SE465777B - 5h-2,3-bensodiazepinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner innehaallande desamma - Google Patents

5h-2,3-bensodiazepinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner innehaallande desamma

Info

Publication number
SE465777B
SE465777B SE8503613A SE8503613A SE465777B SE 465777 B SE465777 B SE 465777B SE 8503613 A SE8503613 A SE 8503613A SE 8503613 A SE8503613 A SE 8503613A SE 465777 B SE465777 B SE 465777B
Authority
SE
Sweden
Prior art keywords
methyl
general formula
benzodiazepine
aminophenyl
dimethoxy
Prior art date
Application number
SE8503613A
Other languages
English (en)
Swedish (sv)
Other versions
SE8503613D0 (sv
SE8503613L (sv
Inventor
T Lang
J Koroesi
F Andrasi
P Botka
T Hamori
P Berzsenyi
K Goldschmidt
G Zolyomi
I Elekes
Z Lang
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SE8503613D0 publication Critical patent/SE8503613D0/xx
Publication of SE8503613L publication Critical patent/SE8503613L/xx
Publication of SE465777B publication Critical patent/SE465777B/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE8503613A 1984-07-27 1985-07-26 5h-2,3-bensodiazepinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner innehaallande desamma SE465777B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842882A HU191698B (en) 1984-07-27 1984-07-27 Process for producing new 1-aryl-5h-2beta-benzodiazepines

Publications (3)

Publication Number Publication Date
SE8503613D0 SE8503613D0 (sv) 1985-07-26
SE8503613L SE8503613L (sv) 1986-01-28
SE465777B true SE465777B (sv) 1991-10-28

Family

ID=10961503

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8503613A SE465777B (sv) 1984-07-27 1985-07-26 5h-2,3-bensodiazepinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner innehaallande desamma

Country Status (23)

Country Link
US (1) US4614740A (es)
JP (1) JPS6143174A (es)
AT (1) AT393123B (es)
BE (1) BE902953A (es)
CA (1) CA1277660C (es)
CH (1) CH667090A5 (es)
CS (1) CS251795B2 (es)
DD (1) DD236527A5 (es)
DE (1) DE3527117C2 (es)
DK (1) DK158727C (es)
ES (1) ES8608494A1 (es)
FI (1) FI84821C (es)
FR (1) FR2568252B1 (es)
GB (1) GB2162184B (es)
GR (1) GR851853B (es)
HU (1) HU191698B (es)
IT (1) IT1187712B (es)
NL (1) NL8502141A (es)
NO (1) NO162115C (es)
PH (1) PH22420A (es)
PL (1) PL145089B1 (es)
PT (1) PT80870B (es)
SE (1) SE465777B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
US5521174A (en) * 1990-12-21 1996-05-28 Gyogyszerkutato Intezet Kv. N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US6288057B1 (en) * 1994-08-31 2001-09-11 Eli Lilly And Company Physical form of dihydro-2,3-benzodiazepine derivative
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
AU2003303312A1 (en) * 2002-12-03 2004-08-30 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
EP1624875A4 (en) * 2003-05-16 2010-01-20 Vela Acquisition Corp TREATMENT OF GASTROINTESTINAL DYSFUNCTION AND RELATED LOADS WITH ENANTIOMERIC PURE (R) 2,3-BENZODIAZEPINE
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
JP4855838B2 (ja) * 2006-02-07 2012-01-18 道夫 本郷 錠剤容器
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30014A (en) * 1860-09-11 Bailboad-joint
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Also Published As

