EA201691144A1 - Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка - Google Patents

Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка

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EA201691144A1
EA201691144A1 EA201691144A EA201691144A EA201691144A1 EA 201691144 A1 EA201691144 A1 EA 201691144A1 EA 201691144 A EA201691144 A EA 201691144A EA 201691144 A EA201691144 A EA 201691144A EA 201691144 A1 EA201691144 A1 EA 201691144A1
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Eurasian Patent Office
Prior art keywords
cell
methods
diffuse large
malignant
myoid
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EA201691144A
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English (en)
Inventor
Мэттью Уилльям Бернелл Троттер
Патрик Хагнер
Кортни Дж. Хэвенз
Раджеш Чопра
Анита Гандхи
Анке Клиппел
Мария Инлинь Ванг
Майк Брейдер
Сьюзанн Стурлини Кауто
Ян Рен
Пол Холленбах
Кайл Макбет
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Селджин Корпорейшн
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Application filed by Селджин Корпорейшн filed Critical Селджин Корпорейшн
Publication of EA201691144A1 publication Critical patent/EA201691144A1/ru

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Abstract

В некоторых вариантах осуществления настоящее изобретение относится к способам применения конкретных цереблон-ассоциированных белков, таких как Aiolos, Ikaros, интерферон (ИФН) и белки пути ИФН, казеинкиназы 1 альфа 1 (CSNK1A1) и ZFP9, в качестве биомаркеров для применения в прогнозировании и мониторинге клинической чувствительности и терапевтического ответа на конкретные соединения у пациентов, имеющих различные заболевания и нарушения, такие как злокачественные новообразования (например, диффузная крупноклеточная В-клеточная лимфома (DLBCL), множественная миелома (ММ), миелодиспластические синдромы (MDS) и острый миелолейкоз (AML)) и ИФН-ассоциированные нарушения. Кроме того, в определенных вариантах осуществления настоящее изобретение относится к способам определения эффективности иммуномодулирующего соединения.
EA201691144A 2013-12-06 2014-12-05 Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка EA201691144A1 (ru)

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