SI3473629T1 - Postopek za izdelavo substituiranega policikličnega piridonskega derivata in njegovega kristala - Google Patents
Postopek za izdelavo substituiranega policikličnega piridonskega derivata in njegovega kristalaInfo
- Publication number
- SI3473629T1 SI3473629T1 SI201731296T SI201731296T SI3473629T1 SI 3473629 T1 SI3473629 T1 SI 3473629T1 SI 201731296 T SI201731296 T SI 201731296T SI 201731296 T SI201731296 T SI 201731296T SI 3473629 T1 SI3473629 T1 SI 3473629T1
- Authority
- SI
- Slovenia
- Prior art keywords
- crystal
- same
- substituted polycyclic
- pyridone derivative
- producing substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016121453 | 2016-06-20 | ||
| EP17815337.5A EP3473629B1 (en) | 2016-06-20 | 2017-06-19 | Method for producing substituted polycyclic pyridone derivative and crystal of same |
| PCT/JP2017/022478 WO2017221869A1 (ja) | 2016-06-20 | 2017-06-19 | 置換された多環性ピリドン誘導体の製造方法およびその結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3473629T1 true SI3473629T1 (sl) | 2023-02-28 |
Family
ID=60783429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201731296T SI3473629T1 (sl) | 2016-06-20 | 2017-06-19 | Postopek za izdelavo substituiranega policikličnega piridonskega derivata in njegovega kristala |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11261198B2 (enExample) |
| EP (2) | EP3473629B1 (enExample) |
| JP (2) | JP6212678B1 (enExample) |
| KR (2) | KR102586854B1 (enExample) |
| CN (2) | CN109311911B (enExample) |
| AR (1) | AR108812A1 (enExample) |
| AU (1) | AU2017282305B2 (enExample) |
| BR (1) | BR112018076600A2 (enExample) |
| ES (1) | ES2936077T3 (enExample) |
| HR (1) | HRP20221540T1 (enExample) |
| IL (1) | IL263812B2 (enExample) |
| MX (1) | MX2018016267A (enExample) |
| PL (1) | PL3473629T3 (enExample) |
| SG (1) | SG11201810655QA (enExample) |
| SI (1) | SI3473629T1 (enExample) |
| TW (1) | TWI750188B (enExample) |
| WO (1) | WO2017221869A1 (enExample) |
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| JP6323860B2 (ja) | 2015-12-15 | 2018-05-16 | 塩野義製薬株式会社 | キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬 |
| SG11201810655QA (en) * | 2016-06-20 | 2019-01-30 | Shionogi & Co | Method for producing substituted polycyclic pyridone derivative and crystal of same |
| AU2017310774B2 (en) * | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
| EP3686201A4 (en) | 2017-09-18 | 2021-04-28 | Sunshine Lake Pharma Co., Ltd. | INFLUENCE VIRUS REPLICATION INHIBITOR AND ITS USES |
| AU2018344739B2 (en) | 2017-10-06 | 2023-04-13 | Shionogi & Co., Ltd. | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| CN110357850A (zh) * | 2018-03-26 | 2019-10-22 | 广东东阳光药业有限公司 | 一种含硫杂环化合物的制备方法 |
| MX395463B (es) | 2018-04-24 | 2025-03-25 | Shionogi & Co | Forma de dosificacion solida que tiene excelente estabilidad |