Publication number Publication date
GB2162184A (en) 1986-01-29
NL8502141A (nl) 1986-02-17
HUT38324A (en) 1986-05-28
DE3527117C2 (de) 1996-08-08
PL145089B1 (en) 1988-08-31
NO162115B (no) 1989-07-31
DK340685D0 (da) 1985-07-26
ES8608494A1 (es) 1986-07-16
DK340685A (da) 1986-01-28
ES545559A0 (es) 1986-07-16
CA1277660C (en) 1990-12-11
SE8503613D0 (sv) 1985-07-26
CH667090A5 (de) 1988-09-15
AT393123B (de) 1991-08-26
PL254701A1 (en) 1986-09-09
PT80870B (pt) 1987-09-18
FR2568252A1 (fr) 1986-01-31
GB2162184B (en) 1987-12-31
HU191698B (en) 1987-03-30
ATA220185A (de) 1991-01-15
GR851853B (es) 1985-12-02
JPS6143174A (ja) 1986-03-01
DK158727C (da) 1990-12-10
SE8503613L (sv) 1986-01-28
DD236527A5 (de) 1986-06-11
IT1187712B (it) 1987-12-23
FI84821C (fi) 1992-01-27
IT8521725A0 (it) 1985-07-26
PH22420A (en) 1988-09-12
FI852906L (fi) 1986-01-28
NO852973L (no) 1986-01-28
DE3527117A1 (de) 1986-01-30
FR2568252B1 (fr) 1987-03-20
GB8518971D0 (en) 1985-09-04
BE902953A (fr) 1986-01-22
JPH0413347B2 (es) 1992-03-09
FI84821B (fi) 1991-10-15
NO162115C (no) 1989-11-08
PT80870A (en) 1985-08-01
FI852906A0 (fi) 1985-07-26
CS251795B2 (en) 1987-08-13
DK158727B (da) 1990-07-09
US4614740A (en) 1986-09-30

Similar Documents

Publication Publication Date Title
SE465777B (sv) 5h-2,3-bensodiazepinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner innehaallande desamma
DE69128236T2 (de) N-Acyl-2,3-benzodiazepin-Derivate, diese enthaltende pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung
WO1998056792A1 (de) 3-substituierte 3,4-dihydro-thieno[2,3-d]pyrimidin-derivate, ihre herstellung und verwendung
US3466274A (en) Fluoreno-(1,9-ef)-1,4-diazepine-1-oxides and 1,3-diazafluoranthene-1-oxides
KR20200138087A (ko) 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 호모프탈이미드 유도체 화합물 및 이를 포함하는 약제학적 조성물
EP1025100B1 (de) 3-substituierte tetrahydropyridopyrimidinon-derivate, ihre herstellung und verwendung
CN101481323A (zh) 苯并环庚烯类衍生物、其制备方法及医药用途
US3760074A (en) Pharmaceutical compositions containing a 5-phenyl-7-bromo-1h-1,5-benzodiazepine-2,4-(3h,5h)-dione
HU191586B (en) Process for preparing new derivatives of pyridazine and pyrimidine
DE19629378A1 (de) Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DK141846B (da) Analogifremgangsmåde til fremstilling af 1-oxo- eller 1-thioxo-s-triazolo(4,3-a)(1,4)benzodiazepinderivater.
KR870001681B1 (ko) 히단토인 유도체의 제조방법
DE2509155A1 (de) 1,4-benzoxazinderivate und verfahren zu ihrer herstellung
US3660406A (en) 2-chloro-7-hydroxy-11-(1-piperazinyl)dibenz(b f)(1 4)oxazepines
EP0068240B1 (de) 2-Acylaminomethyl-1,4-benzodiazepin-Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
RU2057754C1 (ru) Гетероциклические соединения или их кислотно-аддитивные соли
EP0273239A1 (de) Neue kondensierte Diazepinone, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US3696093A (en) 2,4-benzodiazepines
US3309369A (en) Imidazo- and pyrimido-quinazolines
US3328406A (en) Amide and piperazides of carbazole-9-glyoxylic acid
WO1998056793A1 (de) 3-SUBSTITUIERTE PYRIDO [3',4':4,5] THIENO [2,3-d] PYRIMIDIN-DERIVATE, IHRE HERSTELLUNG UND VERWENDUNG
WO1997040020A1 (de) Phthalazinderivate, deren herstellung und verwendung als arzneimittel
HU194233B (en) Process for preparing 3,7-diazabicyclo/3.3.1/nonane derivatives and pharmaceuticals comprising these compounds
US4056529A (en) Dibenzopyrimidoazepines
Spano et al. 1-Adamantanecarboxylic acid amide of 4-aminoantipyrine

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8503613-5

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8503613-5

Format of ref document f/p: F