ES8704154A1 - Un procedimiento para la preparacion de 1-(4-pirimidiniloxi)-3(hetarilalquilamino)-2-propanoles - Google Patents

Un procedimiento para la preparacion de 1-(4-pirimidiniloxi)-3(hetarilalquilamino)-2-propanoles

Info

Publication number
ES8704154A1
ES8704154A1 ES545198A ES545198A ES8704154A1 ES 8704154 A1 ES8704154 A1 ES 8704154A1 ES 545198 A ES545198 A ES 545198A ES 545198 A ES545198 A ES 545198A ES 8704154 A1 ES8704154 A1 ES 8704154A1
Authority
ES
Spain
Prior art keywords
pyrimidinyloxy
propanols
hetaryl
alkylamino
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545198A
Other languages
English (en)
Other versions
ES545198A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8704154A1 publication Critical patent/ES8704154A1/es
Publication of ES545198A0 publication Critical patent/ES545198A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 1-(4-PIRIMIDINILOXI)-3-(HETARILALQUILAMINO)-2-PROPANOLES, DE FORMULA ESTRUCTURAL (I), Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE COPULA UN PIRIMIDINA X-SUSTITUIDA DE FORMULA GENERAL (II), EN LA QUE X ES HIDROXILO O HALOGENO; Y R1 ES ALQUILO C1-6, AMINO, ACILAMINO O CIANO, CON UNA OXAZOLIDINA; SEGUNDA, EL PRODUCTO INTERMEDIO OBTENIDO EN LA REACCION ANTERIOR SE SOMETE A HIDROLISIS, PARA FORMAR UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE ALQ ES ALQUILENO C1-6; Y POR ULTIMO, EL COMPUESTO DE FORMULA GENERAL (III) SE SOMETE A UN TRATAMIENTO CON HIDRAZINA. DE APLICACION COMO AGENTES CARDIOVASCULARES E HIPERTENSIVOS.
ES545198A 1983-05-09 1985-07-15 Un procedimiento para la preparacion de 1-(4-pirimidiniloxi)-3(hetarilalquilamino)-2-propanoles Expired ES8704154A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/493,124 US4517188A (en) 1983-05-09 1983-05-09 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols

Publications (2)

Publication Number Publication Date
ES8704154A1 true ES8704154A1 (es) 1987-03-16
ES545198A0 ES545198A0 (es) 1987-03-16

Family

ID=23958998

Family Applications (3)

Application Number Title Priority Date Filing Date
ES532282A Expired ES8604529A1 (es) 1983-05-09 1984-05-08 Un procedimiento para la preparacion de 1-(4 pirimidiniloxi)-3(heterilalquilamino)-2-propanoles.
ES545198A Expired ES8704154A1 (es) 1983-05-09 1985-07-15 Un procedimiento para la preparacion de 1-(4-pirimidiniloxi)-3(hetarilalquilamino)-2-propanoles
ES551966A Expired ES8702372A1 (es) 1983-05-09 1986-02-13 Un procedimiento para la preparacion de 1-(4-pirimidiniloxi)-3-(hetarilalquilamino)-2-propanoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES532282A Expired ES8604529A1 (es) 1983-05-09 1984-05-08 Un procedimiento para la preparacion de 1-(4 pirimidiniloxi)-3(heterilalquilamino)-2-propanoles.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES551966A Expired ES8702372A1 (es) 1983-05-09 1986-02-13 Un procedimiento para la preparacion de 1-(4-pirimidiniloxi)-3-(hetarilalquilamino)-2-propanoles

Country Status (25)

Country Link
US (1) US4517188A (es)
JP (1) JPS59206364A (es)
KR (1) KR900005015B1 (es)
AT (1) AT392966B (es)
AU (1) AU576761B2 (es)
BE (1) BE899608A (es)
CA (1) CA1279064C (es)
CH (1) CH659247A5 (es)
CY (1) CY1522A (es)
DE (1) DE3416976A1 (es)
DK (1) DK166583C (es)
ES (3) ES8604529A1 (es)
FI (1) FI80268C (es)
FR (1) FR2545825B1 (es)
GB (1) GB2139623B (es)
GR (1) GR81557B (es)
HK (1) HK17590A (es)
IE (1) IE57410B1 (es)
IT (1) IT1175492B (es)
LU (1) LU85354A1 (es)
NL (1) NL8401450A (es)
PT (1) PT78570A (es)
SE (1) SE466309B (es)
SG (1) SG4890G (es)
ZA (1) ZA843378B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
US5177215A (en) * 1984-11-12 1993-01-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic compounds and pharmaceutical use thereof
PH22520A (en) * 1984-11-12 1988-10-17 Yamanouchi Pharma Co Ltd Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them
JPS6242974A (ja) * 1985-08-20 1987-02-24 Ube Ind Ltd ピリミジニルオキシアルカン酸アミド誘導体および除草剤
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
AU726659B2 (en) * 1996-04-09 2000-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
US20040009980A1 (en) * 2000-10-25 2004-01-15 Pradip Bhatnagar Calcilytic compounds
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
EP1664798B1 (en) 2003-09-08 2013-05-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (16)

