AR088989A1 - Derivados biciclicos de dihidroisoquinolin-1-ona - Google Patents
Derivados biciclicos de dihidroisoquinolin-1-onaInfo
- Publication number
- AR088989A1 AR088989A1 ARP120104439A ARP120104439A AR088989A1 AR 088989 A1 AR088989 A1 AR 088989A1 AR P120104439 A ARP120104439 A AR P120104439A AR P120104439 A ARP120104439 A AR P120104439A AR 088989 A1 AR088989 A1 AR 088989A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- heterocycloalkyl
- cycloalkyl
- alkyl
- heteroaryl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos son útiles para tratar enfermedades renales crónicas hipertensión, aldosterismo primario y síndrome de Cushing. Reivindicación 1: Compuestos de la fórmula (1) en la que: R¹, R², R³ y R⁴ se eligen con independencia entre H, alquilo, cicloalquilo, cicloalquilalquilo, haloalquilo, halocicloalquilo, hidroxialquilo, alcoxialquilo, haloalcoxialquilo, halocicloalquilalquilo, heterocicloalquilo sustituido, heterocicloalquilalquilo sustituido, arilalquilo sustituido y heteroarilalquilo sustituido, dichos heterocicloalquilo sustituido, heterocicloalquilalquilo sustituido, arilalquilo sustituido y heteroarilalquilo sustituido están sustituidos por R¹², R¹³ y R¹⁴; o R² y R⁴ juntos forman un doble enlace, pero en el caso de que R² y R⁴ juntos formen un doble enlace, entonces R⁵ es H; o R¹ y R² junto con el átomo de carbono al que están unidos forman un cicloalquilo sustituido o un heterocicloalquilo sustituido, dichos cicloalquilo sustituido y heterocicloalquilo sustituido están sustituidos por R²², R²³ y R²⁴; o R³ y R⁴ junto con el átomo de carbono al que están unidos forman un cicloalquilo sustituido o un heterocicloalquilo sustituido, dichos cicloalquilo sustituido y heterocicloalquilo sustituido están sustituidos por R²⁹, R³⁰ y R³¹; o R¹ y R³ junto con el átomo de carbono al que están unidos forman un cicloalquilo sustituido o un heterocicloalquilo sustituido, dichos cicloalquilo sustituido y heterocicloalquilo sustituido están sustituidos por R⁴⁴, R⁴⁵ y R⁴⁶; A¹ es CR⁸ o N; A² es CR⁹ o N; A³ es CR¹⁰ o N; A⁴ es CR¹¹ o N; A⁵ es CR⁶ o N; uno de R⁵, R⁶, R⁷ y R⁸ se elige entre halógeno, ciano, alcoxi, hidroxialcoxi, haloalquilo, haloalcoxi e hidroxi y los demás se eligen con independencia entre sí entre H, halógeno, ciano, alcoxi, hidroxialcoxi, haloalcoxi e hidroxi; R⁹ es H, halógeno, hidroxi, ciano, alquilo, hidroxialquilo, haloalquilo, cicloalquilo, cicloalquilalquilo, alquilcicloalquilo, halocicloalquilo, alquilcicloalquilalquilo, alcoxicicloalquilalquilo, halocicloalquilalquilo, cicloalquilalcoxi, cicloalquilalcoxialquilo, cicloalcoxi, cicloalcoxialquilo, halocicloalcoxi, halocicloalcoxialquilo, alquilcicloalcoxi, alquilcicloalcoxialquilo, alcoxi, alcoxialquilo, alcoxicicloalquilalquilo, dialcoxialquilo, haloalcoxi, haloalcoxialquilo, alcoxialcoxi, alcoxialcoxialquilo, haloalcoxialcoxi, haloalcoxialcoxialquilo, arilalquilo sustituido, arilhidroxialquilo