PL3114145T3 - Przeciwciała przeciw ludzkiemu białku pomocniczemu receptora interleukiny-1 (il1rap) i ich zastosowania - Google Patents

Przeciwciała przeciw ludzkiemu białku pomocniczemu receptora interleukiny-1 (il1rap) i ich zastosowania

Info

Publication number
PL3114145T3
PL3114145T3 PL15714603T PL15714603T PL3114145T3 PL 3114145 T3 PL3114145 T3 PL 3114145T3 PL 15714603 T PL15714603 T PL 15714603T PL 15714603 T PL15714603 T PL 15714603T PL 3114145 T3 PL3114145 T3 PL 3114145T3
Authority
PL
Poland
Prior art keywords
il1rap
interleukin
receptor
antibodies against
human protein
Prior art date
Application number
PL15714603T
Other languages
English (en)
Inventor
Helena ÅGERSTAM
Thoas Fioretos
Marcus JÄRÅS
Cecilia Ann-Christin Malmborg Hager
Kjell SJÖSTRÖM
Agneta Svedberg
Karin Von Wachenfeldt
Original Assignee
Cantargia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50490826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3114145(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cantargia Ab filed Critical Cantargia Ab
Publication of PL3114145T3 publication Critical patent/PL3114145T3/pl

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PL15714603T 2014-03-05 2015-03-05 Przeciwciała przeciw ludzkiemu białku pomocniczemu receptora interleukiny-1 (il1rap) i ich zastosowania PL3114145T3 (pl)

