GB699812A
(en)
|
1950-11-29 |
1953-11-18 |
British Ind Solvents Ltd |
Manufacture of substituted pyrimidones
|
DE1249281B
(fr)
|
1963-05-18 |
|
|
|
DE1670912C3
(de)
|
1967-08-18 |
1981-06-11 |
Bayer Ag, 5090 Leverkusen |
Herbizide Mittel auf Basis von 1,2,4-Triazin-5-onen
|
GB1377642A
(en)
|
1971-01-14 |
1974-12-18 |
Koninklijke Gist Spiritus |
Penicillanic and cephalosporanic acid derivatives
|
US3960949A
(en)
|
1971-04-02 |
1976-06-01 |
Schering Aktiengesellschaft |
1,2-Biguanides
|
DE2150686A1
(de)
|
1971-10-12 |
1973-04-19 |
Basf Ag |
6-amino-uracil-5-carbonsaeurethioamide
|
BE792206A
(fr)
|
1971-12-02 |
1973-06-01 |
Byk Gulden Lomberg Chem Fab |
|
AU5996573A
(en)
|
1972-09-11 |
1975-03-06 |
Commonwealth Scientific And Industrial Research Organisation |
Pyridinium salts
|
US3823135A
(en)
|
1972-12-26 |
1974-07-09 |
Shell Oil Co |
Pyrimidone herbicides
|
GB1464248A
(en)
|
1973-11-01 |
1977-02-09 |
Ici Ltd |
Substituted triazinediones their preparation and use as herbicides
|
DE2361551A1
(de)
|
1973-12-11 |
1975-06-19 |
Basf Ag |
Wasserloesliche azofarbstoffe
|
DE2500024A1
(de)
|
1975-01-02 |
1976-07-08 |
Basf Ag |
Wasserloesliche azofarbstoffe
|
JPS535180A
(en)
|
1976-07-01 |
1978-01-18 |
Sumitomo Chem Co Ltd |
Preparation of 3,4-dihydro-2 (1h) quinazoline derivatives
|
DE2720085A1
(de)
|
1977-05-05 |
1978-11-16 |
Hoechst Ag |
Pyrimido(6,1-a)isochinolin-2-on- derivate
|
US4494978A
(en)
|
1976-12-30 |
1985-01-22 |
Chevron Research Company |
Herbicidal N-(N'-hydrocarbyloxycarbamylalkyl)-2,6-dialkyl-alpha-haloacetanilides
|
CH657851A5
(de)
|
1983-06-28 |
1986-09-30 |
Ciba Geigy Ag |
Chromogene chinazolonverbindungen.
|
AR240698A1
(es)
*
|
1985-01-19 |
1990-09-28 |
Takeda Chemical Industries Ltd |
Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
|
US5614492A
(en)
|
1986-05-05 |
1997-03-25 |
The General Hospital Corporation |
Insulinotropic hormone GLP-1 (7-36) and uses thereof
|
DE3856378T2
(de)
*
|
1987-09-04 |
2000-05-11 |
Beecham Group Plc |
Substituierte Thiazolidindionderivate
|
US4935493A
(en)
|
1987-10-06 |
1990-06-19 |
E. I. Du Pont De Nemours And Company |
Protease inhibitors
|
GB8900382D0
(en)
|
1989-01-09 |
1989-03-08 |
Janssen Pharmaceutica Nv |
2-aminopyrimidinone derivatives
|
US5433955A
(en)
|
1989-01-23 |
1995-07-18 |
Akzo N.V. |
Site specific in vivo activation of therapeutic drugs
|
IE63502B1
(en)
|
1989-04-21 |
1995-05-03 |
Zeneca Ltd |
Aminopyrimidine derivatives useful for treating cardiovascular disorders
|
US5366862A
(en)
|
1990-02-14 |
1994-11-22 |
Receptor Laboratories, Inc. |
Method for generating and screening useful peptides
|
US5814460A
(en)
|
1990-02-14 |
1998-09-29 |
Diatide, Inc. |
Method for generating and screening useful peptides
|
EP0442473B1
(fr)
|
1990-02-15 |
1998-08-19 |
Takeda Chemical Industries, Ltd. |
Dérivés de la pyrimidinedione, leur préparation et leur utilisation
|
US5462928A
(en)
|
1990-04-14 |
1995-10-31 |
New England Medical Center Hospitals, Inc. |
Inhibitors of dipeptidyl-aminopeptidase type IV
|
DE4110019C2
(de)
|
1991-03-27 |
2000-04-13 |
Merck Patent Gmbh |
Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
|
US5387512A
(en)
|
1991-06-07 |
1995-02-07 |
Merck & Co. Inc. |
Preparation of 3-[z-benzoxazol-2-yl)ethyl]-5-(1-hydroxyethyl)-6-methyl-2-(1H)-pyridinone by biotransformation
|
WO1993008259A2
(fr)
|
1991-10-22 |
1993-04-29 |
New England Medical Center Hospitals, Inc. |
Inhibiteurs de dipeptidyl-aminopeptidase de type iv
|
US6825169B1
(en)
|
1991-10-22 |
2004-11-30 |
Trustees Of Tufts College |
Inhibitors of dipeptidyl-aminopeptidase type IV
|
US5350752A
(en)
|
1991-12-16 |
1994-09-27 |
E. R. Squibb & Sons, Inc. |
Dihydropyrimidine derivatives
|
DE4141788A1
(de)
|
1991-12-18 |
1993-06-24 |
Merck Patent Gmbh |
Imidazopyridine
|
DE4305602A1
(de)
|
1992-06-17 |
1993-12-23 |
Merck Patent Gmbh |
Imidazopyridine
|
IL106877A
(en)
|
1992-09-10 |
1998-03-10 |
Lilly Co Eli |
Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease
|
IL106998A0
(en)
|
1992-09-17 |
1993-12-28 |
Univ Florida |
Brain-enhanced delivery of neuroactive peptides by sequential metabolism
|
US5811281A
(en)
|
1993-07-12 |
1998-09-22 |
Cornell Research Foundation, Inc. |
Immortalized intestinal epithelial cell lines
|
IL111785A0
(en)
|
1993-12-03 |
1995-01-24 |
Ferring Bv |
Dp-iv inhibitors and pharmaceutical compositions containing them
|
DE4341453A1
(de)
|
1993-12-06 |
1995-06-08 |
Merck Patent Gmbh |
Imidazopyridine
|
ATE202567T1
(de)
|
1994-03-08 |
2001-07-15 |
Otsuka Pharma Co Ltd |
Phosphorsäurediester-derivate
|
US5580979A
(en)
|
1994-03-15 |
1996-12-03 |
Trustees Of Tufts University |
Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
|
US5543396A
(en)
|
1994-04-28 |
1996-08-06 |
Georgia Tech Research Corp. |
Proline phosphonate derivatives
|
WO1995034538A2
(fr)
|
1994-06-10 |
1995-12-21 |
Universitaire Instelling Antwerpen |
Purification de proteases serines, et leurs inhibiteurs synthetiques
|
US5601986A
(en)
|
1994-07-14 |
1997-02-11 |
Amgen Inc. |
Assays and devices for the detection of extrahepatic biliary atresia
|
DE4432860A1
(de)
|
1994-09-15 |
1996-03-21 |
Merck Patent Gmbh |
Imidazopyridine
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
US5614379A
(en)
|
1995-04-26 |
1997-03-25 |
Eli Lilly And Company |
Process for preparing anti-obesity protein
|
JP2002515724A
(ja)
|
1995-06-01 |
2002-05-28 |
ダナ−ファーバー キャンサー インスティテュート インコーポレイテッド |
ヒト血清中に見出されたジペプチジルペプチダーゼiv(cd26)の新規形態、その抗体および利用法
|
US6325989B1
(en)
|
1995-06-01 |
2001-12-04 |
Dana-Farber Cancer Institute, Inc. |
Form of dipeptidylpeptidase IV (CD26) found in human serum
|
ES2157366T3
(es)
|
1995-06-09 |
2001-08-16 |
Hoffmann La Roche |
Derivados de pirimidindiona, pirimidintriona, triacindiona como antagonistas de receptores alfa-1-adrenergicos.
