TW275616B - - Google Patents

Info

Publication number
TW275616B
TW275616B TW081106768A TW81106768A TW275616B TW 275616 B TW275616 B TW 275616B TW 081106768 A TW081106768 A TW 081106768A TW 81106768 A TW81106768 A TW 81106768A TW 275616 B TW275616 B TW 275616B
Authority
TW
Taiwan
Prior art keywords
disclosed
novel
compounds
substituted
organisms
Prior art date
Application number
TW081106768A
Other languages
English (en)
Chinese (zh)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW275616(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of TW275616B publication Critical patent/TW275616B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)
  • Moulding By Coating Moulds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
TW081106768A 1991-10-04 1992-08-27 TW275616B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
TW275616B true TW275616B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) 1996-05-11

Family

ID=25092264

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081106768A TW275616B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) 1991-10-04 1992-08-27

Country Status (27)

Country Link
EP (1) EP0536515B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
JP (1) JP3186863B2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
KR (1) KR100269072B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CN (1) CN1048240C (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
AT (1) ATE211128T1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
AU (1) AU654049B2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
BR (1) BR1100853A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CA (1) CA2079692C (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CL (1) CL2004001623A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CZ (2) CZ284159B6 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
DE (4) DE69232302D1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
DK (1) DK0536515T3 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
ES (1) ES2168254T3 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
FI (1) FI114911B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
HU (2) HU219973B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
IL (3) IL119590A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
LU (1) LU91279I2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
MX (1) MX9205532A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
NL (1) NL300244I2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
NO (3) NO301472B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
NZ (1) NZ244585A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
PL (4) PL176333B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
PT (1) PT536515E (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
SG (1) SG52361A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
SK (2) SK284826B6 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
TW (1) TW275616B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
ZA (1) ZA927607B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI453183B (zh) * 2008-08-08 2014-09-21 Tetraphase Pharmaceuticals Inc Ｃ７－氟取代的四環素化合物
US9573895B2 (en) 2012-08-31 2017-02-21 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US9624166B2 (en) 2009-08-28 2017-04-18 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US10961190B2 (en) 2016-10-19 2021-03-30 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5834450A (en) * 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
IL148482A0 (en) 1999-09-14 2002-09-12 Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
ES2288945T3 (es) * 2000-03-31 2008-02-01 Trustees Of Tufts College Compuestos de tetraciclina 7 y 9-carbamato, urea, tiourea, tiocarbamato y heteroaril-amino sustituidos.
WO2001087824A2 (en) * 2000-05-15 2001-11-22 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
CZ303702B6 (cs) * 2000-07-07 2013-03-20 Trustees Of Tufts College Minocyklinové slouceniny
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP2301913A1 (en) 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072506A2 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
DE60235083D1 (de) * 2001-04-24 2010-03-04 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
US20040063674A1 (en) 2001-07-13 2004-04-01 Levy Stuart B. Tetracycline compounds having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
EP1474380A4 (en) 2002-01-08 2007-04-18 Paratek Pharm Innc 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS
EP2316450A1 (en) * 2002-03-08 2011-05-04 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EA200600221A1 (ru) 2003-07-09 2006-06-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
CA2767912C (en) 2004-05-21 2015-08-11 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
US7534766B2 (en) 2004-11-05 2009-05-19 Wyeth Glucuronide metabolites and epimers thereof of tigecycline
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
BRPI0615300A2 (pt) * 2005-08-31 2009-07-14 Wyeth Corp composto; composição farmacêutica; método para a preparação, tratamento ou controle de infecções bacterianas em animais de sangue quente; uso de um composto; e método para a preparação de compostos representados pela fórmula (i)
CA2652346A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
AU2008331163B2 (en) 2007-11-29 2014-01-30 Idorsia Pharmaceuticals Ltd Phosphonic acid derivates and their use as P2Y12 receptor antagonists
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202021946A (zh) 2008-05-19 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CN107021887A (zh) 2009-05-08 2017-08-08 四相制药公司 四环素类化合物
CN102970992B (zh) 2010-05-12 2016-07-06 莱姆派克斯制药公司 四环素组合物
WO2013013504A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 替加环素衍生物
US20160143925A1 (en) 2013-11-12 2016-05-26 Galenicum Health S.L. Stable pharmaceutical compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI453183B (zh) * 2008-08-08 2014-09-21 Tetraphase Pharmaceuticals Inc Ｃ７－氟取代的四環素化合物
TWI508934B (zh) * 2008-08-08 2015-11-21 Tetraphase Pharmaceuticals Inc Ｃ７-氟取代的四環素化合物
TWI585077B (zh) * 2008-08-08 2017-06-01 四相製藥公司 Ｃ７-氟取代的四環素化合物
US9624166B2 (en) 2009-08-28 2017-04-18 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US9573895B2 (en) 2012-08-31 2017-02-21 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US10315992B2 (en) 2012-08-31 2019-06-11 Tetraphase Pharmaceuticals, Inc. Tetracyline compounds
US10913712B2 (en) 2012-08-31 2021-02-09 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US10961190B2 (en) 2016-10-19 2021-03-30 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline
US11578044B2 (en) 2016-10-19 2023-02-14 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline
US12269807B2 (en) 2016-10-19 2025-04-08 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline

