RU2474580C2 - Гетероциклические амидные соединения как ингибиторы протеинкиназ - Google Patents

Гетероциклические амидные соединения как ингибиторы протеинкиназ Download PDF

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RU2474580C2
RU2474580C2 RU2010105678/04A RU2010105678A RU2474580C2 RU 2474580 C2 RU2474580 C2 RU 2474580C2 RU 2010105678/04 A RU2010105678/04 A RU 2010105678/04A RU 2010105678 A RU2010105678 A RU 2010105678A RU 2474580 C2 RU2474580 C2 RU 2474580C2
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disease
protein kinase
heterocyclic amide
kinase inhibitors
amide compounds
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Пандуранга Адулла П. РЭДДИ
Лианниун ЖАО
Правеен К. ТАДИКОНДА
Тжу Тшин ВОНГ
Шуйи ТАНГ
Льюис И. ТОРРЕС
Дэвид Ф. мл. КАБЛ
Тимоти Дж. ГАЗИ
М. Аршад СИДДИКИ
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Шеринг Корпорейшн
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

Настоящее изобретение касается нового гетероциклического амидного соединения формулы I:
Figure 00000258
или его фармацевтически приемлемой соли. Также описана фармацевтическая композиция, содержащая указанное соединение, обладающая свойствами ингибитора, регулятора или модулятора протеинкиназ, что приемлемо для лечения или профилактики пролиферативного заболевания, антипролиферативного нарушения, воспаления, артрита, неврологического или нейродегенеративного заболевания, сердечно-сосудистого заболевания, облысения, нейронного заболевания, ишемического нарушения, вирусного заболевания или грибкового заболевания. 2 н.п. ф-лы, 20 табл.

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Claims (2)

1. Соединение, имеющее формулу
Figure 00000257

или его фармацевтически приемлемая соль.
2. Фармацевтическая композиция, обладающая свойствами ингибитора, регулятора или модулятора протеинкиназ, содержащая терапевтически эффективное количество соединения по п.1 или его фармацевтически приемлемую соль в комбинации с, по меньшей мере, одним фармацевтически приемлемым носителем.
RU2010105678/04A 2007-07-19 2008-07-17 Гетероциклические амидные соединения как ингибиторы протеинкиназ RU2474580C2 (ru)

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PCT/US2008/008749 WO2009014637A2 (en) 2007-07-19 2008-07-17 Heterocyclic amide compounds as protein kinase inhibitors

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