-26 2019-05-21 (주)투라인스 질증 치료용 조성물
RU2619281C2 (ru) * 2015-07-24 2017-05-15 Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт технологии консервирования Способ выработки ферментированного растительного сырья
JP6957452B2 (ja) * 2015-08-25 2021-11-02 イムネバイオテック・メディカル・スウェーデン・エービー 腸の感染症及び炎症の治療及び予防のための組成物及び方法
KR20170032815A (ko) * 2015-09-15 2017-03-23 경희대학교 산학협력단 신규 유산균 및 퇴행성 뇌질환 또는 인지기능의 예방, 개선 또는 치료용 조성물
CN105362296A (zh) * 2015-11-27 2016-03-02 成都吉氧屋科技有限公司 乳酸菌洗鼻液
KR101720145B1 (ko) * 2016-07-08 2017-04-07 (주)정가진면역연구소 여성 질염 예방 및 개선 기능성 조성물
RU2675110C1 (ru) * 2018-04-09 2018-12-17 Федеральное государственное бюджетное учреждение науки Институт общей генетики им. Н.И. Вавилова Российской академии наук (ИОГЕН РАН) Фармацевтическая композиция для терапии воспалительных заболеваний слизистых оболочек кишечника на основе штамма Lactobacillus brevis 47f, проявляющая местную противовоспалительную активность
CA3101175A1 (en) * 2018-05-23 2019-11-28 Ko Biolabs, Inc. Lactobacillus gasseri kbl697 strain and use thereof
CN112236155B (zh) * 2018-05-31 2024-10-18 深圳华大生命科学研究院 一种组合物及其应用
KR102063554B1 (ko) 2018-09-12 2020-01-09 (주)성운파마코피아 항진균 활성 또는 항균 활성을 갖는 락토바실러스 가세리 swpm102
KR102164906B1 (ko) * 2018-09-12 2020-10-14 (주)성운파마코피아 락토바실러스 살리바리우스 swpm101 및 락토바실러스 가세리 swpm102를 포함하는 골질환의 예방, 개선 또는 치료용 조성물
SG11202103567RA (en) * 2018-10-10 2021-05-28 Servatus Ltd Methods of treatment of inflammatory conditions and associated infections
CN111088178B (zh) * 2018-10-23 2022-11-22 上海上药信谊药厂有限公司 一种产乳酸和h2o2的乳杆菌及其应用
EP3952848A1 (en) 2019-04-09 2022-02-16 Dermbiont, Inc. Compositions and methods for improving skin health and for the treatment and prevention of diseases, disorders and conditions associated with pathogenic microbes
KR102364448B1 (ko) * 2019-12-31 2022-02-17 심민보 프로바이오틱스 및 항생제를 포함하는 항염증용 약학적 조성물 및 이를 이용한 방법
KR102162470B1 (ko) * 2020-03-19 2020-10-06 주식회사 비피도 비피도박테리움 슈도카테눌라튬 c-rapo (kctc13986bp), 비피도박테리움 비피덤 att (kctc13474bp) 균주를 포함하는 쇼그렌증후군 억제용 식품 조성물 및 약학 조성물
CN111548970B (zh) * 2020-05-29 2021-03-26 江南大学 一株能够预防和/或治疗幽门螺杆菌感染的卷曲乳杆菌
CN111617025B (zh) * 2020-06-12 2021-01-29 广州市千邦化妆品有限公司 美白祛斑抗糖化的发酵产物化妆品
CN113082149A (zh) * 2021-04-28 2021-07-09 宋颖鹰 植物草本益生菌口腔含片及其制备方法
KR102646766B1 (ko) * 2023-06-14 2024-03-13 일동바이오사이언스(주) 잇몸 질환을 예방하고 구취 생성 억제능을 가지는 비피도박테리움 브레베 idcc 4401 균주를 포함하는 조성물 및 건강기능식품
CN117535209B (zh) * 2024-01-04 2024-03-29 四川厌氧生物科技有限责任公司 左旋短乳杆菌及其在女性生殖道健康中的应用
CN118542885A (zh) * 2024-04-08 2024-08-27 杭州核力欣健实业股份有限公司 一种乳酸菌二联活菌制剂、其制备方法及应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0353581A2 (en) * 1988-08-05 1990-02-07 Dr. A. Tosi Farmaceutici S.R.L. Pharmaceutical compositions comprising selected lactobacillus strains
EP0555618A2 (en) * 1992-02-10 1993-08-18 Renata Maria Anna Cavaliere Vesely Dietetic and/or pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use
US5705160A (en) * 1985-12-31 1998-01-06 Research Corporation Technologies, Inc. Lactobacillus compositions and methods for treating urinary tract infections
WO1999042568A1 (en) * 1998-02-20 1999-08-26 Mendes S.R.L. Use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction and pharmaceutical or dietetic compositions containing such bacteria
EP0956858A1 (en) * 1998-04-30 1999-11-17 Renata Maria Anna Cavaliere Vesely Pharmaceutical compositions containing lactobacilli for treatment of vaginal infections

