DK3293202T3 - Anti human interleukin-1 receptor accessory protein (il1rap) antibodies and uses thereof - Google Patents

Anti human interleukin-1 receptor accessory protein (il1rap) antibodies and uses thereof Download PDF

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Publication number
DK3293202T3
DK3293202T3 DK17185792.3T DK17185792T DK3293202T3 DK 3293202 T3 DK3293202 T3 DK 3293202T3 DK 17185792 T DK17185792 T DK 17185792T DK 3293202 T3 DK3293202 T3 DK 3293202T3
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Prior art keywords
il1rap
antibodies
human interleukin
anti human
accessory protein
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DK17185792.3T
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English (en)
Inventor
Thoas Fioretos
Hager Cecilia Ann-Christin Malmborg
Kjell Sjöström
Agneta Svedberg
Wachenfeldt Karin Von
Helena Ågerstam
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Cantargia Ab
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07ORGANIC CHEMISTRY
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    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N2333/7155Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]

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DK17185792.3T 2014-03-05 2015-03-05 Anti human interleukin-1 receptor accessory protein (il1rap) antibodies and uses thereof DK3293202T3 (da)

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Application Number Priority Date Filing Date Title
GBGB1403875.6A GB201403875D0 (en) 2014-03-05 2014-03-05 Novel antibodies and uses thereof
EP15714603.6A EP3114145B1 (en) 2014-03-05 2015-03-05 Anti human interleukin-1 receptor accessory protein (il1rap) antibodies and uses thereof

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DK3293202T3 true DK3293202T3 (da) 2021-03-15

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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
EP3508498A1 (en) 2011-01-19 2019-07-10 Cantargia AB Novel agents and uses thereof
PL3105246T3 (pl) 2014-02-10 2021-11-29 Merck Patent Gmbh Ukierunkowane hamowanie tgf beta
EP3218515B1 (en) 2014-11-10 2023-04-26 F. Hoffmann-La Roche AG Therapeutic and diagnostic methods for il-33-mediated disorders
TWI705976B (zh) 2014-11-10 2020-10-01 美商建南德克公司 抗介白素-33抗體及其用途
CN115505042A (zh) 2015-06-26 2022-12-23 赛诺菲生物技术公司 单克隆抗il-1racp抗体
CN116063567A (zh) * 2015-10-01 2023-05-05 热生物制品有限公司 作为异源嵌合蛋白邻接i型和ii型胞外结构域的组合物和方法
US20180275121A1 (en) * 2015-10-02 2018-09-27 Tgr Biosciences Pty Ltd. Analyte Detection with Multiple Substrates
US20170121420A1 (en) * 2015-11-02 2017-05-04 Janssen Pharmaceutica Nv Anti-il1rap antibodies, bispecific antigen binding molecules that bind il1rap and cd3, and uses thereof
EP3241845A1 (en) 2016-05-06 2017-11-08 MAB Discovery GmbH Humanized anti-il-1r3 antibodies
CN110036028B (zh) * 2016-10-16 2023-09-08 坎塔吉亚有限责任公司 抗il1-rap抗体
JP7105235B2 (ja) 2016-12-01 2022-07-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 免疫petイメージングのための放射性標識された抗pd-l1抗体
EP3579870A4 (en) 2017-02-07 2020-12-30 Seattle Children's Hospital (DBA Seattle Children's Research Institute) PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS
IL268667B1 (en) 2017-02-10 2024-08-01 Regeneron Pharma Radiolabeled antibodies against LAG3 for immuno-PET imaging
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Car t細胞療法のための組成物および方法
TW201837175A (zh) * 2017-03-13 2018-10-16 美商凱特製藥公司 用於黑色素瘤之嵌合抗原受體及其用途
US11433148B2 (en) 2017-05-05 2022-09-06 Centre For Probe Development And Commercialization IGF-1R monoclonal antibodies and uses thereof
WO2018204869A1 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Pharmacokinetic enhancements of bifunctional chelates and uses thereof
US10093741B1 (en) * 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
EP3401332A1 (en) 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions
EP3638697A4 (en) * 2017-06-12 2021-07-07 Bluefin Biomedicine, Inc. ANTI-IL1RAP ANTIBODIES AND ANTIBODY INGREDIENT CONJUGATES
MA49683A (fr) 2017-07-24 2020-06-03 Regeneron Pharma Anticorps anti-cd8 et leurs utilisations
CN111246882A (zh) * 2017-08-01 2020-06-05 希望之城 抗il1rap抗体
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
US11779602B2 (en) 2018-01-22 2023-10-10 Endocyte, Inc. Methods of use for CAR T cells
CN110759989B (zh) * 2018-07-27 2021-08-17 中国人民解放军总医院 IL-36γ作为动脉粥样硬化的标志物
CN112638946A (zh) * 2018-08-16 2021-04-09 坎塔吉亚有限责任公司 抗il1rap抗体组合物
TW202021618A (zh) 2018-08-17 2020-06-16 美商23與我有限公司 抗il1rap抗體及其使用方法
IT201800009282A1 (it) * 2018-10-09 2020-04-09 Metis Prec Medicine Sb Srl Nuovo agente terapeutico per il trattamento di un tumore e/o metastasi
BR112021010670A2 (pt) * 2018-12-03 2021-08-24 Fusion Pharmaceuticals Inc. Terapia de combinação de radioimunoconjugado e inibidor de danos e reparo do dna
EA202191656A1 (ru) 2018-12-21 2021-10-26 23Эндми, Инк. Анти-il-36 антитела и способы их применения
CN110564848A (zh) * 2019-04-15 2019-12-13 上海市同仁医院 白介素-36在制备结直肠癌预后产品中的应用
WO2020215051A1 (en) * 2019-04-19 2020-10-22 Rpi Consulting Llc Treatments for pregnancy-related conditions
US20230295313A1 (en) * 2019-06-26 2023-09-21 Glaxosmithkline Intellectual Property Development Limited Il1rap binding proteins
EP4013794A4 (en) * 2019-08-12 2023-11-22 City of Hope ANTI-IL1RAP ANTIBODIES
KR20220152262A (ko) 2020-03-13 2022-11-15 제넨테크, 인크. 항-인터루킨-33 항체 및 이의 용도
EP4132658A4 (en) * 2020-04-10 2024-08-21 Seattle Childrens Hospital Dba Seattle Childrens Res Inst CHIMERIC ANTIGEN BINDERS AND RECEPTORS SPECIFIC TO THE ACCESSORY PROTEIN OF THE INTERLEUKIN-1 RECEPTOR
JP2023541627A (ja) * 2020-09-14 2023-10-03 イシュノス サイエンシズ ソシエテ アノニム Il1rapに結合する抗体及びその使用
MX2023007611A (es) 2020-12-23 2023-07-12 Cantargia Ab Anticuerpo anti-il1rap.
US20220411517A1 (en) 2021-05-21 2022-12-29 Leo Pharma A/S IL-1 Receptor Accessory Protein Inhibitors and Uses Thereof
WO2024011189A2 (en) * 2022-07-06 2024-01-11 Bluefin Biomedicine, Inc. Methods of treating disease using anti-il1rap antibodies and antibody drug conjugates
WO2024062074A1 (en) 2022-09-21 2024-03-28 Sanofi Biotechnology Humanized anti-il-1r3 antibody and methods of use

