DK3169703T3 - Kimær antigenreceptor og anvendelse deraf - Google Patents

Kimær antigenreceptor og anvendelse deraf Download PDF

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Publication number
DK3169703T3
DK3169703T3 DK15738356.3T DK15738356T DK3169703T3 DK 3169703 T3 DK3169703 T3 DK 3169703T3 DK 15738356 T DK15738356 T DK 15738356T DK 3169703 T3 DK3169703 T3 DK 3169703T3
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DK
Denmark
Prior art keywords
chimary
antigen receptor
antigen
receptor
chimary antigen
Prior art date
Application number
DK15738356.3T
Other languages
English (en)
Other versions
DK3169703T4 (da
Inventor
Hinrich Abken
Andreas Hombach
Original Assignee
Hinrich Abken
Andreas Hombach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51178778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3169703(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hinrich Abken, Andreas Hombach filed Critical Hinrich Abken
Publication of DK3169703T3 publication Critical patent/DK3169703T3/da
Application granted granted Critical
Publication of DK3169703T4 publication Critical patent/DK3169703T4/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK15738356.3T 2014-07-16 2015-07-16 Kimær antigenreceptor og anvendelse deraf DK3169703T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14177278 2014-07-16
PCT/EP2015/066252 WO2016008973A1 (en) 2014-07-16 2015-07-16 Chimeric antigen receptor and its use

Publications (2)

Publication Number Publication Date
DK3169703T3 true DK3169703T3 (da) 2020-11-16
DK3169703T4 DK3169703T4 (da) 2024-02-26

Family

ID=51178778

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15738356.3T DK3169703T4 (da) 2014-07-16 2015-07-16 Kimær antigenreceptor og anvendelse deraf

Country Status (6)

Country Link
US (2) US10865243B2 (da)
EP (1) EP3169703B2 (da)
DK (1) DK3169703T4 (da)
ES (1) ES2833162T5 (da)
FI (1) FI3169703T4 (da)
WO (1) WO2016008973A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3039040T3 (da) 2013-08-26 2022-02-07 Hinrich Abken Kimær anti cd30-antigenreceptor og anvendelse deraf
AU2016219350A1 (en) * 2015-02-10 2017-08-24 Minerva Biotechnologies Corporation Humanized anti-MUC1* antibodies
EP3098237B1 (en) * 2015-05-28 2018-08-01 Universität Zu Köln Anti-toso chimeric antigen receptor and its use
CN109705211B (zh) * 2017-10-26 2020-08-18 苏州复融生物技术有限公司 一种IgG1 Fc单体及其应用
GB201721833D0 (en) * 2017-12-22 2018-02-07 Cancer Research Tech Ltd Fusion proteins
WO2019184886A1 (zh) * 2018-03-26 2019-10-03 上海原能细胞医学技术有限公司 促进免疫细胞增殖的方法
CN112601546B (zh) * 2018-06-12 2024-04-16 湖南远泰生物技术有限公司 Plap-car-效应细胞
WO2020135426A1 (zh) * 2018-12-24 2020-07-02 信达生物制药(苏州)有限公司 全人源的抗cd30单链抗体及其应用
EP3902838A4 (en) * 2018-12-26 2022-12-21 Nanjing Legend Biotech Co., Ltd. CD30 BINDING FRACTIONS, CHEMERA ANTIGEN RECEPTORS AND THEIR USES
EP3747904A1 (en) * 2019-06-03 2020-12-09 Universität Regensburg Cd25-specific chimeric antigen receptors and their uses
WO2021221927A1 (en) 2020-04-27 2021-11-04 Parsons Corporation Narrowband iq signal obfuscation
US20230263890A1 (en) 2020-06-05 2023-08-24 Tessa Therapeutics Ltd. Treatment of cd30-positive cancer
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
CN117015456A (zh) 2021-02-08 2023-11-07 艾沛克斯品牌公司 具有远端接合区域的螺栓提取器
WO2022232797A2 (en) 2021-04-27 2022-11-03 Baylor College Of Medicine Virus-specific immune cells expressing chimeric antigen receptors
WO2022266192A1 (en) 2021-06-16 2022-12-22 Instil Bio, Inc. Receptors providing targeted costimulation for adoptive cell therapy
TW202321443A (zh) 2021-10-26 2023-06-01 新加坡商泰莎治療有限公司 用於生產編碼car之反轉錄病毒載體的細胞株
WO2023104910A1 (en) 2021-12-08 2023-06-15 Tessa Therapeutics Ltd. Treatment of lymphoma
WO2023198744A1 (en) 2022-04-13 2023-10-19 Tessa Therapeutics Ltd. Therapeutic t cell product
WO2024165024A1 (zh) * 2023-02-09 2024-08-15 星尘生物科技(上海)有限公司 一种嵌合抗原受体及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033205T2 (en) * 2010-12-23 2017-11-28 Janssen Biotech Inc Active, protease-resistant antibody-FC mutant
JP6850528B2 (ja) 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
US20130280220A1 (en) * 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
DK3039040T3 (da) * 2013-08-26 2022-02-07 Hinrich Abken Kimær anti cd30-antigenreceptor og anvendelse deraf

Also Published As

Publication number Publication date
WO2016008973A1 (en) 2016-01-21
US10865243B2 (en) 2020-12-15
EP3169703B1 (en) 2020-09-02
ES2833162T5 (es) 2024-06-12
FI3169703T4 (fi) 2024-03-01
US20170145095A1 (en) 2017-05-25
EP3169703B2 (en) 2023-12-13
DK3169703T4 (da) 2024-02-26
EP3169703A1 (en) 2017-05-24
US20220002401A1 (en) 2022-01-06
ES2833162T3 (es) 2021-06-14

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