IT1167123B - BENZOAZACYCLOALKYLSPYRO-IMIDAZOLIDINE, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
BENZOAZACYCLOALKYLSPYRO-IMIDAZOLIDINE, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- IT1167123B IT1167123B IT48155/83A IT4815583A IT1167123B IT 1167123 B IT1167123 B IT 1167123B IT 48155/83 A IT48155/83 A IT 48155/83A IT 4815583 A IT4815583 A IT 4815583A IT 1167123 B IT1167123 B IT 1167123B
- Authority
- IT
- Italy
- Prior art keywords
- benzoazacycloalkylspyro
- imidazolidine
- prepare
- procedure
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8207203A FR2525603A1 (en) | 1982-04-27 | 1982-04-27 | BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8348155A0 IT8348155A0 (en) | 1983-04-26 |
| IT1167123B true IT1167123B (en) | 1987-05-13 |
Family
ID=9273425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT48155/83A IT1167123B (en) | 1982-04-27 | 1983-04-26 | BENZOAZACYCLOALKYLSPYRO-IMIDAZOLIDINE, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5910584A (en) |
| KR (1) | KR840004428A (en) |
| AT (1) | ATA125383A (en) |
| AU (1) | AU1395383A (en) |
| BE (1) | BE896572A (en) |
| DD (1) | DD209833A5 (en) |
| DE (1) | DE3315106A1 (en) |
| DK (1) | DK183583A (en) |
| ES (1) | ES8405796A1 (en) |
| FR (1) | FR2525603A1 (en) |
| GB (1) | GB2133401B (en) |
| GR (1) | GR78481B (en) |
| IL (1) | IL68497A0 (en) |
| IT (1) | IT1167123B (en) |
| LU (1) | LU84770A1 (en) |
| MA (1) | MA19783A1 (en) |
| NL (1) | NL8301476A (en) |
| NO (1) | NO831473L (en) |
| OA (1) | OA07412A (en) |
| PT (1) | PT76595B (en) |
| SE (1) | SE8302347L (en) |
| ZA (1) | ZA832927B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| WO2005003096A1 (en) | 2003-06-17 | 2005-01-13 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases |
| ES2571220T3 (en) | 2003-06-17 | 2016-05-24 | Arena Pharm Inc | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
| US8168624B2 (en) | 2004-12-21 | 2012-05-01 | Arena Pharmaceuticals, Inc. | Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
| CN102627607A (en) | 2004-12-23 | 2012-08-08 | 艾尼纳制药公司 | 5HT2c receptor modulator compositions and methods of use |
| CA2646044A1 (en) | 2006-04-03 | 2007-10-25 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto |
| SG177128A1 (en) | 2006-12-05 | 2012-01-30 | Arena Pharm Inc | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
| US8822727B2 (en) | 2008-03-04 | 2014-09-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
| WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| CN103189053A (en) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
| WO2012030957A2 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
| MX2013002418A (en) | 2010-09-01 | 2013-08-01 | Arena Pharm Inc | Administration of lorcaserin to individuals with renal impairment. |
| MX2013002422A (en) | 2010-09-01 | 2013-05-17 | Arena Pharm Inc | Salts of lorcaserin with optically active acids. |
| MY181736A (en) | 2012-10-09 | 2021-01-05 | Arena Pharm Inc | Method of weight management |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/en active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/en not_active IP Right Cessation
- 1983-04-25 DD DD83250187A patent/DD209833A5/en unknown
- 1983-04-25 LU LU84770A patent/LU84770A1/en unknown
- 1983-04-26 NL NL8301476A patent/NL8301476A/en not_active Application Discontinuation
- 1983-04-26 ZA ZA832927A patent/ZA832927B/en unknown
- 1983-04-26 NO NO831473A patent/NO831473L/en unknown
- 1983-04-26 JP JP58073687A patent/JPS5910584A/en active Pending
- 1983-04-26 PT PT76595A patent/PT76595B/en unknown
- 1983-04-26 IT IT48155/83A patent/IT1167123B/en active
- 1983-04-26 SE SE8302347A patent/SE8302347L/en not_active Application Discontinuation
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-26 IL IL68497A patent/IL68497A0/en unknown
- 1983-04-26 BE BE0/210633A patent/BE896572A/en not_active IP Right Cessation
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/en not_active Application Discontinuation
- 1983-04-26 DK DK183583A patent/DK183583A/en not_active Application Discontinuation
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/en not_active Withdrawn
- 1983-04-27 MA MA20003A patent/MA19783A1/en unknown
- 1983-04-27 OA OA57984A patent/OA07412A/en unknown
- 1983-04-27 ES ES521895A patent/ES8405796A1/en not_active Expired
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL68497A0 (en) | 1983-07-31 |
| PT76595B (en) | 1986-01-21 |
| GR78481B (en) | 1984-09-27 |
| GB2133401B (en) | 1985-10-23 |
| AU1395383A (en) | 1983-11-03 |
| FR2525603A1 (en) | 1983-10-28 |
| GB8311508D0 (en) | 1983-06-02 |
| KR840004428A (en) | 1984-10-15 |
| ES521895A0 (en) | 1984-06-16 |
| PT76595A (en) | 1983-05-01 |
| SE8302347D0 (en) | 1983-04-26 |
| NL8301476A (en) | 1983-11-16 |
| FR2525603B1 (en) | 1984-09-14 |
| MA19783A1 (en) | 1983-12-31 |
| ZA832927B (en) | 1984-06-27 |
| DD209833A5 (en) | 1984-05-23 |
| SE8302347L (en) | 1983-10-28 |
| BE896572A (en) | 1983-10-26 |
| JPS5910584A (en) | 1984-01-20 |
| ES8405796A1 (en) | 1984-06-16 |
| OA07412A (en) | 1984-11-30 |
| DK183583D0 (en) | 1983-04-26 |
| NO831473L (en) | 1983-10-28 |
| ATA125383A (en) | 1986-05-15 |
| DE3315106A1 (en) | 1983-11-03 |
| GB2133401A (en) | 1984-07-25 |
| DK183583A (en) | 1983-10-28 |
| IT8348155A0 (en) | 1983-04-26 |
| LU84770A1 (en) | 1984-11-28 |
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