UA74560C2 - Tyrosine kinase inhibitors and a pharmaceutical composition based thereon - Google Patents

Tyrosine kinase inhibitors and a pharmaceutical composition based thereon Download PDF

Info

Publication number
UA74560C2
UA74560C2 UA2002054058A UA2002054058A UA74560C2 UA 74560 C2 UA74560 C2 UA 74560C2 UA 2002054058 A UA2002054058 A UA 2002054058A UA 2002054058 A UA2002054058 A UA 2002054058A UA 74560 C2 UA74560 C2 UA 74560C2
Authority
UA
Ukraine
Prior art keywords
indol
oxo
heterocyclyl
quinolinone
inhibitor
Prior art date
Application number
UA2002054058A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of UA74560C2 publication Critical patent/UA74560C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
UA2002054058A 1999-10-19 2000-10-16 Tyrosine kinase inhibitors and a pharmaceutical composition based thereon UA74560C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16035699P 1999-10-19 1999-10-19
PCT/US2000/028625 WO2001029025A2 (fr) 1999-10-19 2000-10-16 Inhibiteurs de tyrosine kinases

Publications (1)

Publication Number Publication Date
UA74560C2 true UA74560C2 (en) 2006-01-16

Family

ID=22576544

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002054058A UA74560C2 (en) 1999-10-19 2000-10-16 Tyrosine kinase inhibitors and a pharmaceutical composition based thereon

Country Status (40)

Country Link
US (1) US6306874B1 (fr)
EP (1) EP1226136B1 (fr)
JP (2) JP3822494B2 (fr)
KR (1) KR100681724B1 (fr)
CN (1) CN1213045C (fr)
AR (1) AR035626A1 (fr)
AT (1) ATE286045T1 (fr)
AU (1) AU778588B2 (fr)
BG (1) BG65585B1 (fr)
BR (1) BR0014843A (fr)
CA (1) CA2387351C (fr)
CO (1) CO5261601A1 (fr)
CZ (1) CZ20021390A3 (fr)
DE (1) DE60017179T2 (fr)
DZ (1) DZ3223A1 (fr)
EA (1) EA005812B1 (fr)
EE (1) EE05107B1 (fr)
EG (1) EG24381A (fr)
ES (1) ES2234698T3 (fr)
GE (1) GEP20053530B (fr)
HK (1) HK1054931A1 (fr)
HR (1) HRP20020349A2 (fr)
HU (1) HUP0203323A3 (fr)
IL (2) IL148891A0 (fr)
IS (1) IS2165B (fr)
MX (1) MXPA02003887A (fr)
MY (1) MY137656A (fr)
NO (1) NO325696B1 (fr)
NZ (1) NZ518001A (fr)
PE (1) PE20010749A1 (fr)
PL (1) PL202842B1 (fr)
PT (1) PT1226136E (fr)
RS (1) RS50380B (fr)
SA (2) SA06270148B1 (fr)
SK (1) SK286628B6 (fr)
TR (1) TR200201051T2 (fr)
TW (1) TWI239957B (fr)
UA (1) UA74560C2 (fr)
WO (1) WO2001029025A2 (fr)
ZA (1) ZA200202985B (fr)