sustituido, heterocicloalquilalquilo sustituido o heteroarilalquilo sustituido, dichos arilalquilo sustituido, arilhidroxialquilo sustituido, heterocicloalquilalquilo sustituido y heteroarilalquilo sustituido están sustituidos por R³², R³³ y R³⁴; R¹⁰ es -Oₘ-(CR¹⁵R¹⁶)ₚ-(CR¹⁷R¹⁸)q-(CR¹⁹R²⁰)ʳ-R²¹; o R⁹ y R¹⁰ junto con los átomos de carbono a los que están unidos forman un cicloalquilo sustituido, un heterocicloalquilo sustituido, un arilo sustituido o un heteroarilo sustituido, dichos cicloalquilo sustituido, heterocicloalquilo sustituido, arilo sustituido y heteroarilo sustituido están sustituidos por R³⁵, R³⁶ y R³⁷; R¹¹ es H; R¹⁵, R¹⁷ y R¹⁹ se eligen con independencia entre H, alquilo, cicloalquilo, haloalquilo y halocicloalquilo; R¹⁶, R¹⁸ y R²⁰ se eligen con independencia entre H, hidroxi, halógeno y alquilo; o R¹⁵ y R¹⁶ junto con el átomo de carbono al que están unidos forman un cicloalquilo; o R¹⁷ y R¹⁸ junto con el átomo de carbono al que están unidos forman un cicloalquilo; o R¹⁹ y R²⁰ junto con el átomo de carbono al que están unidos forman un cicloalquilo; o R¹⁵ y R¹⁷ juntos forman un -(CH₂)ᵛ-; o R¹⁵ y R¹⁹ juntos forman un -(CH₂)ʷ-; o R¹⁷ y R¹⁹ juntos forman un -(CH₂)ˣ-; R²¹ es H, halógeno, ciano, -OR²⁵, -SR²⁵, -S(O)R²⁵, -S(O)₂R²⁵, -NR²⁵R²⁶, -NR²⁶SO₂R²⁵, -NR²⁶SO₂NR²⁵R²⁷, -NR²⁶C(O)R²⁵, -NR²⁶C(O)-NR²⁵R²⁷, -C(O)R²⁸, -C(O)NR²⁵R²⁶, cicloalquilo, heterociclo-alquilo sustituido, heteroarilo sustituido o arilo sustituido, dichos heterocicloalquilo sustituido, heteroarilo sustituido, heteroarilalquilo sustituido y arilo sustituido están sustituidos por R³⁸, R³⁹ y R⁴⁰; R²⁵ es H, alquilo, hidroxialquilo, carboxialquilo, haloalquilo, cicloalquilo, cicloalquilalquilo, alquilcicloalquilo, halocicloalquilo, alquilcicloalquilalquilo, alcoxicicloalquilalquilo, halocicloalquilalquilo, cicloalquilalcoxi-alquilo, cicloalcoxialquilo, halocicloalcoxialquilo, alquilcicloalcoxialquilo, alcoxialquilo, haloalcoxialquilo, alcoxialcoxialquilo, haloalcoxialcoxialquilo, heterociclo-alquilo sustituido, heterocicloalquilalquilo sustituido, heteroarilo sustituido, heteroarilalquilo sustituido, arilo sustituido o arilalquilo sustituido, dichos heterocicloalquil sustituido, heterocicloalquilalquilo sustituido, heteroarilo, heteroarilalquilo sustituido, arilo sustituido y arilalquilo sustituido están sustituidos por R⁴¹, R⁴² y R⁴³; R²⁶ y R²⁷ se eligen con independencia entre H, alquilo, cicloalquilo, haloalquilo y halocicloalquilo; o R¹⁵ y R²⁶ junto con el átomo de nitrógeno y el átomo de carbono al que están unidos forman un heterocicloalquilo sustituido o un heteroarilo sustituido, dichos heterocicloalquilo sustituido y heteroarilo sustituido están sustituidos por R⁴⁷, R⁴⁸ y R⁴⁹; o R¹⁷ y R²⁶ junto con el átomo de nitrógeno y el átomo de carbono al que están unidos forman un heterocicloalquilo sustituido o un heteroarilo sustituido, dichos heterocicloalquilo sustituido y heteroarilo sustituido están sustituidos