IT1187712B - Derivati di 5h-2,3-benzodiazepine,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono - Google Patents

Derivati di 5h-2,3-benzodiazepine,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Info

Publication number
IT1187712B
IT1187712B IT21725/85A IT2172585A IT1187712B IT 1187712 B IT1187712 B IT 1187712B IT 21725/85 A IT21725/85 A IT 21725/85A IT 2172585 A IT2172585 A IT 2172585A IT 1187712 B IT1187712 B IT 1187712B
Authority
IT
Italy
Prior art keywords
benzodiazepine
derivatives
procedure
contain
preparation
Prior art date
Application number
IT21725/85A
Other languages
English (en)
Other versions
IT8521725A0 (it
Inventor
Tibor Lang
Jeno Korosi
Ferenc Andrasi
Peter Botka
Tamas Hamori
Pal Berzsenyi
Katalin Nee Horvat Goldschmidt
Gabor Zolyomi
Istvan Elekes
Zsuzsusanne Nee Rihmer Lang
Original Assignee
Egis Gyogyszegyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszegyar filed Critical Egis Gyogyszegyar
Publication of IT8521725A0 publication Critical patent/IT8521725A0/it
Application granted granted Critical
Publication of IT1187712B publication Critical patent/IT1187712B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT21725/85A 1984-07-27 1985-07-26 Derivati di 5h-2,3-benzodiazepine,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono IT1187712B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842882A HU191698B (en) 1984-07-27 1984-07-27 Process for producing new 1-aryl-5h-2beta-benzodiazepines

Publications (2)

Publication Number Publication Date
IT8521725A0 IT8521725A0 (it) 1985-07-26
IT1187712B true IT1187712B (it) 1987-12-23

Family

ID=10961503

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21725/85A IT1187712B (it) 1984-07-27 1985-07-26 Derivati di 5h-2,3-benzodiazepine,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Country Status (23)

Country Link
US (1) US4614740A (it)
JP (1) JPS6143174A (it)
AT (1) AT393123B (it)
BE (1) BE902953A (it)
CA (1) CA1277660C (it)
CH (1) CH667090A5 (it)
CS (1) CS251795B2 (it)
DD (1) DD236527A5 (it)
DE (1) DE3527117C2 (it)
DK (1) DK158727C (it)
ES (1) ES8608494A1 (it)
FI (1) FI84821C (it)
FR (1) FR2568252B1 (it)
GB (1) GB2162184B (it)
GR (1) GR851853B (it)
HU (1) HU191698B (it)
IT (1) IT1187712B (it)
NL (1) NL8502141A (it)
NO (1) NO162115C (it)
PH (1) PH22420A (it)
PL (1) PL145089B1 (it)
PT (1) PT80870B (it)
SE (1) SE465777B (it)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5521174A (en) * 1990-12-21 1996-05-28 Gyogyszerkutato Intezet Kv. N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
EP1575521A4 (en) * 2002-12-03 2008-04-30 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
WO2004103154A2 (en) * 2003-05-16 2004-12-02 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
JP4855838B2 (ja) * 2006-02-07 2012-01-18 道夫 本郷 錠剤容器
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30014A (en) * 1860-09-11 Bailboad-joint
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Also Published As

Publication number Publication date
DE3527117C2 (de) 1996-08-08
DK340685D0 (da) 1985-07-26
DE3527117A1 (de) 1986-01-30
FI84821B (fi) 1991-10-15
FI852906A0 (fi) 1985-07-26
BE902953A (fr) 1986-01-22
HU191698B (en) 1987-03-30
DK340685A (da) 1986-01-28
GB8518971D0 (en) 1985-09-04
PL145089B1 (en) 1988-08-31
JPS6143174A (ja) 1986-03-01
FI852906L (fi) 1986-01-28
CS251795B2 (en) 1987-08-13
GB2162184B (en) 1987-12-31
ATA220185A (de) 1991-01-15
FR2568252A1 (fr) 1986-01-31
SE8503613D0 (sv) 1985-07-26
CH667090A5 (de) 1988-09-15
NO162115B (no) 1989-07-31
AT393123B (de) 1991-08-26
PL254701A1 (en) 1986-09-09
GB2162184A (en) 1986-01-29
GR851853B (it) 1985-12-02
NL8502141A (nl) 1986-02-17
ES545559A0 (es) 1986-07-16
DK158727C (da) 1990-12-10
FI84821C (fi) 1992-01-27
PT80870B (pt) 1987-09-18
SE8503613L (sv) 1986-01-28
HUT38324A (en) 1986-05-28
CA1277660C (en) 1990-12-11
FR2568252B1 (fr) 1987-03-20
PH22420A (en) 1988-09-12
NO852973L (no) 1986-01-28
ES8608494A1 (es) 1986-07-16
NO162115C (no) 1989-11-08
DD236527A5 (de) 1986-06-11
PT80870A (en) 1985-08-01
JPH0413347B2 (it) 1992-03-09
IT8521725A0 (it) 1985-07-26
DK158727B (da) 1990-07-09
US4614740A (en) 1986-09-30
SE465777B (sv) 1991-10-28

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960712