IT1256279B - Derivati 5h-benzodiazepinici, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione. - Google Patents

Derivati 5h-benzodiazepinici, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione.

Info

Publication number
IT1256279B
IT1256279B ITMI912745A ITMI912745A IT1256279B IT 1256279 B IT1256279 B IT 1256279B IT MI912745 A ITMI912745 A IT MI912745A IT MI912745 A ITMI912745 A IT MI912745A IT 1256279 B IT1256279 B IT 1256279B
Authority
IT
Italy
Prior art keywords
benzodiazepinic
derivatives
procedure
preparation
pharmaceutical compositions
Prior art date
Application number
ITMI912745A
Other languages
English (en)
Inventor
Eva Tomori
Original Assignee
Eva Tomori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eva Tomori filed Critical Eva Tomori
Publication of ITMI912745A0 publication Critical patent/ITMI912745A0/it
Publication of ITMI912745A1 publication Critical patent/ITMI912745A1/it
Application granted granted Critical
Publication of IT1256279B publication Critical patent/IT1256279B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invenzione riguarda l'originale 1-(3-clorofenil)-4-idrossimetil-7,8-dimetossi 5H-2,3-benzodiazepina della formula (I) (FORMULA I) e suoi sali di addizione acida farmaceuticamente accettabili, ed inoltre un procedimento per preparare questi composti; I composti in conformità della presente invenzione posseggono validi effetti ansiolitici, antiaggressivi e antidepressivi ed hanno contemporaneamente valori di tossicità acuta favorevoli, in modo tale che essi possono essere usati vantaggiosamente in terapia.
ITMI912745A 1990-10-17 1991-10-17 Derivati 5h-benzodiazepinici, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione. IT1256279B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU906469A HU207055B (en) 1990-10-17 1990-10-17 Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same

Publications (3)

Publication Number Publication Date
ITMI912745A0 ITMI912745A0 (it) 1991-10-17
ITMI912745A1 ITMI912745A1 (it) 1993-04-17
IT1256279B true IT1256279B (it) 1995-11-29

Family

ID=10971685

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912745A IT1256279B (it) 1990-10-17 1991-10-17 Derivati 5h-benzodiazepinici, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione.

Country Status (28)

Country Link
US (1) US5204343A (it)
JP (1) JPH04282374A (it)
KR (1) KR920008011A (it)
CN (1) CN1033582C (it)
AT (1) AT399506B (it)
AU (1) AU648111B2 (it)
BE (1) BE1004995A3 (it)
BG (1) BG95336A (it)
CA (1) CA2053622A1 (it)
CH (1) CH682400A5 (it)
CZ (1) CZ282249B6 (it)
DE (1) DE4134402A1 (it)
DK (1) DK174891A (it)
ES (1) ES2036137B1 (it)
FI (1) FI914918A (it)
FR (1) FR2668148B1 (it)
GB (1) GB2248838B (it)
GR (1) GR1001068B (it)
HU (1) HU207055B (it)
IL (1) IL99637A (it)
IT (1) IT1256279B (it)
NL (1) NL9101741A (it)
NO (1) NO914056L (it)
PL (1) PL167108B1 (it)
RU (1) RU2058982C1 (it)
SE (1) SE506380C2 (it)
YU (1) YU47859B (it)
ZA (1) ZA918273B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
AU2003303312A1 (en) * 2002-12-03 2004-08-30 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2257274A1 (en) * 1974-01-16 1975-08-08 Synthelabo Substd. 1,2-diazepin-7-one analgesic and psychotropic agents - prepd by cyclizing a delta keto acid and a substd hydrazine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
GR1001068B (el) 1993-04-28
ITMI912745A0 (it) 1991-10-17
BE1004995A3 (fr) 1993-03-16
NL9101741A (nl) 1992-05-18
IL99637A (en) 1996-06-18
ATA207191A (de) 1994-10-15
CN1033582C (zh) 1996-12-18
DK174891A (da) 1992-04-18
NO914056L (no) 1992-04-21
PL167108B1 (pl) 1995-07-31
FR2668148B1 (fr) 1993-07-30
BG95336A (bg) 1993-12-24
ITMI912745A1 (it) 1993-04-17
YU166991A (sh) 1994-06-10
CA2053622A1 (en) 1992-04-18
DE4134402A1 (de) 1992-05-14
RU2058982C1 (ru) 1996-04-27
IL99637A0 (en) 1992-08-18
FI914918A0 (fi) 1991-10-17
CH682400A5 (de) 1993-09-15
HU207055B (en) 1993-03-01
GR910100426A (en) 1992-09-25
CN1060838A (zh) 1992-05-06
DK174891D0 (da) 1991-10-16
JPH04282374A (ja) 1992-10-07
HUT59381A (en) 1992-05-28
NO914056D0 (no) 1991-10-16
SE9103022L (sv) 1992-04-18
ZA918273B (en) 1994-10-04
FI914918A (fi) 1992-04-18
PL292091A1 (en) 1992-06-26
AU648111B2 (en) 1994-04-14
ES2036137A1 (es) 1993-05-01
GB2248838B (en) 1994-04-06
HU906469D0 (en) 1991-04-29
US5204343A (en) 1993-04-20
SE9103022D0 (sv) 1991-10-17
SE506380C2 (sv) 1997-12-08
YU47859B (sh) 1996-02-19
AT399506B (de) 1995-05-26
AU8592291A (en) 1992-04-30
KR920008011A (ko) 1992-05-27
GB2248838A (en) 1992-04-22
GB9122090D0 (en) 1991-11-27
CS314191A3 (en) 1992-05-13
ES2036137B1 (es) 1994-03-01
CZ282249B6 (cs) 1997-06-11
FR2668148A1 (fr) 1992-04-24

