CA1239150A - Urees trisubstituees anti-atherosclerotiques - Google Patents

Urees trisubstituees anti-atherosclerotiques

Info

Publication number
CA1239150A
CA1239150A CA000459032A CA459032A CA1239150A CA 1239150 A CA1239150 A CA 1239150A CA 000459032 A CA000459032 A CA 000459032A CA 459032 A CA459032 A CA 459032A CA 1239150 A CA1239150 A CA 1239150A
Authority
CA
Canada
Prior art keywords
urea
chloro
phenyl
compound
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000459032A
Other languages
English (en)
Inventor
Vern G. Devries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of CA1239150A publication Critical patent/CA1239150A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000459032A 1983-07-19 1984-07-17 Urees trisubstituees anti-atherosclerotiques Expired CA1239150A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51532183A 1983-07-19 1983-07-19
US515,321 1983-07-19

Publications (1)

Publication Number Publication Date
CA1239150A true CA1239150A (fr) 1988-07-12

Family

ID=24050874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000459032A Expired CA1239150A (fr) 1983-07-19 1984-07-17 Urees trisubstituees anti-atherosclerotiques

Country Status (7)

Country Link
JP (1) JPS6041655A (fr)
AT (1) AT394191B (fr)
BE (1) BE900178A (fr)
CA (1) CA1239150A (fr)
FR (1) FR2549473B1 (fr)
GB (1) GB2149394B (fr)
NL (1) NL8402272A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH642342A5 (fr) * 1979-09-13 1984-04-13 Firmenich & Cie Procede pour la preparation de muscone.
US5003106A (en) * 1983-07-19 1991-03-26 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US5032608A (en) * 1986-09-10 1991-07-16 Dudrick Stanley J Method and substrate composition for treating atherosclerosis
US5248688A (en) * 1986-09-10 1993-09-28 Dudrick Medical Research Fund I, Ltd. Method and substrate composition for treating atherosclerosis
US4994465A (en) * 1989-02-17 1991-02-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
GB9020841D0 (en) * 1990-09-25 1990-11-07 Wellcome Found Anti-atherosclerotic aryl compounds
DK0559898T3 (da) * 1990-11-26 1996-08-19 Taisho Pharmaceutical Co Ltd Anilidderivater
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
CA2126663A1 (fr) * 1991-12-25 1993-07-08 Masakazu Sato Derives anilides
JPH05320143A (ja) * 1992-03-18 1993-12-03 Mochida Pharmaceut Co Ltd 新規ピリミジン誘導体
US5378728A (en) * 1992-11-03 1995-01-03 Sandoz Ltd. Benzoic acid derivatives as antidiabetic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5224104B2 (fr) * 1974-10-07 1977-06-29
JPS5461149A (en) * 1977-10-20 1979-05-17 Kumiai Chem Ind Co Ltd 3-chloro-4-fluorophenyl urea derivative, its preparation and herbicide containing the same
IL67417A (en) * 1982-01-26 1989-10-31 American Cyanamid Co Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
US4387105A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Also Published As

Publication number Publication date
GB8417126D0 (en) 1984-08-08
FR2549473A1 (fr) 1985-01-25
NL8402272A (nl) 1985-02-18
GB2149394B (en) 1986-09-24
BE900178A (fr) 1985-01-18
AT394191B (de) 1992-02-10
GB2149394A (en) 1985-06-12
ATA231284A (de) 1991-08-15
JPH0585543B2 (fr) 1993-12-07
FR2549473B1 (fr) 1988-07-22
JPS6041655A (ja) 1985-03-05

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Legal Events

Date Code Title Description
MKEX Expiry