SI2970216T1 - Biaril-amidne spojine kot kinazni inhibitorji - Google Patents

Biaril-amidne spojine kot kinazni inhibitorji Download PDF

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SI2970216T1
SI2970216T1 SI201430516T SI201430516T SI2970216T1 SI 2970216 T1 SI2970216 T1 SI 2970216T1 SI 201430516 T SI201430516 T SI 201430516T SI 201430516 T SI201430516 T SI 201430516T SI 2970216 T1 SI2970216 T1 SI 2970216T1
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Slovenia
Prior art keywords
pharmaceutically acceptable
acceptable salt
cancer
compound according
compound
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SI201430516T
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English (en)
Inventor
Robert Aversa
Paul A. Barsanti
Matthew Burger
Michael Patrick Dillon
Alan Dipesa
Cheng Hu
Yan Lou
Gisele Nishiguchi
Yue Pan
Valery Polyakov
Savithri Ramurthy
Alice Rico
Lina Setti
Aaron Smith
Sharadha Subramanian
Benjamin Taft
Huw Tanner
Lifeng Wan
Naeem Yusuff
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Novartis Ag
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Publication of SI2970216T1 publication Critical patent/SI2970216T1/sl

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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Claims (10)

  1. EP 2 970 216 BI Biaril-amidne spojine kot kinazni inhibitorji Patentni zahtevki
    1. Spojina, izbrana izmed: ali
    ali njena farmacevtsko sprejemljiva sol.
  2. 2. Spojina po zahtevku 1, ki je:
    ali njena farmacevtsko sprejemljiva sol.
  3. 3. Spojina po zahtevku 1, kije:
    ali njena farmacevtsko sprejemljiva sol.
  4. 4. Spojina po zahtevku 1, kije:
    ali njena farmacevtsko sprejemljiva sol.
  5. 5. Spojina po zahtevku 1, ki je:
    ali njena farmacevtsko sprejemljiva sol.
  6. 6. Farmacevtski sestavek, ki obsega spojino po katerem koli od zahtevkov od 1 do 5, ali njeno farmacevtsko sprejemljivo sol, in enega ali več farmacevtsko sprejemljivih nosilcev.
  7. 7. Kombinacija, ki obsega spojino po katerem koli od zahtevkov od 1 do 5, ali njeno farmacevtsko sprejemljivo sol, in eno ali več terapevtsko aktivnih so-sredstev.
  8. 8. Kombinacija po zahtevku 7, kjer je eno ali več terapevtsko aktivnih so-sredstev izbranih izmed paklitaksela, docetaksela, temozolomida, platinov, doksorubicinov, vinblastinov, ciklofosfamida, topotekana, gemcitamina, ifosfamida, etopozida in irinotekana.
  9. 9. Spojina po katerem koli od zahtevkov od 1 do 5, ali njena farmacevtsko sprejemljivo sol, za uporabo pri zdravljenju raka.
  10. 10. Spojina ali njena farmacevtsko sprejemljiva sol za uporabo po zahtevku 9, kjer je rak izbran izmed solidnih tumorjev, melanoma, raka dojke, pljučnega raka, raka jeter, sarkoma, tumorjev gastrointestinalnega trakta, kot so gastrointestinalni stromalni tumorji, raka jajčnikov, kolorektalnega raka, raka ščitnice in raka trebušne slinavke.
SI201430516T 2013-03-14 2014-03-13 Biaril-amidne spojine kot kinazni inhibitorji SI2970216T1 (sl)

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