| KR102501180B1 (ko) | 2018-04-24 | 2023-02-21 | 시오노기세야쿠 가부시키가이샤 | 안정성이 우수한 고형 제제 |
| CN108558907B (zh) * | 2018-06-01 | 2019-08-09 | 海化生命(厦门)科技有限公司 | 一种关键中间体2的制备方法 |
| CN110872247A (zh) * | 2018-08-29 | 2020-03-10 | 上海复星星泰医药科技有限公司 | Xofluza含硫杂环化合物、其中间体及制备方法 |
| CN109134428A (zh) * | 2018-10-25 | 2019-01-04 | 南京科技职业学院 | 一种巴洛沙韦中间体的制备方法 |
| CN111170875B (zh) * | 2018-11-09 | 2022-12-27 | 广东东阳光药业有限公司 | 一种二烷氧基胺类化合物的制备方法 |
| CN109721585B (zh) * | 2018-12-19 | 2020-09-29 | 浙江工业大学 | 一种巴洛沙韦关键中间体的制备方法 |
| CN109516998B (zh) * | 2018-12-25 | 2021-06-25 | 深圳市华先医药科技有限公司 | 一种巴洛沙韦中间体的合成方法 |
| CN109504721B (zh) * | 2018-12-26 | 2021-07-09 | 杭州科巢生物科技有限公司 | 一种抗流感药物的合成方法 |
| CN111484508B (zh) * | 2019-01-29 | 2022-11-25 | 北京四环制药有限公司 | 一种用于制备巴罗萨韦或其衍生物的化合物及其制备方法和其应用 |
| CN111574386B (zh) * | 2019-02-19 | 2024-02-23 | 广东东阳光药业股份有限公司 | 一种氧代乙胺化合物的纯化方法 |
| EP3934758A1 (en) | 2019-03-05 | 2022-01-12 | Assia Chemical Industries Ltd | Solid state forms of baloxavir marboxil |
| KR20210137140A (ko) | 2019-03-12 | 2021-11-17 | 시오노기 앤드 컴파니, 리미티드 | 인플루엔자 및 합병증 위험 인자를 갖는 대상체에서 치환된 폴리사이클릭 피리돈 유도체 및 그의 전구약물을 사용한 인플루엔자 치료 |
| CN111825699B (zh) * | 2019-04-15 | 2023-02-21 | 上海复星星泰医药科技有限公司 | 含硫杂环化合物及其制备方法 |
| CN110143941B (zh) * | 2019-06-04 | 2021-05-25 | 北京四环制药有限公司 | 一种巴罗萨韦玛波酯中间体的合成方法 |
| CN110105327A (zh) * | 2019-06-05 | 2019-08-09 | 南京焕然生物科技有限公司 | 一种7,8-二氟-6,11-二氢-二苯并噻吩并-11-醇的制备方法 |
| CN110305091B (zh) * | 2019-06-19 | 2021-05-18 | 江苏理工学院 | 一种巴洛沙韦中间体化合物的制备方法 |
| CN112521386B (zh) * | 2019-09-19 | 2023-05-26 | 周雨恬 | 具有抗病毒作用的多环吡啶酮化合物及其药物组合和用途 |
| WO2021057834A1 (zh) * | 2019-09-27 | 2021-04-01 | 广东东阳光药业有限公司 | 一种酯化合物的晶型及其制备方法 |
| CN112707862B (zh) * | 2019-10-24 | 2022-09-27 | 广东东阳光药业有限公司 | 一种并环吡啶酮化合物的制备方法 |
| CN111057070A (zh) * | 2019-10-30 | 2020-04-24 | 浙江工业大学 | 一种巴洛沙韦关键中间体的合成方法 |
| WO2021093860A1 (zh) * | 2019-11-13 | 2021-05-20 | 南京知和医药科技有限公司 | 取代的双三环化合物及其药物组合物和用途 |
| WO2021129602A1 (zh) * | 2019-12-23 | 2021-07-01 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
| CN119080592A (zh) * | 2020-03-07 | 2024-12-06 | 广东东阳光药业股份有限公司 | 一种杂环化合物的合成方法 |
| CN111875619B (zh) * | 2020-07-30 | 2021-06-25 | 深圳市新阳唯康科技有限公司 | 巴洛沙韦酯的晶型及其制备方法 |
| CN114539285B (zh) * | 2020-11-25 | 2025-10-17 | 上海迪赛诺生物医药有限公司 | 一种玛巴洛沙韦的制备方法 |
| WO2022128934A1 (en) | 2020-12-15 | 2022-06-23 | Synthon B.V. | Solid forms of baloxavir, salts of baloxavir and cocrystals of baloxavir |
| CN114671889A (zh) * | 2020-12-24 | 2022-06-28 | 江苏威凯尔医药科技有限公司 | 一种取代三环吡啶酮衍生物的晶型及其制备方法 |
| CN115594692B (zh) * | 2021-07-08 | 2025-04-11 | 重庆博腾制药科技股份有限公司 | 一种制备抗流感病毒药物中间体的方法 |
| WO2023286078A1 (en) * | 2021-07-13 | 2023-01-19 | Natco Pharma Limited | An improved process for the preparation of an intermediate of baloxavir morboxil |
| CN113717199B (zh) * | 2021-08-13 | 2022-04-01 | 北京北朋科技有限公司 | 巴洛沙韦的氘代衍生物及其在抗流感病毒中的应用 |
