BE901224A - Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation. - Google Patents
Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation.Info
- Publication number
- BE901224A BE901224A BE0/214125A BE214125A BE901224A BE 901224 A BE901224 A BE 901224A BE 0/214125 A BE0/214125 A BE 0/214125A BE 214125 A BE214125 A BE 214125A BE 901224 A BE901224 A BE 901224A
- Authority
- BE
- Belgium
- Prior art keywords
- intermediates
- preparation
- indole derivatives
- medicaments
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Nouveaux dérivés de l'indole de la formule générale (I), dans laquelle les substituants possèdent des significations définies, procédés pour leur préparation tels qu'une cyclisation d'un composé de la formule générale (II) et utilisation de ces composés de leurs sels physiologiquement acceptables et de produits de solvatation, qui possèdent une action vasoconstrictrice, pour le traitement de douleurs comme la migraine; composés intermédiaires et compositions pharmaceutique contenant ces substances.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838332435A GB8332435D0 (en) | 1983-12-06 | 1983-12-06 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BE901224A true BE901224A (fr) | 1985-06-06 |
Family
ID=10552845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/214125A BE901224A (fr) | 1983-12-06 | 1984-12-06 | Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation. |
Country Status (27)
Country | Link |
---|---|
US (1) | US4994483A (fr) |
JP (2) | JPH062733B2 (fr) |
KR (1) | KR850004459A (fr) |
CN (2) | CN85104233A (fr) |
AT (1) | AT381934B (fr) |
AU (1) | AU575365B2 (fr) |
BE (1) | BE901224A (fr) |
CA (1) | CA1233183A (fr) |
CH (1) | CH663411A5 (fr) |
CY (1) | CY1562A (fr) |
DE (1) | DE3444572C2 (fr) |
DK (2) | DK583684A (fr) |
ES (2) | ES8607234A1 (fr) |
FI (1) | FI80260C (fr) |
FR (1) | FR2555987B1 (fr) |
GB (2) | GB8332435D0 (fr) |
HK (1) | HK85690A (fr) |
HU (2) | HU196752B (fr) |
IL (1) | IL73756A (fr) |
IT (1) | IT1178268B (fr) |
NL (1) | NL8403719A (fr) |
NO (1) | NO162764C (fr) |
NZ (1) | NZ210469A (fr) |
PT (1) | PT80572B (fr) |
SE (1) | SE458446B (fr) |
SG (1) | SG65790G (fr) |
ZA (1) | ZA849498B (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
GB8419575D0 (en) * | 1984-08-01 | 1984-09-05 | Glaxo Group Ltd | Chemical compounds |
AU584142B2 (en) * | 1984-12-04 | 1989-05-18 | Glaxo Group Limited | Indole derivatives |
GB8430624D0 (en) * | 1984-12-04 | 1985-01-09 | Glaxo Group Ltd | Chemical compounds |
GB8600397D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
GB8601959D0 (en) * | 1986-01-28 | 1986-03-05 | Glaxo Group Ltd | Indole derivatives |
US5270333A (en) * | 1986-01-28 | 1993-12-14 | Glaxo Group Limited | Indole derivatives |
GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
KR0131327B1 (en) * | 1987-08-13 | 1998-04-17 | Glaxo Group Ltd | Indole derivatives |
US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
JPH01312506A (ja) * | 1988-06-13 | 1989-12-18 | Mitsui Petrochem Ind Ltd | カラーフィルター |
HU219974B (hu) * | 1990-06-07 | 2001-10-28 | Astrazeneca Ab, | Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények |
GB9209882D0 (en) * | 1992-05-07 | 1992-06-24 | Glaxo Lab Sa | Compositions |
GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
ES2055651B1 (es) * | 1992-07-20 | 1995-03-01 | Vita Invest Sa | Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles. |
IT1264813B1 (it) * | 1993-07-28 | 1996-10-10 | Oxon Italia Spa | Procedimento per la preparazione di alcansolfonammidi |
EP0875513A1 (fr) * | 1997-04-14 | 1998-11-04 | Eli Lilly And Company | Composés hétéroaromatiques substitués agonistes du récepteur 5-HT1F |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
GB9926250D0 (en) * | 1999-11-06 | 2000-01-12 | Knoll Ag | Chemical process |
US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
CN1729174B (zh) * | 2002-12-20 | 2015-10-21 | 西巴特殊化学品控股有限公司 | 胺的合成以及用于合成胺的中间体 |
WO2004099141A1 (fr) * | 2003-05-12 | 2004-11-18 | Ramesh Babu Potluri | Nouveau procede pour la preparation de derives d'indole |
EP1765300A2 (fr) * | 2004-06-10 | 2007-03-28 | Duramed Pharmaceuticals, Inc. | Formulations de sumatriptan absorbables au travers des membranes biologiques, et methodes de production et d'utilisation desdites formulations |
