ATA220185A - Verfahren zur herstellung von neuen -aryl-5h-2,3-benzodiazepin-derivaten und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen -aryl-5h-2,3-benzodiazepin-derivaten und deren saeureadditionssalzen

Info

Publication number
ATA220185A
ATA220185A AT0220185A AT220185A ATA220185A AT A220185 A ATA220185 A AT A220185A AT 0220185 A AT0220185 A AT 0220185A AT 220185 A AT220185 A AT 220185A AT A220185 A ATA220185 A AT A220185A
Authority
AT
Austria
Prior art keywords
aryl
acid addition
addition salts
producing new
benzodiazepine derivatives
Prior art date
Application number
AT0220185A
Other languages
English (en)
Other versions
AT393123B (de
Inventor
Tibor Dr Lang
Jenoe Dr Koeroesi
Ferenc Dr Andrasi
Peter Ing Botka
Tamas Ing Hamori
Pal Dr Berzsenyi
Katalin Dr Goldschmidt
Gabor Dr Zolyomi
Istvan Dr Elekes
Zsuzsanne Dr Lang
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ATA220185A publication Critical patent/ATA220185A/de
Application granted granted Critical
Publication of AT393123B publication Critical patent/AT393123B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT2201/85A 1984-07-27 1985-07-25 Verfahren zur herstellung von neuen -aryl-5h-2,3-benzodiazepin-derivaten und deren saeureadditionssalzen AT393123B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842882A HU191698B (en) 1984-07-27 1984-07-27 Process for producing new 1-aryl-5h-2beta-benzodiazepines

Publications (2)

Publication Number Publication Date
ATA220185A true ATA220185A (de) 1991-01-15
AT393123B AT393123B (de) 1991-08-26

Family

ID=10961503

Family Applications (1)

Application Number Title Priority Date Filing Date
AT2201/85A AT393123B (de) 1984-07-27 1985-07-25 Verfahren zur herstellung von neuen -aryl-5h-2,3-benzodiazepin-derivaten und deren saeureadditionssalzen

Country Status (23)

Country Link
US (1) US4614740A (de)
JP (1) JPS6143174A (de)
AT (1) AT393123B (de)
BE (1) BE902953A (de)
CA (1) CA1277660C (de)
CH (1) CH667090A5 (de)
CS (1) CS251795B2 (de)
DD (1) DD236527A5 (de)
DE (1) DE3527117C2 (de)
DK (1) DK158727C (de)
ES (1) ES8608494A1 (de)
FI (1) FI84821C (de)
FR (1) FR2568252B1 (de)
GB (1) GB2162184B (de)
GR (1) GR851853B (de)
HU (1) HU191698B (de)
IT (1) IT1187712B (de)
NL (1) NL8502141A (de)
NO (1) NO162115C (de)
PH (1) PH22420A (de)
PL (1) PL145089B1 (de)
PT (1) PT80870B (de)
SE (1) SE465777B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5521174A (en) * 1990-12-21 1996-05-28 Gyogyszerkutato Intezet Kv. N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US6288057B1 (en) * 1994-08-31 2001-09-11 Eli Lilly And Company Physical form of dihydro-2,3-benzodiazepine derivative
DE19604920A1 (de) 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
CA2525273C (en) * 2003-05-16 2012-04-17 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
JP4855838B2 (ja) * 2006-02-07 2012-01-18 道夫 本郷 錠剤容器
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30014A (en) * 1860-09-11 Bailboad-joint
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Also Published As

Publication number Publication date
BE902953A (fr) 1986-01-22
GB8518971D0 (en) 1985-09-04
ES8608494A1 (es) 1986-07-16
JPH0413347B2 (de) 1992-03-09
NO162115B (no) 1989-07-31
NO162115C (no) 1989-11-08
SE8503613L (sv) 1986-01-28
DK158727C (da) 1990-12-10
FI84821B (fi) 1991-10-15
DK340685A (da) 1986-01-28
JPS6143174A (ja) 1986-03-01
FR2568252A1 (fr) 1986-01-31
DE3527117A1 (de) 1986-01-30
GR851853B (de) 1985-12-02
PT80870A (en) 1985-08-01
DK158727B (da) 1990-07-09
SE465777B (sv) 1991-10-28
ES545559A0 (es) 1986-07-16
SE8503613D0 (sv) 1985-07-26
HUT38324A (en) 1986-05-28
FI852906L (fi) 1986-01-28
FR2568252B1 (fr) 1987-03-20
PH22420A (en) 1988-09-12
DE3527117C2 (de) 1996-08-08
PT80870B (pt) 1987-09-18
CH667090A5 (de) 1988-09-15
PL254701A1 (en) 1986-09-09
HU191698B (en) 1987-03-30
DD236527A5 (de) 1986-06-11
FI84821C (fi) 1992-01-27
GB2162184A (en) 1986-01-29
IT1187712B (it) 1987-12-23
NO852973L (no) 1986-01-28
DK340685D0 (da) 1985-07-26
CS251795B2 (en) 1987-08-13
AT393123B (de) 1991-08-26
NL8502141A (nl) 1986-02-17
CA1277660C (en) 1990-12-11
GB2162184B (en) 1987-12-31
FI852906A0 (fi) 1985-07-26
PL145089B1 (en) 1988-08-31
US4614740A (en) 1986-09-30
IT8521725A0 (it) 1985-07-26

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee