AT383120B - Verfahren zur herstellung von neuen 3,4-dihydro-5h-2,3-benzodiazepinderivaten sowie von deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen 3,4-dihydro-5h-2,3-benzodiazepinderivaten sowie von deren saeureadditionssalzen

Info

Publication number
AT383120B
AT383120B AT0096982A AT96982A AT383120B AT 383120 B AT383120 B AT 383120B AT 0096982 A AT0096982 A AT 0096982A AT 96982 A AT96982 A AT 96982A AT 383120 B AT383120 B AT 383120B
Authority
AT
Austria
Prior art keywords
dihydro
acid addition
addition salts
producing new
benzodiazepine derivatives
Prior art date
Application number
AT0096982A
Other languages
English (en)
Other versions
ATA96982A (de
Inventor
Jenoe Dr Chem Ing Koeroesi
Tibor Dr Chem Ing Lang
Ferenc Dr Andrasi
Jozsef Dr Szekely
Tamas Chem Ing Hamori
Tibor Dr Chem Ing Balogh
Lajos Chem Ing Ila
Katalin Dr Goldschmidt
Eleonora Dr Sineger
Imre Chem Ing Moravcsik
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ATA96982A publication Critical patent/ATA96982A/de
Application granted granted Critical
Publication of AT383120B publication Critical patent/AT383120B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0096982A 1981-03-12 1982-03-11 Verfahren zur herstellung von neuen 3,4-dihydro-5h-2,3-benzodiazepinderivaten sowie von deren saeureadditionssalzen AT383120B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU81620A HU186760B (en) 1981-03-12 1981-03-12 Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Publications (2)

Publication Number Publication Date
ATA96982A ATA96982A (de) 1986-10-15
AT383120B true AT383120B (de) 1987-05-25

Family

ID=10950496

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0096982A AT383120B (de) 1981-03-12 1982-03-11 Verfahren zur herstellung von neuen 3,4-dihydro-5h-2,3-benzodiazepinderivaten sowie von deren saeureadditionssalzen

Country Status (23)

Country Link
US (1) US4423044A (de)
JP (1) JPS57159772A (de)
AT (1) AT383120B (de)
AU (1) AU550388B2 (de)
BE (1) BE892395A (de)
CA (1) CA1178584A (de)
CH (1) CH648553A5 (de)
CS (1) CS224646B2 (de)
DD (1) DD204698A5 (de)
DE (1) DE3209100A1 (de)
DK (1) DK106882A (de)
ES (1) ES8302671A1 (de)
FI (1) FI820839L (de)
FR (1) FR2501686A1 (de)
GB (1) GB2097387B (de)
GR (1) GR76111B (de)
HU (1) HU186760B (de)
IL (1) IL65076A (de)
IT (1) IT1190732B (de)
NL (1) NL8201005A (de)
NO (1) NO820798L (de)
SE (1) SE8201537L (de)
SU (1) SU1151206A3 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971179A (en) * 1969-08-13 1976-07-27 Andrew Bodocsi Non-bonded framing system
DE3124013A1 (de) * 1981-06-19 1982-12-30 Kali-Chemie Pharma Gmbh, 3000 Hannover 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
EP0322582A3 (de) * 1987-12-07 1989-09-13 Hoechst-Roussel Pharmaceuticals Incorporated 4-Heteroaryl-1,3-benzodiazepine und 2-substituierte Alpha-(heteroaryl) benzenethanamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
EP0726256A1 (de) * 1995-02-09 1996-08-14 Egis Gyogyszergyar Rt. 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
US6080736A (en) * 1999-10-27 2000-06-27 Janus Pharmaceuticals, Inc. Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7745431B2 (en) * 2002-12-03 2010-06-29 Vela Acquisition Corporation Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
MXPA05005893A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3-hidroxi -4-metoxifenil) -4-metil-5 -etil-7, 8-dimetoxi- 5h-2, 3-benzodiazepina y usos de la misma.
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
JP4611308B2 (ja) * 2003-05-16 2011-01-12 ヴェラ アクイジション コーポレイション 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2439189B1 (de) * 1978-10-19 1984-11-30 Egyt Gyogyszervegyeszeti Gyar

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2439189B1 (de) * 1978-10-19 1984-11-30 Egyt Gyogyszervegyeszeti Gyar