|
JPH0928376A
(ja)
|
1995-07-21 |
1997-02-04 |
Ajinomoto Co Inc |
新規ジペプチジルペプチダーゼivとその製造方法
|
JPH11511137A
(ja)
*
|
1995-08-08 |
1999-09-28 |
ファイブロゲン,インコーポレーテッド |
コラーゲンの過剰生産に関係した疾患を治療するためのc−プロテイナーゼ阻害剤
|
US6492428B1
(en)
*
|
2000-07-26 |
2002-12-10 |
The Picower Institute For Medical Research |
Compounds having MIF antagonist activity
|
US20020006899A1
(en)
|
1998-10-06 |
2002-01-17 |
Pospisilik Andrew J. |
Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
|
DE122010000020I1
(de)
|
1996-04-25 |
2010-07-08 |
Prosidion Ltd |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
US5965532A
(en)
|
1996-06-28 |
1999-10-12 |
Trustees Of Tufts College |
Multivalent compounds for crosslinking receptors and uses thereof
|
KR100579765B1
(ko)
|
1996-07-01 |
2006-12-28 |
닥터 레디스 레보러터리즈 리미티드 |
신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도
|
US5885997A
(en)
|
1996-07-01 |
1999-03-23 |
Dr. Reddy's Research Foundation |
Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
|
US7235627B2
(en)
|
1996-08-30 |
2007-06-26 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
US6006753A
(en)
|
1996-08-30 |
1999-12-28 |
Eli Lilly And Company |
Use of GLP-1 or analogs to abolish catabolic changes after surgery
|
US6458924B2
(en)
|
1996-08-30 |
2002-10-01 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
US6011155A
(en)
|
1996-11-07 |
2000-01-04 |
Novartis Ag |
N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
GB9702701D0
(en)
|
1997-02-01 |
1997-04-02 |
Univ Newcastle Ventures Ltd |
Quinazolinone compounds
|
US20030060434A1
(en)
|
1997-02-18 |
2003-03-27 |
Loretta Nielsen |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
|
US6100234A
(en)
|
1997-05-07 |
2000-08-08 |
Tufts University |
Treatment of HIV
|
CN1227363C
(zh)
|
1997-05-16 |
2005-11-16 |
诺沃奇梅兹生物技术有限公司 |
具有脯氨酰二肽氨肽酶活性的多肽和编码该多肽的核酸
|
EP0897012A1
(fr)
|
1997-07-05 |
1999-02-17 |
Societe Des Produits Nestle S.A. |
Clonage de la prolyl-dipeptidyl-peptidase d'Aspergillus oryzae
|
US6235493B1
(en)
|
1997-08-06 |
2001-05-22 |
The Regents Of The University Of California |
Amino acid substituted-cresyl violet, synthetic fluorogenic substrates for the analysis of agents in individual in vivo cells or tissue
|
US6258597B1
(en)
|
1997-09-29 |
2001-07-10 |
Point Therapeutics, Inc. |
Stimulation of hematopoietic cells in vitro
|
US6485955B1
(en)
|
1997-10-06 |
2002-11-26 |
The Trustees Of Tufts University |
Quiescent cell dipeptidyl peptidase: a novel cytoplasmic serine protease
|
US6342611B1
(en)
|
1997-10-10 |
2002-01-29 |
Cytovia, Inc. |
Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
|
WO1999025719A1
(fr)
|
1997-11-18 |
1999-05-27 |
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai |
Substance physiologiquement active, la sulphostine, procede de fabrication et utilisation
|
FR2771004B1
(fr)
|
1997-11-19 |
2000-02-18 |
Inst Curie |
Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
|
WO1999031226A1
(fr)
|
1997-12-16 |
1999-06-24 |
Novo Nordisk A/S |
Polypeptides a activite aminopeptidase, et acides nucleiques codant ces polypeptides
|
US6380357B2
(en)
|
1997-12-16 |
2002-04-30 |
Eli Lilly And Company |
Glucagon-like peptide-1 crystals
|
WO1999038501A2
(fr)
|
1998-02-02 |
1999-08-05 |
Trustees Of Tufts College |
Procede de regulation du metabolisme du glucose et reactifs afferents
|
US20020061839A1
(en)
|
1998-03-09 |
2002-05-23 |
Scharpe Simon Lodewijk |
Serine peptidase modulators
|
JP2003504301A
(ja)
|
1998-04-01 |
2003-02-04 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
インテグリンアンタゴニスト
|
FR2777283B1
(fr)
|
1998-04-10 |
2000-11-24 |
Adir |
Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
DE19823831A1
(de)
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
EP1084129B1
(fr)
|
1998-06-05 |
2003-01-22 |
Point Therapeutics, Inc. |
Composes cycliques de boroproline
|
DE19828114A1
(de)
|
1998-06-24 |
2000-01-27 |
Probiodrug Ges Fuer Arzneim |
Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
|
DE19828113A1
(de)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
US6129911A
(en)
|
1998-07-10 |
2000-10-10 |
Rhode Island Hospital, A Lifespan Partner |
Liver stem cell
|
DE19834591A1
(de)
|
1998-07-31 |
2000-02-03 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Steigerung des Blutglukosespiegels in Säugern
|
AU776514B2
(en)
|
1998-08-10 |
2004-09-09 |
General Hospital Corporation, The |
Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof
|
WO2000015211A2
(fr)
|
1998-09-17 |
2000-03-23 |
Akesis Pharmaceuticals, Inc. |
Compositions et traitements contre les troubles du metabolisme du glucose
|
US20030176357A1
(en)
|
1998-10-06 |
2003-09-18 |
Pospisilik Andrew J. |
Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
|
CO5150173A1
(es)
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
ES2353728T3
(es)
|
1999-02-10 |
2011-03-04 |
Curis, Inc. |
Péptido yy (pyy) para tratar trastornos metabólicos de la glucosa.
|
GB9906715D0
(en)
|
1999-03-23 |
1999-05-19 |
Ferring Bv |
Compositions for promoting growth
|
GB9906714D0
(en)
|
1999-03-23 |
1999-05-19 |
Ferring Bv |
Compositions for improving fertility
|
WO2000057721A2
(fr)
|
1999-03-26 |
2000-10-05 |
Akesis Pharmaceuticals, Inc. |
Solides comestibles utilises dans le traitement des troubles du metabolisme glucosique
|
US6548529B1
(en)
|
1999-04-05 |
2003-04-15 |
Bristol-Myers Squibb Company |
Heterocyclic containing biphenyl aP2 inhibitors and method
|
EP1171438A1
(fr)
|
1999-04-20 |
2002-01-16 |
Novo Nordisk A/S |
Composes, preparation et utilisation associees
|
EA003922B1
(ru)
|
1999-05-17 |
2003-10-30 |
Конджачем, Инк. |
Продолжительно действующие инсулинотропные пептиды
|
DE19926233C1
(de)
|
1999-06-10 |
2000-10-19 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Herstellung von Thiazolidin
|
US6172081B1
(en)
|
1999-06-24 |
2001-01-09 |
Novartis Ag |
Tetrahydroisoquinoline 3-carboxamide derivatives
|
US6107317A
(en)
|
1999-06-24 |
2000-08-22 |
Novartis Ag |
N-(substituted glycyl)-thiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
US6110949A
(en)
|
1999-06-24 |
2000-08-29 |
Novartis Ag |
N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
US6528486B1
(en)
|
1999-07-12 |
2003-03-04 |
Zealand Pharma A/S |
Peptide agonists of GLP-1 activity
|
US6617340B1
(en)
|
1999-07-29 |
2003-09-09 |
Novartis Ag |
N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
DE19940130A1
(de)
|
1999-08-24 |
2001-03-01 |
Probiodrug Ges Fuer Arzneim |
Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
|
US6559188B1
(en)
|
1999-09-17 |
2003-05-06 |
Novartis Ag |
Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
|
US6414002B1
(en)
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
CA2385918A1
(fr)
|
1999-09-28 |
2001-04-05 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Quinazolinones
|
US6447772B1
(en)
|
1999-10-01 |
2002-09-10 |
Klaire Laboratories, Inc. |
Compositions and methods relating to reduction of symptoms of autism
|
US6251391B1
(en)
|
1999-10-01 |
2001-06-26 |
Klaire Laboratories, Inc. |
Compositions containing dipepitidyl peptidase IV and tyrosinase or phenylalaninase for reducing opioid-related symptons
|
CA2392209A1
(fr)
|
1999-10-08 |
2001-04-19 |
Kazuyuki Fujishima |
Derives d'acide benzoique a substitution m presentant un antagonisme contre l'integrine .alpha.v.beta.3
|
US6261794B1
(en)
|
1999-10-14 |
2001-07-17 |
Saint Louis University |
Methods for identifying inhibitors of methionine aminopeptidases
|
US7230000B1
(en)
|
1999-10-27 |
2007-06-12 |
Cytokinetics, Incorporated |
Methods and compositions utilizing quinazolinones
|
US6358954B1
(en)
*
|
1999-11-09 |
2002-03-19 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same
|
US20040152745A1
(en)
|
1999-11-12 |
2004-08-05 |
Guilford Pharmaceuticals, Inc. |
Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors
|
JP2003535034A
(ja)
|
1999-11-12 |
2003-11-25 |
ギルフォード ファーマシューティカルズ インコーポレイテッド |
ジペプチジルペプチダーゼiv阻害剤並びにジペプチジルペプチダーゼiv阻害剤の製造及び使用法
|
GB9928330D0
(en)
|
1999-11-30 |
2000-01-26 |
Ferring Bv |
Novel antidiabetic agents
|
WO2001041779A2
(fr)
|
1999-12-08 |
2001-06-14 |
1149336 Ontario Inc. |
Traitement relatif a la chimiotherapie
|
US6380398B2
(en)
|
2000-01-04 |
2002-04-30 |
Novo Nordisk A/S |
Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
|
PT1741447E
(pt)
|
2000-01-21 |
2013-12-11 |
Novartis Ag |
Combinações que compreendem o inibidor da dipeptidilpeptidase-iv
|
DK1257577T3
(da)
|
2000-01-27 |
2004-08-02 |
Lilly Co Eli |
Fremgangsmåde til oplösning af glucagon som peptidforbindelse
|
US6569901B2
(en)
|
2000-01-28 |
2003-05-27 |
Novo Nordisk A/S |
Alkynyl-substituted propionic acid derivatives, their preparation and use
|
US7217722B2
(en)
|
2000-02-01 |
2007-05-15 |
Kirin Beer Kabushiki Kaisha |
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
|
JP2003523396A
(ja)
|
2000-02-25 |
2003-08-05 |
ノボ ノルディスク アクティーゼルスカブ |
ベータ細胞変性の抑制
|
US6395767B2
(en)
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
US6448045B1
(en)
|
2000-03-10 |
2002-09-10 |
The Regents Of The University Of California |
Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1
|
US6608038B2
(en)
|
2000-03-15 |
2003-08-19 |
Novartis Ag |
Methods and compositions for treatment of diabetes and related conditions via gene therapy
|
EP1136482A1
(fr)
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
Dérivés de 2-amino-3-(alkyl)-pyrimidone comme inhibiteurs de GSK3bêta
|
US6555519B2
(en)
|
2000-03-30 |
2003-04-29 |
Bristol-Myers Squibb Company |
O-glucosylated benzamide SGLT2 inhibitors and method
|
US6500804B2
(en)
|
2000-03-31 |
2002-12-31 |
Probiodrug Ag |
Method for the improvement of islet signaling in diabetes mellitus and for its prevention
|
US6573096B1
(en)
|
2000-04-01 |
2003-06-03 |
The Research Foundation At State University Of New York |
Compositions and methods for inhibition of cancer invasion and angiogenesis
|
US6545170B2
(en)
|
2000-04-13 |
2003-04-08 |
Pharmacia Corporation |
2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
|
ATE502941T1
(de)
|
2000-04-25 |
2011-04-15 |
Icos Corp |
Hemmer der menschlichen phosphatidyl-inositol-3- kinase delta
|
GB0010188D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
GB0010183D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
US6783757B2
(en)
|
2000-06-01 |
2004-08-31 |
Kirkman Group, Inc. |
Composition and method for increasing exorphin catabolism to treat autism
|
TW583185B
(en)
|
2000-06-13 |
2004-04-11 |
Novartis Ag |
N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
|
US6432969B1
(en)
|
2000-06-13 |
2002-08-13 |
Novartis Ag |
N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
US6627636B2
(en)
|
2000-06-15 |
2003-09-30 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
US6620821B2
(en)
|
2000-06-15 |
2003-09-16 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
GB0014969D0
(en)
|
2000-06-19 |
2000-08-09 |
Smithkline Beecham Plc |
Novel method of treatment
|
US7078397B2
(en)
|
2000-06-19 |
2006-07-18 |
Smithkline Beecham Corporation |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
|
AU2001268958B2
(en)
|
2000-07-04 |
2006-03-09 |
Novo Nordisk A/S |
Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv
|
JP2002042960A
(ja)
|
2000-07-25 |
2002-02-08 |
Yazaki Corp |
コネクタ支持機構
|
JP2004512271A
(ja)
|
2000-08-01 |
2004-04-22 |
ファルマシア・コーポレーション |
誘導型一酸化窒素シンターゼ阻害薬としてのヘキサヒドロ−7−1h−アゼピン−2−イル−ヘキサン酸誘導体
|
ES2311532T3
(es)
|
2000-08-04 |
2009-02-16 |
Warner-Lambert Company Llc |
2-(4-pirdil)amino-6-dialcoxifenil-pirido(2.3-d)pirimidin-7-onas.
|
JP4101053B2
(ja)
|
2000-08-10 |
2008-06-11 |
田辺三菱製薬株式会社 |
プロリン誘導体及びその医薬用途
|
US20020165237A1
(en)
|
2000-08-11 |
2002-11-07 |
Fryburg David Albert |
Treatment of the insulin resistance syndrome
|
US20020037829A1
(en)
|
2000-08-23 |
2002-03-28 |
Aronson Peter S. |
Use of DPPIV inhibitors as diuretic and anti-hypertensive agents
|
US6900226B2
(en)
|
2000-09-06 |
2005-05-31 |
Hoffman-La Roche Inc. |
Neuropeptide Y antagonists
|
CA2423141A1
(fr)
|
2000-09-27 |
2002-04-04 |
Merck & Co., Inc. |
Derives d'acide benzopyrancarboxylique utilises pour le traitement du diabete et des troubles lipidiques
|
US20020064736A1
(en)
|
2000-09-27 |
2002-05-30 |
Fuji Photo Film Co., Ltd. |
Dye-forming coupler, silver halide photographic light-sensitive material, and method for producing an azomethine dye
|
CN1257891C
(zh)
|
2000-10-06 |
2006-05-31 |
田边制药株式会社 |
含氮五员环化合物
|
IL155245A0
(en)
|
2000-10-12 |
2003-11-23 |
Ferring Bv |
Novel serine protease genes related to dppiv
|
IL155116A0
(en)
|
2000-10-27 |
2003-10-31 |
Probiodrug Ag |
Pharmaceutical compositions containing as inhibitor of dipeptidyl peptidase iv and of similar enzymes
|
AUPR107800A0
(en)
|
2000-10-27 |
2000-11-23 |
University Of Sydney, The |
Peptide and nucleic acid molecule ii
|
US6686337B2
(en)
|
2000-10-30 |
2004-02-03 |
Ortho-Mcneil Pharmaceutical, Inc. |
Combination therapy comprising anti-diabetic and anticonvulsant agents
|
AU2002246568A1
(en)
|
2000-10-31 |
2002-08-06 |
Vanderbilt University |
Biological markers and diagnostic tests for angiotensin converting enzyme inhibitor- and vasopeptidase inhibitor-associated angioedema
|
AU2002248221B2
(en)
|
2000-10-31 |
2006-08-17 |
Merck & Co., Inc. |
Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
|
WO2002038742A2
(fr)
|
2000-11-08 |
2002-05-16 |
The University Of Georgia Research Foundation, Inc. |
Dipeptidylpeptidases et leurs procedes d'utilisation
|
US20030055052A1
(en)
|
2000-11-10 |
2003-03-20 |
Stefan Peters |
FAP-activated anti-tumor compounds
|
TWI243162B
(en)
|
2000-11-10 |
2005-11-11 |
Taisho Pharmaceutical Co Ltd |
Cyanopyrrolidine derivatives
|
US20020155565A1
(en)
|
2000-11-10 |
2002-10-24 |
Pilar Garin-Chesa |
FAP-activated anti-tumor compounds
|
US20030203946A1
(en)
|
2000-11-17 |
2003-10-30 |
Carsten Behrens |
Glucagon antagonists/inverse agonists
|
AU2002237664A1
(en)
|
2000-11-20 |
2002-05-27 |
Bristol-Myers Squibb Company |
Pyridone derivatives as AP2 inhibitors
|
MXPA03005152A
(es)
|
2000-12-11 |
2004-10-14 |
Tularik Inc |
Antogonista de cxcr3.