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354894B2 (en) * 1998-08-18 2008-04-08 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
EP1970058A1 (fr) * 1998-08-18 2008-09-17 The Regents of the University of California Office of Technology Transfer Antagonistes EGF-R pour le traitement de l'hypersécretion de mucus par voie respiratoire
US6846799B1 (en) * 1998-08-18 2005-01-25 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
CN100360505C (zh) 1999-02-10 2008-01-09 阿斯特拉曾尼卡有限公司 中间体化合物、它们在制备喹唑啉衍生物中的用途以及它们的制备方法
JP3822494B2 (ja) * 1999-10-19 2006-09-20 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤
US6403581B1 (en) * 2000-01-19 2002-06-11 American Cyanamid Company Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
US6420382B2 (en) * 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1289952A1 (fr) 2000-05-31 2003-03-12 AstraZeneca AB Derives d'indole possedant une activite endommageant les vaisseaux sanguins
US20020041880A1 (en) * 2000-07-05 2002-04-11 Defeo-Jones Deborah Method of treating cancer
AR030357A1 (es) 2000-08-18 2003-08-20 Lundbeck & Co As H Derivados 4 -, 5 -, 6 - y 7-indol
AU2001293233A1 (en) 2000-09-01 2002-03-13 Chiron Corporation Aza heterocyclic derivatives and their therapeutic use
US20030028018A1 (en) * 2000-09-11 2003-02-06 Chiron Coporation Quinolinone derivatives
DE60115069T2 (de) 2000-09-11 2006-08-03 Chiron Corp., Emeryville Chinolinonderivate als tyrosin-kinase inhibitoren
US6960590B2 (en) * 2000-10-17 2005-11-01 Merck & Co. Inc. Orally active salts with tyrosine kinase activity
US20020198252A1 (en) * 2001-05-24 2002-12-26 Joseph Payack Process for the preparation of alkylamine substituted indoles
EP1406855A4 (fr) * 2001-06-13 2006-04-19 Teva Gyogyszergyar Reszvenytar Nouveau procede pour la preparation de rac-bicalutamide et des produits intermediaires de celui-ci
US7102026B2 (en) * 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
US7642278B2 (en) 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
DE10134196B4 (de) * 2001-07-13 2005-08-18 Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
US6872715B2 (en) * 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
US6927293B2 (en) * 2001-08-30 2005-08-09 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2002323406A1 (en) * 2001-08-30 2003-03-18 Merck And Co., Inc. Tyrosine kinase inhibitors
WO2003024969A1 (fr) * 2001-09-14 2003-03-27 Merck & Co., Inc. Inhibiteurs des tyrosine kinases
AU2002361577A1 (en) * 2001-10-30 2003-05-12 Merck And Co., Inc. Tyrosine kinase inhibitors
PL373848A1 (en) * 2001-12-12 2005-09-19 Pfizer Products Inc. Quinazoline derivatives for the treatment of abnormal cell growth
HUP0402588A3 (en) 2002-02-01 2009-09-28 Astrazeneca Ab Quinazoline derivatives, pharmaceutical compositions containing them, process for producing them and their use
US6822097B1 (en) 2002-02-07 2004-11-23 Amgen, Inc. Compounds and methods of uses
WO2003070248A1 (fr) * 2002-02-22 2003-08-28 The Government Of The United States The Department Of Veterans Affairs Utilisation de 4-(4-methylpiperazine-1-ylmethyl)-n[4-methyl-3-(4-pyridine-3-yl)pyrimidine-2-ylamino)phenyl]-benzamide dans le traitement de seminomes
CA2479257A1 (fr) * 2002-03-21 2003-10-02 Dana-Farber Cancer Institute, Inc. Inhibition de reponses de mort cellulaire induite par stress oxydatif
GB0207362D0 (en) * 2002-03-28 2002-05-08 Univ Liverpool Chemotherapy
JP2005532280A (ja) 2002-04-03 2005-10-27 アストラゼネカ アクチボラグ 化合物
WO2003088900A2 (fr) * 2002-04-16 2003-10-30 Merck & Co., Inc. Formes solides de sels a activite tyrosine kinase
US6770660B2 (en) * 2002-05-06 2004-08-03 Artery Llc Method for inhibiting platelet aggregation
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
EP2573079A3 (fr) * 2002-08-23 2015-03-11 Novartis AG Dérivés de benzimidazoles quinolinones et leurs utilisations
US7825132B2 (en) * 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
US20050256157A1 (en) * 2002-08-23 2005-11-17 Chiron Corporation Combination therapy with CHK1 inhibitors