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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
RU2597831C2 (ru) 2011-01-19 2016-09-20 Кантаргия Аб Анти-il1rap антитела и их применение при лечении людей
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
US9676863B2 (en) 2014-02-10 2017-06-13 Merck Patent Gmbh Targeted TGFβ inhibitors
GB201403875D0 (en) 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
TWI705976B (zh) 2014-11-10 2020-10-01 美商建南德克公司 抗介白素-33抗體及其用途
CN107109494B (zh) 2014-11-10 2023-10-27 豪夫迈·罗氏有限公司 Il-33介导型疾病的治疗方法和诊断方法
JP7114460B2 (ja) 2015-06-26 2022-08-08 サノフィ・バイオテクノロジー モノクローナル抗ＩＬ－１ＲＡｃＰ抗体
RU2766200C1 (ru) * 2015-10-01 2022-02-09 Хит Байолоджикс, Инк. Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков
HK1254374A1 (zh) * 2015-10-02 2019-07-19 Tgr生物科学私人有限公司 使用多基质的分析物检测
AU2016350705A1 (en) * 2015-11-02 2018-05-17 Janssen Pharmaceutica Nv Anti-IL1RAP antibodies, bispecific antigen binding molecules that bind IL1RAP and CD3, and uses thereof
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Ｃａｒ ｔ細胞療法のための方法および組成物
EP3241845A1 (en) * 2016-05-06 2017-11-08 MAB Discovery GmbH Humanized anti-il-1r3 antibodies
CA3084459A1 (en) 2016-10-16 2018-04-19 Cellerant Therapeutics, Inc. Anti-il1-rap antibodies
EP3548515B1 (en) 2016-12-01 2026-01-21 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
CN110612119B (zh) 2017-02-07 2024-10-29 西雅图儿童医院（Dba西雅图儿童研究所） 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂
CA3053348A1 (en) 2017-02-10 2018-08-16 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-lag3 antibodies for immuno-pet imaging
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞療法のための組成物および方法
WO2018169922A2 (en) * 2017-03-13 2018-09-20 Kite Pharma, Inc. Chimeric antigen receptors for melanoma and uses thereof
US10093741B1 (en) * 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
CA3062538A1 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
KR102612882B1 (ko) 2017-05-05 2023-12-11 센터 포 프로브 디벨롭먼트 앤드 커머셜리제이션 이관능성 킬레이트 및 그의 용도의 약동학적 증진
EP3401332A1 (en) * 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions
CA3066918A1 (en) * 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
KR102880156B1 (ko) 2017-07-24 2025-11-05 리제너론 파마슈티칼스 인코포레이티드 항cd8 항체 및 이의 용도
KR20200038490A (ko) * 2017-08-01 2020-04-13 시티 오브 호프 항-il1rap 항체
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
JP7549303B2 (ja) 2018-01-22 2024-09-11 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞の使用方法
SG11202007426XA (en) 2018-02-06 2020-09-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
CN112105382A (zh) 2018-02-23 2020-12-18 恩多塞特公司 用于car t细胞疗法的顺序方法
CN110759989B (zh) * 2018-07-27 2021-08-17 中国人民解放军总医院 IL-36γ作为动脉粥样硬化的标志物
US12209131B2 (en) * 2018-08-16 2025-01-28 Cantargia Ab Anti-IL1RAP antibody compositions
TW202021618A (zh) 2018-08-17 2020-06-16 美商２３與我有限公司 抗ｉｌ１ｒａｐ抗體及其使用方法
IT201800009282A1 (it) * 2018-10-09 2020-04-09 Metis Prec Medicine Sb Srl Nuovo agente terapeutico per il trattamento di un tumore e/o metastasi
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
EA202191556A1 (ru) * 2018-12-03 2021-10-14 Фьюжн Фармасьютикалз Инк. Комбинированная терапия радиоиммуноконъюгатами и ингибиторами контрольных точек
US11884719B2 (en) 2018-12-21 2024-01-30 23Andme, Inc. Anti-IL-36 antibodies and methods of use thereof
CN113710229B (zh) 2019-02-25 2026-01-06 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
CN110564848A (zh) * 2019-04-15 2019-12-13 上海市同仁医院 白介素-36在制备结直肠癌预后产品中的应用
WO2020215051A1 (en) * 2019-04-19 2020-10-22 Rpi Consulting Llc Treatments for pregnancy-related conditions
KR20220026585A (ko) * 2019-06-26 2022-03-04 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Il1rap 결합 단백질
US12503513B2 (en) 2019-08-12 2025-12-23 City Of Hope IL1RAP antibodies
US11896682B2 (en) 2019-09-16 2024-02-13 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof
AU2021217003A1 (en) 2020-02-04 2022-09-15 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-dinitrophenol chimeric antigen receptors
AU2021236306A1 (en) 2020-03-13 2022-09-15 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
WO2021207709A1 (en) * 2020-04-10 2021-10-14 Seattle Children's Hospital (dba Seattle Children's Research Institute) Binders and chimeric antigen receptors specific for interleukin-1 receptor accessory protein
MX2022014243A (es) * 2020-05-12 2022-12-02 Chia Tai Tianqing Pharmaceutical Group Co Ltd Proteina de union al antigeno st2.
US11970539B2 (en) 2020-09-14 2024-04-30 Ichnos Sciences SA Antibodies that bind to IL1RAP and uses thereof
JP2024500920A (ja) 2020-12-23 2024-01-10 カンタージア アクチエボラーグ 抗ｉｌ１ｒａｐ抗体
US20240317868A1 (en) * 2021-02-05 2024-09-26 Boehringer Ingelheim International Gmbh Anti-il1rap antibodies
JP2024520338A (ja) 2021-05-21 2024-05-24 レオ ファーマ アクティーゼルスカブ 抗ｉｌ－１受容体アクセサリータンパク質抗体
JP2025525479A (ja) * 2022-07-06 2025-08-05 ブルーフィン バイオメディスン，インコーポレイテッド 抗ｉｌ１ｒａｐ抗体及び抗体薬物複合体を用いた疾患の治療方法
AU2023345467A1 (en) 2022-09-21 2025-05-08 Sanofi Biotechnology Humanized anti-il-1r3 antibody and methods of use
WO2024231251A1 (en) * 2023-05-05 2024-11-14 Cantargia Ab Anti-il1rap antibodies
TW202530255A (zh) * 2023-12-15 2025-08-01 法商亞維西亞有限公司 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物
WO2025201513A1 (zh) * 2024-03-29 2025-10-02 珠海丹序生物制药有限公司 抗il1rap抗体及其用途
WO2026022232A1 (en) 2024-07-24 2026-01-29 Almirall, S.A. Il-1rap inhibitor for treating or preventing hidradenitis suppurativa
CN118772268B (zh) * 2024-09-10 2025-02-11 山东第二医科大学 猴痘病毒a29l单克隆抗体、试剂盒及应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
PE64396A1 (es) † 1995-01-23 1997-01-28 Hoffmann La Roche Proteina accesoria del receptor de la interleucina 1
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US20030215453A1 (en) 2002-05-14 2003-11-20 Dedera Douglas A. Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein
GB0131112D0 (en) 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP1639090A4 (en) 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
GB0316294D0 (en) 2003-07-11 2003-08-13 Polytherics Ltd Conjugated biological molecules and their preparation
PL1776384T3 (pl) 2004-08-04 2013-10-31 Mentrik Biotech Llc WARIANTY REGIONÓW Fc
JP2010507366A (ja) * 2006-10-19 2010-03-11 メルク アンド カンパニー インコーポレイテッド インターロイキン−１３受容体α１の抗体アンタゴニスト
CN104524567A (zh) * 2007-01-16 2015-04-22 阿布维公司 用于治疗银屑病的方法
CA2965198C (en) 2008-01-15 2021-02-16 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
JP2011515497A (ja) 2008-03-26 2011-05-19 セレラント セラピューティクス インコーポレイテッド 骨髄性血液学的増殖性疾患と関連する免疫グロブリンおよび／またはＴｏｌｌ様受容体タンパク質ならびにその使用
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
RU2597831C2 (ru) 2011-01-19 2016-09-20 Кантаргия Аб Анти-il1rap антитела и их применение при лечении людей
CA2837651A1 (en) * 2011-06-21 2012-12-27 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
CN103077969B (zh) 2011-10-26 2016-03-30 中国科学院微电子研究所 一种mos器件及其制造方法
US10126304B2 (en) † 2013-01-16 2018-11-13 George Mason Research Foundation, Inc. Binding domain mapping
GB201403875D0 (en) 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
GB201413913D0 (en) 2014-08-06 2014-09-17 Cantargia Ab Novel antibodies and uses thereof
JP7114460B2 (ja) 2015-06-26 2022-08-08 サノフィ・バイオテクノロジー モノクローナル抗ＩＬ－１ＲＡｃＰ抗体
AU2016350705A1 (en) 2015-11-02 2018-05-17 Janssen Pharmaceutica Nv Anti-IL1RAP antibodies, bispecific antigen binding molecules that bind IL1RAP and CD3, and uses thereof
WO2018071910A2 (en) 2016-10-16 2018-04-19 Cellerant Therapeutics, Inc. Anti-il1-rap antibodies
CA3084459A1 (en) 2016-10-16 2018-04-19 Cellerant Therapeutics, Inc. Anti-il1-rap antibodies

