DK106882A - Fremgangsmaade til fremstilling af 3,4-dihydro-5h-2,3-benzodiazepin-derivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents
Fremgangsmaade til fremstilling af 3,4-dihydro-5h-2,3-benzodiazepin-derivater eller farmaceutisk acceptable syreadditionssalte deraf Download PDFInfo
- Publication number
- DK106882A DK106882A DK106882A DK106882A DK106882A DK 106882 A DK106882 A DK 106882A DK 106882 A DK106882 A DK 106882A DK 106882 A DK106882 A DK 106882A DK 106882 A DK106882 A DK 106882A
- Authority
- DK
- Denmark
- Prior art keywords
- dihydro
- preparing
- acid addition
- addition salts
- acceptable acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU81620A HU186760B (en) | 1981-03-12 | 1981-03-12 | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK106882A true DK106882A (da) | 1982-09-13 |
Family
ID=10950496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK106882A DK106882A (da) | 1981-03-12 | 1982-03-11 | Fremgangsmaade til fremstilling af 3,4-dihydro-5h-2,3-benzodiazepin-derivater eller farmaceutisk acceptable syreadditionssalte deraf |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4423044A (de) |
| JP (1) | JPS57159772A (de) |
| AT (1) | AT383120B (de) |
| AU (1) | AU550388B2 (de) |
| BE (1) | BE892395A (de) |
| CA (1) | CA1178584A (de) |
| CH (1) | CH648553A5 (de) |
| CS (1) | CS224646B2 (de) |
| DD (1) | DD204698A5 (de) |
| DE (1) | DE3209100A1 (de) |
| DK (1) | DK106882A (de) |
| ES (1) | ES510348A0 (de) |
| FI (1) | FI820839L (de) |
| FR (1) | FR2501686A1 (de) |
| GB (1) | GB2097387B (de) |
| GR (1) | GR76111B (de) |
| HU (1) | HU186760B (de) |
| IL (1) | IL65076A (de) |
| IT (1) | IT1190732B (de) |
| NL (1) | NL8201005A (de) |
| NO (1) | NO820798L (de) |
| SE (1) | SE8201537L (de) |
| SU (1) | SU1151206A3 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3971179A (en) * | 1969-08-13 | 1976-07-27 | Andrew Bodocsi | Non-bonded framing system |
| DE3124013A1 (de) * | 1981-06-19 | 1982-12-30 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
| US5204339A (en) * | 1986-01-31 | 1993-04-20 | Whitby Research, Inc. | Penetration enhancers for transdermal delivery of systemic agents |
| HU198494B (en) * | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
| EP0322582A3 (de) * | 1987-12-07 | 1989-09-13 | Hoechst-Roussel Pharmaceuticals Incorporated | 4-Heteroaryl-1,3-benzodiazepine und 2-substituierte Alpha-(heteroaryl) benzenethanamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| HU206719B (en) * | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
| EP0726256A1 (de) * | 1995-02-09 | 1996-08-14 | Egis Gyogyszergyar Rt. | 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems |
| HU224435B1 (hu) * | 1995-02-09 | 2005-10-28 | EGIS Gyógyszergyár Rt. | Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények |
| SK283859B6 (sk) * | 1995-02-09 | 2004-03-02 | EGIS Gyógyszergyár Rt. | 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie |
| DE19604920A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
| ES2111493B1 (es) * | 1996-02-08 | 1999-08-01 | Egyt Gyogyszervegyeszeti Gyar | Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. |
| ZA972746B (en) * | 1996-04-04 | 1998-10-09 | Egyt Gyogyszervegyeszeti Gyar | Novel 2,3-benzodiazepine derivatives |
| US6080736A (en) * | 1999-10-27 | 2000-06-27 | Janus Pharmaceuticals, Inc. | Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam |
| US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
| US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| EP1567161A4 (de) * | 2002-12-03 | 2008-09-03 | Vela Acquisition Corp | Pharmazeutische zusammensetzung aus 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepinund ihre verwendung |
| MXPA05005893A (es) * | 2002-12-03 | 2006-02-08 | Vela Pharmaceuticals Inc | Composicion farmaceutica de 1-(3-hidroxi -4-metoxifenil) -4-metil-5 -etil-7, 8-dimetoxi- 5h-2, 3-benzodiazepina y usos de la misma. |