SG148864A1 (en) * 2002-11-13 2009-01-29 Chiron Corp Methods of treating cancer and related methods
WO2004048366A1 (fr) * 2002-11-22 2004-06-10 Yamanouchi Pharmaceutical Co., Ltd. Derives 2-oxoindoline
CA2519106A1 (fr) * 2003-03-27 2004-10-14 Merck & Co., Inc. Formulations pour inhibiteurs de la tyrosine kinase
WO2004089930A1 (fr) * 2003-04-02 2004-10-21 Imclone Systems Incorporated Derives de 4- fluoroquinolone et leur utilisation comme inhibiteurs de kinase
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
WO2005000833A1 (fr) * 2003-05-19 2005-01-06 Irm, Llc Composes immunosuppresseurs et compositions
US20050054625A1 (en) * 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors
US20050054589A1 (en) * 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics
US20050026893A1 (en) * 2003-05-30 2005-02-03 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants
US20050020557A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors
US7691838B2 (en) * 2003-05-30 2010-04-06 Kosan Biosciences Incorporated Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics
US20050020534A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites
US20050020556A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes
US20070054921A1 (en) * 2003-06-05 2007-03-08 Davies Ian W Substituted indoles and a process for preparing substituted indoles
AU2004263900A1 (en) 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
JP4724665B2 (ja) * 2003-11-07 2011-07-13 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド キノリノン化合物を合成する方法
WO2005054183A2 (fr) * 2003-12-01 2005-06-16 The Scripps Research Institute Inhibiteurs de proteines kinases a base de quinolinone
GB0330002D0 (en) 2003-12-24 2004-01-28 Astrazeneca Ab Quinazoline derivatives
WO2005072766A2 (fr) * 2004-01-27 2005-08-11 Boys Town National Research Hospital Peptides se liant aux proteines hsp90
BRPI0507891A (pt) * 2004-02-20 2007-07-24 Chiron Corp modulação dos processos inflamatório e metastático
US7914771B2 (en) 2004-03-09 2011-03-29 Arriva Pharmaceuticals, Inc. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
EP1737472B1 (fr) 2004-03-29 2014-08-13 University Of South Florida Traitement efficace des tumeurs et du cancer à l'aide de la triciribine
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20110223154A1 (en) * 2008-05-12 2011-09-15 University Of South Florida Compositions including triciribine and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
EP1598348A1 (fr) 2004-05-18 2005-11-23 Aventis Pharma Deutschland GmbH Dérivés de pyridazinone comme inhibiteurs de CDK2
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
CN101035537A (zh) * 2004-10-01 2007-09-12 默克公司 治疗眼部疾病的组合物和方法
KR101387985B1 (ko) * 2005-01-27 2014-04-25 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 전이 종양의 치료
AU2006324144A1 (en) * 2005-01-28 2007-08-02 Merck Sharp & Dohme Corp. Inhibitors of checkpoint kinases
EP1883403A4 (fr) * 2005-04-29 2011-02-16 Univ Ohio State Res Found Inhibiteurs specifiques contre la tyrosine du recepteur du facteur de croissance des keratinocytes utiles pour prevenir les metastases cancereuses
RU2426539C2 (ru) 2005-05-13 2011-08-20 Новартис Аг Способы лечения устойчивого к лекарственным средствам рака
EP1888556B1 (fr) 2005-05-17 2011-10-26 Novartis AG Procede de synthese de composes heterocycliques
EP2270000B1 (fr) * 2005-05-23 2015-07-29 Novartis AG Formes cristallines et autres de sels d'acide lactique 4-amino-5-fluoro-3-[6-(4-méthylpipérazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one
WO2007058482A1 (fr) * 2005-11-16 2007-05-24 Lg Life Sciences, Ltd. Inhibiteurs de la proteine kinase
US8658633B2 (en) * 2006-02-16 2014-02-25 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200812615A (en) * 2006-03-22 2008-03-16 Hoffmann La Roche Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
ATE537450T1 (de) 2006-06-30 2011-12-15 Schering Corp Igfbp2-biomarker
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
