BE902953A - Derives de 5h-2,3-benzodiazepine procede pour les preparer et compositions pharmaceutiques les contenant - Google Patents

Derives de 5h-2,3-benzodiazepine procede pour les preparer et compositions pharmaceutiques les contenant

Info

Publication number
BE902953A
BE902953A BE1/011304A BE1011304A BE902953A BE 902953 A BE902953 A BE 902953A BE 1/011304 A BE1/011304 A BE 1/011304A BE 1011304 A BE1011304 A BE 1011304A BE 902953 A BE902953 A BE 902953A
Authority
BE
Belgium
Prior art keywords
preparation
benzodiazepine derivatives
pharmaceutical compositions
compositions containing
alkyl group
Prior art date
Application number
BE1/011304A
Other languages
English (en)
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of BE902953A publication Critical patent/BE902953A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nouveaux dérivés de 5H-2,3-benzodiazépine qui correspondent à la formule (I) dans laquelle R et R1 représentent un atome d'hydrogène, du chlore, un groupe alcoyle en C1-4, ou alcoxy; R2 est un atome d'hydrogène ou un groupe alcoyle en C1-4; R3 et R4 represéntent un groupe alcoyle en C1-4 ou forment ensemble un radical méthylène. Les composés décrits exercent des propriétés notables sur le système nerveux central.
BE1/011304A 1984-07-27 1985-07-22 Derives de 5h-2,3-benzodiazepine procede pour les preparer et compositions pharmaceutiques les contenant BE902953A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842882A HU191698B (en) 1984-07-27 1984-07-27 Process for producing new 1-aryl-5h-2beta-benzodiazepines

Publications (1)

Publication Number Publication Date
BE902953A true BE902953A (fr) 1986-01-22

Family

ID=10961503

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011304A BE902953A (fr) 1984-07-27 1985-07-22 Derives de 5h-2,3-benzodiazepine procede pour les preparer et compositions pharmaceutiques les contenant

Country Status (23)

Country Link
US (1) US4614740A (fr)
JP (1) JPS6143174A (fr)
AT (1) AT393123B (fr)
BE (1) BE902953A (fr)
CA (1) CA1277660C (fr)
CH (1) CH667090A5 (fr)
CS (1) CS251795B2 (fr)
DD (1) DD236527A5 (fr)
DE (1) DE3527117C2 (fr)
DK (1) DK158727C (fr)
ES (1) ES8608494A1 (fr)
FI (1) FI84821C (fr)
FR (1) FR2568252B1 (fr)
GB (1) GB2162184B (fr)
GR (1) GR851853B (fr)
HU (1) HU191698B (fr)
IT (1) IT1187712B (fr)
NL (1) NL8502141A (fr)
NO (1) NO162115C (fr)
PH (1) PH22420A (fr)
PL (1) PL145089B1 (fr)
PT (1) PT80870B (fr)
SE (1) SE465777B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717080A1 (de) * 1986-05-21 1987-11-26 Egyt Gyogyszervegyeszeti Gyar 1-(hydroxystyryl)-5h-2,3-benzodiazepinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
US5521174A (en) * 1990-12-21 1996-05-28 Gyogyszerkutato Intezet Kv. N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US6288057B1 (en) * 1994-08-31 2001-09-11 Eli Lilly And Company Physical form of dihydro-2,3-benzodiazepine derivative
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
EP1296960A2 (fr) * 2000-06-16 2003-04-02 Annovis, Inc. Antagonistes 5h-2,3-benzodiazepine de recepteurs d'acide amine excitateurs
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
MXPA05005895A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3, 4-dimetoxifenil)-4 -metil-5-etil -7-metoxi-8 -hidroxi- 5h-2, 3-benzodiacepina y usos de la misma.
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
CA2525273C (fr) * 2003-05-16 2012-04-17 Vela Pharmaceuticals, Inc. Traitement d'un dysfonctionnement gastro-intestinal et du stress associe au moyen d'une (r) 2,3-benzodiazepine pure sur le plan enantiomere
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
JP4855838B2 (ja) * 2006-02-07 2012-01-18 道夫 本郷 錠剤容器
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30014A (en) * 1860-09-11 Bailboad-joint
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717080A1 (de) * 1986-05-21 1987-11-26 Egyt Gyogyszervegyeszeti Gyar 1-(hydroxystyryl)-5h-2,3-benzodiazepinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3717080C2 (de) * 1986-05-21 1996-02-08 Egyt Gyogyszervegyeszeti Gyar 1-(Hydroxystyryl)-5H-2,3-benzodiazepinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
DK340685A (da) 1986-01-28
FI852906L (fi) 1986-01-28
ES8608494A1 (es) 1986-07-16
SE8503613D0 (sv) 1985-07-26
HU191698B (en) 1987-03-30
GB8518971D0 (en) 1985-09-04
DK340685D0 (da) 1985-07-26
PL254701A1 (en) 1986-09-09
JPH0413347B2 (fr) 1992-03-09
DE3527117C2 (de) 1996-08-08
PH22420A (en) 1988-09-12
SE465777B (sv) 1991-10-28
CA1277660C (fr) 1990-12-11
DD236527A5 (de) 1986-06-11
IT1187712B (it) 1987-12-23
SE8503613L (sv) 1986-01-28
GB2162184A (en) 1986-01-29
NO852973L (no) 1986-01-28
NL8502141A (nl) 1986-02-17
AT393123B (de) 1991-08-26
FI84821B (fi) 1991-10-15
DK158727C (da) 1990-12-10
PT80870B (pt) 1987-09-18
PL145089B1 (en) 1988-08-31
ES545559A0 (es) 1986-07-16
NO162115B (no) 1989-07-31
PT80870A (en) 1985-08-01
ATA220185A (de) 1991-01-15
FR2568252A1 (fr) 1986-01-31
GB2162184B (en) 1987-12-31
JPS6143174A (ja) 1986-03-01
DE3527117A1 (de) 1986-01-30
DK158727B (da) 1990-07-09
HUT38324A (en) 1986-05-28
NO162115C (no) 1989-11-08
CS251795B2 (en) 1987-08-13
IT8521725A0 (it) 1985-07-26
GR851853B (fr) 1985-12-02
FI852906A0 (fi) 1985-07-26
FR2568252B1 (fr) 1987-03-20
US4614740A (en) 1986-09-30
FI84821C (fi) 1992-01-27
CH667090A5 (de) 1988-09-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: EGIS GYOGYSZERGYAR

Effective date: 19990731