| US6638928B1 (en) | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
| US20040224943A1 (en) * | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines |
| US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam |
| JP4611308B2 (ja) * | 2003-05-16 | 2011-01-12 | ヴェラ アクイジション コーポレイション | 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療 |
| US20070021412A1 (en) * | 2003-05-16 | 2007-01-25 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine |
| US20040254173A1 (en) * | 2003-06-13 | 2004-12-16 | Leventer Steven M. | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines |
| US7541355B2 (en) * | 2005-05-23 | 2009-06-02 | Vela Acquisition Corporation | Conversion process for 2,3-benzodiazepine enantiomers |
| TW200902024A (en) * | 2007-04-02 | 2009-01-16 | Teva Pharma | Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK118660B (da) * | 1966-12-09 | 1970-09-21 | Egyt Gyogyszervegyeszeti Gyar | Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid. |
| USRE30014E (en) | 1966-12-09 | 1979-05-29 | Egyesult Gyogyazer-es Tapozergyar | 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine |
| HU179018B (en) * | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
-
1981
- 1981-03-12 HU HU81620A patent/HU186760B/hu unknown
-
1982
- 1982-02-22 IL IL65076A patent/IL65076A/xx unknown
- 1982-02-25 US US06/352,346 patent/US4423044A/en not_active Expired - Fee Related
- 1982-03-08 BE BE1/10448A patent/BE892395A/fr not_active IP Right Cessation
- 1982-03-10 FR FR8203989A patent/FR2501686A1/fr active Granted
- 1982-03-11 GB GB8207168A patent/GB2097387B/en not_active Expired
- 1982-03-11 JP JP57038847A patent/JPS57159772A/ja active Pending
- 1982-03-11 IT IT20094/82A patent/IT1190732B/it active
- 1982-03-11 ES ES510348A patent/ES510348A0/es active Granted
- 1982-03-11 FI FI820839A patent/FI820839L/fi not_active Application Discontinuation
- 1982-03-11 CA CA000398115A patent/CA1178584A/en not_active Expired
- 1982-03-11 AT AT0096982A patent/AT383120B/de not_active IP Right Cessation
- 1982-03-11 DK DK106882A patent/DK106882A/da not_active Application Discontinuation
- 1982-03-11 NL NL8201005A patent/NL8201005A/nl not_active Application Discontinuation
- 1982-03-11 GR GR67555A patent/GR76111B/el unknown
- 1982-03-11 AU AU81308/82A patent/AU550388B2/en not_active Expired - Fee Related
- 1982-03-11 SE SE8201537A patent/SE8201537L/xx not_active Application Discontinuation
- 1982-03-11 CH CH1490/82A patent/CH648553A5/de not_active IP Right Cessation
- 1982-03-11 NO NO820798A patent/NO820798L/no unknown
- 1982-03-12 SU SU823404160A patent/SU1151206A3/ru active
- 1982-03-12 CS CS821739A patent/CS224646B2/cs unknown
- 1982-03-12 DD DD82238112A patent/DD204698A5/de unknown
- 1982-03-12 DE DE19823209100 patent/DE3209100A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IL65076A (en) | 1984-12-31 |
| NO820798L (no) | 1982-09-13 |
| US4423044A (en) | 1983-12-27 |
| AU550388B2 (en) | 1986-03-20 |
| FI820839L (fi) | 1982-09-13 |
| DD204698A5 (de) | 1983-12-07 |
| FR2501686B1 (de) | 1985-03-01 |
| GB2097387A (en) | 1982-11-03 |
| IT8220094A0 (it) | 1982-03-11 |
| ATA96982A (de) | 1986-10-15 |
| HU186760B (en) | 1985-09-30 |
| GB2097387B (en) | 1984-09-19 |
| AU8130882A (en) | 1982-09-16 |
| AT383120B (de) | 1987-05-25 |
| BE892395A (fr) | 1982-09-08 |
| NL8201005A (nl) | 1982-10-01 |
| SU1151206A3 (ru) | 1985-04-15 |
| GR76111B (de) | 1984-08-03 |
| DE3209100A1 (de) | 1982-10-28 |
| ES8302671A1 (es) | 1983-02-01 |
| CA1178584A (en) | 1984-11-27 |
| SE8201537L (sv) | 1982-09-13 |
| IT1190732B (it) | 1988-02-24 |
| JPS57159772A (en) | 1982-10-01 |
| ES510348A0 (es) | 1983-02-01 |
| CS224646B2 (en) | 1984-01-16 |
| CH648553A5 (de) | 1985-03-29 |
| FR2501686A1 (fr) | 1982-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |