FR2568252B1 - Derives de 5h-2,3-benzodiazepine, procede pour les preparer et compositions pharmaceutiques les contenant - Google Patents

Derives de 5h-2,3-benzodiazepine, procede pour les preparer et compositions pharmaceutiques les contenant

Info

Publication number
FR2568252B1
FR2568252B1 FR8511444A FR8511444A FR2568252B1 FR 2568252 B1 FR2568252 B1 FR 2568252B1 FR 8511444 A FR8511444 A FR 8511444A FR 8511444 A FR8511444 A FR 8511444A FR 2568252 B1 FR2568252 B1 FR 2568252B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
benzodiazepine derivatives
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8511444A
Other languages
English (en)
Other versions
FR2568252A1 (fr
Inventor
Tibor Lang
Jeno Korosi
Ferenc Andrasi
Peter Botka
Tamas Hamori
Pal Berzsenyi
Katali Goldschmidt-Nee-Horvath
Gabor Zolyomi
Istvan Elekes
Zsuzsanna Lang-Nee-Rihmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of FR2568252A1 publication Critical patent/FR2568252A1/fr
Application granted granted Critical
Publication of FR2568252B1 publication Critical patent/FR2568252B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR8511444A 1984-07-27 1985-07-26 Derives de 5h-2,3-benzodiazepine, procede pour les preparer et compositions pharmaceutiques les contenant Expired FR2568252B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842882A HU191698B (en) 1984-07-27 1984-07-27 Process for producing new 1-aryl-5h-2beta-benzodiazepines

Publications (2)

Publication Number Publication Date
FR2568252A1 FR2568252A1 (fr) 1986-01-31
FR2568252B1 true FR2568252B1 (fr) 1987-03-20

Family

ID=10961503

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8511444A Expired FR2568252B1 (fr) 1984-07-27 1985-07-26 Derives de 5h-2,3-benzodiazepine, procede pour les preparer et compositions pharmaceutiques les contenant

Country Status (23)

Country Link
US (1) US4614740A (fr)
JP (1) JPS6143174A (fr)
AT (1) AT393123B (fr)
BE (1) BE902953A (fr)
CA (1) CA1277660C (fr)
CH (1) CH667090A5 (fr)
CS (1) CS251795B2 (fr)
DD (1) DD236527A5 (fr)
DE (1) DE3527117C2 (fr)
DK (1) DK158727C (fr)
ES (1) ES8608494A1 (fr)
FI (1) FI84821C (fr)
FR (1) FR2568252B1 (fr)
GB (1) GB2162184B (fr)
GR (1) GR851853B (fr)
HU (1) HU191698B (fr)
IT (1) IT1187712B (fr)
NL (1) NL8502141A (fr)
NO (1) NO162115C (fr)
PH (1) PH22420A (fr)
PL (1) PL145089B1 (fr)
PT (1) PT80870B (fr)
SE (1) SE465777B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
US5521174A (en) * 1990-12-21 1996-05-28 Gyogyszerkutato Intezet Kv. N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
WO2001098280A2 (fr) * 2000-06-16 2001-12-27 Annovis, Inc. Antagonistes 5h-2,3-benzodiazepine de recepteurs d'acide amine excitateurs
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
WO2004069155A2 (fr) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Composition pharmaceutique de 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine et utilisations de celle-ci
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
MXPA05005895A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3, 4-dimetoxifenil)-4 -metil-5-etil -7-metoxi-8 -hidroxi- 5h-2, 3-benzodiacepina y usos de la misma.
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
WO2004103154A2 (fr) * 2003-05-16 2004-12-02 Vela Pharmaceuticals, Inc. Traitement d'un dysfonctionnement gastro-intestinal et du stress associe au moyen d'une (r) 2,3-benzodiazepine pure sur le plan enantiomere
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
JP4855838B2 (ja) * 2006-02-07 2012-01-18 道夫 本郷 錠剤容器
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30014A (en) * 1860-09-11 Bailboad-joint
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Also Published As

Publication number Publication date
PH22420A (en) 1988-09-12
GB2162184A (en) 1986-01-29
ES8608494A1 (es) 1986-07-16
DE3527117C2 (de) 1996-08-08
HUT38324A (en) 1986-05-28
NO852973L (no) 1986-01-28
PL145089B1 (en) 1988-08-31
ES545559A0 (es) 1986-07-16
SE465777B (sv) 1991-10-28
FI852906A0 (fi) 1985-07-26
HU191698B (en) 1987-03-30
US4614740A (en) 1986-09-30
DE3527117A1 (de) 1986-01-30
PT80870B (pt) 1987-09-18
FI84821B (fi) 1991-10-15
DK340685D0 (da) 1985-07-26
PL254701A1 (en) 1986-09-09
NL8502141A (nl) 1986-02-17
CH667090A5 (de) 1988-09-15
CA1277660C (fr) 1990-12-11
IT8521725A0 (it) 1985-07-26
DK158727C (da) 1990-12-10
DK158727B (da) 1990-07-09
NO162115C (no) 1989-11-08
PT80870A (en) 1985-08-01
JPH0413347B2 (fr) 1992-03-09
DD236527A5 (de) 1986-06-11
FR2568252A1 (fr) 1986-01-31
FI852906L (fi) 1986-01-28
AT393123B (de) 1991-08-26
JPS6143174A (ja) 1986-03-01
DK340685A (da) 1986-01-28
SE8503613D0 (sv) 1985-07-26
IT1187712B (it) 1987-12-23
NO162115B (no) 1989-07-31
GB2162184B (en) 1987-12-31
GB8518971D0 (en) 1985-09-04
ATA220185A (de) 1991-01-15
BE902953A (fr) 1986-01-22
CS251795B2 (en) 1987-08-13
FI84821C (fi) 1992-01-27
GR851853B (fr) 1985-12-02
SE8503613L (sv) 1986-01-28

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Legal Events

Date Code Title Description
ST Notification of lapse