|
JPWO2002051836A1
(ja)
|
2000-12-27 |
2004-04-22 |
協和醗酵工業株式会社 |
ジペプチジルペプチダーゼ−iv阻害剤
|
US7229969B2
(en)
|
2001-01-02 |
2007-06-12 |
Imtm Gmbh |
Combinations of enzyme inhibitors and the use thereof
|
DE10100053A1
(de)
|
2001-01-02 |
2002-08-22 |
Keyneurotek Ag I G |
Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
|
DE60221098T2
(de)
|
2001-02-02 |
2008-01-24 |
Takeda Pharmaceutical Co. Ltd. |
Kondensierte heterocyclische derivate
|
TWI255817B
(en)
|
2001-02-14 |
2006-06-01 |
Kissei Pharmaceutical |
Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
|
KR100883277B1
(ko)
|
2001-02-24 |
2009-02-12 |
베링거 잉겔하임 파르마 게엠베하 운트 코 카게 |
크산틴 유도체 및 이의 제조방법
|
US6337069B1
(en)
|
2001-02-28 |
2002-01-08 |
B.M.R.A. Corporation B.V. |
Method of treating rhinitis or sinusitis by intranasally administering a peptidase
|
JP4178816B2
(ja)
|
2001-03-15 |
2008-11-12 |
田辺三菱製薬株式会社 |
医薬組成物
|
DK1372650T3
(da)
|
2001-03-19 |
2009-03-16 |
Novartis Ag |
Kombinationer indeholdende et antidiarrémiddel og en epothilon eller et epothilonderivat
|
US7026316B2
(en)
|
2001-03-27 |
2006-04-11 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
FR2822826B1
(fr)
|
2001-03-28 |
2003-05-09 |
Servier Lab |
Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
DE10115921A1
(de)
|
2001-03-30 |
2002-10-02 |
Boehringer Ingelheim Pharma |
Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
|
US6890905B2
(en)
|
2001-04-02 |
2005-05-10 |
Prosidion Limited |
Methods for improving islet signaling in diabetes mellitus and for its prevention
|
GB0109146D0
(en)
|
2001-04-11 |
2001-05-30 |
Ferring Bv |
Treatment of type 2 diabetes
|
PE20021080A1
(es)
|
2001-04-12 |
2003-02-12 |
Boehringer Ingelheim Int |
Un anticuerpo especifico fapo bibh1 en el tratamiento del cancer
|
US6573287B2
(en)
|
2001-04-12 |
2003-06-03 |
Bristo-Myers Squibb Company |
2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
|
FR2824825B1
(fr)
|
2001-05-15 |
2005-05-06 |
Servier Lab |
Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
US20030060494A1
(en)
|
2001-05-18 |
2003-03-27 |
Nobuyuki Yasuda |
Pharmaceutical use of N-carbamoylazole derivatives
|
IL143366A0
(en)
|
2001-05-24 |
2002-04-21 |
Harasit Medical Res Services & |
Treatment of renal fibrosis
|
US7105556B2
(en)
|
2001-05-30 |
2006-09-12 |
Bristol-Myers Squibb Company |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
|
US6794379B2
(en)
|
2001-06-06 |
2004-09-21 |
Tularik Inc. |
CXCR3 antagonists
|
US7253172B2
(en)
|
2001-06-20 |
2007-08-07 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
EP1406872B1
(fr)
|
2001-06-20 |
2007-12-19 |
Merck & Co., Inc. |
Inhibiteurs de dipeptidyle peptidase pour le traitement du diabete
|
GB0115517D0
(en)
|
2001-06-25 |
2001-08-15 |
Ferring Bv |
Novel antidiabetic agents
|
US7368421B2
(en)
|
2001-06-27 |
2008-05-06 |
Probiodrug Ag |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
|
ATE374181T1
(de)
|
2001-06-27 |
2007-10-15 |
Smithkline Beecham Corp |
Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren
|
DE60224879D1
(de)
|
2001-06-27 |
2008-03-20 |
Probiodrug Ag |
Verwendung von dpiv-inhibitoren als therapeutika für krankhafte neurologische zustände
|
DE10150203A1
(de)
|
2001-10-12 |
2003-04-17 |
Probiodrug Ag |
Peptidylketone als Inhibitoren der DPIV
|
AU2002316437A1
(en)
|
2001-06-27 |
2003-03-03 |
Smithkline Beecham Corporation |
Pyrrolidines as dipeptidyl peptidase inhibitors
|
DE10154689A1
(de)
|
2001-11-09 |
2003-05-22 |
Probiodrug Ag |
Substituierte Aminoketonverbindungen
|
EP1399433B1
(fr)
|
2001-06-27 |
2007-08-22 |
Smithkline Beecham Corporation |
Fluoropyrrolidines inhibitrices de la dipeptidyl peptidase
|
US20030135023A1
(en)
|
2001-06-27 |
2003-07-17 |
Hans-Ulrich Demuth |
Peptide structures useful for competitive modulation of dipeptidyl peptidase IV catalysis
|
US20030130199A1
(en)
|
2001-06-27 |
2003-07-10 |
Von Hoersten Stephan |
Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
|
US6869947B2
(en)
|
2001-07-03 |
2005-03-22 |
Novo Nordisk A/S |
Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
|
UA74912C2
(en)
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
US20030144350A1
(en)
|
2001-07-20 |
2003-07-31 |
Adipogenix, Inc. |
Fat accumulation-modulation compounds
|
AU2002330672A1
(en)
|
2001-07-25 |
2003-02-17 |
Genset S.A. |
Gmg-1 polynucleotides and polypeptides and uses thereof
|
JP2005502332A
(ja)
|
2001-07-26 |
2005-01-27 |
ジェンセット ソシエテ アノニム |
Gmg−2ポリヌクレオチド及びポリペプチド並びにそれらの使用
|
AU2002317599B2
(en)
|
2001-07-31 |
2008-04-03 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
GLP-1 exendin-4 peptide analogs and uses thereof
|
US20040002468A1
(en)
|
2001-08-08 |
2004-01-01 |
Genzyme Corporation |
Methods of treating diabetes and other blood sugar disorders
|
AU2002328946A1
(en)
|
2001-08-13 |
2003-03-03 |
Probiodrug Ag |
Irreversible cysteine protease inhibitors of legumain
|
EP1285922A1
(fr)
*
|
2001-08-13 |
2003-02-26 |
Warner-Lambert Company |
1-alkyl ou 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones comme inhibiteurs de phosphodiestérase
|
JP2003128551A
(ja)
|
2001-08-15 |
2003-05-08 |
Sankyo Co Ltd |
新規抗糖尿病医薬組成物
|
DE10143840A1
(de)
|
2001-09-06 |
2003-03-27 |
Probiodrug Ag |
Neue Inhibitoren der Dipeptidylpeptidase I
|
US6844316B2
(en)
|
2001-09-06 |
2005-01-18 |
Probiodrug Ag |
Inhibitors of dipeptidyl peptidase I
|
US6673829B2
(en)
|
2001-09-14 |
2004-01-06 |
Novo Nordisk A/S |
Aminoazetidine,-pyrrolidine and -piperidine derivatives
|
WO2003024942A1
(fr)
|
