ATA152284A - Verfahren zur herstellung von neuen pyrimidinverbindungen und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen pyrimidinverbindungen und deren saeureadditionssalzen

Info

Publication number
ATA152284A
ATA152284A AT0152284A AT152284A ATA152284A AT A152284 A ATA152284 A AT A152284A AT 0152284 A AT0152284 A AT 0152284A AT 152284 A AT152284 A AT 152284A AT A152284 A ATA152284 A AT A152284A
Authority
AT
Austria
Prior art keywords
acid addition
addition salts
pyrimidine compounds
producing new
new pyrimidine
Prior art date
Application number
AT0152284A
Other languages
English (en)
Other versions
AT392966B (de
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ATA152284A publication Critical patent/ATA152284A/de
Application granted granted Critical
Publication of AT392966B publication Critical patent/AT392966B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Indole Compounds (AREA)
AT1522/84A 1983-05-09 1984-05-09 Verfahren zur herstellung von neuen pyrimidin verbindungen und deren saeureadditionssalzen AT392966B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/493,124 US4517188A (en) 1983-05-09 1983-05-09 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols

Publications (2)

Publication Number Publication Date
ATA152284A true ATA152284A (de) 1990-12-15
AT392966B AT392966B (de) 1991-07-25

Family

ID=23958998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT1522/84A AT392966B (de) 1983-05-09 1984-05-09 Verfahren zur herstellung von neuen pyrimidin verbindungen und deren saeureadditionssalzen

Country Status (25)

Country Link
US (1) US4517188A (de)
JP (1) JPS59206364A (de)
KR (1) KR900005015B1 (de)
AT (1) AT392966B (de)
AU (1) AU576761B2 (de)
BE (1) BE899608A (de)
CA (1) CA1279064C (de)
CH (1) CH659247A5 (de)
CY (1) CY1522A (de)
DE (1) DE3416976A1 (de)
DK (1) DK166583C (de)
ES (3) ES8604529A1 (de)
FI (1) FI80268C (de)
FR (1) FR2545825B1 (de)
GB (1) GB2139623B (de)
GR (1) GR81557B (de)
HK (1) HK17590A (de)
IE (1) IE57410B1 (de)
IT (1) IT1175492B (de)
LU (1) LU85354A1 (de)
NL (1) NL8401450A (de)
PT (1) PT78570A (de)
SE (1) SE466309B (de)
SG (1) SG4890G (de)
ZA (1) ZA843378B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
PH22520A (en) * 1984-11-12 1988-10-17 Yamanouchi Pharma Co Ltd Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them
US5177215A (en) * 1984-11-12 1993-01-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic compounds and pharmaceutical use thereof
JPS6242974A (ja) * 1985-08-20 1987-02-24 Ube Ind Ltd ピリミジニルオキシアルカン酸アミド誘導体および除草剤
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
JP2001501584A (ja) 1996-04-09 2001-02-06 エヌピーエス・ファーマシウティカルズ・インコーポレイテッド カルシリチック化合物
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
BR0114884A (pt) * 2000-10-25 2004-07-06 Smithkline Beecham Corp Compostos calcilìticos
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP1664798B1 (de) * 2003-09-08 2013-05-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Nicht peptidische agonisten und antagonisten von adrenomedullin und gastrin freisetzende peptide
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
EP3395372B1 (de) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Freisetzungssystem für glutathionbasiertes arzneimittel
SG175896A1 (en) 2009-05-06 2011-12-29 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300886A (de) * 1962-11-23
US4193995A (en) * 1972-05-05 1980-03-18 Merck Sharp & Dohme (I.A.) Corp. 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions
US4042586A (en) * 1972-05-05 1977-08-16 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
AR208397A1 (es) * 1973-02-20 1976-12-27 Ciba Geigy Ag Procedimiento para la elaboracion de compuestos de 1-piridiloxi-2-hidroxi-3-amino-propano1-piraziniloxi-2-hidroxi-3-amino-propano y 1-pirimidiniloxi-2-hidroxi-3-amino-propan
CH584209A5 (en) * 1973-02-20 1977-01-31 Ciba Geigy Ag 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity
US4195090A (en) * 1973-02-20 1980-03-25 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith
CH567484A5 (de) * 1973-04-05 1975-10-15 Sandoz Ag
JPS5839832B2 (ja) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト 新規ピラジン化合物の製法
US4139623A (en) * 1974-05-14 1979-02-13 C-G Corp. Cyclic-substituted derivatives of 1-amino-2-propanol
CH588308A5 (de) * 1975-02-18 1977-05-31 Escher Wyss Ag
GB1585950A (en) * 1976-08-02 1981-03-11 Ici Ltd Pyrimidine compoudns and their use as herbicides
IT1165040B (it) * 1979-04-23 1987-04-22 Isf Spa Alcossialchilidenidrazinopiridazione e procedimento per la loro preparazione
JPS55151570A (en) * 1979-05-15 1980-11-26 Takeda Chem Ind Ltd Pyrimidine derivatives, their preparation and antimicrobial for agriculture
US4312398A (en) * 1979-09-28 1982-01-26 The Boeing Company Method of forming fiber and metal composite structures
US4400201A (en) * 1980-12-15 1983-08-23 Sandoz Ltd. Novel pyrimidinyl ethers, their use as herbicides, herbicidal compositions comprising said pyrimidinyl ethers and processes for the preparation thereof
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols

