BR112016012795A2 - Métodos para a determinação da eficácia do fármaco para o tratamento de linfoma difuso de grandes células b, mieloma múltiplo e cânceres mieloides - Google Patents

Métodos para a determinação da eficácia do fármaco para o tratamento de linfoma difuso de grandes células b, mieloma múltiplo e cânceres mieloides

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Publication number
BR112016012795A2
BR112016012795A2 BR112016012795A BR112016012795A BR112016012795A2 BR 112016012795 A2 BR112016012795 A2 BR 112016012795A2 BR 112016012795 A BR112016012795 A BR 112016012795A BR 112016012795 A BR112016012795 A BR 112016012795A BR 112016012795 A2 BR112016012795 A2 BR 112016012795A2
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BR
Brazil
Prior art keywords
methods
effectiveness
determining
cell lymphoma
multiple myeloma
Prior art date
Application number
BR112016012795A
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English (en)
Inventor
William Burnell Trotter Matthew
Hagner Patrick
G Havens Courtney
Chopra Rajesh
Gandhi Anita
Klippel Anke
Yinglin Wang Maria
Breider Mike
Sturlini COUTO Suzana
Ren Yan
Hollenbach Paul
Macbeth Kyle
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Celgene Corp
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Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BR112016012795A2 publication Critical patent/BR112016012795A2/pt

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Abstract

MÉTODOS PARA A DETERMINAÇÃO DA EFICÁCIA DO FÁRMACO PARA O TRATAMENTO DE LINFOMA DIFUSO DE GRANDES CÉLULAS B, MIELOMA MÚLTIPLO E CÂNCERES MIELOIDES. A presente invenção refere-se, em algumas modalidades, a métodos de uso de certas proteínas associadas a cereblon, tais como Aiolos, Ikaros, interferon (IFN) e proteínas do caminho de IFN, caseína cinase 1, alfa 1 (CSNK1A1), e ZFP9, como biomarcadores para o uso na previsão e monitoramento da sensibilidade clínica e resposta terapêutica a certos compostos em pacientes tendo várias doenças e distúrbios, tais como os cânceres (por exemplo, linfoma difuso de grandes células B (DLBCL), mieloma múltiplo (MM), síndromes mielodisplásicas (MDS) e leucemia mieloide aguda (AML)) e distúrbios associado a IFN. Também provido aqui, em certas modalidades, são os métodos de determinar a eficácia de um composto imunomodulador.
BR112016012795A 2013-12-06 2014-12-05 Métodos para a determinação da eficácia do fármaco para o tratamento de linfoma difuso de grandes células b, mieloma múltiplo e cânceres mieloides BR112016012795A2 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361913003P 2013-12-06 2013-12-06
US201461947963P 2014-03-04 2014-03-04
US201461990621P 2014-05-08 2014-05-08
US201462061050P 2014-10-07 2014-10-07
US201462064413P 2014-10-15 2014-10-15
US201462077835P 2014-11-10 2014-11-10
US201462087111P 2014-12-03 2014-12-03
PCT/US2014/068795 WO2015085172A2 (en) 2013-12-06 2014-12-05 Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers

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BR112016012795A2 true BR112016012795A2 (pt) 2017-08-08