2001-09-14 |
2003-03-27 |
Mitsubishi Pharma Corporation |
Derive thiazolidine et son utilisation medicamenteuse
|
US20030186963A1
(en)
|
2001-09-14 |
2003-10-02 |
Dorwald Florencio Zaragoza |
Substituted piperidines
|
JP2005509603A
(ja)
|
2001-09-19 |
2005-04-14 |
ノボ ノルディスク アクティーゼルスカブ |
Dpp−iv酵素の阻害剤であるヘテロ環化合物
|
AU2002341693B2
(en)
|
2001-09-21 |
2008-05-29 |
Bristol-Myers Squibb Holdings Ireland Unlimited Company |
Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
|
KR100881821B1
(ko)
|
2001-09-21 |
2009-02-03 |
미쓰비시 타나베 파마 코퍼레이션 |
3-치환-4-피리미돈 유도체
|
BR0212893A
(pt)
|
2001-09-21 |
2004-08-03 |
Mitsubishi Pharma Corp |
Derivados de 4-pirimidona-3-substituìdo
|
US7019010B2
(en)
|
2001-09-27 |
2006-03-28 |
Novertis Ag |
Combinations
|
ATE447565T1
(de)
|
2001-10-01 |
2009-11-15 |
Bristol Myers Squibb Co |
Spiro-hydantoin-verbindungen, die sich als entzündungshemmende mittel eignen
|
WO2003030946A1
(fr)
|
2001-10-09 |
2003-04-17 |
Novartis Ag |
Regulation de la production d'insuline
|
US7064135B2
(en)
|
2001-10-12 |
2006-06-20 |
Novo Nordisk Inc. |
Substituted piperidines
|
CN1630709A
(zh)
|
2001-10-18 |
2005-06-22 |
百时美施贵宝公司 |
人胰高血糖素样多肽-1模拟物和它们在治疗糖尿病和相关状况中的应用
|
TWI301834B
(en)
|
2001-10-22 |
2008-10-11 |
Eisai R&D Man Co Ltd |
Pyrimidone compound and pharmaceutical composition including the same
|
GB0125445D0
(en)
|
2001-10-23 |
2001-12-12 |
Ferring Bv |
Protease Inhibitors
|
US6861440B2
(en)
|
2001-10-26 |
2005-03-01 |
Hoffmann-La Roche Inc. |
DPP IV inhibitors
|
WO2003040114A1
(fr)
|
2001-11-06 |
2003-05-15 |
Bristol-Myers Squibb Company |
Derives d'acides substitues en tant qu'agents de lutte contre le diabete et contre l'obesite, et procede associe
|
US20030125304A1
(en)
|
2001-11-09 |
2003-07-03 |
Hans-Ulrich Demuth |
Substituted amino ketone compounds
|
US20030089935A1
(en)
|
2001-11-13 |
2003-05-15 |
Macronix International Co., Ltd. |
Non-volatile semiconductor memory device with multi-layer gate insulating structure
|
AU2002360453C1
(en)
|
2001-11-26 |
2009-06-18 |
The Brigham And Women's Hospital, Inc. |
Methods for treating autoimmune disorders, and reagents related thereto
|
CA2467857C
(fr)
|
2001-11-26 |
2010-08-24 |
Duane A. Burnett |
Antagonistes de la mch a base de piperidine pour le traitement de l'obesite et des troubles lies au systeme nerveux central (cns)
|
EP2316470A3
(fr)
|
2001-11-26 |
2011-08-24 |
Trustees Of Tufts College |
Inhibiteurs peptidomimétiques d'enzymes de clivage post-proline
|
WO2003048081A2
(fr)
|
2001-12-04 |
2003-06-12 |
Bristol-Myers Squibb Company |
Glycinamides en tant qu'inhibiteurs du facteur xa
|
GB0129988D0
(en)
|
2001-12-14 |
2002-02-06 |
Ferring Bv |
Imidazolidineacetic acid derivatives
|
EP1458374A2
(fr)
|
2001-12-14 |
2004-09-22 |
Novo Nordisk A/S |
Composes ralentissant l'activite de la lipase hormono-sensible
|
SE0104340D0
(sv)
|
2001-12-20 |
2001-12-20 |
Astrazeneca Ab |
New compounds
|
TW200301698A
(en)
|
2001-12-21 |
2003-07-16 |
Bristol Myers Squibb Co |
Acridone inhibitors of IMPDH enzyme
|
JP2005518391A
(ja)
|
2001-12-21 |
2005-06-23 |
ノボ ノルディスク アクティーゼルスカブ |
Gk活性化剤としてのアミド誘導体
|
WO2003057144A2
(fr)
|
2001-12-26 |
2003-07-17 |
Guilford Pharmaceuticals |
Changement d'inhibiteurs de la dipeptidyl peptidase iv
|
US6727261B2
(en)
|
2001-12-27 |
2004-04-27 |
Hoffman-La Roche Inc. |
Pyrido[2,1-A]Isoquinoline derivatives
|
EP1790353A1
(fr)
|
2001-12-29 |
2007-05-30 |
Novo Nordisk A/S |
Utilisation combinée d'un composé GLP-1 et d'un modulateur de complications diabétiques tardives
|
WO2003057200A2
(fr)
|
2002-01-11 |
2003-07-17 |
Novo Nordisk A/S |
Methode et composition permettant de traiter le diabete, l'hypertension, l'insuffisance cardiaque chronique et les troubles de retention de fluide
|
DE60317631T2
(de)
|
2002-02-01 |
2008-09-25 |
Merck & Co., Inc. |
11-beta-hydroxysteroid-dehydrogenase-1-hemmer zur behandlung von diabetes, adipositas und dyslipidämie
|
WO2003063903A2
(fr)
|
2002-02-01 |
2003-08-07 |
Probiodrug Ag |
Modulation des lymphocytes t au moyen d'inhibiteurs de la dp iv
|
US7101898B2
(en)
|
2002-02-01 |
2006-09-05 |
Novo Nordisk A/S |
Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
|
AU2003206833B2
(en)
|
2002-02-13 |
2006-07-20 |
F. Hoffmann-La Roche Ag |
Novel pyridin- and pyrimidin-derivatives
|
WO2003068748A1
(fr)
|
2002-02-13 |
2003-08-21 |
F. Hoffmann-La Roche Ag |
Nouveaux derives de pyridine et de quinoline
|
DE60301491T2
(de)
|
2002-02-27 |
2006-05-18 |
Pfizer Products Inc., Groton |
Acc-hemmer
|
PL372316A1
(en)
|
2002-02-28 |
2005-07-11 |
Prosidion Limited |
Glutaminyl based dpiv inhibitors
|
HUP0200849A2
(hu)
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
DE60336901D1
(de)
|
2002-03-07 |
2011-06-09 |
X Ceptor Therapeutics Inc |
Chinazolinon modulatoren von nukleinrezeptoren
|
AR039090A1
(es)
|
2002-03-22 |
2005-02-09 |
Novartis Ag |
Combinacion de compuestos organicos
|
EP1490335B1
(fr)
|
2002-03-25 |
2007-09-19 |
Merck & Co., Inc. |
Inhibiteurs de la dipeptidyl peptidase beta-amino heterocycliques pour le traitement ou la prevention du diabete
|
US20030232761A1
(en)
|
2002-03-28 |
2003-12-18 |
Hinke Simon A. |
Novel analogues of glucose-dependent insulinotropic polypeptide
|
RU2004132719A
(ru)
|
2002-04-08 |
2005-08-27 |
Торрент Фармасьютикалз Лтд. (In) |
Тиазолидин-4-карбонитрилы и их аналоги, применение указанных соединений в качестве ингибиторов дипептидилпептидаз
|
US20040106802A1
(en)
|
2002-04-08 |
2004-06-03 |
Torrent Pharmaceuticals Ltd. |
