SG155938A1 - Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors - Google Patents

Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

Info

Publication number
SG155938A1
SG155938A1 SG200906238-1A SG2009062381A SG155938A1 SG 155938 A1 SG155938 A1 SG 155938A1 SG 2009062381 A SG2009062381 A SG 2009062381A SG 155938 A1 SG155938 A1 SG 155938A1
Authority
SG
Singapore
Prior art keywords
mglur2
compounds
receptors
diseases
positive allosteric
Prior art date
Application number
SG200906238-1A
Other languages
English (en)
Inventor
Hassan Julien Imogai
Cid-N
Original Assignee
Janssen Pharmaceutica Nv
Addex Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Addex Pharmaceuticals Sa filed Critical Janssen Pharmaceutica Nv
Publication of SG155938A1 publication Critical patent/SG155938A1/en

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
SG200906238-1A 2004-09-17 2005-09-16 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors SG155938A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators

Publications (1)

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SG155938A1 true SG155938A1 (en) 2009-10-29

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US (2) US8399493B2 (ru)
EP (1) EP1799646B1 (ru)
JP (2) JP5179873B2 (ru)
KR (1) KR20070085262A (ru)
CN (1) CN101061098B (ru)
AU (1) AU2005284098B2 (ru)
BR (1) BRPI0515412A (ru)
CA (1) CA2581144C (ru)
EA (1) EA013740B1 (ru)
ES (1) ES2527418T3 (ru)
GB (1) GB0420722D0 (ru)
IL (1) IL181742A0 (ru)
MX (1) MX2007003006A (ru)
NO (1) NO20071660L (ru)
NZ (1) NZ554041A (ru)
SG (1) SG155938A1 (ru)
TW (1) TW200633982A (ru)
UA (1) UA98098C2 (ru)
WO (1) WO2006030032A1 (ru)
ZA (1) ZA200703088B (ru)

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GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
EP1834527A1 (en) * 2006-03-13 2007-09-19 Purac Biochem BV Food product comprising a mixture of calcium salts or a calcium double salt
AR059898A1 (es) * 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
GB2453058A (en) 2006-04-04 2009-03-25 Univ California Kinase antagonists
TW200808763A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
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