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IL247459A0 (en) 2016-11-30
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US20220106396A1 (en) 2022-04-07
ES2646550T3 (es) 2017-12-14
ES2861582T5 (es) 2024-09-18
CA2941437A1 (en) 2015-09-11
US20170029516A1 (en) 2017-02-02
IL247459B (en) 2019-10-31
US10287357B2 (en) 2019-05-14
JP2017515792A (ja) 2017-06-15
US20250340657A1 (en) 2025-11-06
CN106459195A (zh) 2017-02-22
SG11201607322PA (en) 2016-10-28
WO2015132602A1 (en) 2015-09-11
US20190202924A1 (en) 2019-07-04
AU2015225948A1 (en) 2016-09-08
GB201403875D0 (en) 2014-04-16
RU2710787C2 (ru) 2020-01-13
US10752692B2 (en) 2020-08-25
ES2861582T3 (es) 2021-10-06
JP6396488B2 (ja) 2018-09-26
US11236172B2 (en) 2022-02-01
EP3293202A1 (en) 2018-03-14
EP3114145B1 (en) 2017-09-13
DK3114145T3 (da) 2017-11-06
PT3114145T (pt) 2017-11-15
RU2016139068A3 (pl) 2018-12-14
US9796783B2 (en) 2017-10-24
CA2941437C (en) 2023-09-26
EP3293202B1 (en) 2021-02-24
MX2016011414A (es) 2016-12-02
LT3114145T (lt) 2017-11-10
CN106459195B (zh) 2018-07-20
MX360497B (es) 2018-11-05
DK3293202T3 (da) 2021-03-15
AU2015225948B2 (en) 2020-05-07
BR112016020315A2 (pt) 2017-10-17
RU2016139068A (ru) 2018-04-25
KR102519196B1 (ko) 2023-04-06
KR20160127131A (ko) 2016-11-02
EP3293202B2 (en) 2024-02-07
US12398213B2 (en) 2025-08-26
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