Also Published As

Publication number Publication date
PL175957B1 (pl) 1999-03-31
CL2004001623A1 (es) 2005-06-03
HK1011348A1 (en) 1999-07-09
HU211172A9 (en) 1995-11-28
CN1048240C (zh) 2000-01-12
CZ298492A3 (en) 1993-05-12
IL119590A0 (en) 1997-02-18
IL103320A0 (en) 1993-03-15
FI114911B (fi) 2005-01-31
DE122006000058I2 (de) 2007-09-13
ATE211128T1 (de) 2002-01-15
FI924454A0 (fi) 1992-10-02
SK280837B6 (sk) 2000-08-14
IL103320A (en) 1998-12-06
AU654049B2 (en) 1994-10-20
JP3186863B2 (ja) 2001-07-11
PL173311B1 (pl) 1998-02-27
DE69232302T2 (de) 2002-08-14
HUT63145A (en) 1993-07-28
BR1100853A (pt) 1999-12-07
ES2168254T3 (es) 2002-06-16
NO923857D0 (no) 1992-10-02
CA2079692C (en) 2004-06-08
EP0536515A1 (en) 1993-04-14
DK0536515T3 (da) 2002-04-08
PL172282B1 (pl) 1997-08-29
HU9203110D0 (en) 1992-12-28
SK284826B6 (sk) 2005-12-01
CZ309397A3 (cs) 1998-09-16
DE69232302D1 (de) 2002-01-31
AU2618392A (en) 1993-04-08
NO2006015I1 (no) 2006-11-27
SK298492A3 (en) 1995-03-08
PL296143A1 (en) 1993-05-31
CA2079692A1 (en) 1993-04-05
NO2006015I2 (no) 2011-03-14
LU91279I2 (fr) 2006-12-11
NL300244I1 (nl) 2007-01-02
CZ284209B6 (cs) 1998-09-16
NO2017037I1 (no) 2017-08-01
SG52361A1 (en) 1998-09-28
KR100269072B1 (ko) 2000-10-16
KR930007894A (ko) 1993-05-20
MX9205532A (es) 1993-04-01
JPH05255219A (ja) 1993-10-05
DE69232302T4 (de) 2003-02-13
FI924454L (fi) 1993-04-05
DE122006000058I1 (de) 2007-01-18
HU219973B (hu) 2001-10-28
PL176333B1 (pl) 1999-05-31
IL119590A (en) 1999-03-12
PT536515E (pt) 2002-05-31
CZ284159B6 (cs) 1998-08-12
NZ244585A (en) 1995-07-26
CN1072172A (zh) 1993-05-19
SK114999A3 (en) 2000-07-11
EP0536515B1 (en) 2001-12-19
NO923857L (no) 1993-04-05
NO2017037I2 (no) 2017-08-01
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
NO301472B1 (no) 1997-11-03

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