TR201904638T4 - pKal aracılı rahatsızlıkların değerlendirilmesi, analizi ve tedavisi. - Google Patents

pKal aracılı rahatsızlıkların değerlendirilmesi, analizi ve tedavisi. Download PDF

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TR201904638T4
TR201904638T4 TR2019/04638T TR201904638T TR201904638T4 TR 201904638 T4 TR201904638 T4 TR 201904638T4 TR 2019/04638 T TR2019/04638 T TR 2019/04638T TR 201904638 T TR201904638 T TR 201904638T TR 201904638 T4 TR201904638 T4 TR 201904638T4
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pkal
mediated
evaluation
treatment
analysis
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TR2019/04638T
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Joseph Kusumam
P Kaplan Allen
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Dyax Corp
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
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    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
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    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
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Abstract

Buluş, plazma kallikrein, Faktör XII veya her ikisine bağlanan plazma proteaz CI inhibitörünün (CI-INH) saptanmasına ilişkin analiz yöntemlerini ve pKal aracılı veya bradikinin aracılık rahatsızlık riski bulunan veya bundan şikayet eden süjelerin tanımlanmasına yönelik kullanımlarını sağlar. Sağlanan yöntemler, plazma kallikrein aracılı anjiyoödem (KMA) veya pKal?nin aracılık ettiği diğer hastalıkları olan hastaların değerlendirmede ve tedavide faydalı olan analizine izin verir.
TR2019/04638T 2013-01-20 2014-01-17 pKal aracılı rahatsızlıkların değerlendirilmesi, analizi ve tedavisi. TR201904638T4 (tr)

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US201361754600P 2013-01-20 2013-01-20

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TR201904638T4 true TR201904638T4 (tr) 2019-04-22

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TR2019/04638T TR201904638T4 (tr) 2013-01-20 2014-01-17 pKal aracılı rahatsızlıkların değerlendirilmesi, analizi ve tedavisi.

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US (2) US10690670B2 (tr)
EP (2) EP3470837A1 (tr)
JP (3) JP6656926B2 (tr)
KR (2) KR102419640B1 (tr)
CN (2) CN110208533B (tr)
AU (3) AU2014207409B2 (tr)
CA (1) CA2898446A1 (tr)
CY (1) CY1121872T1 (tr)
DK (1) DK2946206T3 (tr)
ES (1) ES2718347T3 (tr)
HK (1) HK1214361A1 (tr)
HR (1) HRP20190528T1 (tr)
HU (1) HUE044285T2 (tr)
IL (1) IL239957B (tr)
LT (1) LT2946206T (tr)
PL (1) PL2946206T3 (tr)
PT (1) PT2946206T (tr)
RS (1) RS58635B1 (tr)
SI (1) SI2946206T1 (tr)
TR (1) TR201904638T4 (tr)
WO (1) WO2014113701A1 (tr)

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