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6191126A (ja) * 1984-10-09 1986-05-09 Advance Res & Dev Co Ltd 抗歯周症剤
JPS60190707A (ja) * 1984-03-09 1985-09-28 Advance Res & Dev Co Ltd 抗う蝕剤
US5413960A (en) * 1987-05-01 1995-05-09 Biogaia Ab Antibiotic reuterin
US5286478A (en) * 1987-11-04 1994-02-15 Rhone-Poulenc Chimie Dentifrice-compatible silica particulates
RU2031586C1 (ru) * 1993-02-05 1995-03-27 Тамара Георгиевна Извекова Биологически активный кисломолочный продукт "ацидолакт-наринэ" и способ его получения
EP0688169A4 (en) * 1993-03-10 1998-01-28 Commw Scient Ind Res Org BIOCONTROL AGENTS FOR USE IN AGRICULTURE
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
EP0684307B1 (fr) * 1994-05-27 1999-12-15 Agrano Ag Procédé de préparation de milieux de culture utilisables pour la culture individuelle de levures et de bactéries lactiques ou la coculture de levures et de bactéries lactiques.
JP3004890B2 (ja) * 1995-03-28 2000-01-31 雪印乳業株式会社 病原体感染防御剤
JPH08298982A (ja) * 1995-05-02 1996-11-19 Aasu Giken:Kk 複合微生物製剤
WO1997029762A1 (en) * 1996-02-14 1997-08-21 The Procter & Gamble Company Urogenital and intestinal compositions
JP4021951B2 (ja) * 1996-03-01 2007-12-12 わかもと製薬株式会社 乳酸菌を有効成分とする抗胃炎剤、抗潰瘍剤および醗酵食品
IT1283225B1 (it) * 1996-03-11 1998-04-16 Renata Maria Anna Ve Cavaliere Ceppi di batteri, composizione farmaceutica contenente uno o piu' di tali ceppi e uso dei medesimi per la prevenzione e la terapia delle
EP0856259B1 (en) * 1996-12-23 1998-08-12 SITIA-YOMO S.p.A. Composition for feed use comprising lyophilized live lactic bacteria
JP3028214B2 (ja) * 1997-06-03 2000-04-04 カルピス株式会社 鳥類用生菌剤の投与方法
KR100266752B1 (ko) * 1997-08-07 2001-03-02 오종석 인체 구강내 치태형성을 억제하는 신규한 유산균
IT1306716B1 (it) * 1999-06-21 2001-10-02 Mendes S U R L Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705160A (en) * 1985-12-31 1998-01-06 Research Corporation Technologies, Inc. Lactobacillus compositions and methods for treating urinary tract infections
EP0353581A2 (en) * 1988-08-05 1990-02-07 Dr. A. Tosi Farmaceutici S.R.L. Pharmaceutical compositions comprising selected lactobacillus strains
EP0555618A2 (en) * 1992-02-10 1993-08-18 Renata Maria Anna Cavaliere Vesely Dietetic and/or pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use
WO1999042568A1 (en) * 1998-02-20 1999-08-26 Mendes S.R.L. Use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction and pharmaceutical or dietetic compositions containing such bacteria
EP0956858A1 (en) * 1998-04-30 1999-11-17 Renata Maria Anna Cavaliere Vesely Pharmaceutical compositions containing lactobacilli for treatment of vaginal infections