Novel compounds and therapeutic uses thereof
|
JP2003300977A
(ja)
|
2002-04-10 |
2003-10-21 |
Sumitomo Pharmaceut Co Ltd |
キサンチン誘導体
|
WO2003092605A2
(fr)
|
2002-04-30 |
2003-11-13 |
Trustees Of Tufts College |
Inhibiteurs de protease
|
TW200307667A
(en)
|
2002-05-06 |
2003-12-16 |
Bristol Myers Squibb Co |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
|
US7057046B2
(en)
|
2002-05-20 |
2006-06-06 |
Bristol-Myers Squibb Company |
Lactam glycogen phosphorylase inhibitors and method of use
|
ATE478867T1
(de)
|
2002-05-23 |
2010-09-15 |
Novartis Vaccines & Diagnostic |
Substituierte quinazolinone verbindungen
|
GB0212412D0
(en)
|
2002-05-29 |
2002-07-10 |
Novartis Ag |
Combination of organic compounds
|
US6710040B1
(en)
|
2002-06-04 |
2004-03-23 |
Pfizer Inc. |
Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
|
WO2003101449A2
(fr)
|
2002-06-04 |
2003-12-11 |
Pfizer Products Inc. |
Synthese de 3,3,4,4-tetrafluoropyrrolidine et nouvel inhibiteur de dipeptidyl peptidase-iv
|
CA2487636A1
(fr)
|
2002-06-04 |
2003-12-11 |
Janice Catherine Parker |
Amides cycliques fluores utilises comme inhibiteurs de la dipeptidyl peptidase iv
|
WO2003104229A1
(fr)
|
2002-06-06 |
2003-12-18 |
エーザイ株式会社 |
Nouveau derive d'imidazole fondu
|
AR040241A1
(es)
|
2002-06-10 |
2005-03-23 |
Merck & Co Inc |
Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
|
HUP0202001A2
(hu)
|
2002-06-14 |
2005-08-29 |
Sanofi-Aventis |
DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
|
US20040009972A1
(en)
|
2002-06-17 |
2004-01-15 |
Ding Charles Z. |
Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase
|
WO2003106416A2
(fr)
|
2002-06-17 |
2003-12-24 |
Smithkline Beecham Corporation |
Processus chimique
|
SE0201976D0
(sv)
*
|
2002-06-24 |
2002-06-24 |
Astrazeneca Ab |
Novel compounds
|
US20040006004A1
(en)
|
2002-06-27 |
2004-01-08 |
Markku Koulu |
Method for prevention and treatment of diseases or disorders related to excessive formation of vascular tissue or blood vessels
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
US20040054171A1
(en)
|
2002-07-04 |
2004-03-18 |
Jensen Anette Frost |
Polymorphic forms of a 4H-thieno[3,2-E]-1,2,4-thiadiazine 1,1-dioxide derivative
|
EP1656368A4
(fr)
|
2002-07-09 |
2009-08-26 |
Bristol Myers Squibb Co |
Derives heterocycliqes substitues utiles comme agents antidiabetique et antiabesite et leur procede de fabrication
|
JP2006507352A
(ja)
|
2002-07-09 |
2006-03-02 |
ポイント セラピューティクス, インコーポレイテッド |
イソロイシンのボロプロリン化合物に関する方法および組成物
|
WO2004004655A2
(fr)
|
2002-07-09 |
2004-01-15 |
Bristol-Myers Squibb Company |
Derives heterocycliques substitues utiles comme agents antidiabetique et anti-obesite et procede correspondant
|
DE60322224D1
(de)
|
2002-08-08 |
2008-08-28 |
Takeda Pharmaceutical |
Kondensierte heterozyklische verbindungen als petidase inhibitoren
|
DK1528931T3
(da)
|
2002-08-09 |
2008-09-08 |
Prosidion Ltd |
Dipeptidylpeptidase-IV-inhibitorer til reduktion af hastigheden af kronisk vægtforögelse
|
PL216134B1
(pl)
|
2002-08-21 |
2014-03-31 |
Boehringer Ingelheim Pharma |
8-[3-aminopiperydyn-1-ylo]-ksantyny, kompozycja farmaceutyczna je zawierająca, zastosowanie związków oraz sposób ich wytwarzania
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
DE10238470A1
(de)
|
2002-08-22 |
2004-03-04 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
|
US7495005B2
(en)
|
2002-08-22 |
2009-02-24 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, their preparation and their use in pharmaceutical compositions
|
US6998502B1
(en)
*
|
2002-09-05 |
2006-02-14 |
Sabinsa Corporation |
Convenient process of manufacture for difluoromethylornithine and related compounds
|
EP1398032A1
(fr)
|
2002-09-10 |
2004-03-17 |
PheneX Pharmaceuticals AG |
4-oxoquinazolines se liant au récepteur nucléair LXR
|
JP2004123738A
(ja)
|
2002-09-11 |
2004-04-22 |
Takeda Chem Ind Ltd |
徐放性製剤
|
DE60331747D1
(de)
|
2002-09-18 |
2010-04-29 |
Prosidion Ltd |
Sekundäre bindungsstelle von dipeptidylpeptidase iv (dp iv)
|
US20040058876A1
(en)
|
2002-09-18 |
2004-03-25 |
Torsten Hoffmann |
Secondary binding site of dipeptidyl peptidase IV (DP IV)
|
CA2497725C
(fr)
|
2002-09-19 |
2012-04-10 |
Abbott Laboratories |
Compositions pharmaceutiques utiles comme inhibiteurs de la peptidase-iv dipeptidyl (dpp-iv)
|
US7262207B2
(en)
|
2002-09-19 |
2007-08-28 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
US6869966B2
(en)
|
2002-09-30 |
2005-03-22 |
Banyu Pharmaceutical Co., Ltd. |
N-substituted-2-oxodihydropyridine derivatives
|
JP4491346B2
(ja)
|
2002-10-07 |
2010-06-30 |
メルク・シャープ・エンド・ドーム・コーポレイション |
抗糖尿病ベータアミノ複素環ジペプチジルペプチダーゼ阻害剤
|
AU2003269850A1
(en)
|
2002-10-08 |
2004-05-04 |
Novo Nordisk A/S |
Hemisuccinate salts of heterocyclic dpp-iv inhibitors
|
AU2003282510A1
(en)
|
2002-10-11 |
2004-05-04 |
Bristol-Myers Squibb Company |
Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
|
AU2003298596B2
(en)
|
2002-10-18 |
2008-12-18 |
Merck Sharp & Dohme Corp. |
Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
US20040132732A1
(en)
|
2002-10-21 |
2004-07-08 |
Wei Han |
Quinazolinones and derivatives thereof as factor Xa inhibitors
|
DE60332856D1
(de)
|
2002-10-23 |
2010-07-15 |
Bristol Myers Squibb Co |
Auf glycinnitril basierende hemmer der dipeptidylpeptidase iv
|
US7482337B2
(en)
|
2002-11-08 |
2009-01-27 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
MXPA05005260A
(es)
|
2002-11-18 |
2005-07-25 |
Pfizer Prod Inc |
Amidas ciclicas fluoradas que inhiben la dipeptidil peptidasa iv.