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NL300886A (es) * 1962-11-23
US4193995A (en) * 1972-05-05 1980-03-18 Merck Sharp & Dohme (I.A.) Corp. 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions
US4042586A (en) * 1972-05-05 1977-08-16 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US4195090A (en) * 1973-02-20 1980-03-25 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith
AR208397A1 (es) * 1973-02-20 1976-12-27 Ciba Geigy Ag Procedimiento para la elaboracion de compuestos de 1-piridiloxi-2-hidroxi-3-amino-propano1-piraziniloxi-2-hidroxi-3-amino-propano y 1-pirimidiniloxi-2-hidroxi-3-amino-propan
CH584209A5 (en) * 1973-02-20 1977-01-31 Ciba Geigy Ag 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity
CH567484A5 (es) * 1973-04-05 1975-10-15 Sandoz Ag
JPS5839832B2 (ja) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト 新規ピラジン化合物の製法
US4139623A (en) * 1974-05-14 1979-02-13 C-G Corp. Cyclic-substituted derivatives of 1-amino-2-propanol
CH588308A5 (es) * 1975-02-18 1977-05-31 Escher Wyss Ag
GB1585950A (en) * 1976-08-02 1981-03-11 Ici Ltd Pyrimidine compoudns and their use as herbicides
IT1165040B (it) * 1979-04-23 1987-04-22 Isf Spa Alcossialchilidenidrazinopiridazione e procedimento per la loro preparazione
JPS55151570A (en) * 1979-05-15 1980-11-26 Takeda Chem Ind Ltd Pyrimidine derivatives, their preparation and antimicrobial for agriculture
US4312398A (en) * 1979-09-28 1982-01-26 The Boeing Company Method of forming fiber and metal composite structures
US4400201A (en) * 1980-12-15 1983-08-23 Sandoz Ltd. Novel pyrimidinyl ethers, their use as herbicides, herbicidal compositions comprising said pyrimidinyl ethers and processes for the preparation thereof
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols

Also Published As

Publication number Publication date
ES8604529A1 (es) 1986-02-01
AU576761B2 (en) 1988-09-08
FR2545825B1 (fr) 1987-10-09
SE8402476L (sv) 1984-11-10
CY1522A (en) 1990-11-16
FR2545825A1 (fr) 1984-11-16
ES8702372A1 (es) 1986-12-16
SG4890G (en) 1990-07-13
DE3416976A1 (de) 1984-11-15
FI841841A (fi) 1984-11-10
ES545198A0 (es) 1987-03-16
IT8420841A0 (it) 1984-05-08
ES532282A0 (es) 1986-02-01
DK166583C (da) 1993-10-25
KR840008798A (ko) 1984-12-19
KR900005015B1 (ko) 1990-07-16
FI80268B (fi) 1990-01-31
DK227884D0 (da) 1984-05-08
GR81557B (es) 1984-12-11
GB8411636D0 (en) 1984-06-13
IT1175492B (it) 1987-07-01
ES551966A0 (es) 1986-12-16
SE466309B (sv) 1992-01-27
ZA843378B (en) 1984-12-24
AU2779284A (en) 1984-11-15
CH659247A5 (de) 1987-01-15
GB2139623B (en) 1987-01-21
IT8420841A1 (it) 1985-11-08
SE8402476D0 (sv) 1984-05-08
CA1279064C (en) 1991-01-15
IE57410B1 (en) 1992-08-26
JPS59206364A (ja) 1984-11-22
DK166583B (da) 1993-06-14
FI841841A0 (fi) 1984-05-08
AT392966B (de) 1991-07-25
PT78570A (en) 1984-06-01
NL8401450A (nl) 1984-12-03
ATA152284A (de) 1990-12-15
DK227884A (da) 1984-11-10
GB2139623A (en) 1984-11-14
LU85354A1 (fr) 1985-03-21
FI80268C (fi) 1990-05-10
BE899608A (fr) 1984-11-08
US4517188A (en) 1985-05-14
IE841137L (en) 1984-11-09
HK17590A (en) 1990-03-16

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Legal Events

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FD1A Patent lapsed

Effective date: 19970401