SI2718257T1 - Postopek za pripravo kristaliničnega dimetil fumarata z visoko čistostjo - Google Patents
Postopek za pripravo kristaliničnega dimetil fumarata z visoko čistostjo Download PDFInfo
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- SI2718257T1 SI2718257T1 SI201231204T SI201231204T SI2718257T1 SI 2718257 T1 SI2718257 T1 SI 2718257T1 SI 201231204 T SI201231204 T SI 201231204T SI 201231204 T SI201231204 T SI 201231204T SI 2718257 T1 SI2718257 T1 SI 2718257T1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/62—Use of additives, e.g. for stabilisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/60—Maleic acid esters; Fumaric acid esters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (10)
- POSTOPEK ZA PRIPRAVO KRISTALINIČNEGA DIMETIL FUMARATA Z VISOKO ČISTOSTJO Patentni zahtevki1. Metoda za pripravo dimetil fumarata, ki zajema: reakcijo: (a) fumarne kisline; in (b) metanola; v prisotnosti žveplove kisline; v razmerju metanola in fumarne kisline od približno 5,7 litra do približno 8,6 litra metanola na kilogram fumarne kisline; v reakcijski zmesi za pridobivanje zmesi produkta, ki vključuje nizko raven dimetil sulfata, pri čemer je raven dimetil sulfata nižja od 4,0 ppm; pri čemer izraz »približno« pomeni določeno številko plus ali minus od 1 do 10 %.
- 2. Metoda iz patentnega zahtevka 1, pri čemer je raven dimetil sulfata nižja od 3,0 ppm.
- 3. Metoda iz patentnega zahtevka 1, pri čemer je raven dimetil sulfata nižja od 2,0 ppm, pri čemer je raven dimetil sulfata po možnosti nižja od 1,0 ppm.
- 4. Metoda iz katerega koli patentnega zahtevka 1-3, pri čemer je razmerje fumarna kislina : žveplova kislina v obsegu od približno 1 : 0,01 molarnega ekvivalenta do približno 1 : 0,50 molarnega ekvivalenta; pri čemer izraz »približno« pomeni določeno številko plus ali minus od 1 do 10 %.
- 5. Metoda iz katerega koli patentnega zahtevka 1-4, pri čemer reagiranje traja od približno 3,0 ure do približno 48 ur; pri čemer izraz »približno« pomeni določeno številko plus ali minus od 1 do 10 %.
- 6. Metoda iz katerega koli patentnega zahtevka 1-5, pri čemer reagiranje poteka pri temperaturi od približno 60 °C do približno 70 °C; pri čemer izraz »približno« pomeni določeno številko plus ali minus od 1 do 10 %.
- 7. Metoda iz katerega koli patentnega zahtevka 1-6, pri čemer je količina vode v vhodnih reakcijskih snoveh od približno 2,0 % do približno 5,0 %, pri čemer izraz »približno« pomeni določeno številko plus ali minus od 1 do 10 %.
- 8. Metoda iz katerega koli patentnega zahtevka 1-7, pri čemer je razmerje molarnih ekvivalentov fumarna kislina : žveplova kislina v obsegu od približno 1 : 0,01 molarnega ekvivalenta do približno 1 : 0,50 molarnega ekvivalenta, pri čemer je količina vode v vhodnih reakcijskih snoveh od približno 2,0 % do približno 5,0 % in reagiranje traja od približno 3,0 ure do približno 48 ur pri temperaturi od približno 60 °C do približno 70 °C; pri čemer izraz »približno« pomeni določeno številko plus ali minus od 1 do 10 %.
- 9. Metoda iz katerega koli patentnega zahtevka 1-8, ki dodatno zajema: zmanjšanje velikosti delcev dimetil fumarata.
- 10. Metoda iz patentnega zahtevka 9, pri čemer je zmanjšanje velikosti delcev dimetil fumarata v obsegu od približno 20 pm do približno 250 pm; pri čemer izraz »približno« pomeni določeno številko plus ali minus od 1 do 10 %.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161494775P | 2011-06-08 | 2011-06-08 | |
PCT/US2012/041715 WO2012170923A1 (en) | 2011-06-08 | 2012-06-08 | Process for preparing high purity and crystalline dimethyl fumarate |
EP12796164.7A EP2718257B1 (en) | 2011-06-08 | 2012-06-08 | Process for preparing high purity and crystalline dimethyl fumarate |
Publications (1)
Publication Number | Publication Date |
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SI2718257T1 true SI2718257T1 (sl) | 2018-04-30 |
Family
ID=47296498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201231204T SI2718257T1 (sl) | 2011-06-08 | 2012-06-08 | Postopek za pripravo kristaliničnega dimetil fumarata z visoko čistostjo |
Country Status (30)
Country | Link |
---|---|
US (1) | US9422226B2 (sl) |
EP (1) | EP2718257B1 (sl) |
JP (3) | JP6385273B6 (sl) |
KR (2) | KR20140035995A (sl) |
CN (1) | CN103649041A (sl) |
AU (1) | AU2012267524A1 (sl) |
BR (1) | BR112013031616A2 (sl) |
CA (1) | CA2838271A1 (sl) |
CL (1) | CL2013003483A1 (sl) |
CO (1) | CO6821956A2 (sl) |
CY (1) | CY1119920T1 (sl) |
DK (1) | DK2718257T3 (sl) |
EA (1) | EA201391638A1 (sl) |
EC (1) | ECSP14013123A (sl) |
ES (1) | ES2659771T3 (sl) |
HR (1) | HRP20180203T1 (sl) |
HU (1) | HUE036085T2 (sl) |
IL (1) | IL229656A0 (sl) |
LT (1) | LT2718257T (sl) |
ME (1) | ME02960B (sl) |
MX (1) | MX355421B (sl) |
NO (1) | NO2820009T3 (sl) |
NZ (1) | NZ618178A (sl) |
PE (1) | PE20141639A1 (sl) |
PL (1) | PL2718257T3 (sl) |
PT (1) | PT2718257T (sl) |
RS (1) | RS56972B1 (sl) |
SG (1) | SG195227A1 (sl) |
SI (1) | SI2718257T1 (sl) |
WO (1) | WO2012170923A1 (sl) |
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