EP2088863A2 (fr) 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Inhibiteurs de tyrosine kinase en tant qu'agents anti-kinétolastides et anti-apicomplexes
KR100799821B1 (ko) * 2007-02-05 2008-01-31 동화약품공업주식회사 신규한 이마티닙 캠실레이트 및 그의 제조방법
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
PL2200985T3 (pl) 2007-09-14 2011-12-30 Ortho Mcneil Janssen Pharmaceuticals Inc 1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony
EP2203439B1 (fr) 2007-09-14 2011-01-26 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 4-phényl-3,4,5,6-tétrahydro-2h,1'h-ý1, 4'¨bipyridinyl-2'-ones 1', 3'-disusbstituées
CA2702637A1 (fr) 2007-10-22 2009-04-30 Schering Corporation Anticorps anti-vegf entierement humains et leurs procedes d'utilisation
JP2012501298A (ja) * 2008-05-12 2012-01-19 ユニヴァーシティ オブ サウス フロリダ トリシリビン含有組成物、及びその使用方法
RU2500680C2 (ru) * 2008-06-24 2013-12-10 Ф.Хоффманн-Ля Рош Аг Новые замещенные пиридин-2-оны и пиридазин-3-оны
CA2735764C (fr) 2008-09-02 2016-06-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Derives de 3-azabicyclo[3.1.0]hexyle comme modulateurs des recepteurs metabotropiques du glutamate
AU2009319387B2 (en) 2008-11-28 2012-05-10 Addex Pharma S.A. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US8410144B2 (en) 2009-03-31 2013-04-02 Arqule, Inc. Substituted indolo-pyridinone compounds
TWI410418B (zh) 2009-04-29 2013-10-01 Ind Tech Res Inst 氮雜薁化合物、藥學組合物與抑制一細胞中蛋白質激酶之活性的方法
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
RS53075B (en) 2009-05-12 2014-04-30 Janssen Pharmaceuticals Inc. 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
AU2010246607B2 (en) 2009-05-12 2012-09-27 Addex Pharma S.A. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
CN102822200A (zh) 2009-07-20 2012-12-12 百时美施贵宝公司 对增殖性疾病进行协同性治疗的抗ctla-4抗体与各种治疗方案的组合
WO2011050069A1 (fr) 2009-10-20 2011-04-28 Prometheus Laboratories Inc. Dosages à médiation de proximité pour détecter des protéines de fusion oncogènes
KR100953511B1 (ko) * 2009-12-28 2010-04-21 (주)지노믹트리 건선 진단용 키트 및 칩
WO2011133687A2 (fr) * 2010-04-20 2011-10-27 President And Fellows Of Harvard College Méthodes et compositions inhibant la dégradation des récepteurs β2-adrénergiques
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
WO2012062751A1 (fr) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. Dérivés de 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2
CN103298809B (zh) 2010-11-08 2016-08-31 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
MX344673B (es) 2011-02-17 2017-01-04 Nestec Sa Aparato y método para aislar leucocitos y células tumorales por filtración.
KR102125658B1 (ko) 2012-05-04 2020-06-22 화이자 인코포레이티드 전립선 관련된 항원 및 백신 기재 면역치료 요법
EP2875020B1 (fr) 2012-07-19 2017-09-06 Boehringer Ingelheim International GmbH Procédé de pràparation de une sel d'acide fumarique de la 9-[4-(3-chloro-2-fluoro-phénylamino)-7-méthoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undécan-5-one
CN105142624A (zh) 2013-01-10 2015-12-09 普尔莫凯恩股份有限公司 非选择性激酶抑制剂
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
BR112016002008B1 (pt) 2013-08-02 2021-06-22 Pfizer Inc. Anticorpos anti-cxcr4, seu uso, conjugado anticorpo-fármaco e composição farmacêutica
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
CN106132403B (zh) 2013-10-11 2020-04-28 普尔莫凯恩股份有限公司 喷雾干燥制剂
PT3096790T (pt) 2014-01-21 2019-10-15 Janssen Pharmaceutica Nv Combinações compreendendo moduladores alostéricos positivos ou agonistas ortostéricos do recetor glutamatérgico metabotrópico do subtipo 2 e seu uso
KR20220049612A (ko) 2014-01-21 2022-04-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
US9388239B2 (en) 2014-05-01 2016-07-12 Consejo Nacional De Investigation Cientifica Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B
US10704104B2 (en) 2014-10-20 2020-07-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening a subject for a cancer
JP6864953B2 (ja) 2014-12-09 2021-04-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Axlに対するヒトモノクローナル抗体
WO2016135041A1 (fr) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Protéines de fusion et anticorps les contenant pour favoriser l'apoptose
