IT1203647B - REPLACED UREAS AND THIOURAS HAVING ANTI-THEROSCLEROTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

REPLACED UREAS AND THIOURAS HAVING ANTI-THEROSCLEROTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IT1203647B
IT1203647B IT47605/83A IT4760583A IT1203647B IT 1203647 B IT1203647 B IT 1203647B IT 47605/83 A IT47605/83 A IT 47605/83A IT 4760583 A IT4760583 A IT 4760583A IT 1203647 B IT1203647 B IT 1203647B
Authority
IT
Italy
Prior art keywords
thiouras
therosclerotic
ureas
activities
replaced
Prior art date
Application number
IT47605/83A
Other languages
Italian (it)
Other versions
IT8347605A0 (en
Inventor
Vern Gordon Devries
Elwood Eugene Largis
Ransom Brown Conrow
Original Assignee
American Cianamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by American Cianamid Co filed Critical American Cianamid Co
Publication of IT8347605A0 publication Critical patent/IT8347605A0/en
Application granted granted Critical
Publication of IT1203647B publication Critical patent/IT1203647B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
IT47605/83A 1982-01-26 1983-01-25 REPLACED UREAS AND THIOURAS HAVING ANTI-THEROSCLEROTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IT1203647B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Publications (2)

Publication Number Publication Date
IT8347605A0 IT8347605A0 (en) 1983-01-25
IT1203647B true IT1203647B (en) 1989-02-15

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47605/83A IT1203647B (en) 1982-01-26 1983-01-25 REPLACED UREAS AND THIOURAS HAVING ANTI-THEROSCLEROTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (20)

Country Link
KR (1) KR890001808B1 (en)
AT (1) AT391313B (en)
AU (1) AU562699B2 (en)
CH (1) CH654571A5 (en)
DE (1) DE3247581A1 (en)
DK (1) DK160869C (en)
ES (2) ES8406422A1 (en)
FI (1) FI85013C (en)
FR (1) FR2521134B1 (en)
GB (1) GB2113684B (en)
GR (1) GR77186B (en)
HU (1) HU200746B (en)
IE (1) IE54683B1 (en)
IL (1) IL67417A (en)
IT (1) IT1203647B (en)
NL (1) NL8300269A (en)
NO (1) NO158417C (en)
PL (1) PL143836B1 (en)
PT (1) PT76138A (en)
SE (1) SE462653B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
EP0344425B1 (en) * 1988-03-30 1993-12-08 Warner-Lambert Company N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents
WO1991011994A1 (en) * 1990-02-14 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
HUT67475A (en) * 1992-07-20 1995-04-28 Eisai Co Ltd Benzene derivatives and pharmaceutical compositions containing them as active components
WO1999007672A1 (en) * 1997-08-05 1999-02-18 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
CA2284864A1 (en) * 1998-01-21 1999-07-29 Zymogenetics, Inc. Dialkyl ureas as calcitonin mimetics
JP5504484B2 (en) * 2007-07-10 2014-05-28 アムジエン・インコーポレーテツド Urea derivatives and related diamines, methods for their production and use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL212631A (en) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (en) * 1979-07-14 1981-01-29 Bayer Ag USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS

Also Published As

Publication number Publication date
ES519246A0 (en) 1984-08-01
AT391313B (en) 1990-09-25
FI830247L (en) 1983-07-27
ES8505943A1 (en) 1985-07-01
GR77186B (en) 1984-09-11
IL67417A (en) 1989-10-31
KR890001808B1 (en) 1989-05-23
DE3247581A1 (en) 1983-08-04
FI85013C (en) 1992-02-25
AU1068183A (en) 1983-08-04
FI830247A0 (en) 1983-01-25
FR2521134B1 (en) 1987-01-09
ES8406422A1 (en) 1984-08-01
ES531508A0 (en) 1985-07-01
SE462653B (en) 1990-08-06
IT8347605A0 (en) 1983-01-25
DK28683D0 (en) 1983-01-25
NL8300269A (en) 1983-08-16
FI85013B (en) 1991-11-15
IE54683B1 (en) 1990-01-03
NO158417B (en) 1988-05-30
GB8301863D0 (en) 1983-02-23
PL143836B1 (en) 1988-03-31
AU562699B2 (en) 1987-06-18
DK28683A (en) 1983-07-27
GB2113684B (en) 1985-12-18
SE8300370D0 (en) 1983-01-25
CH654571A5 (en) 1986-02-28
DK160869C (en) 1991-10-14
HU200746B (en) 1990-08-28
DK160869B (en) 1991-04-29
NO158417C (en) 1988-09-07
PT76138A (en) 1983-02-01
IE830146L (en) 1983-07-26
PL240284A1 (en) 1985-01-02
KR840002773A (en) 1984-07-16
NO830238L (en) 1983-07-27
FR2521134A1 (en) 1983-08-12
ATA23983A (en) 1990-03-15
SE8300370L (en) 1983-07-27
GB2113684A (en) 1983-08-10

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Effective date: 19950131