BR112016020315A2 - anticorpos de proteína acessória do receptor de interleucina-1 humana (il1rap) e seus usos - Google Patents
anticorpos de proteína acessória do receptor de interleucina-1 humana (il1rap) e seus usosInfo
- Publication number
- BR112016020315A2 BR112016020315A2 BR112016020315A BR112016020315A BR112016020315A2 BR 112016020315 A2 BR112016020315 A2 BR 112016020315A2 BR 112016020315 A BR112016020315 A BR 112016020315A BR 112016020315 A BR112016020315 A BR 112016020315A BR 112016020315 A2 BR112016020315 A2 BR 112016020315A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor
- human interleukin
- accessory protein
- il1rap
- protein antibodies
- Prior art date
Links
- 102000019223 Interleukin-1 receptor Human genes 0.000 title 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 1
- 101000960952 Homo sapiens Interleukin-1 receptor accessory protein Proteins 0.000 abstract 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000046828 human IL1RAP Human genes 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
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- Physics & Mathematics (AREA)
Abstract
a presente divulgação fornece um anticorpo ou um fragmento de ligação de antígeno do mesmo com especificidade de ligação para a proteína acessória do receptor de interleucina-1 humana (il1 rap), em que o anticorpo ou fragmento de ligação ao antígeno do mesmo é capaz de inibir a ligação do anticorpo de referência ?can04? a il1 rap humano. a divulgação fornece ainda o uso de tais anticorpos ou fragmentos de ligação ao antígeno no tratamento e/ou diagnóstico de doenças e condições associadas a il-1, incluindo cânceres, tais como leucemia mieloide aguda e melanoma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1403875.6A GB201403875D0 (en) | 2014-03-05 | 2014-03-05 | Novel antibodies and uses thereof |
GB1403875.6 | 2014-03-05 | ||
PCT/GB2015/050647 WO2015132602A1 (en) | 2014-03-05 | 2015-03-05 | Anti human interleukin-1 receptor accessory protein (il1 rap) antibodies and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016020315A2 true BR112016020315A2 (pt) | 2017-10-17 |
BR112016020315B1 BR112016020315B1 (pt) | 2024-05-07 |
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