US20180201687A1 (en) 2015-07-07 2018-07-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to myosin 18a and uses thereof
ES2955775T3 (es) 2015-08-27 2023-12-07 Inst Nat Sante Rech Med Métodos para predecir el tiempo de supervivencia de pacientes que padecen cáncer de pulmón
WO2017055327A1 (fr) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de cellules endothéliales dans un échantillon de tissu
WO2017055322A1 (fr) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de neutrophiles dans un prélèvement de tissu
WO2017055326A1 (fr) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de cellules dendritiques myéloïdes dans un prélèvement de tissu
WO2017055324A1 (fr) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de cellules d'origine monocytaire dans un prélèvement de tissu
CA3013333A1 (fr) 2016-02-26 2017-08-31 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anticorps presentant une specificite pour btla et leurs utilisations
IL263224B2 (en) 2016-05-25 2024-03-01 Inst Nat Sante Rech Med Use of a HISTONE DEACETYLASE inhibitor and a population of activation-free pluripotent cells for cancer treatment
WO2018011166A2 (fr) 2016-07-12 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de cellules dendritiques myéloïdes dans un échantillon de tissu
WO2018020000A1 (fr) 2016-07-29 2018-02-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticorps ciblant les macrophages associés aux tumeurs et leurs utilisations
EP3529262B1 (fr) 2016-10-21 2021-07-21 INSERM - Institut National de la Santé et de la Recherche Médicale Procédés et compositions pharmaceutiques permettant de favoriser la réaction des lymphocytes t
CN110087653A (zh) 2016-10-27 2019-08-02 普尔莫凯恩股份有限公司 用于治疗肺高血压的组合疗法
EP3538140A1 (fr) 2016-11-14 2019-09-18 Institut National de la Sante et de la Recherche Medicale (INSERM) Procédés et compositions pharmaceutiques pour moduler la prolifération ou la différenciation de cellules souches
US11274160B2 (en) 2017-03-02 2022-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale Antibodies having specificity to Nectin-4 and uses thereof
WO2018185516A1 (fr) 2017-04-05 2018-10-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques destinées à traiter une toxicité cardiovasculaire induite par une thérapie anticancéreuse
WO2018189403A1 (fr) 2017-04-14 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques destinées au traitement du cancer
EP3624798A1 (fr) 2017-05-18 2020-03-25 Institut National de la Sante et de la Recherche Medicale (INSERM) Méthodes et compositions pharmaceutiques pour le traitement de maladies mastocytaires
WO2019072885A1 (fr) 2017-10-11 2019-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Nanoparticules magnétiques pour le traitement du cancer
WO2019072888A1 (fr) 2017-10-11 2019-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction de la réponse thérapeutique dans le cancer hépatocellulaire
WO2019099336A1 (fr) 2017-11-14 2019-05-23 Bristol-Myers Squibb Company Composés d'indole substitués
EP3713596A1 (fr) 2017-11-24 2020-09-30 Institut National de la Santé Et de la Recherche Médicale Méthodes et compositions de traitement de cancers
WO2019110750A1 (fr) 2017-12-07 2019-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de dépistage d'un cancer chez un sujet
US12030878B2 (en) 2017-12-15 2024-07-09 Bristol-Myers Squibb Company Substituted indole ether compounds
EP3728221B1 (fr) * 2017-12-19 2022-06-01 Bristol-Myers Squibb Company Composés d'indole à substitution amide utiles en tant qu'inhibiteurs de tlr
AU2018390543A1 (en) 2017-12-19 2020-08-06 Bristol-Myers Squibb Company 6-azaindole compounds
CN111491930B (zh) * 2017-12-19 2023-09-26 百时美施贵宝公司 可用作tlr抑制剂的经取代的吲哚化合物
EA202091480A1 (ru) 2017-12-20 2020-11-06 Бристол-Маерс Сквибб Компани Аминоиндольные соединения, пригодные в качестве ингибиторов tlr
US11420958B2 (en) 2017-12-20 2022-08-23 Bristol-Myers Squibb Company Aryl and heteroaryl substituted indole compounds