Also Published As

Publication number Publication date
ES510348A0 (es) 1983-02-01
ES8302671A1 (es) 1983-02-01
US4423044A (en) 1983-12-27
CA1178584A (en) 1984-11-27
IT1190732B (it) 1988-02-24
IT8220094A0 (it) 1982-03-11
SU1151206A3 (ru) 1985-04-15
CH648553A5 (de) 1985-03-29
FR2501686B1 (de) 1985-03-01
DD204698A5 (de) 1983-12-07
FI820839L (fi) 1982-09-13
BE892395A (fr) 1982-09-08
DE3209100A1 (de) 1982-10-28
GB2097387B (en) 1984-09-19
GR76111B (de) 1984-08-03
NL8201005A (nl) 1982-10-01
NO820798L (no) 1982-09-13
IL65076A (en) 1984-12-31
JPS57159772A (en) 1982-10-01
CS224646B2 (en) 1984-01-16
FR2501686A1 (fr) 1982-09-17
GB2097387A (en) 1982-11-03
HU186760B (en) 1985-09-30
DK106882A (da) 1982-09-13
ATA96982A (de) 1986-10-15
SE8201537L (sv) 1982-09-13
AU8130882A (en) 1982-09-16
AU550388B2 (en) 1986-03-20

Similar Documents

Publication Publication Date Title
AT383120B (de) Verfahren zur herstellung von neuen 3,4-dihydro-5h-2,3-benzodiazepinderivaten sowie von deren saeureadditionssalzen
AT376665B (de) Verfahren zur herstellung von neuen imidazolderivaten und von deren saeureadditionssalzen
AT373589B (de) Verfahren zur herstellung von neuen 5h-2,3benzodiazepin-derivaten und deren saeureadditions- salzen
ATA220185A (de) Verfahren zur herstellung von neuen -aryl-5h-2,3-benzodiazepin-derivaten und deren saeureadditionssalzen
AT384805B (de) Verfahren zur herstellung von neuen 1,2-diaminocyclobuten-3,4-dionen und deren salzen
ATA267888A (de) Verfahren zur herstellung von neuen 1,4-dihydro-4-oxonaphthydridin-derivaten und deren salzen
AT386198B (de) Verfahren zur herstellung von neuen carbostyrilderivaten und von deren pharmazeutisch annehmbaren salzen
AT380015B (de) Verfahren zur herstellung von 1,5-benzothiazepinderivaten sowie von deren saeureadditionssalzen
AT387963B (de) Verfahren zur herstellung von neuen antidepressiven 1,2,4-triazolonverbindungen und von deren pharmazeutisch zulaessigen saeureadditionssalzen
AT381705B (de) Verfahren zur herstellung von neuen thiazolidindion-derivaten und deren salzen
AT368156B (de) Verfahren zur herstellung von neuen 4-oxo-4hpyrido(1,2-a)pyrimidinderivaten sowie von deren saeureadditions- oder quaternaeren salzen
AT368138B (de) Verfahren zur herstellung von 3-hydroxy-6-phenyl1,2,3,4-tetrahydro-1,5-benzodiazocinen sowie von deren saeureadditionssalzen
AT376983B (de) Verfahren zur herstellung von neuen 7-acylaminocephalosporansaeurederivaten und deren salzen
ATA272382A (de) Verfahren zur herstellung von neuen 3,7-diazabicyclo/3,3,1/ nonanderivaten, deren stereoisomren und physiologisch vertraeglichen saeureadditionssalzen
AT381308B (de) Verfahren zur herstellung von neuen fluorprostacyclinen und von deren salzen
AT386204B (de) Verfahren zur herstellung von neuen substituierten carbapenemen sowie von deren salzen
ATA238683A (de) Verfahren zur herstellung von neuen eburnan-oxim-aether-derivaten und von deren saeureadditionssalzen
AT361910B (de) Verfahren zur herstellung von neuen 2,4- dichlorphenyl-imidazolyl-aethanonen(olen) sowie von deren salzen
AT384425B (de) Verfahren zur herstellung von neuen, acylierten 1,2,4-triazolderivaten und von deren saeureadditionssalzen
ATA36984A (de) Verfahren zur herstellung von neuen substituierten 2-phenylmethylen-1aminoalkyloximinocycloalkanen und deren saeureadditionssalzen
AT382371B (de) Verfahren zur herstellung von neuen iminderivaten, sowie von deren salzen
AT381303B (de) Verfahren zur herstellung von neuen, optisch aktiven und racemischen 5-substituierten-4-oxo -pgi1-derivaten sowie von deren salzen
ATA238583A (de) Verfahren zur herstellung von neuen eburnanderivaten und deren saeureadditionssalzen
AT381094B (de) Verfahren zur herstellung von neuen 2, 4, 8-triazaphenalenium-salzen sowie von deren geometrischen und optischen isomeren
ATA139182A (de) Verfahren zur herstellung von neuen, optisch aktiven und racemischen 4-oxo-pgi(2)-derivaten sowie von deren salzen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
ELJ Ceased due to non-payment of the annual fee
RZN Patent revoked