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037862A2 (en) * 1999-11-25 2001-05-31 Vakcina Kft A vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
WO2001037862A3 (en) * 1999-11-25 2001-11-22 Ujhelyi Ottilia Hf A vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
US20160051657A1 (en) * 1999-11-25 2016-02-25 Vakcina Kft Vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
US9056073B2 (en) 1999-11-25 2015-06-16 Vakcina Kft Vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
KR100484480B1 (ko) * 2001-05-04 2005-04-20 정 호 김 표면 막처리된 락토바실러스 퍼멘텀 yl-3 캡슐
EP1287745A1 (en) 2001-08-24 2003-03-05 The Procter & Gamble Company Chewable compositions with probiotic agents
WO2003022255A2 (en) * 2001-09-05 2003-03-20 Vsl Pharmaceuticals, Inc. Lactic acid bacteria comprising unmethylated cytosine-guanine dinucleotides for use in therapy
WO2003022255A3 (en) * 2001-09-05 2003-10-23 Simone Claudio De Lactic acid bacteria comprising unmethylated cytosine-guanine dinucleotides for use in therapy
JP2003171292A (ja) * 2001-11-29 2003-06-17 Biofuerumin Seiyaku Kk 歯周病の予防または治療剤
WO2004035072A2 (en) * 2002-10-15 2004-04-29 Actial Farmaceutica, Lda. Identifying and treating vaginal infections
WO2004035072A3 (en) * 2002-10-15 2004-07-08 Actial Farmaceutica Lda Identifying and treating vaginal infections
EP1481681A1 (en) * 2003-05-30 2004-12-01 Claudio De Simone Lactic acid bacteria combination and compositions thereof
EA012488B1 (ru) * 2004-12-23 2009-10-30 Атьял Фармасеутика Лда. Приспособление и способ для идентификации и лечения вагинальных заболеваний
WO2006080035A1 (en) * 2004-12-23 2006-08-03 Actial Farmacêutica Lda. Device and method for identifying and treating vaginal affections
EP1934327B1 (en) * 2005-09-13 2013-01-09 Basf Se Microorganisms inhibiting the formation of axillary malodor
WO2007040445A1 (en) * 2005-10-06 2007-04-12 Probi Ab Use of lactobacillus for treatment of virus infections
WO2007044666A2 (en) * 2005-10-06 2007-04-19 E. I. Du Pont De Nemours And Company Enzymatic production of peracids using lactobacilli having perhydrolysis activity
WO2007044666A3 (en) * 2005-10-06 2007-06-14 Du Pont Enzymatic production of peracids using lactobacilli having perhydrolysis activity
WO2007040444A1 (en) * 2005-10-06 2007-04-12 Probi Ab Method, device and computer program product for diagnosing of at least one exhaust emission control unit
US8691214B2 (en) 2005-10-06 2014-04-08 Probi Ab Use of Lactobacillus for treatment of virus infections
US8420376B2 (en) 2005-10-06 2013-04-16 Probi Ab Use of Lactobacillus for treatment of virus infections
WO2009021585A1 (en) * 2007-08-13 2009-02-19 Dsm Ip Assets B.V. Probiotic bacteria for rducing the occurence of symptoms of winter infections
US8506953B2 (en) 2008-06-11 2013-08-13 Basf Se Use and methods for preventing and/or treating oral malodour
US11564785B2 (en) 2008-06-13 2023-01-31 ProBiora Health, LLC Hydrogen peroxide-producing bacterial composition
US11096770B2 (en) 2008-06-13 2021-08-24 ProBiora Health, LLC Use of hydrogen peroxide-producing bacteria for tooth whitening
EP2315569A4 (en) * 2008-06-13 2013-10-16 Oragenics Inc USE OF HYDROGEN PEROXIDE PRODUCING BACTERIA FOR LIGHTING THE TEETH
EP2315569A1 (en) * 2008-06-13 2011-05-04 Oragenics, Inc. Use of hydrogen peroxide-producing bacteria for tooth whitening
US9636196B2 (en) 2008-06-13 2017-05-02 ProBiora Health, LLC Use of hydrogen peroxide-producing bacteria for tooth whitening
EP2548563A4 (en) * 2010-03-19 2013-09-04 Kitii Co Ltd ANTIALLERGIC COMPOSITION