Also Published As

Publication number Publication date
FI80268B (fi) 1990-01-31
IE57410B1 (en) 1992-08-26
GR81557B (de) 1984-12-11
IT8420841A1 (it) 1985-11-08
DK227884A (da) 1984-11-10
IT1175492B (it) 1987-07-01
KR840008798A (ko) 1984-12-19
BE899608A (fr) 1984-11-08
FR2545825A1 (fr) 1984-11-16
LU85354A1 (fr) 1985-03-21
AU2779284A (en) 1984-11-15
SG4890G (en) 1990-07-13
KR900005015B1 (ko) 1990-07-16
GB8411636D0 (en) 1984-06-13
FI841841A (fi) 1984-11-10
IE841137L (en) 1984-11-09
DK166583B (da) 1993-06-14
NL8401450A (nl) 1984-12-03
CY1522A (en) 1990-11-16
ZA843378B (en) 1984-12-24
ES551966A0 (es) 1986-12-16
DK227884D0 (da) 1984-05-08
PT78570A (en) 1984-06-01
ES8704154A1 (es) 1987-03-16
ES8702372A1 (es) 1986-12-16
IT8420841A0 (it) 1984-05-08
SE8402476L (sv) 1984-11-10
AU576761B2 (en) 1988-09-08
SE8402476D0 (sv) 1984-05-08
ES545198A0 (es) 1987-03-16
GB2139623A (en) 1984-11-14
FR2545825B1 (fr) 1987-10-09
JPS59206364A (ja) 1984-11-22
CA1279064C (en) 1991-01-15
HK17590A (en) 1990-03-16
AT392966B (de) 1991-07-25
ES532282A0 (es) 1986-02-01
SE466309B (sv) 1992-01-27
FI841841A0 (fi) 1984-05-08
US4517188A (en) 1985-05-14
ES8604529A1 (es) 1986-02-01
FI80268C (fi) 1990-05-10
CH659247A5 (de) 1987-01-15
DK166583C (da) 1993-10-25
DE3416976A1 (de) 1984-11-15
GB2139623B (en) 1987-01-21

Similar Documents

Publication Publication Date Title
AT376665B (de) Verfahren zur herstellung von neuen imidazolderivaten und von deren saeureadditionssalzen
AT386825B (de) Verfahren zur herstellung von neuen benzimidazolderivaten und von deren salzen
AT385758B (de) Verfahren zur herstellung von neuen cephemverbindungen und deren salzen
ATA152284A (de) Verfahren zur herstellung von neuen pyrimidinverbindungen und deren saeureadditionssalzen
AT387963B (de) Verfahren zur herstellung von neuen antidepressiven 1,2,4-triazolonverbindungen und von deren pharmazeutisch zulaessigen saeureadditionssalzen
AT381705B (de) Verfahren zur herstellung von neuen thiazolidindion-derivaten und deren salzen
AT376983B (de) Verfahren zur herstellung von neuen 7-acylaminocephalosporansaeurederivaten und deren salzen
AT381943B (de) Verfahren zur herstellung von 2-heterocyclylthio- methylpenemverbindungen und deren salzen
ATA101986A (de) Verfahren zur herstellung von neuen 5-pyrimidincarboxamiden und deren additionssalzen
AT372677B (de) Verfahren zur herstellung von neuen basischen oximaethern und von deren saeureadditionssalzen und quaternaeren ammoniumsalzen
AT370728B (de) Verfahren zur herstellung von pyrimidinverbindungen und von deren salzen
AT381308B (de) Verfahren zur herstellung von neuen fluorprostacyclinen und von deren salzen
ATA36984A (de) Verfahren zur herstellung von neuen substituierten 2-phenylmethylen-1aminoalkyloximinocycloalkanen und deren saeureadditionssalzen
AT384810B (de) Verfahren zur herstellung von psoralenfreien neuen 6-alkylangelicinen und von deren salzen
ATA238683A (de) Verfahren zur herstellung von neuen eburnan-oxim-aether-derivaten und von deren saeureadditionssalzen
AT385508B (de) Verfahren zur herstellung von basischen oximaethern und deren salzen
AT386204B (de) Verfahren zur herstellung von neuen substituierten carbapenemen sowie von deren salzen
AT372081B (de) Verfahren zur herstellung von neuen substituierten n-iminomethylpiperidinen und von deren saeureadditionssalzen
AT387965B (de) Verfahren zur herstellung von pyrimidonverbindungen und deren saeureadditionssalzen
ATA238583A (de) Verfahren zur herstellung von neuen eburnanderivaten und deren saeureadditionssalzen
ATA154183A (de) Verfahren zur herstellung von neuen imidazochinoxalinen und von deren salzen
ATA30987A (de) Verfahren zur herstellung von neuen cephemverbindungen und deren salzen
AT386827B (de) Verfahren zur herstellung von neuen azepino(1,2-a)pyrimidinderivaten und von deren saeureadditonssalzen
ATA332684A (de) Verfahren zur herstellung von neuen benzolsulfonamiden und deren salzen
ATA36085A (de) Verfahren zur herstellung von neuen phenylpropargylaminderivaten und deren saeureadditionssalzen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
REN Ceased due to non-payment of the annual fee