ZA200709038B (en) | 2005-04-13 | 2009-01-28 | Neuraxon Inc | Substituted indole compounds having nos inhibitory activity |
CA2643822A1 (fr) * | 2006-04-13 | 2007-10-25 | Neuraxon, Inc | Indoles 1,5- et 3,6-substitues a activite inhibitrice vis-a-vis de nos |
WO2008056378A2 (fr) * | 2006-11-09 | 2008-05-15 | Natco Pharma Limited | Nouveau procédé destiné à la préparation de naratriptan |
CA2677838C (fr) * | 2007-02-11 | 2017-08-01 | Map Pharmaceuticals, Inc. | Procede d'administration therapeutique de dhe pour procurer un soulagement rapide de la migraine tout en minimisant le profil des effets secondaires |
CA2705422A1 (fr) * | 2007-11-16 | 2009-05-22 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Procedes de traitement de la douleur viscerale |
US20090131503A1 (en) * | 2007-11-16 | 2009-05-21 | Annedi Subhash C | 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity |
NZ586082A (en) | 2007-11-16 | 2013-03-28 | Neuraxon Inc | Indole compounds and methods for treating visceral pain |
US20110171141A1 (en) * | 2009-06-26 | 2011-07-14 | Kellerman Donald J | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
US11337962B2 (en) | 2009-09-25 | 2022-05-24 | Upsher-Smith Laboratories, Llc | Formulations comprising triptan compounds |
EP2480197B1 (fr) | 2009-09-25 | 2015-11-11 | Dr. Reddy's Laboratories Ltd. | Formulations comprenant des composés triptan |
JPWO2012165262A1 (ja) * | 2011-05-27 | 2015-02-23 | 国立大学法人徳島大学 | ベンジルアミン誘導体 |
EP2734634B1 (fr) | 2011-07-22 | 2019-08-21 | The University of Chicago | Igf-1 pour le traitement de la migraine |
CN102827062A (zh) * | 2012-09-17 | 2012-12-19 | 扬子江药业集团四川海蓉药业有限公司 | 苹果酸阿莫曲坦的制备方法 |
US9394314B2 (en) | 2012-12-21 | 2016-07-19 | Map Pharmaceuticals, Inc. | 8′-hydroxy-dihydroergotamine compounds and compositions |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3322787A (en) * | 1964-09-25 | 1967-05-30 | Merck & Co Inc | Alpha-hydrazino-beta-(3-indolyl) alkanoic acid derivatives |
US3472870A (en) * | 1966-08-29 | 1969-10-14 | Mead Johnson & Co | Sulfonamidotryptamines |
US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
IT1036004B (it) * | 1968-05-21 | 1979-10-30 | Abc Ist Biolog Chem Spa | Acidt 3 indolil adetoidrossamici |
US3730723A (en) * | 1971-06-17 | 1973-05-01 | Eastman Kodak Co | Direct positive processes utilizing silver halide surface image emulsions containing desensitizers |
US4283410A (en) * | 1978-06-15 | 1981-08-11 | Miles Laboratories, Inc. | 3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives |
ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
BE889929A (fr) * | 1980-08-12 | 1982-02-11 | Glaxo Group Ltd | Derives de l'indole, leur preparation et leurs utilisations therapeutiques |
ZW19381A1 (en) * | 1980-08-12 | 1983-03-09 | Glaxo Group Ltd | Heterocyclic compounds |
GB2083463B (en) * | 1980-08-12 | 1984-05-10 | Glaxo Group Ltd | Heterocyclic compounds |
IT1170387B (it) * | 1982-06-07 | 1987-06-03 | Glaxo Group Ltd | Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono |
GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
AU584142B2 (en) * | 1984-12-04 | 1989-05-18 | Glaxo Group Limited | Indole derivatives |
-
1983
- 1983-12-06 GB GB838332435A patent/GB8332435D0/en active Pending
- 1983-12-06 HU HU834168A patent/HU196752B/hu unknown
-
1984
- 1984-12-05 FI FI844789A patent/FI80260C/fi not_active IP Right Cessation
- 1984-12-06 JP JP59258409A patent/JPH062733B2/ja not_active Expired - Lifetime
- 1984-12-06 AU AU36367/84A patent/AU575365B2/en not_active Ceased
- 1984-12-06 GB GB08430810A patent/GB2150932B/en not_active Expired
- 1984-12-06 BE BE0/214125A patent/BE901224A/fr not_active IP Right Cessation
- 1984-12-06 FR FR8418618A patent/FR2555987B1/fr not_active Expired
- 1984-12-06 DE DE3444572A patent/DE3444572C2/de not_active Expired - Fee Related
- 1984-12-06 AT AT0387384A patent/AT381934B/de not_active IP Right Cessation
- 1984-12-06 NL NL8403719A patent/NL8403719A/nl not_active Application Discontinuation
- 1984-12-06 CH CH5810/84A patent/CH663411A5/fr not_active IP Right Cessation
- 1984-12-06 IL IL73756A patent/IL73756A/xx unknown
