AU562699B2 - Ureas ant thioureas - Google Patents

Ureas ant thioureas

Info

Publication number
AU562699B2
AU562699B2 AU10681/83A AU1068183A AU562699B2 AU 562699 B2 AU562699 B2 AU 562699B2 AU 10681/83 A AU10681/83 A AU 10681/83A AU 1068183 A AU1068183 A AU 1068183A AU 562699 B2 AU562699 B2 AU 562699B2
Authority
AU
Australia
Prior art keywords
thioureas
ureas
ant
ureas ant
ant thioureas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU10681/83A
Other versions
AU1068183A (en
Inventor
Ransom Brown Conrow
Vern Gordon Devries
Elwood Eugene Largis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AU1068183A publication Critical patent/AU1068183A/en
Application granted granted Critical
Publication of AU562699B2 publication Critical patent/AU562699B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
AU10681/83A 1982-01-26 1983-01-21 Ureas ant thioureas Ceased AU562699B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US342693 1982-01-26
US342698 1982-01-26

Publications (2)

Publication Number Publication Date
AU1068183A AU1068183A (en) 1983-08-04
AU562699B2 true AU562699B2 (en) 1987-06-18

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10681/83A Ceased AU562699B2 (en) 1982-01-26 1983-01-21 Ureas ant thioureas

Country Status (20)

Country Link
KR (1) KR890001808B1 (en)
AT (1) AT391313B (en)
AU (1) AU562699B2 (en)
CH (1) CH654571A5 (en)
DE (1) DE3247581A1 (en)
DK (1) DK160869C (en)
ES (2) ES519246A0 (en)
FI (1) FI85013C (en)
FR (1) FR2521134B1 (en)
GB (1) GB2113684B (en)
GR (1) GR77186B (en)
HU (1) HU200746B (en)
IE (1) IE54683B1 (en)
IL (1) IL67417A (en)
IT (1) IT1203647B (en)
NL (1) NL8300269A (en)
NO (1) NO158417C (en)
PL (1) PL143836B1 (en)
PT (1) PT76138A (en)
SE (1) SE462653B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
EP0344425B1 (en) * 1988-03-30 1993-12-08 Warner-Lambert Company N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents
EP0515684A4 (en) * 1990-02-14 1993-04-21 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
EP0609457B1 (en) * 1992-07-20 1997-10-29 Eisai Co., Ltd. Benzene derivative
EP1019367A1 (en) * 1997-08-05 2000-07-19 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
WO1999037604A2 (en) * 1998-01-21 1999-07-29 Zymogenetics, Inc. Dialkyl ureas as calcitonin mimetics
JP5504484B2 (en) * 2007-07-10 2014-05-28 アムジエン・インコーポレーテツド Urea derivatives and related diamines, methods for their production and use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (en) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (en) * 1979-07-14 1981-01-29 Bayer Ag USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS

Also Published As

Publication number Publication date
DK160869C (en) 1991-10-14
CH654571A5 (en) 1986-02-28
GB8301863D0 (en) 1983-02-23
FI85013C (en) 1992-02-25
DK28683A (en) 1983-07-27
FR2521134B1 (en) 1987-01-09
NO158417B (en) 1988-05-30
NO830238L (en) 1983-07-27
GB2113684B (en) 1985-12-18
AU1068183A (en) 1983-08-04
IT1203647B (en) 1989-02-15
ES8406422A1 (en) 1984-08-01
HU200746B (en) 1990-08-28
ES519246A0 (en) 1984-08-01
IE54683B1 (en) 1990-01-03
AT391313B (en) 1990-09-25
SE8300370L (en) 1983-07-27
SE8300370D0 (en) 1983-01-25
FI830247L (en) 1983-07-27
IE830146L (en) 1983-07-26
PL143836B1 (en) 1988-03-31
ATA23983A (en) 1990-03-15
NO158417C (en) 1988-09-07
GB2113684A (en) 1983-08-10
DK28683D0 (en) 1983-01-25
DE3247581A1 (en) 1983-08-04
SE462653B (en) 1990-08-06
KR890001808B1 (en) 1989-05-23
PL240284A1 (en) 1985-01-02
KR840002773A (en) 1984-07-16
IL67417A (en) 1989-10-31
IT8347605A0 (en) 1983-01-25
FI85013B (en) 1991-11-15
GR77186B (en) 1984-09-11
FI830247A0 (en) 1983-01-25
FR2521134A1 (en) 1983-08-12
DK160869B (en) 1991-04-29
NL8300269A (en) 1983-08-16
PT76138A (en) 1983-02-01
ES531508A0 (en) 1985-07-01
ES8505943A1 (en) 1985-07-01

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