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Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2420497T3 (en) 2006-09-26 2016-03-07 Celgene Corp 5-substituted quinazolinone derivatives as anticancer agents
RS58523B1 (sr) 2010-02-11 2019-04-30 Celgene Corp Derivati arilmetoksi izoindolina i kombinacije koje ih obuhvataju i postupci njihove upotrebe
MX2013010360A (es) 2011-03-11 2014-04-14 Celgene Corp Formas solidas sde 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-pi peridin-2,6-diona, y sus composiciones farmaceuticas y usos.
ES2814952T3 (es) 2012-09-04 2021-03-29 Celgene Corp Isotopólogos de 3-(5-amino-2-metil-4-oxoquinazolin-3(4H)-il) piperidina-2-6-diona y métodos de preparación de los mismos
US9695145B2 (en) 2013-01-22 2017-07-04 Celgene Corporation Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
EP3594359B1 (en) 2013-11-06 2022-05-18 The United States of America, as represented by the Secretary, Department of Health and Human Services Method for subtyping lymphoma types by means of expression profiling
EP3077548B1 (en) 2013-12-06 2021-11-10 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
JP6640126B2 (ja) 2014-06-27 2020-02-05 セルジーン コーポレイション セレブロン及び他のｅ３ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法
IL294449B1 (en) 2015-03-31 2024-01-01 Syros Pharmaceuticals Inc Methods for stratifying patients for treatment with retinoic acid alpha receptor agonists
WO2016196580A1 (en) 2015-06-02 2016-12-08 Celgene Corporation Methods for determining drug efficacy for treatment of cancer using ratios of cereblon associated proteins
JP2018523823A (ja) * 2015-08-04 2018-08-23 セルジーン コーポレイション 慢性リンパ球性白血病の治療方法及び免疫調節療法に対する臨床的感度の予測因子としてのバイオマーカーの利用
US20180231561A1 (en) * 2015-08-12 2018-08-16 Celgene Corporation Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
EP3352756A1 (en) * 2015-09-25 2018-08-01 Celgene Corporation Methods for treating diffuse large b-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs
WO2017100259A1 (en) * 2015-12-08 2017-06-15 Icahn School Of Medicine At Mount Sinai Pretransplant prediction of post-transplant acute rejection
WO2017117118A1 (en) * 2015-12-28 2017-07-06 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
MX2018008421A (es) 2016-01-08 2019-12-09 Celgene Corp Métodos para tratar cáncer y el uso de biomarcadores como predictor de sensibilidad clínica a terapias.
US11311540B2 (en) 2016-02-17 2022-04-26 Acetylon Pharmaceuticals, Inc. Increasing expression of interferon regulated genes with combinations of histone deacetylase inhibitors and immunomodulatory drugs
AU2017248187B2 (en) * 2016-04-08 2023-03-16 Syros Pharmaceuticals, Inc. Rara agonists for the treatment of AML and MDS
US9868994B2 (en) 2016-04-08 2018-01-16 Syros Pharmaceuticals, Inc. Methods of stratifying patients for treatment with retinoic acid receptor-α agonists
US11725248B2 (en) 2016-04-20 2023-08-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Evaluation of mantle cell lymphoma and methods related thereto
SG10201607303YA (en) * 2016-09-01 2018-04-27 Agency Science Tech & Res Antisense oligonucleotides to induce exon skipping
BR112019011065A2 (pt) 2016-12-03 2019-10-01 Juno Therapeutics Inc métodos para determinação da dosagem de células t car
WO2018102786A1 (en) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methods for modulation of car-t cells
US20180238886A1 (en) * 2017-01-31 2018-08-23 Celgene Corporation Methods for treating hematological cancer and the use of biomarkers as a predictor for responsiveness to treatment compounds