por R⁴⁷, R⁴⁸ y R⁴⁹; o R¹⁹ y R²⁶ junto con el átomo de nitrógeno y el átomo de carbono al que están unidos forman un heterocicloalquilo sustituido o un heteroarilo sustituido, dichos heterocicloalquilo sustituido y heteroarilo sustituido están sustituidos por R⁴⁷, R⁴⁸ y R⁴⁹; R²⁸ es H, hidroxi, alquilo, hidroxialquilo, haloalquilo, cicloalquilo, cicloalquilalquilo, alquilcicloalquilo, halocicloalquilo, alquilcicloalquilalquilo, alcoxicicloalquil, halocicloalquilalquilo, cicloalquilalcoxi, cicloalquilalcoxialquilo, cicloalcoxi, cicloalcoxialquilo, halocicloalcoxi, halocicloalcoxialquilo, alquilcicloalcoxi, alquilcicloalcoxialquilo, alcoxi, alcoxialquilo, haloalcoxi, haloalcoxialquilo, alcoxialcoxi, alcoxialcoxi-alquilo, haloalcoxialcoxi, haloalcoxialcoxialquilo, heterocicloalquilo sustituido, heterocicloalquilalquilo sustituido, heteroarilo sustituido, heteroarilalquilo sustituido, arilo sustituido o arilalquilo sustituido, dichos heterocicloalquilo sustituido, heterocicloalquilalquilo sustituido, heteroarilo sustituido heteroarilalquilo sustituido, arilo sustituido y arilalquilo sustituido están sustituidos por R⁵⁰, R⁵¹ y R⁵²; R¹², R¹³, R¹⁴, R²², R²³, R²⁴, R²⁹, R³⁰, R³¹, R³², R³³, R³⁴, R³⁵, R³⁶, R³⁷, R³⁸, R³⁹, R⁴⁰, R⁴¹, R⁴², R⁴³, R⁴⁴, R⁴⁵, R⁴⁶, R⁴⁷, R⁴⁸, R⁴⁹, R⁵⁰, R⁵¹ y R⁵² se eligen con independencia entre H, halógeno, hidroxi, amino, nitro, ciano, oxo, alquilo, alquilcarbonilo, alquilsulfonilo, hidroxialquilo, haloalquilo, cicloalquilo, cicloalquilalquilo, alquilcicloalquilo, halocicloalquilo, alquilcicloalquilalquilo, alquilcarbonil-amino, alquilsulfonilo, alquilsulfonilamino, alcoxicicloalquilalquilo, halocicloalquilalquilo, cicloalquilalcoxi, cicloalquilalcoxialquilo, cicloalcoxi, cicloalcoxialquilo, halocicloalcoxi, halocicloalcoxialquilo, alquilcicloalcoxi, alquilcicloalcoxialquilo, alcoxi, alcoxicarbonilo, alcoxialquilo, haloalcoxi, haloalcoxialquilo, alcoxialcoxi, alcoxialcoxialquilo, haloalcoxialcoxi, halo-alcoxialcoxialquilo, cloropiridinilcarbonilo y heterocicloalquilo; n es el número cero ó 1; m es el número cero ó 1; p, q y r se eligen con independencia entre cero y 1; v y x se eligen con independencia entre 1, 2, 3 y 4; w es el número cero, 1, 2 ó 3; con la condición de que no más de dos de A², A³ y A⁴ sean N; y las sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011083229 | 2011-11-30 |
Publications (1)
Publication Number | Publication Date |
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AR088989A1 true AR088989A1 (es) | 2014-07-23 |
Family
ID=47297189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120104439A AR088989A1 (es) | 2011-11-30 | 2012-11-27 | Derivados biciclicos de dihidroisoquinolin-1-ona |
Country Status (32)
Country | Link |
---|---|
US (1) | US9133158B2 (es) |
EP (2) | EP3587401A1 (es) |
JP (1) | JP6382108B2 (es) |
KR (1) | KR102089927B1 (es) |
AR (1) | AR088989A1 (es) |
AU (1) | AU2012344041B2 (es) |
BR (1) | BR112014013136B1 (es) |