EP2548563A1 (en) * 2010-03-19 2013-01-23 Kitii Co., Ltd. Anti-allergic composition
US10052354B2 (en) 2010-03-19 2018-08-21 Kitii Co., Ltd. Anti-allergic composition
RU2584610C2 (ru) * 2010-08-18 2016-05-20 Аб-Биотикс С.А. Пробиотическая композиция для здоровья полости рта
CN109554435A (zh) * 2011-07-21 2019-04-02 生命大地女神有限公司 细菌组胺的产生和应用
EP2740482A4 (en) * 2011-08-05 2015-03-04 Yakult Honsha Kk PROPHYLACTIC OR THERAPEUTIC FOR DISEASES OF THE MOUTH VALVE
AU2012293231B2 (en) * 2011-08-05 2017-04-13 Kabushiki Kaisha Yakult Honsha Prophylactic or therapeutic agent for oral diseases
US9730883B2 (en) 2011-08-05 2017-08-15 Kabushiki Kaisha Yakult Honsha Prophylactic or therapeutic agent for oral diseases
FR2981273A1 (fr) * 2011-10-14 2013-04-19 Gilles Andre Yves Bhat Nouvelle composition pour les muqueuses: tocopherol, macerat huileux de fleurs de calendula dans de l'huile de rose musquee, palmitate de retinol, ubiquinone, ascorbyl palmitate et lactobacillus
RU2494724C2 (ru) * 2012-01-13 2013-10-10 Владимир Николаевич Иванов Зубная паста, содержащая лиофилизированную массу живых бифидобактерий
US10660923B2 (en) 2012-04-13 2020-05-26 The Regents Of The University Of California Sinusitis diagnostics and treatments
WO2013155370A1 (en) * 2012-04-13 2013-10-17 The Regents Of The University Of California Sinusitis diagnostics and treatments
US10857090B2 (en) 2013-07-05 2020-12-08 Stellar Biome Inc. Oral compositions
KR20160030956A (ko) * 2013-07-05 2016-03-21 인테그라 메디컬 인코포레이티드 구강 조성물
EP3016667A4 (en) * 2013-07-05 2017-01-25 Integra Medical Inc. Oral compositions
KR102443570B1 (ko) 2013-07-05 2022-09-14 인테그라 메디컬 인코포레이티드 구강 조성물
CN104694414A (zh) * 2014-11-21 2015-06-10 北京百益恒源科技有限公司 一株詹氏乳酸杆菌(Lactobacillus jensenii)及其制药用途
CN104694414B (zh) * 2014-11-21 2019-05-24 北京百益恒源科技有限公司 一株詹氏乳酸杆菌(Lactobacillus jensenii)及其制药用途
US10893695B2 (en) 2016-01-19 2021-01-19 Probi Ab Probiotic bacterial strain of Lactobacillus plantarum and compositions and uses thereof in the treatment of inflammation
US11020441B2 (en) 2016-01-19 2021-06-01 Symrise Ag Probiotics for use as anti-inflammatory agents in the oral cavity
US11198848B2 (en) 2016-01-19 2021-12-14 Symrise Ag Probiotics for altering the composition of oral biofilms
US11338001B2 (en) 2017-01-18 2022-05-24 Symrise Ag Probiotics for aggregation with disease-associated species in the oral cavity
US11406674B2 (en) 2018-01-26 2022-08-09 Probisearch, S.L.U. Composition comprising new Lactobacillus salivarius strains and method for the prevention and treatment of otitis and upper respiratory infections
EP3517119A1 (en) * 2018-01-26 2019-07-31 Probisearch, S.L.U. Composition comprising new lactobacillus salivarius strain and method for the prevention and treatment of otitis and upper respiratory infections
WO2019145476A1 (en) * 2018-01-26 2019-08-01 Probisearch, S.L.U Composition comprising new lactobacillus salivarius strains and method for the prevention and treatment of otitis and upper respiratory infections
US11903983B2 (en) 2018-01-26 2024-02-20 Probisearch, S.L.U. Composition comprising new Lactobacillus salivarius strains and method for the prevention and treatment of otitis and upper respiratory infections
EP3798299A4 (en) * 2018-05-23 2022-03-30 Ko Biolabs, Inc. LACTOBACILLUS CRISPATUS KBL693 STRAIN AND USE THEREOF
US11633439B2 (en) 2018-05-23 2023-04-25 Kobiolabs, Inc. Lactobacillus crispatus KBL693 strain and use thereof
US12128129B2 (en) 2019-06-26 2024-10-29 Symrise Ag Lactobacillus plantarum for skin care