- 1984-12-06 NO NO84844879A patent/NO162764C/no unknown
- 1984-12-06 ES ES538336A patent/ES8607234A1/es not_active Expired
- 1984-12-06 CA CA000469528A patent/CA1233183A/fr not_active Expired
- 1984-12-06 DK DK583684A patent/DK583684A/da not_active Application Discontinuation
- 1984-12-06 IT IT49265/84A patent/IT1178268B/it active
- 1984-12-06 SE SE8406200A patent/SE458446B/sv not_active IP Right Cessation
- 1984-12-06 NZ NZ210469A patent/NZ210469A/xx unknown
- 1984-12-06 ZA ZA849498A patent/ZA849498B/xx unknown
- 1984-12-06 KR KR1019840007709A patent/KR850004459A/ko not_active Application Discontinuation
-
1985
- 1985-05-30 HU HU852083A patent/HUT40624A/hu unknown
- 1985-05-31 PT PT80572A patent/PT80572B/pt not_active IP Right Cessation
- 1985-06-03 CN CN198585104233A patent/CN85104233A/zh active Pending
- 1985-08-19 CN CN85106225A patent/CN1015055B/zh not_active Expired
- 1985-09-02 ES ES546631A patent/ES8800150A1/es not_active Expired
-
1989
- 1989-11-30 US US07/443,874 patent/US4994483A/en not_active Expired - Fee Related
-
1990
- 1990-08-06 SG SG65790A patent/SG65790G/en unknown
- 1990-09-06 DK DK214090A patent/DK214090A/da not_active Application Discontinuation
- 1990-10-18 HK HK856/90A patent/HK85690A/xx not_active IP Right Cessation
- 1990-11-29 JP JP2326200A patent/JPH03184958A/ja active Pending
-
1991
- 1991-05-17 CY CY1562A patent/CY1562A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE901224A (fr) | Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation. | |
FR2430412A1 (fr) | Derives substitues de propanolamine utiles comme medicaments et procede de leur preparation | |
FR2416234A1 (fr) | Derives de metronidazole et compositions pharmaceutiques en contenant | |
MA26733A1 (fr) | Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
MA28747B1 (fr) | Dérivés de pyridine | |
MA25035A1 (fr) | Derives de 3-azabicyclo [3,1,0] hexane nouveaux, procede pour leur preparation et compositions les contenant | |
BE903334A (fr) | Nouveaux derives naphtaleniques a action retinoique, leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant | |
BE902953A (fr) | Derives de 5h-2,3-benzodiazepine procede pour les preparer et compositions pharmaceutiques les contenant | |
FR2444031A1 (fr) | Nouveaux derives d'imidazole, leur procede de production et composition pharmaceutique les contenant | |
BE903183A (fr) | Nouveaux derives du benzonorbornene, leurs procedes de preparation et composition medicamenteuse et cosmetique les contenant | |
BE899132A (fr) | Derives de thiazolidine, procede pour leur preparation et compositions pharmaceutiques les contenant | |
FR2397403A1 (fr) | Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes | |
FR2375187A1 (fr) | Cyclopentane-1-amines, procede pour leur preparation et produits contenant ces composes | |
FR2403989A1 (fr) | Nouveaux derives a-halogenomethyles d'amines utiles comme medicaments et procedes de leur preparation | |
FR2374307A1 (fr) | Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant | |
FR2433527A1 (fr) | Nouveaux derives de type pyrimidinone, procede pour leur preparation et composition pharmaceutique les contenant | |
FR2394542A1 (fr) | Derives de 3-(1-pyrazolyl)-pyridazine et leur procede de preparation et nouveaux medicaments les contenant | |
FR2370744A1 (fr) | Nouveaux derives d'aminopropanol, procede pour leur preparation et medicaments contenant ces composes | |
FR2358382A1 (fr) | Nouveaux nonapeptides, leurs procedes de preparation et compositions pharmaceutiques les contenant | |
FR2354766A1 (fr) | Derives n-aminoalkyles d'indole et procedes pour les preparer | |
FR2362845A1 (fr) | Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant | |
BE900178A (fr) | Urees et thio-urees anti-atherosclerotiques. | |
BE903376A (fr) | Derives de la vitamine d et precurseurs de ceux-ci et compositions pharmaceutiques en contenant | |
MA19952A1 (fr) | Nouveaux derives de la nitrosouree, leur procede de preparation et les compositions pharmaceutiques les renfermant | |
BE902249A (fr) | Derives d'iminothiazolidine, procede pour leur preparation et compositions pharmaceutiques les contenant. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: GLAXO GROUP LTD Effective date: 19911231 |