WO2018165482A1 (en) * 2017-03-10 2018-09-13 Memorial Sloan Kettering Cancer Center Methods for treatment or prevention of leukemia
IL310031A (en) 2017-05-01 2024-03-01 Juno Therapeutics Inc A combination of cellular therapy and an immune modulatory compound
AU2018275894A1 (en) 2017-06-02 2019-12-12 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
CA3067602A1 (en) 2017-06-29 2019-01-03 Juno Therapeutics, Inc. Mouse model for assessing toxicities associated with immunotherapies
US20210024997A1 (en) * 2017-10-16 2021-01-28 Massachusetts Institute Of Technology Cell atlas of healthy and diseased tissues
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
US11623961B2 (en) 2017-11-01 2023-04-11 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for B-cell maturation antigen
JP2021508317A (ja) 2017-12-01 2021-03-04 ジュノー セラピューティクス インコーポレイテッド 遺伝子操作された細胞の投与および調節のための方法
KR20210018199A (ko) * 2018-03-26 2021-02-17 씨4 테라퓨틱스, 인코포레이티드 이카로스의 분해를 위한 세레블론 결합제
CN110448548B (zh) * 2018-05-08 2023-05-05 四川大学华西医院 Ifitm2抑制剂在制备治疗乙型肝炎的药物中的用途
WO2019226770A1 (en) * 2018-05-23 2019-11-28 Celgene Corporation Treating multiple myeloma and the use of biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-4-yl)oxy)methyl)benzyl) piperazin-1-yl)-3-fluorobenzonitrile
US20220008477A1 (en) 2018-11-08 2022-01-13 Juno Therapeutics, Inc. Methods and combinations for treatment and t cell modulation
SG11202105084VA (en) 2018-11-16 2021-06-29 Juno Therapeutics Inc Methods of dosing engineered t cells for the treatment of b cell malignancies
JP2022513685A (ja) 2018-11-30 2022-02-09 ジュノー セラピューティクス インコーポレイテッド 養子細胞療法を用いた処置のための方法
CN109583222A (zh) * 2018-12-07 2019-04-05 浪潮(北京)电子信息产业有限公司 分布式文件系统元数据服务器回收客户端权限方法及装置
US20220096651A1 (en) 2019-01-29 2022-03-31 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)
SG11202109024YA (en) 2019-04-12 2021-09-29 C4 Therapeutics Inc Tricyclic degraders of ikaros and aiolos
US20220299513A1 (en) * 2019-05-10 2022-09-22 University Of Massachusetts Irf2 as a prognostic biomarker and target for augmenting immunotherapy
CA3147887A1 (en) * 2019-07-19 2021-01-28 Pascal Biosciences Inc. Composition and methods of targeting the pre-b cell receptor for the treatment of leukemias and lymphomas
WO2021102420A1 (en) * 2019-11-22 2021-05-27 The Regents Of The University Of California Interferon signaling as a cancer biomarker
CN111187755B (zh) * 2020-02-20 2021-10-22 中国人民解放军军事科学院军事医学研究院 抗tpd52单克隆抗体杂交瘤细胞株及其单克隆抗体与应用
US11366101B1 (en) 2020-12-31 2022-06-21 Elephas Biosciences Corporation Ex vivo systems and methods for determining the effect of a drug or other agent on a tissue
CA3208313A1 (en) 2021-01-13 2022-07-21 Monte Rosa Therapeutics Ag Isoindolinone compounds
WO2022169731A1 (en) * 2021-02-03 2022-08-11 Curis Inc. Biomarkers for fimepinostat therapy
KR102629955B1 (ko) * 2021-02-19 2024-01-25 가톨릭대학교 산학협력단 Ewsr1의 발현 또는 활성 촉진제를 포함하는 비알콜성 지방간염 예방 또는 치료용 약학적 조성물
CN113025720B (zh) * 2021-04-28 2022-12-27 深圳市人民医院 一种用于检测原发性乳腺弥漫性大b细胞淋巴瘤的标志物及其试剂盒和应用
WO2023039405A1 (en) * 2021-09-08 2023-03-16 The Curators Of The University Of Missouri Methods of using usp15 inhibitors
WO2023222565A1 (en) * 2022-05-16 2023-11-23 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation
WO2023250400A1 (en) 2022-06-22 2023-12-28 Juno Therapeutics, Inc. Treatment methods for second line therapy of cd19-targeted car t cells