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
PE64396A1 (es) 1995-01-23 1997-01-28 Hoffmann La Roche Proteina accesoria del receptor de la interleucina 1
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US20030215453A1 (en) 2002-05-14 2003-11-20 Dedera Douglas A. Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein
GB0131112D0 (en) 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
WO2005005601A2 (en) 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
GB0316294D0 (en) 2003-07-11 2003-08-13 Polytherics Ltd Conjugated biological molecules and their preparation
CA2573192C (en) 2004-08-04 2013-09-10 Applied Molecular Evolution Inc. Variant fc regions
CA2667067A1 (en) * 2006-10-19 2008-04-24 Merck & Co., Inc. Antibody antagonists of interleukin-13 receptor .alpha.1
KR20090100461A (ko) * 2007-01-16 2009-09-23 아보트 러보러터리즈 건선의 치료방법
PT3043181T (pt) 2008-01-15 2020-06-17 Univ Leland Stanford Junior Marcadores de células estaminais de leucemia mielóide aguda
US20110044894A1 (en) 2008-03-26 2011-02-24 Cellerant Therapeutics, Inc. Immunoglobulin and/or Toll-Like Receptor Proteins Associated with Myelogenous Haematological Proliferative Disorders and Uses Thereof
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
EP3508498A1 (en) * 2011-01-19 2019-07-10 Cantargia AB Novel agents and uses thereof
US20150030586A1 (en) * 2011-06-21 2015-01-29 Sarah Ellen Warren Compositions and methods for the therapy and diagnosis of cancer
CN103077969B (zh) 2011-10-26 2016-03-30 中国科学院微电子研究所 一种mos器件及其制造方法
WO2014113433A1 (en) 2013-01-16 2014-07-24 George Mason University Binding domain mapping
GB201413913D0 (en) 2014-08-06 2014-09-17 Cantargia Ab Novel antibodies and uses thereof
CN115505042A (zh) 2015-06-26 2022-12-23 赛诺菲生物技术公司 单克隆抗il-1racp抗体
US20170121420A1 (en) 2015-11-02 2017-05-04 Janssen Pharmaceutica Nv Anti-il1rap antibodies, bispecific antigen binding molecules that bind il1rap and cd3, and uses thereof
CN110036028B (zh) 2016-10-16 2023-09-08 坎塔吉亚有限责任公司 抗il1-rap抗体
WO2018071910A2 (en) 2016-10-16 2018-04-19 Cellerant Therapeutics, Inc. Anti-il1-rap antibodies

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AU2015225948A1 (en) 2016-09-08
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US10287357B2 (en) 2019-05-14
PT3114145T (pt) 2017-11-15
JP6396488B2 (ja) 2018-09-26
AU2015225948B2 (en) 2020-05-07
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DK3114145T3 (da) 2017-11-06
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US20220106396A1 (en) 2022-04-07
US9796783B2 (en) 2017-10-24
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US20200339696A1 (en) 2020-10-29
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GB201403875D0 (en) 2014-04-16
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