CY1121872T1 - Αξιολογηση, δοκιμασιες και θεραπεια των pkal-μεσολαβουμενων διαταραχων - Google Patents
Αξιολογηση, δοκιμασιες και θεραπεια των pkal-μεσολαβουμενων διαταραχωνInfo
- Publication number
- CY1121872T1 CY1121872T1 CY20191100391T CY191100391T CY1121872T1 CY 1121872 T1 CY1121872 T1 CY 1121872T1 CY 20191100391 T CY20191100391 T CY 20191100391T CY 191100391 T CY191100391 T CY 191100391T CY 1121872 T1 CY1121872 T1 CY 1121872T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pkal
- mediated
- evaluation
- treatment
- testing
- Prior art date
Links
- 238000011156 evaluation Methods 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 4
- 102000003827 Plasma Kallikrein Human genes 0.000 abstract 2
- 108090000113 Plasma Kallikrein Proteins 0.000 abstract 2
- 208000028185 Angioedema Diseases 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- 108010080865 Factor XII Proteins 0.000 abstract 1
- 102000000429 Factor XII Human genes 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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Abstract
Η εφεύρεση παρέχει μεθόδους δοκιμασιών για την ανίχνευση του αναστολέα πρωτεάσης C1 πλάσματος (C1-INH) που προσδένεται στην καλλικρεΐνη πλάσματος, στον Παράγοντα XII ή και στα δύο και χρήσεις αυτών για την ταυτοποίηση υποκειμένων που βρίσκονται σε κίνδυνο ή πάσχουν από μια μεσολαβούμενη από pKal ή μεσολαβούμενη από βραδυκινίνη διαταραχή. Οι παρεχόμενες μέθοδοι επιτρέπουν την ανάλυση ασθενών με μεσολαβούμενο από καλλικρεΐνη πλάσματος αγγειοοίδημα (ΚΜΑ) ή άλλες νόσους που μεσολαβούνται από την pKal, χρήσιμες στην αξιολόγηση και τη θεραπεία.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361754600P | 2013-01-20 | 2013-01-20 | |
PCT/US2014/012090 WO2014113701A1 (en) | 2013-01-20 | 2014-01-17 | Evaluation, assays and treatment of pkal-mediated disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121872T1 true CY1121872T1 (el) | 2020-10-14 |
Family
ID=51210104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100391T CY1121872T1 (el) | 2013-01-20 | 2019-04-09 | Αξιολογηση, δοκιμασιες και θεραπεια των pkal-μεσολαβουμενων διαταραχων |
Country Status (21)
Country | Link |
---|---|
US (2) | US10690670B2 (el) |
EP (2) | EP3470837A1 (el) |
JP (3) | JP6656926B2 (el) |
KR (3) | KR102658793B1 (el) |
CN (2) | CN110208533B (el) |
AU (3) | AU2014207409B2 (el) |
CA (1) | CA2898446A1 (el) |
CY (1) | CY1121872T1 (el) |
DK (1) | DK2946206T3 (el) |
ES (1) | ES2718347T3 (el) |
HK (1) | HK1214361A1 (el) |
HR (1) | HRP20190528T1 (el) |
HU (1) | HUE044285T2 (el) |
IL (1) | IL239957B (el) |
LT (1) | LT2946206T (el) |
PL (1) | PL2946206T3 (el) |
PT (1) | PT2946206T (el) |
RS (1) | RS58635B1 (el) |
SI (1) | SI2946206T1 (el) |
TR (1) | TR201904638T4 (el) |
WO (1) | WO2014113701A1 (el) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
SI2521568T1 (sl) | 2010-01-06 | 2019-01-31 | Dyax Corp. | Proteini, ki vežejo plazemski kalikrein |
IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | KALLIKREIN PLASMA BINDING PROTEINS |
CN110208533B (zh) | 2013-01-20 | 2023-01-10 | 武田药品工业株式会社 | Pkal-介导的病症的评估、测定和治疗 |
AU2014224599B2 (en) * | 2013-03-08 | 2018-11-08 | Csl Behring Gmbh | Treatment and prevention of remote ischemia-reperfusion injury |
EP2970502A4 (en) | 2013-03-15 | 2016-11-30 | Dyax Corp | ANTI-PLASMA KALLIKREIN ANTIBODY |
KR20220107077A (ko) | 2014-01-21 | 2022-08-01 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도 |
BR112016022318A2 (pt) * | 2014-03-27 | 2017-10-31 | Dyax Corp | método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo |
AU2015373910B2 (en) * | 2015-01-02 | 2021-11-18 | Takeda Pharmaceutical Company Limited | Bispecific antibodies against plasma kallikrein and factor XII |
US10214731B2 (en) * | 2015-05-28 | 2019-02-26 | Cornell University | Adeno-associated virus mediated delivery of C1E1 as a therapy for angioedema |
EP3302540A4 (en) * | 2015-05-28 | 2018-08-22 | Cornell University | Adeno-associated virus mediated delivery of c1ei as a therapy for angioedema |
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