EP3728264B1 (fr) 2017-12-20 2021-12-01 Bristol-Myers Squibb Company Composés de diazaindole
WO2019185683A1 (fr) 2018-03-28 2019-10-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement du cancer
US20210164984A1 (en) 2018-04-13 2021-06-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer
WO2019211370A1 (fr) 2018-05-03 2019-11-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement du cancer
WO2019211369A1 (fr) 2018-05-03 2019-11-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement du cancer
US20210213020A1 (en) 2018-05-30 2021-07-15 Inserm (Institut National De La Santé Et De La Rechirche Médicale) Methods and pharmaceutical compositions for treating cancer
WO2019234221A1 (fr) 2018-06-08 2019-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de stratification et de traitement d'un patient souffrant de leucémie lymphoïde chronique
CN112703011A (zh) 2018-08-06 2021-04-23 国家医疗保健研究所 用于治疗癌症的方法和组合物
US20220047701A1 (en) 2018-09-10 2022-02-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of her2/neu antibody with heme for treating cancer
CA3115472A1 (fr) 2018-10-05 2020-04-09 Annapurna Bio, Inc. Composes et compositions destines au traitement d'etats pathologiques associes a une activite du recepteur de l'apj
KR20210080462A (ko) 2018-10-24 2021-06-30 브리스톨-마이어스 스큅 컴퍼니 치환된 인돌 이량체 화합물
US20220098674A1 (en) 2019-02-13 2022-03-31 Inserm (Institut National De La Santé Et Dr La Recherch Médicale) Methods and compositions for selecting a cancer treatment in a subject suffering from cancer
EP3935193A1 (fr) 2019-03-06 2022-01-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé de diagnostic du syndrome cmmrd
WO2020234399A1 (fr) 2019-05-20 2020-11-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Nouveaux anticorps anti-cd25
CA3140017A1 (fr) 2019-07-19 2021-01-28 Aurore HICK Derives d'uree polyaromatiques et leur utilisation dans le traitement de maladies musculaires
EP4007820A1 (fr) 2019-08-02 2022-06-08 Institut National de la Santé et de la Recherche Médicale (INSERM) Procedes de depistage d'un cancer chez un sujet
EP3800201A1 (fr) 2019-10-01 2021-04-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Stimulation cd28h améliorant des activités de destruction de cellules nk
US20230040928A1 (en) 2019-12-09 2023-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to her4 and uses thereof
WO2021228956A1 (fr) 2020-05-12 2021-11-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Nouveau procédé de traitement de lymphomes cutanés à lymphocytes t et de lymphomes dérivés de tfh
WO2022101463A1 (fr) 2020-11-16 2022-05-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Utilisation des derniers résidus de l'extrémité c-terminale m31/41 de l'ectodomaine zikv m pour déclencher la mort cellulaire apoptotique
EP4029501A1 (fr) 2021-01-19 2022-07-20 Anagenesis Biotechnologies Combinaison de dérivés polyaromatiques de l'urée et d'inhibiteur glucocorticoïde ou hdac pour le traitement de maladies ou d'affections associées aux cellules musculaires et/ou aux cellules satellites
US20240318256A1 (en) 2021-01-29 2024-09-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to diagnose msi cancer
US20220389104A1 (en) 2021-05-28 2022-12-08 Ose Immunotherapeutics Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent
WO2024052503A1 (fr) 2022-09-08 2024-03-14 Institut National de la Santé et de la Recherche Médicale Anticorps présentant une spécificité pour ltbp2 et leurs utilisations
WO2024061930A1 (fr) 2022-09-22 2024-03-28 Institut National de la Santé et de la Recherche Médicale Nouveau procédé de traitement et de diagnostic du lymphome périphérique à cellules t (lcpt)
WO2024127053A1 (fr) 2022-12-14 2024-06-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé de prédiction d'une réponse à des inhibiteurs de point de contrôle immunitaire chez un patient atteint d'un cancer du type msi
WO2024161015A1 (fr) 2023-02-03 2024-08-08 Institut National de la Santé et de la Recherche Médicale Méthode de traitement de maladies liées à l'âge