Also Published As

Publication number Publication date
EP1194525A2 (en) 2002-04-10
IT1306716B1 (it) 2001-10-02
NO20016291L (no) 2002-02-20
NO20016291D0 (no) 2001-12-20
MA25775A1 (fr) 2003-07-01
NO329324B1 (no) 2010-09-27
IL146889A (en) 2009-11-18
ATE325614T1 (de) 2006-06-15
KR20020033643A (ko) 2002-05-07
HK1047132B (zh) 2006-04-13
CA2373375C (en) 2014-01-14
IL146889A0 (en) 2002-08-14
US20020094328A1 (en) 2002-07-18
HK1047132A1 (en) 2003-02-07
MXPA01013239A (es) 2004-06-03
AR086677A2 (es) 2014-01-15
JP2012110334A (ja) 2012-06-14
ES2262522T3 (es) 2006-12-01
JP5969764B2 (ja) 2016-08-17
ITRM990400A0 (it) 1999-06-21
JP6043325B2 (ja) 2016-12-14
HUP0202051A2 (hu) 2003-01-28
EA006037B1 (ru) 2005-08-25
US7052688B2 (en) 2006-05-30
DE60027894T2 (de) 2006-11-16
KR100712286B1 (ko) 2007-04-27
SI1194525T1 (sl) 2006-10-31
DK1194525T3 (da) 2006-09-18
CZ20014220A3 (cs) 2002-04-17
ZA200200461B (en) 2002-09-25
NZ516022A (en) 2003-10-31
CN1357038A (zh) 2002-07-03
EE04620B1 (et) 2006-04-17
PT1194525E (pt) 2006-09-29
EA200200059A1 (ru) 2003-02-27
JP2003502375A (ja) 2003-01-21
CN1227354C (zh) 2005-11-16
DZ3167A1 (fr) 2000-12-28
BRPI0017622B1 (pt) 2016-12-06
JP2015043775A (ja) 2015-03-12
AU5566000A (en) 2001-01-09
MX236443B (es) 2006-05-03
BR0011799A (pt) 2002-03-12
AR024579A1 (es) 2002-10-16
TR200103606T2 (tr) 2002-04-22
AU775452B2 (en) 2004-08-05
CA2373375A1 (en) 2001-11-27
BRPI0011799B1 (pt) 2016-12-20
SK17172001A3 (sk) 2002-05-09
WO2000078322A3 (en) 2001-06-28
UA76696C2 (uk) 2006-09-15
CZ298682B6 (cs) 2007-12-19
EE200100682A (et) 2003-04-15
IN2001KO01233A (uk) 2006-03-17
HUP0202051A3 (en) 2004-07-28
JP4949580B2 (ja) 2012-06-13
ITRM990400A1 (it) 2000-12-21
IS6177A (is) 2001-11-27
PL352805A1 (en) 2003-09-08
EP1194525B1 (en) 2006-05-10
DE60027894D1 (de) 2006-06-14

Similar Documents

Publication Publication Date Title
CA2373375C (en) Combination of lactic acid bacteria and its use for the prevention and/or treatment of infections and inflammatory conditions
JP2003502375A5 (uk)
US9308227B2 (en) Lactic acid bacteria and compositions containing them against bacterial colds
CN109069556B (zh) 用作口腔内抗炎剂的益生菌
Meurman et al. Recovery of Lactobacillus strain GG (ATCC 53103) from saliva of healthy volunteers after consumption of yoghurt prepared with the bacterium
EP1863899B1 (en) Skin treatment compositions
ES2344689T3 (es) Composicion antimicrobiana.
CN108738308B (zh) 新颖的胚芽乳杆菌益生菌菌株和其组合物及其在炎症治疗中的用途
PT2555785E (pt) Utilização de streptococcus salivarius para o tratamento de infeções crónicas do trato respiratório
KR20200032672A (ko) 신규 락토바실러스 프란타룸 균주를 포함하는 구강용 조성물
Bhardwaj Probiotics and oral health
CN118028182B (zh) 一种改善口腔健康的约翰逊氏乳杆菌及其用途
Sonawane et al. Probiotics: The Nano Soldiers for Periodontium

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 00809309.1

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2001/01233/KO

Country of ref document: IN

Ref document number: IN/PCT/2001/01233

Country of ref document: IN

Ref document number: 17172001

Country of ref document: SK

WWE Wipo information: entry into national phase

Ref document number: PV2001-4220

Country of ref document: CZ

ENP Entry into the national phase

Ref document number: 2373375

Country of ref document: CA

Ref document number: 2373375

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: DZP2001000032

Country of ref document: DZ

WWE Wipo information: entry into national phase

Ref document number: 55660/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 516022

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2001/03606

Country of ref document: TR

ENP Entry into the national phase

Ref document number: 2001 504385

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/013239

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2000940762

Country of ref document: EP

Ref document number: 1020017016367

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 10024199

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2002/00461

Country of ref document: ZA

Ref document number: 200200461

Country of ref document: ZA

Ref document number: 200200059

Country of ref document: EA

WWP Wipo information: published in national office

Ref document number: 2000940762

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV2001-4220

Country of ref document: CZ

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 55660/00

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 2000940762

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: PV2001-4220

Country of ref document: CZ