BE900178A - Urees et thio-urees anti-atherosclerotiques. - Google Patents

Urees et thio-urees anti-atherosclerotiques.

Info

Publication number
BE900178A
BE900178A BE0/213345A BE213345A BE900178A BE 900178 A BE900178 A BE 900178A BE 0/213345 A BE0/213345 A BE 0/213345A BE 213345 A BE213345 A BE 213345A BE 900178 A BE900178 A BE 900178A
Authority
BE
Belgium
Prior art keywords
urea
atherosclerotic
thio
ureas
hyperlipidemia
Prior art date
Application number
BE0/213345A
Other languages
English (en)
Inventor
G Devries V
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of BE900178A publication Critical patent/BE900178A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nouvelles urées contenant des groupes qui sont ramifiés sur le pénultième atome de carbone de la chaine alkylique. Ces composés répondent à la formule de structure (I). L'invention concerne aussi la synthèse chimique de ces urées, les compositions pharmaceutiques qui les contiennent et leur emploi pour le traitement de l'arthérosclérose et l'hyperlipidémie.
BE0/213345A 1983-07-19 1984-07-18 Urees et thio-urees anti-atherosclerotiques. BE900178A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51532183A 1983-07-19 1983-07-19

Publications (1)

Publication Number Publication Date
BE900178A true BE900178A (fr) 1985-01-18

Family

ID=24050874

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213345A BE900178A (fr) 1983-07-19 1984-07-18 Urees et thio-urees anti-atherosclerotiques.

Country Status (7)

Country Link
JP (1) JPS6041655A (fr)
AT (1) AT394191B (fr)
BE (1) BE900178A (fr)
CA (1) CA1239150A (fr)
FR (1) FR2549473B1 (fr)
GB (1) GB2149394B (fr)
NL (1) NL8402272A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378728A (en) * 1992-11-03 1995-01-03 Sandoz Ltd. Benzoic acid derivatives as antidiabetic agents

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH642373A5 (fr) * 1979-09-13 1984-04-13 Firmenich & Cie Compose pyrannique, procede pour sa preparation et son utilisation a titre d'intermediaire de synthese.
US5003106A (en) * 1983-07-19 1991-03-26 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US5248688A (en) * 1986-09-10 1993-09-28 Dudrick Medical Research Fund I, Ltd. Method and substrate composition for treating atherosclerosis
US5032608A (en) * 1986-09-10 1991-07-16 Dudrick Stanley J Method and substrate composition for treating atherosclerosis
US4994465A (en) * 1989-02-17 1991-02-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
GB9020841D0 (en) * 1990-09-25 1990-11-07 Wellcome Found Anti-atherosclerotic aryl compounds
WO1992009572A1 (fr) * 1990-11-26 1992-06-11 Taisho Pharmaceutical Co., Ltd. Derive d'anilide
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
WO1993013086A1 (fr) * 1991-12-25 1993-07-08 Taisho Pharmaceutical Co., Ltd. Derive d'anilide
JPH05320143A (ja) * 1992-03-18 1993-12-03 Mochida Pharmaceut Co Ltd 新規ピリミジン誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5224104B2 (fr) * 1974-10-07 1977-06-29
JPS5461149A (en) * 1977-10-20 1979-05-17 Kumiai Chem Ind Co Ltd 3-chloro-4-fluorophenyl urea derivative, its preparation and herbicide containing the same
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
IL67417A (en) * 1982-01-26 1989-10-31 American Cyanamid Co Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them
US4387105A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378728A (en) * 1992-11-03 1995-01-03 Sandoz Ltd. Benzoic acid derivatives as antidiabetic agents

Also Published As

Publication number Publication date
NL8402272A (nl) 1985-02-18
ATA231284A (de) 1991-08-15
GB2149394B (en) 1986-09-24
JPH0585543B2 (fr) 1993-12-07
AT394191B (de) 1992-02-10
CA1239150A (fr) 1988-07-12
FR2549473A1 (fr) 1985-01-25
GB2149394A (en) 1985-06-12
JPS6041655A (ja) 1985-03-05
FR2549473B1 (fr) 1988-07-22
GB8417126D0 (en) 1984-08-08

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: AMERICAN CYANAMID CY

Effective date: 19990731