AT387216B - Verfahren zur herstellung von 2,4-diamino-5benzyl-pyrimidin-derivaten und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von 2,4-diamino-5benzyl-pyrimidin-derivaten und deren saeureadditionssalzen

Info

Publication number
AT387216B
AT387216B AT0290583A AT290583A AT387216B AT 387216 B AT387216 B AT 387216B AT 0290583 A AT0290583 A AT 0290583A AT 290583 A AT290583 A AT 290583A AT 387216 B AT387216 B AT 387216B
Authority
AT
Austria
Prior art keywords
5benzyl
diamino
producing
acid addition
addition salts
Prior art date
Application number
AT0290583A
Other languages
English (en)
Other versions
ATA290583A (de
Inventor
Ivan Dr Beck
Janos Egri
Elemer Jakfalvi
Gyoergyi Chem Ing Kovanyi
Eva Furdyga
Istvan Dr Simonyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ATA290583A publication Critical patent/ATA290583A/de
Application granted granted Critical
Publication of AT387216B publication Critical patent/AT387216B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Liquid Crystal Substances (AREA)
AT0290583A 1982-08-13 1983-08-11 Verfahren zur herstellung von 2,4-diamino-5benzyl-pyrimidin-derivaten und deren saeureadditionssalzen AT387216B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822604A HU188588B (en) 1982-08-13 1982-08-13 Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives

Publications (2)

Publication Number Publication Date
ATA290583A ATA290583A (de) 1988-05-15
AT387216B true AT387216B (de) 1988-12-27

Family

ID=10960229

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0290583A AT387216B (de) 1982-08-13 1983-08-11 Verfahren zur herstellung von 2,4-diamino-5benzyl-pyrimidin-derivaten und deren saeureadditionssalzen

Country Status (8)

Country Link
JP (1) JPS5993061A (de)
AT (1) AT387216B (de)
CH (1) CH657611A5 (de)
DE (1) DE3329226A1 (de)
GB (1) GB2125044B (de)
HU (1) HU188588B (de)
IT (1) IT1194372B (de)
SU (1) SU1222194A3 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1455736A (en) * 1973-07-27 1976-11-17 Hoffmann La Roche Benzylpyrimidine derivatives
DE2635765B2 (de) * 1976-08-09 1978-06-22 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Verfahren zur Herstellung von 2,4-Diamino-5-(3>,4'3'-trimethoxybenzyD-pyrimidin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR94837E (fr) * 1966-02-19 1969-11-28 Wellcome Found Procédé de préparation de dérivés de la pyrimidine.
DK136470B (da) * 1973-11-08 1977-10-17 Hoffmann La Roche Analogifremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimidinderivater eller salte deraf.
AR207671A1 (es) * 1975-01-03 1976-10-22 Prayon Procedimiento para la obtencion de un pigmento basico de oxido de hierro en forma alfa-fe2o3
DE2559752C3 (de) * 1975-10-17 1978-12-07 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5-(3-methoxy-4-hydroxy-5-methyl-benzyl)-pyrimidin, Verfahren zu seiner Herstellung und diese Verbindung enthaltendes Arzneimittel
DE2546667C3 (de) * 1975-10-17 1978-10-12 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-DiamüH»-5-(3-methoxy-4-hydroxy-5-halogenbenzyl)-pyrimidine, und diese Verbindungen enthaltende Arzneimittel
DE2617967C3 (de) * 1976-04-24 1978-11-02 Nordmark-Werke Gmbh, 2000 Hamburg Verfahren zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen
PT69656A (en) * 1978-05-24 1979-06-01 Wellcome Found Benzylpyrimidine compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1455736A (en) * 1973-07-27 1976-11-17 Hoffmann La Roche Benzylpyrimidine derivatives
DE2635765B2 (de) * 1976-08-09 1978-06-22 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Verfahren zur Herstellung von 2,4-Diamino-5-(3>,4'3'-trimethoxybenzyD-pyrimidin

Also Published As

Publication number Publication date
IT8322540A1 (it) 1985-02-12
DE3329226A1 (de) 1984-02-23
HU188588B (en) 1986-04-28
GB8321618D0 (en) 1983-09-14
IT1194372B (it) 1988-09-22
CH657611A5 (de) 1986-09-15
JPS5993061A (ja) 1984-05-29
ATA290583A (de) 1988-05-15
SU1222194A3 (ru) 1986-03-30
GB2125044A (en) 1984-02-29
IT8322540A0 (it) 1983-08-12
GB2125044B (en) 1985-09-18

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee