SG11201810245WA - Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide - Google Patents

Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide

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Publication number
SG11201810245WA
SG11201810245WA SG11201810245WA SG11201810245WA SG11201810245WA SG 11201810245W A SG11201810245W A SG 11201810245WA SG 11201810245W A SG11201810245W A SG 11201810245WA SG 11201810245W A SG11201810245W A SG 11201810245WA SG 11201810245W A SG11201810245W A SG 11201810245WA
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SG
Singapore
Prior art keywords
formula
pyrrolidin
pyrimidin
international
difluorophenyl
Prior art date
Application number
SG11201810245WA
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English (en)
Inventor
Mark Reynolds
Charles Todd Eary
Stacey Spencer
Derrick Juengst
Bruno Hache
Yutong Jiang
Julia Haas
Steven W Andrews
Original Assignee
Mark Reynolds
Charles Todd Eary
Stacey Spencer
Derrick Juengst
Bruno Hache
Yutong Jiang
Julia Haas
Steven W Andrews
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58794189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201810245W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mark Reynolds, Charles Todd Eary, Stacey Spencer, Derrick Juengst, Bruno Hache, Yutong Jiang, Julia Haas, Steven W Andrews filed Critical Mark Reynolds
Publication of SG11201810245WA publication Critical patent/SG11201810245WA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SG11201810245WA 2016-05-18 2017-05-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide SG11201810245WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662338359P 2016-05-18 2016-05-18
PCT/US2017/033257 WO2017201241A1 (en) 2016-05-18 2017-05-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide

Publications (1)

Publication Number Publication Date
SG11201810245WA true SG11201810245WA (en) 2018-12-28

Family

ID=58794189

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810245WA SG11201810245WA (en) 2016-05-18 2017-05-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide

Country Status (28)

Country Link
US (1) US11214571B2 (ja)
EP (2) EP3458456B1 (ja)
JP (1) JP7443057B2 (ja)
KR (1) KR102566858B1 (ja)
CN (1) CN110049987B (ja)
AU (1) AU2017268371B2 (ja)
BR (1) BR112018073504A2 (ja)
CA (1) CA3024603A1 (ja)
CL (1) CL2018003264A1 (ja)
CO (1) CO2018013015A2 (ja)
DK (2) DK3458456T3 (ja)
ES (2) ES2952056T3 (ja)
FI (1) FI3800189T3 (ja)
HR (2) HRP20230704T1 (ja)
HU (2) HUE053643T2 (ja)
IL (1) IL262964B (ja)
LT (2) LT3458456T (ja)
MX (1) MX2018014116A (ja)
PE (1) PE20190437A1 (ja)
PL (2) PL3800189T3 (ja)
PT (2) PT3458456T (ja)
RS (2) RS61463B1 (ja)
RU (1) RU2745953C2 (ja)
SG (1) SG11201810245WA (ja)
SI (2) SI3800189T1 (ja)
UA (1) UA127826C2 (ja)
WO (1) WO2017201241A1 (ja)
ZA (1) ZA201808534B (ja)

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JP6916562B2 (ja) * 2017-08-11 2021-08-11 テリジーン リミテッドＴｅｌｉｇｅｎｅ Ｌｔｄ． 化合物、その薬学的に許容される塩、溶媒和物、立体異性体及び互変異性体、並びに薬物組成物、過剰増殖性障害治療剤、過剰増殖性障害予防剤、薬物、癌治療剤、癌予防剤、及びキナーゼシグナル伝達調節剤
CN109232582B (zh) * 2018-11-28 2021-02-05 安礼特（上海）医药科技有限公司 拉洛替尼硫酸氢盐晶型及其制备和应用
CN112457231A (zh) * 2019-09-09 2021-03-09 上海医药工业研究院 一种拉罗替尼（Larotrectinib）中间体的消旋化方法
CN110804059B (zh) * 2019-09-30 2024-03-12 郑州泰基鸿诺医药股份有限公司 氨基甲酸酯类化合物、药物组合物及其应用
CN111138437B (zh) * 2019-12-04 2021-03-05 杭州华东医药集团新药研究院有限公司 取代的吡唑并[1,5-a]嘧啶氨基酸衍生物及其用途
CN112624950A (zh) * 2020-12-10 2021-04-09 北京蓝博特科技有限公司 一种(r)-2-(2,5-二氟苯基)吡咯烷的合成方法
WO2022168115A1 (en) 2021-02-05 2022-08-11 Mylan Laboratories Limited A process for the preparation of larotrectinib or its salts
CN113444070A (zh) * 2021-07-28 2021-09-28 深圳市真味生物科技有限公司 一种由手性叔丁基亚磺酰胺合成手性尼古丁的制备方法
CN115872905A (zh) * 2021-09-29 2023-03-31 凯特立斯（深圳）科技有限公司 一种拉罗替尼中间体的制备方法
WO2024023836A1 (en) 2022-07-27 2024-02-01 Mylan Laboratories Limited Polymorphic form of larotrectinib sulfate

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