CA (1) | CA2850700C (es) |
CL (1) | CL2014001389A1 (es) |
CO (1) | CO6920296A2 (es) |
CR (1) | CR20140229A (es) |
DK (1) | DK2785695T3 (es) |
EA (1) | EA035454B1 (es) |
ES (1) | ES2811806T3 (es) |
HR (1) | HRP20201277T1 (es) |
HU (1) | HUE050431T2 (es) |
IL (1) | IL232570B (es) |
LT (1) | LT2785695T (es) |
MA (1) | MA35664B1 (es) |
MX (1) | MX350717B (es) |
MY (1) | MY178867A (es) |
PE (1) | PE20141283A1 (es) |
PH (1) | PH12014501179B1 (es) |
PL (1) | PL2785695T3 (es) |
PT (1) | PT2785695T (es) |
RS (1) | RS60660B1 (es) |
SG (1) | SG11201402199QA (es) |
SI (1) | SI2785695T1 (es) |
TW (1) | TWI583678B (es) |
UA (1) | UA112565C2 (es) |
WO (1) | WO2013079452A1 (es) |
ZA (1) | ZA201402908B (es) |
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JP6533217B2 (ja) * | 2013-05-17 | 2019-06-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | B型肝炎ウイルス感染症の治療および予防のための6−架橋ヘテロアリールジヒドロピリミジン類 |
EP3004089B1 (en) * | 2013-05-27 | 2020-05-06 | F.Hoffmann-La Roche Ag | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
MY176401A (en) | 2014-04-24 | 2020-08-05 | Mitsubishi Tanabe Pharma Corp | Novel disubstituted 1,2,4-triazine compound |
CR20170118A (es) * | 2014-10-08 | 2017-07-10 | Hoffmann La Roche | Derivados espirodiamina como inhibidores de la aldosterona sintasa |
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US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
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CN109810171B (zh) * | 2017-11-21 | 2020-12-01 | 首都医科大学 | 二氢异喹啉-3-甲酰-LARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
CN111801314B (zh) | 2018-01-02 | 2023-10-31 | 西尔洛克治疗公司 | Ask1抑制剂化合物及其用途 |
WO2020002969A1 (en) * | 2018-06-26 | 2020-01-02 | Zhejiang Vimgreen Pharmaceuticals, Ltd | Triazolotriazine derivatives as a2a receptor antagonists |
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WO2021224818A1 (en) * | 2020-05-08 | 2021-11-11 | Pfizer Inc. | Isoindolone compounds as hpk1 inhibitors |
WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
WO2024061371A1 (zh) * | 2022-09-23 | 2024-03-28 | 广州威诺森医药科技有限公司 | 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用 |
WO2024102026A1 (en) * | 2022-11-10 | 2024-05-16 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
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PT79699B (en) | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
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ES2442347T3 (es) * | 2006-03-29 | 2014-02-11 | Novartis Ag | Imidazoles como inhibidores de aldosterona sintasa |
AR067585A1 (es) * | 2007-07-19 | 2009-10-14 | Schering Corp | Compuestos heterociclicos de amidas como inhibidores de la proteincinasa |
TW200918062A (en) * | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
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JP2013537210A (ja) * | 2010-09-16 | 2013-09-30 | ノバルティス アーゲー | 17α−ヒドロキシラーゼ/C17,20−リアーゼ阻害剤 |
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