IL67417A - Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them - Google Patents

Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL67417A
IL67417A IL67417A IL6741782A IL67417A IL 67417 A IL67417 A IL 67417A IL 67417 A IL67417 A IL 67417A IL 6741782 A IL6741782 A IL 6741782A IL 67417 A IL67417 A IL 67417A
Authority
IL
Israel
Prior art keywords
antiatherosclerotic
preparation
pharmaceutical compositions
compositions containing
substituted ureas
Prior art date
Application number
IL67417A
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL67417A publication Critical patent/IL67417A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
IL67417A 1982-01-26 1982-12-05 Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them IL67417A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Publications (1)

Publication Number Publication Date
IL67417A true IL67417A (en) 1989-10-31

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67417A IL67417A (en) 1982-01-26 1982-12-05 Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
KR (1) KR890001808B1 (en)
AT (1) AT391313B (en)
AU (1) AU562699B2 (en)
CH (1) CH654571A5 (en)
DE (1) DE3247581A1 (en)
DK (1) DK160869C (en)
ES (2) ES519246A0 (en)
FI (1) FI85013C (en)
FR (1) FR2521134B1 (en)
GB (1) GB2113684B (en)
GR (1) GR77186B (en)
HU (1) HU200746B (en)
IE (1) IE54683B1 (en)
IL (1) IL67417A (en)
IT (1) IT1203647B (en)
NL (1) NL8300269A (en)
NO (1) NO158417C (en)
PL (1) PL143836B1 (en)
PT (1) PT76138A (en)
SE (1) SE462653B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
ES2060682T3 (en) * 1988-03-30 1994-12-01 Warner Lambert Co N - ((FENIL (2,6-DISUBSTITUTED)) - N'-ARIL) UREAS AS ANTI-HYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS.
ZA911101B (en) * 1990-02-14 1991-11-27 Chugai Pharmaceutical Co Ltd Inhibition of modified ldl products
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
EP0609457B1 (en) * 1992-07-20 1997-10-29 Eisai Co., Ltd. Benzene derivative
AU8534198A (en) * 1997-08-05 1999-03-01 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6221913B1 (en) * 1998-01-21 2001-04-24 Zymogenetics, Inc. Dialkyl ureas as calcitonin mimetics
US8324396B2 (en) * 2007-07-10 2012-12-04 Amgen Inc. Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (en) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (en) * 1979-07-14 1981-01-29 Bayer Ag USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS

Also Published As

Publication number Publication date
FI85013C (en) 1992-02-25
AT391313B (en) 1990-09-25
DK28683A (en) 1983-07-27
SE8300370L (en) 1983-07-27
PL143836B1 (en) 1988-03-31
CH654571A5 (en) 1986-02-28
IT8347605A0 (en) 1983-01-25
FR2521134B1 (en) 1987-01-09
KR890001808B1 (en) 1989-05-23
FI830247L (en) 1983-07-27
NO158417B (en) 1988-05-30
IE830146L (en) 1983-07-26
ES8406422A1 (en) 1984-08-01
FI830247A0 (en) 1983-01-25
IE54683B1 (en) 1990-01-03
ES531508A0 (en) 1985-07-01
ATA23983A (en) 1990-03-15
DK160869C (en) 1991-10-14
NO158417C (en) 1988-09-07
IT1203647B (en) 1989-02-15
AU1068183A (en) 1983-08-04
ES519246A0 (en) 1984-08-01
GB2113684B (en) 1985-12-18
GB2113684A (en) 1983-08-10
GB8301863D0 (en) 1983-02-23
FR2521134A1 (en) 1983-08-12
DK28683D0 (en) 1983-01-25
SE8300370D0 (en) 1983-01-25
PT76138A (en) 1983-02-01
DK160869B (en) 1991-04-29
NL8300269A (en) 1983-08-16
HU200746B (en) 1990-08-28
GR77186B (en) 1984-09-11
PL240284A1 (en) 1985-01-02
AU562699B2 (en) 1987-06-18
DE3247581A1 (en) 1983-08-04
SE462653B (en) 1990-08-06
KR840002773A (en) 1984-07-16
FI85013B (en) 1991-11-15
ES8505943A1 (en) 1985-07-01
NO830238L (en) 1983-07-27

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Legal Events

Date Code Title Description
RH Patent void