SE8503613D0 - 5h-2,3-benzodiazepine derivatives, process for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
5h-2,3-benzodiazepine derivatives, process for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- SE8503613D0 SE8503613D0 SE8503613A SE8503613A SE8503613D0 SE 8503613 D0 SE8503613 D0 SE 8503613D0 SE 8503613 A SE8503613 A SE 8503613A SE 8503613 A SE8503613 A SE 8503613A SE 8503613 D0 SE8503613 D0 SE 8503613D0
- Authority
- SE
- Sweden
- Prior art keywords
- preparation
- benzodiazepine derivatives
- pharmaceutical compositions
- same
- compositions containing
- Prior art date
Links
- YVOHCRLDUPTKOH-UHFFFAOYSA-N 5h-2,3-benzodiazepine Chemical class C1C=NN=CC2=CC=CC=C12 YVOHCRLDUPTKOH-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000010513 Stupor Diseases 0.000 abstract 1
- 230000002539 anti-aggressive effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 230000001379 nervous effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002557 soporific effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU842882A HU191698B (en) | 1984-07-27 | 1984-07-27 | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8503613D0 true SE8503613D0 (sv) | 1985-07-26 |
SE8503613L SE8503613L (sv) | 1986-01-28 |
SE465777B SE465777B (sv) | 1991-10-28 |
Family
ID=10961503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8503613A SE465777B (sv) | 1984-07-27 | 1985-07-26 | 5h-2,3-bensodiazepinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner innehaallande desamma |
Country Status (23)
Country | Link |
---|---|
US (1) | US4614740A (sv) |
JP (1) | JPS6143174A (sv) |
AT (1) | AT393123B (sv) |
BE (1) | BE902953A (sv) |
CA (1) | CA1277660C (sv) |
CH (1) | CH667090A5 (sv) |
CS (1) | CS251795B2 (sv) |
DD (1) | DD236527A5 (sv) |
DE (1) | DE3527117C2 (sv) |
DK (1) | DK158727C (sv) |
ES (1) | ES8608494A1 (sv) |
FI (1) | FI84821C (sv) |
FR (1) | FR2568252B1 (sv) |
GB (1) | GB2162184B (sv) |
GR (1) | GR851853B (sv) |
HU (1) | HU191698B (sv) |
IT (1) | IT1187712B (sv) |
NL (1) | NL8502141A (sv) |
NO (1) | NO162115C (sv) |
PH (1) | PH22420A (sv) |
PL (1) | PL145089B1 (sv) |
PT (1) | PT80870B (sv) |
SE (1) | SE465777B (sv) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU195788B (en) * | 1986-05-21 | 1988-07-28 | Gyogyszerkutato Intezet | Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them |
HU198494B (en) * | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
HU207055B (en) * | 1990-10-17 | 1993-03-01 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same |
US5521174A (en) * | 1990-12-21 | 1996-05-28 | Gyogyszerkutato Intezet Kv. | N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith |
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
US5639751A (en) * | 1990-12-21 | 1997-06-17 | Cyogyszerkutato Intezet Kft | N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders |
US6288057B1 (en) * | 1994-08-31 | 2001-09-11 | Eli Lilly And Company | Physical form of dihydro-2,3-benzodiazepine derivative |
TR199501071A2 (tr) * | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem. |
DE19604920A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
US5891871A (en) * | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
UA67749C2 (uk) | 1997-08-12 | 2004-07-15 | Егіш Дьйодьсердьяр Рт. | Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування |
HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
EP1296960A2 (en) * | 2000-06-16 | 2003-04-02 | Annovis, Inc. | 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors |
HU225100B1 (hu) * | 2000-12-21 | 2006-06-28 | Egyt Gyogyszervegyeszeti Gyar | 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk |
US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
US20040152695A1 (en) * | 2002-12-03 | 2004-08-05 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine and uses thereof |
US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
CA2508542A1 (en) * | 2002-12-03 | 2004-06-17 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
US6638928B1 (en) | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
US6858605B2 (en) * | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
US20040224943A1 (en) * | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines |
US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam |
CA2525273C (en) * | 2003-05-16 | 2012-04-17 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine |
US20070021412A1 (en) * | 2003-05-16 | 2007-01-25 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine |
US20040254173A1 (en) * | 2003-06-13 | 2004-12-16 | Leventer Steven M. | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines |
HUP0302449A3 (en) * | 2003-08-04 | 2005-06-28 | Egis Gyogyszergyar Nyilvanosan | 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them |
JP4855838B2 (ja) * | 2006-02-07 | 2012-01-18 | 道夫 本郷 | 錠剤容器 |
TW200902024A (en) * | 2007-04-02 | 2009-01-16 | Teva Pharma | Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US30014A (en) * | 1860-09-11 | Bailboad-joint | ||
DK118660B (da) * | 1966-12-09 | 1970-09-21 | Egyt Gyogyszervegyeszeti Gyar | Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid. |
USRE30014E (en) | 1966-12-09 | 1979-05-29 | Egyesult Gyogyazer-es Tapozergyar | 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine |
HU179018B (en) * | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
-
1984
- 1984-07-27 HU HU842882A patent/HU191698B/hu not_active IP Right Cessation
-
1985
- 1985-07-11 CH CH3011/85A patent/CH667090A5/de not_active IP Right Cessation
- 1985-07-22 BE BE1/011304A patent/BE902953A/fr not_active IP Right Cessation
- 1985-07-24 ES ES545559A patent/ES8608494A1/es not_active Expired
- 1985-07-25 AT AT2201/85A patent/AT393123B/de not_active IP Right Cessation
- 1985-07-26 GR GR851853A patent/GR851853B/el unknown
- 1985-07-26 CA CA000487625A patent/CA1277660C/en not_active Expired - Lifetime
- 1985-07-26 FR FR8511444A patent/FR2568252B1/fr not_active Expired
- 1985-07-26 DK DK340685A patent/DK158727C/da not_active IP Right Cessation
- 1985-07-26 IT IT21725/85A patent/IT1187712B/it active
- 1985-07-26 NL NL8502141A patent/NL8502141A/nl not_active Application Discontinuation
- 1985-07-26 NO NO852973A patent/NO162115C/no unknown
- 1985-07-26 FI FI852906A patent/FI84821C/sv not_active IP Right Cessation
- 1985-07-26 PH PH32569A patent/PH22420A/en unknown
- 1985-07-26 SE SE8503613A patent/SE465777B/sv not_active IP Right Cessation
- 1985-07-26 CS CS855526A patent/CS251795B2/cs unknown
- 1985-07-26 PL PL1985254701A patent/PL145089B1/pl unknown
- 1985-07-26 JP JP60164192A patent/JPS6143174A/ja active Granted
- 1985-07-26 US US06/759,169 patent/US4614740A/en not_active Expired - Lifetime
- 1985-07-26 DD DD85279022A patent/DD236527A5/de not_active IP Right Cessation
- 1985-07-26 GB GB08518971A patent/GB2162184B/en not_active Expired
- 1985-07-26 PT PT80870A patent/PT80870B/pt not_active IP Right Cessation
- 1985-07-29 DE DE3527117A patent/DE3527117C2/de not_active Expired - Fee Related
Also Published As
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Legal Events
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