SG10201501062SA - Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same - Google Patents

Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

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Publication number
SG10201501062SA
SG10201501062SA SG10201501062SA SG10201501062SA SG10201501062SA SG 10201501062S A SG10201501062S A SG 10201501062SA SG 10201501062S A SG10201501062S A SG 10201501062SA SG 10201501062S A SG10201501062S A SG 10201501062SA SG 10201501062S A SG10201501062S A SG 10201501062SA
Authority
SG
Singapore
Prior art keywords
compositions
methods
same
isoindoline derivatives
arylmethoxy isoindoline
Prior art date
Application number
SG10201501062SA
Other languages
English (en)
Inventor
Hon-Wah Man
George W Muller
Alexander Ruchelman
Ehab M Khalil
Roger Shen-Chu Chen
Weihong Zhang
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of SG10201501062SA publication Critical patent/SG10201501062SA/en

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Virology (AREA)
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  • Molecular Biology (AREA)
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  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
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SG10201501062SA 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same SG10201501062SA (en)

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US30361810P 2010-02-11 2010-02-11

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SG10201501062SA true SG10201501062SA (en) 2015-04-29

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SG10201501062SA SG10201501062SA (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
SG10202012179RA SG10202012179RA (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
SG2012059259A SG183257A1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

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SG2012059259A SG183257A1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

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US (8) US8518972B2 (fr)
EP (6) EP3106460B1 (fr)
JP (5) JP2013519675A (fr)
KR (2) KR101812356B1 (fr)
CN (2) CN104693193B (fr)
AR (1) AR081058A1 (fr)
AU (1) AU2011215877C1 (fr)
CA (1) CA2787823C (fr)
CO (1) CO6571916A2 (fr)
CR (1) CR20120414A (fr)
CY (3) CY1119177T1 (fr)
DK (3) DK3202461T3 (fr)
EC (1) ECSP12012098A (fr)
ES (5) ES2730763T3 (fr)
HR (3) HRP20171078T1 (fr)
HU (3) HUE044652T2 (fr)
IL (2) IL220992A (fr)
LT (3) LT2536706T (fr)
ME (2) ME03441B (fr)
MX (3) MX337169B (fr)
NI (1) NI201200132A (fr)
NZ (3) NZ601289A (fr)
PH (1) PH12014501082A1 (fr)
PL (3) PL3202461T3 (fr)
PT (3) PT3202461T (fr)
RS (3) RS56232B1 (fr)
RU (1) RU2567753C2 (fr)
SG (3) SG10201501062SA (fr)
SI (3) SI2536706T1 (fr)
TR (1) TR201903027T4 (fr)
UA (2) UA114856C2 (fr)
WO (1) WO2011100380A1 (fr)

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PT3202461T (pt) * 2010-02-11 2019-03-19 Celgene Corp Derivados arilmetoxi-indolina e composições que os compreendem e métodos para a sua utilização
US9090585B2 (en) * 2011-03-28 2015-07-28 Deuterx, Llc 2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds
CN103688176A (zh) 2011-04-29 2014-03-26 细胞基因公司 利用cereblon作为预报因子治疗癌和炎性疾病的方法
MX358517B (es) 2012-06-29 2018-08-24 Celgene Corp Métodos para determinar eficacia de fármacos usando proteínas asociadas a cereblon.
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CA2878954C (fr) * 2012-08-09 2020-12-08 Benjamin M. Cohen Sels et formes solides de la (s)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione et des compositions les comprenant et ses procedes d'utilisation
CN108245518B (zh) * 2012-08-09 2021-08-31 细胞基因公司 利用3-(4-((4-(吗啉代甲基)苯甲基)氧基)-1-氧代异二氢吲哚-2-基)哌啶-2,6- 二酮治疗癌症的方法
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US9695145B2 (en) 2013-01-22 2017-07-04 Celgene Corporation Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
CA2941560A1 (fr) 2013-03-14 2014-09-25 Deuterx, Llc Derives de 3-(oxoquinazolin-3(4h)-yl-4 substitue)-3-deutero-piperidine-2,6-dione et des compositions les comprenant et des procedes les utilisant
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