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
ATE205542T1 (de) 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7504225B2 (en) 2005-05-12 2009-03-17 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy
US20070099209A1 (en) 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US8445198B2 (en) * 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
WO2008027542A2 (en) 2006-08-30 2008-03-06 Celgene Corporation 5-substituted isoindoline compounds
US8877780B2 (en) 2006-08-30 2014-11-04 Celgene Corporation 5-substituted isoindoline compounds
CA2662508A1 (en) * 2006-09-19 2008-07-10 Novartis Ag Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors
EP2235535B1 (en) * 2007-12-07 2014-11-12 Celgene Corporation Biomarkers for predicting the sensitivity of cells to immunomodulatory compounds during treatment of non-hodgkin's lymphoma
US20090325176A1 (en) * 2008-06-05 2009-12-31 Wyeth Gene Expression Profiles Associated with Asthma Exacerbation Attacks
US20100190656A1 (en) 2008-08-08 2010-07-29 Integrated Diagnostics, Inc. Breast Cancer Specific Markers and Methods of Use
PE20140963A1 (es) 2008-10-29 2014-08-06 Celgene Corp Compuestos de isoindolina para el tratamiento de cancer
AU2010236606A1 (en) * 2009-04-14 2011-11-03 Merck Sharp & Dohme Corp. Interferon-alfa sensitivity biomarkers
WO2010137547A1 (ja) 2009-05-25 2010-12-02 国立大学法人東京工業大学 中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物
CN102576023B (zh) * 2009-10-20 2014-07-09 国立大学法人东京工业大学 利用沙利度胺靶向因子的筛选方法
RS58523B1 (sr) * 2010-02-11 2019-04-30 Celgene Corp Derivati arilmetoksi izoindolina i kombinacije koje ih obuhvataju i postupci njihove upotrebe
WO2011133130A1 (en) 2010-04-21 2011-10-27 Puritan Medical Products Company, Llc Collection device and material
US20110301102A1 (en) * 2010-06-07 2011-12-08 Telik, Inc. Compositions and methods for treating myelodysplastic syndrome
EP3266452B1 (en) * 2011-03-11 2019-07-03 Mayo Foundation for Medical Education and Research Means to treat myelomas which are resistant to thalidomide, lenalidomide or pomalidomide
CA2829592A1 (en) * 2011-03-11 2012-09-20 Celgene Corporation Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
AU2012249491B2 (en) * 2011-04-29 2016-12-15 Celgene Corporation Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
US20130042333A1 (en) * 2011-05-06 2013-02-14 Jean-Gabriel JUDDE Markers for cancer prognosis and therapy and methods of use
CN104737021A (zh) * 2012-01-13 2015-06-24 细胞基因公司 用于治疗肝细胞癌的生物标志物
WO2014004990A2 (en) * 2012-06-29 2014-01-03 Celgene Corporation Methods for determining drug efficacy using cereblon-associated proteins
CN108245518B (zh) * 2012-08-09 2021-08-31 细胞基因公司 利用3-(4-((4-(吗啉代甲基)苯甲基)氧基)-1-氧代异二氢吲哚-2-基)哌啶-2,6- 二酮治疗癌症的方法
US20140314752A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Methods for treating cancer using tor kinase inhibitor combination therapy
US20160282354A1 (en) * 2013-11-08 2016-09-29 The Broad Institute, Inc. Compositions and methods for selecting a treatment for b-cell neoplasias
EP3077547A4 (en) 2013-12-06 2017-11-08 Celgene Corporation Methods for treating hematological cancers and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
EP3077548B1 (en) 2013-12-06 2021-11-10 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
WO2016060702A1 (en) * 2014-10-13 2016-04-21 Celgene Corporaton Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
WO2016196580A1 (en) 2015-06-02 2016-12-08 Celgene Corporation Methods for determining drug efficacy for treatment of cancer using ratios of cereblon associated proteins
JP2018523823A (ja) 2015-08-04 2018-08-23 セルジーン コーポレイション 慢性リンパ球性白血病の治療方法及び免疫調節療法に対する臨床的感度の予測因子としてのバイオマーカーの利用
US20180231561A1 (en) 2015-08-12 2018-08-16 Celgene Corporation Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
EP3352756A1 (en) 2015-09-25 2018-08-01 Celgene Corporation Methods for treating diffuse large b-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs
MX2018008421A (es) 2016-01-08 2019-12-09 Celgene Corp Métodos para tratar cáncer y el uso de biomarcadores como predictor de sensibilidad clínica a terapias.

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