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2102780C (fr) * 1991-05-10 2007-01-09 Alfred P. Spada Composes de type bis-monoaryle, aryle bicyclique et (ou) heteroaryle inhibant l'activite de tyrosine kinase des recepteurs de l'egf et (ou) du pdgf
US5578609A (en) * 1994-03-25 1996-11-26 The Dupont Merck Pharmaceutical Company 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
GB9524104D0 (en) 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
AU3071397A (en) 1996-05-20 1997-12-09 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6413971B1 (en) 1996-11-27 2002-07-02 Pfizer Inc Fused bicyclic pyrimidine derivatives
WO2000009495A1 (fr) 1998-08-11 2000-02-24 Novartis Ag Derives d'isoquinoline possedant une activite d'inhibition de l'angiogenese
JP3822494B2 (ja) * 1999-10-19 2006-09-20 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤

Also Published As

Publication number Publication date
BG65585B1 (bg) 2009-01-30
CA2387351A1 (fr) 2001-04-26
TWI239957B (en) 2005-09-21
CA2387351C (fr) 2009-09-08
NO20021820D0 (no) 2002-04-18
IS2165B (is) 2006-11-15
WO2001029025A3 (fr) 2001-11-01
EG24381A (en) 2009-04-05
CN1409708A (zh) 2003-04-09
CZ20021390A3 (cs) 2002-09-11
JP2006206609A (ja) 2006-08-10
PT1226136E (pt) 2005-04-29
CN1213045C (zh) 2005-08-03
PL354292A1 (en) 2003-12-29
CO5261601A1 (es) 2003-03-31
EA200200473A1 (ru) 2002-10-31
HUP0203323A2 (hu) 2003-02-28
BR0014843A (pt) 2002-06-11
NO20021820L (no) 2002-05-23
RS50380B (sr) 2009-11-10
JP3822494B2 (ja) 2006-09-20
HUP0203323A3 (en) 2004-01-28
TR200201051T2 (tr) 2002-09-23
NO325696B1 (no) 2008-07-07
GEP20053530B (en) 2005-05-25
YU28602A (sh) 2004-12-31
SK6912002A3 (en) 2003-08-05
IL148891A0 (en) 2002-09-12
AU1571001A (en) 2001-04-30
AU778588B2 (en) 2004-12-09
AR035626A1 (es) 2004-06-23
DZ3223A1 (fr) 2001-04-26
US6306874B1 (en) 2001-10-23
EP1226136A2 (fr) 2002-07-31
MXPA02003887A (es) 2002-09-30
JP2003512369A (ja) 2003-04-02
ES2234698T3 (es) 2005-07-01
MY137656A (en) 2009-02-27
EA005812B1 (ru) 2005-06-30
PE20010749A1 (es) 2001-07-16
BG106710A (en) 2003-03-31
IL148891A (en) 2008-12-29
IS6326A (is) 2002-03-27
EE05107B1 (et) 2008-12-15
KR100681724B1 (ko) 2007-02-28
PL202842B1 (pl) 2009-07-31
WO2001029025A2 (fr) 2001-04-26
EP1226136B1 (fr) 2004-12-29
HRP20020349A2 (en) 2004-02-29
DE60017179D1 (de) 2005-02-03
EE200200201A (et) 2003-06-16
SA01220048B1 (ar) 2007-01-23
DE60017179T2 (de) 2006-01-05
ZA200202985B (en) 2003-06-25
KR20020038959A (ko) 2002-05-24
SA06270148B1 (ar) 2007-01-23
SK286628B6 (sk) 2009-02-05
HK1054931A1 (en) 2003-12-19
NZ518001A (en) 2004-05-28
ATE286045T1 (de) 2005-01-15

Similar Documents

Publication Publication Date Title
UA74560C2 (en) Tyrosine kinase inhibitors and a pharmaceutical composition based thereon
US6794393B1 (en) Tyrosine kinase inhibitors
NL1024779C2 (nl) Gecombineerde toediening van een indolinon met een chemotherapeutisch middel voor celproliferatiestoornissen.
EP4107160A1 (fr) Composés macrocycliques et leurs utilisations
CN114761086A (zh) 作为parp7抑制剂的哒嗪酮
UA73976C2 (uk) Заміщені піролом 2-індолінони, фармацевтична композиція, спосіб модуляції каталітичної активності протеїнкінази та спосіб лікування або профілактики захворювання, пов'язаного з протеїнкіназою
KR20190038616A (ko) Tlr7/8 안타고니스트 및 이의 용도
TW201505630A (zh) 用於治療癌症之苯甲酸衍生物mdm2抑制劑
TWI669300B (zh) 嘧啶類衍生物、其製備方法、其藥物組合物以及其在醫藥上的用途
KR20190039583A (ko) 섬유아세포 성장 인자 수용체의 억제제 및 이의 용도
EP3749646B1 (fr) Composés hétéroaryle utilisés en tant qu'inhibiteur de kinase
TW201932473A (zh) 巨環吲哚衍生物
JP2020503321A (ja) キナゾリン化合物並びにその調製方法、使用及び医薬組成物
JP6673932B2 (ja) インドール及びアザインドール誘導体、並びに神経変性疾患におけるそれらの使用
AU2023265886A1 (en) Tetrahydroisoquinoline heterobifunctional bcl-xl degraders
AU2023264537A1 (en) Tetrahydroisoquinoline heterobifunctional bcl-xl degraders