|
DE10254304A1
(de)
|
2002-11-21 |
2004-06-03 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
|
AU2002952946A0
(en)
|
2002-11-27 |
2002-12-12 |
Fujisawa Pharmaceutical Co., Ltd. |
Dpp-iv inhibitor
|
US7109192B2
(en)
|
2002-12-03 |
2006-09-19 |
Boehringer Ingelheim Pharma Gmbh & Co Kg |
Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
|
DE10256264A1
(de)
|
2002-12-03 |
2004-06-24 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue substituierte Imidazo-pyridinone und Imidazo-pyridazinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
JP2006510630A
(ja)
|
2002-12-04 |
2006-03-30 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
|
US7420079B2
(en)
|
2002-12-09 |
2008-09-02 |
Bristol-Myers Squibb Company |
Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
|
US7135467B2
(en)
|
2003-01-13 |
2006-11-14 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
AU2004206812A1
(en)
|
2003-01-17 |
2004-08-05 |
Merck & Co., Inc. |
3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
JP2006516573A
(ja)
|
2003-01-31 |
2006-07-06 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての3−アミノ−4−フェニルブタン酸誘導体
|
WO2004071454A2
(fr)
|
2003-02-13 |
2004-08-26 |
Guilford Pharmaceuticals Inc. |
Composes d'azetidine substitues servant d'inhibiteurs de dipeptidyl peptidase iv
|
DE10308353A1
(de)
|
2003-02-27 |
2004-12-02 |
Aventis Pharma Deutschland Gmbh |
Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
US7148246B2
(en)
|
2003-02-27 |
2006-12-12 |
Sanofi-Aventis Deutschland Gmbh |
Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
|
WO2004078777A2
(fr)
|
2003-03-04 |
2004-09-16 |
Biorexis Pharmaceutical Corporation |
Proteines protegees contre la dipeptidylpeptidase
|
AR043443A1
(es)
|
2003-03-07 |
2005-07-27 |
Merck & Co Inc |
Procedimiento de preparacion de tetrahidrotriazolopirazinas y productos intermedios
|
US20050014732A1
(en)
|
2003-03-14 |
2005-01-20 |
Pharmacia Corporation |
Combination of an aldosterone receptor antagonist and an anti-diabetic agent
|
WO2004085661A2
(fr)
|
2003-03-24 |
2004-10-07 |
Merck & Co., Inc |
Procede de synthese de derives d'acides amines beta chiraux
|
US20040242566A1
(en)
|
2003-03-25 |
2004-12-02 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
TWI357408B
(en)
|
2003-03-26 |
2012-02-01 |
Mitsubishi Tanabe Pharma Corp |
3-substituted-4-pyrimidone derivatives
|
JP2006521400A
(ja)
|
2003-03-26 |
2006-09-21 |
バイエル・フアーマシユーチカルズ・コーポレーシヨン |
糖尿病及び関連障害の処置のための化合物及びそれらの使用
|
WO2004087650A2
(fr)
|
2003-03-27 |
2004-10-14 |
Merck & Co. Inc. |
Procede et intermediaires pour la preparation d'inhibiteurs d'amide d'acide beta-amino de dipeptidyle peptidase-iv
|
EP1622870A2
(fr)
|
2003-05-05 |
2006-02-08 |
Prosidion Ltd. |
Inhibiteurs de la dp iv a base de glutaminyle
|
KR20110059664A
(ko)
|
2003-05-05 |
2011-06-02 |
프로비오드룩 아게 |
글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
|
JP4806628B2
(ja)
*
|
2003-05-05 |
2011-11-02 |
プロビオドルグ エージー |
グルタミニルシクラーゼ阻害剤
|
JP2006528693A
(ja)
|
2003-05-14 |
2006-12-21 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害剤としての3−アミノ−4−フェニルブタン酸誘導体
|
EP1625122A1
(fr)
|
2003-05-14 |
2006-02-15 |
Takeda San Diego, Inc. |
Inhibiteurs de dipeptidyl peptidase
|
US7456204B2
(en)
|
2003-06-17 |
2008-11-25 |
Merck & Co., Inc. |
Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
US7566707B2
(en)
|
2003-06-18 |
2009-07-28 |
Boehringer Ingelheim International Gmbh |
Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
|
DE602004030244D1
(de)
|
2003-06-20 |
2011-01-05 |
Hoffmann La Roche |
Itoren
|
ATE437876T1
(de)
|
2003-06-20 |
2009-08-15 |
Hoffmann La Roche |
Hexahydropyridoisochinoline als dpp-iv- inhibitoren
|
JO2625B1
(en)
|
2003-06-24 |
2011-11-01 |
ميرك شارب اند دوم كوربوريشن |
Phosphoric acid salts of dipeptidyl betidase inhibitor 4
|
DE10330842A1
(de)
|
2003-07-08 |
2005-02-10 |
Institut für Medizintechnologie Magdeburg GmbH, IMTM |
Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit Hyperproliferation und veränderten Differenzierungszuständen von Fibroblasten
|
AU2004261186A1
(en)
|
2003-07-31 |
2005-02-10 |
Merck & Co., Inc. |
Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
US6995183B2
(en)
|
2003-08-01 |
2006-02-07 |
Bristol Myers Squibb Company |
Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
|
US7579357B2
(en)
|
2003-08-13 |
2009-08-25 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
WO2005019168A2
(fr)
|
2003-08-20 |
2005-03-03 |
Pfizer Products Inc. |
Derives fluores de lysine en tant qu'inhibiteurs de la dipeptidylpeptidase iv
|
WO2005026148A1
(fr)
|
2003-09-08 |
2005-03-24 |
Takeda San Diego, Inc. |
Inhibiteurs de la dipeptidylpeptidase
|
US20050065144A1
(en)
|
2003-09-08 |
2005-03-24 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
EP1713780B1
(fr)
*
|
2004-02-05 |
2012-01-18 |
Probiodrug AG |
Nouveaux inhibiteurs de la glutaminyl-cyclase
|
BRPI0418639B8
(pt)
*
|
2004-03-15 |
2021-05-25 |
Takeda Pharmaceutical |
compostos inibidores de dipeptidil peptidase, assim como composição farmacêutica contendo os mesmos
|
US7576076B2
(en)
|
2004-07-02 |
2009-08-18 |
Corcept Therapeutics, Inc. |
Modified pyrimidine glucocorticoid receptor modulators
|
EP1828192B1
(fr)
|
2004-12-21 |
2014-12-03 |
Takeda Pharmaceutical Company Limited |
Inhibiteurs de dipeptidyle peptidase
|
US20080318922A1
(en)
*
|
2004-12-24 |
2008-12-25 |
Dainippon Sumitomo Pharma Co., Ltd. |
Bicyclic Pyrrole Derivatives
|
HRP20140091T4
(hr)
|
2005-09-14 |
2021-12-24 |
Takeda Pharmaceutical Company Limited |
Davanje inhibitora dipeptidil peptidaze
|
CN101374523B
(zh)
*
|
2005-09-14 |
2012-04-11 |
武田药品工业株式会社 |
用于治疗糖尿病的二肽基肽酶抑制剂
|
PE20070622A1
(es)
*
|
2005-09-14 |
2007-08-22 |
Takeda Pharmaceutical |
Administracion de inhibidores de dipeptidil peptidasa
|
TW200745079A
(en)
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|