| CN113717200B (zh) * | 2021-09-13 | 2022-11-22 | 石药集团中奇制药技术（石家庄）有限公司 | 一种巴洛沙韦中间体的制备方法 |
| CN114014874B (zh) * | 2021-12-20 | 2023-04-28 | 中国科学院上海药物研究所 | 一种玛巴洛沙韦中间体的制备方法 |
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| CN116751214A (zh) * | 2022-03-05 | 2023-09-15 | 重庆博腾制药科技股份有限公司 | 一种制备(r)-多环吡啶衍生物的方法、应用及其制备玛巴洛沙韦的方法 |
| CN116082361B (zh) * | 2023-04-11 | 2023-06-13 | 和鼎（南京）医药技术有限公司 | 一种制备玛巴洛沙韦中间体和玛巴洛沙韦的方法 |
| CN116891485A (zh) * | 2023-08-24 | 2023-10-17 | 迪嘉药业集团股份有限公司 | 一种玛巴洛沙韦中间体化合物的晶型及其制备方法 |
| CN117285542B (zh) * | 2023-09-26 | 2025-07-11 | 广西天铭药业有限公司 | 一种巴洛沙韦酯及其关键中间体的制备方法 |
| CN121925422A (zh) | 2023-10-05 | 2026-04-24 | 豪夫迈·罗氏有限公司 | 用于制造玛巴洛沙韦的方法 |
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| CN106519084B (zh) | 2015-09-15 | 2019-02-15 | 中国石油天然气股份有限公司 | 烯烃聚合催化剂用主催化剂及其制备方法与烯烃聚合催化剂 |
| BR112018009920A2 (pt) | 2015-11-17 | 2018-11-13 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação |
| EP3376866A4 (en) | 2015-11-17 | 2019-04-10 | Dow Agrosciences LLC | 4 - ((6- (2- (2,4-DIFLUORPHENYL) -1,1-DIFLUOR-2-OXOETHYL) PYRIDIN-3-YL) BENZONITRIL AND METHOD OF PREPARING THEREOF |
| JP6323860B2 (ja) | 2015-12-15 | 2018-05-16 | 塩野義製薬株式会社 | キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬 |
| CN105820317B (zh) | 2016-05-06 | 2018-05-15 | 合肥工业大学 | 一种序列可控的三嵌段共聚物的制备方法 |
| SG11201810655QA (en) * | 2016-06-20 | 2019-01-30 | Shionogi & Co | Method for producing substituted polycyclic pyridone derivative and crystal of same |
| AU2017310774B2 (en) | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
| US9862675B1 (en) | 2017-07-05 | 2018-01-09 | King Fahd University Of Petroleum And Minerals | Method of N-formylating amines with a phosphonic anhydride |
| AU2018344739B2 (en) | 2017-10-06 | 2023-04-13 | Shionogi & Co., Ltd. | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
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2017
- 2017-06-19 SG SG11201810655QA patent/SG11201810655QA/en unknown
- 2017-06-19 SI SI201731296T patent/SI3473629T1/sl unknown
- 2017-06-19 US US16/310,897 patent/US11261198B2/en active Active
- 2017-06-19 TW TW106120359A patent/TWI750188B/zh active
- 2017-06-19 KR KR1020227019438A patent/KR102586854B1/ko active Active
- 2017-06-19 WO PCT/JP2017/022478 patent/WO2017221869A1/ja not_active Ceased
- 2017-06-19 BR BR112018076600-3A patent/BR112018076600A2/pt unknown
- 2017-06-19 JP JP2017538748A patent/JP6212678B1/ja active Active
- 2017-06-19 IL IL263812A patent/IL263812B2/en unknown
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- 2017-06-19 CN CN201780038096.2A patent/CN109311911B/zh active Active
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- 2017-06-19 EP EP22206730.8A patent/EP4194459A1/en not_active Withdrawn
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