Similar Documents

Publication Publication Date Title
MX9305379A (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y preparado farmaceutico que los contiene.
BG103945A (en) Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a
BG103195A (en) Substituted indazole derivatives and their application as inhibitors of phosphodiesterase (pde) type iv and of the production of a tumournecrotic factor (tnf)
HUP0000323A2 (hu) N-Szubsztituált 2-ciano-pirrolidin-származékok, eljárás előállításukra, valamint a vegyületeket tartalmazó gyógyszerkészítmények
CA2258548A1 (en) Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
IL112622A (en) Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them
MY103850A (en) Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them.
ES8404342A1 (es) Procedimiento para preparar compuestos analgesicos 1-oxa-, aza-y tia-espirociclicos.
MY116915A (en) Substituted indazole analogs
BG103969A (en) C-4"-substituted macrolide derivatives
ES8608494A1 (es) Procedimiento de preparacion de nuevos derivados 5h-2,3-ben-zodiazepinas y de sus sales de adicion acidas
MX9803954A (es) Derivados de aminoacidos, composiciones farmaceuticas que contienen estos compuestos y procesos para prepararlos.
ATE36699T1 (de) Chinonderivate, verfahren zu ihrer herstellung, ihre verwendung und pharmazeutische zusammensetzung.
HK1055117A1 (en) 8,8A-dihydro-indenoÄ11,2-dÜthiazole derivatives, amethod for their production and their use as medi caments.
IT1256279B (it) Derivati 5h-benzodiazepinici, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione.
UA34416C2 (uk) Похідні хроману, активні стосовно 5-нт рецептора, спосіб їх одержання та проміжні сполуки
EE03526B1 (et) Leukotrieen-antagonistliku toimega bensopüraanderivaadid, nende valmistamismeetod ja kasutamine
ES8800679A1 (es) Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza
CA2314154A1 (en) Azepine or larger medium ring derivatives and their use as pharmaceuticals
HUP9602868A2 (hu) Új 1,7,7-trimetil-biciklo[2.2.1]heptán-származékok
AU621191B2 (en) Aminalkoxyphenyl derivatives, process for their preparation and compositions containing them
IL125628A0 (en) Benzo[c] quinolizine derivatives their preparation and use as 5alpha-reductase inhibitors
FR2756826B1 (fr) Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2111492A1 (es) Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central.
YU217390A (sh) Postupak za izradu farmaceutski značajnih 3-aminopirola

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971030