YU217390A - Postupak za izradu farmaceutski značajnih 3-aminopirola - Google Patents

Postupak za izradu farmaceutski značajnih 3-aminopirola

Info

Publication number
YU217390A
YU217390A YU217390A YU217390A YU217390A YU 217390 A YU217390 A YU 217390A YU 217390 A YU217390 A YU 217390A YU 217390 A YU217390 A YU 217390A YU 217390 A YU217390 A YU 217390A
Authority
YU
Yugoslavia
Prior art keywords
preparation
aminopyroles
procedure
aminopyrroles
pharmaceutically significant
Prior art date
Application number
YU217390A
Other languages
English (en)
Other versions
YU48469B (sh
Inventor
J. Liebscher
A. Knoll
A. Uschmajew
A. Rolfs
D. Lohmann
G. Faust
E. Mogenstern
P. Scharfenberg
Original Assignee
Arzneimittelwerk Dresden Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden Gmbh. filed Critical Arzneimittelwerk Dresden Gmbh.
Priority to SI9012173A priority Critical patent/SI20323B/sl
Priority to HR930229A priority patent/HRP930229A2/xx
Publication of YU217390A publication Critical patent/YU217390A/sh
Publication of YU48469B publication Critical patent/YU48469B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pronalazak se odnosi na postupak za izradu farmaceutski značajnih 3-aminopirola opšte formule I kao 3-aminosupstituenti navode se disupstituisane i monosupstituisane amino grupe. Pronalazak nastavlja cilj da razvije većinom nove, CNS-aktivne 3-aminopirole, naročito takve, koji poseduju antikonvulzivne ili analgetska svojstva koa i postupak za njihovu izradu i njihovu primenu kao lekova. Prema pronalasku se sinteza izvodi ciklizovanjem prekursora otvorenog lanca, na primer derivata aminoakrilne kiseline ili modifikovanjem pirola.
YU217390A 1989-11-17 1990-11-15 3-aminopiroli, postupak za njihovu izradu, kao i izrada farmaceutskih sastava koji ih sadrže 3-aminopirroles YU48469B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012173A SI20323B (en) 1989-11-17 1990-11-15 3-Aminopyrrole, process for preparation and its use as a pharmaceutical composition or medicine
HR930229A HRP930229A2 (en) 1989-11-17 1993-02-24 3-aminopyrroles, process for their preparation and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD89334670A DD298912A5 (de) 1989-11-17 1989-11-17 Verfahren zur herstellung von 3-aminopyrrolen

Publications (2)

Publication Number Publication Date
YU217390A true YU217390A (sh) 1993-05-28
YU48469B YU48469B (sh) 1998-08-14

Family

ID=5613902

Family Applications (1)

Application Number Title Priority Date Filing Date
YU217390A YU48469B (sh) 1989-11-17 1990-11-15 3-aminopiroli, postupak za njihovu izradu, kao i izrada farmaceutskih sastava koji ih sadrže 3-aminopirroles

Country Status (10)

Country Link
US (2) US5502051A (sh)
EP (1) EP0431371B1 (sh)
JP (1) JPH07113015B2 (sh)
DD (1) DD298912A5 (sh)
DE (1) DE59010759D1 (sh)
ES (1) ES2108005T3 (sh)
FI (1) FI102169B1 (sh)
HU (1) HUT56343A (sh)
RU (2) RU2120796C1 (sh)
YU (1) YU48469B (sh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4227479A1 (de) * 1992-08-20 1994-02-24 Dresden Arzneimittel Verfahren zur Herstellung von 1-unsubstituierten 3-Aminopyrrolen
US5792778A (en) * 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5837719A (en) * 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997016441A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
US5908858A (en) 1996-04-05 1999-06-01 Sankyo Company, Limited 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
DE19629976A1 (de) * 1996-07-25 1998-01-29 Dresden Arzneimittel Verwendung von 4-(p-Halogenphenyl)-3-morpholinopyrrol-2-carbonsäuremethylester zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
EP2170062A4 (en) 2007-07-12 2010-12-29 Tragara Pharmaceuticals Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER DISORDERS, TUMORS AND TUMOR-DISORDED DISEASES
US9944597B2 (en) 2013-09-16 2018-04-17 The Board Of Regents Of The University Of Texas System Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198502A (en) * 1973-08-22 1980-04-15 Gruppo Lepetit S.P.A. Aminopyrrole derivatives
US4748183A (en) * 1986-06-13 1988-05-31 Warner-Lambert Company N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof

Also Published As

Publication number Publication date
EP0431371B1 (de) 1997-09-10
FI102169B (fi) 1998-10-30
FI102169B1 (fi) 1998-10-30
RU2120796C1 (ru) 1998-10-27
US5684160A (en) 1997-11-04
RU2060991C1 (ru) 1996-05-27
FI905689A0 (fi) 1990-11-16
ES2108005T3 (es) 1997-12-16
JPH07113015B2 (ja) 1995-12-06
DE59010759D1 (de) 1997-10-16
EP0431371A1 (de) 1991-06-12
US5502051A (en) 1996-03-26
JPH03271271A (ja) 1991-12-03
HUT56343A (en) 1991-08-28
HU907176D0 (en) 1991-05-28
YU48469B (sh) 1998-08-14
DD298912A5 (de) 1992-03-19
FI905689A (fi) 1991-05-18

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