ES8405796A1 - Benzoazacycloalkyl-spiro- imidazolidines - Google Patents

Benzoazacycloalkyl-spiro- imidazolidines

Info

Publication number
ES8405796A1
ES8405796A1 ES521895A ES521895A ES8405796A1 ES 8405796 A1 ES8405796 A1 ES 8405796A1 ES 521895 A ES521895 A ES 521895A ES 521895 A ES521895 A ES 521895A ES 8405796 A1 ES8405796 A1 ES 8405796A1
Authority
ES
Spain
Prior art keywords
benzoazacycloalkyl
imidazolidines
spiro
hydrogen atom
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521895A
Other languages
Spanish (es)
Other versions
ES521895A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES8405796A1 publication Critical patent/ES8405796A1/en
Publication of ES521895A0 publication Critical patent/ES521895A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Abstract

The present invention provides a compound of the general formula: < IMAGE > in which - R1 represents a halogen or a hydrogen atom, or a hydroxy or methoxy group, - R2 represents a hydrogen atom, a lower alkyl radical, a phenyl-lower alkyl radical, a lower alkanoyl radical or a p-toluenesulphonyl group, and - n represents 1 or 2, in the racemic form or as an optical isomer, or salts thereof and a process for their preparation. These compounds are useful in the treatment of diabetes.
ES521895A 1982-04-27 1983-04-27 PREPARATION PROCEDURE OF BENZOAZACICLOALQUIL-ESPIROIMIDAZOLIDINA, AS WELL AS ITS SALTS OBTAINED FROM PHARMACEUTICALLY ORGANICALLY BASED MINERAL OR ORGANIC BASES. Granted ES521895A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (en) 1982-04-27 1982-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
ES8405796A1 true ES8405796A1 (en) 1984-06-16
ES521895A0 ES521895A0 (en) 1984-06-16

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521895A Granted ES521895A0 (en) 1982-04-27 1983-04-27 PREPARATION PROCEDURE OF BENZOAZACICLOALQUIL-ESPIROIMIDAZOLIDINA, AS WELL AS ITS SALTS OBTAINED FROM PHARMACEUTICALLY ORGANICALLY BASED MINERAL OR ORGANIC BASES.

Country Status (22)

Country Link
JP (1) JPS5910584A (en)
KR (1) KR840004428A (en)
AT (1) ATA125383A (en)
AU (1) AU1395383A (en)
BE (1) BE896572A (en)
DD (1) DD209833A5 (en)
DE (1) DE3315106A1 (en)
DK (1) DK183583A (en)
ES (1) ES521895A0 (en)
FR (1) FR2525603A1 (en)
GB (1) GB2133401B (en)
GR (1) GR78481B (en)
IL (1) IL68497A0 (en)
IT (1) IT1167123B (en)
LU (1) LU84770A1 (en)
MA (1) MA19783A1 (en)
NL (1) NL8301476A (en)
NO (1) NO831473L (en)
OA (1) OA07412A (en)
PT (1) PT76595B (en)
SE (1) SE8302347L (en)
ZA (1) ZA832927B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CN1805939B (en) 2003-06-17 2010-10-13 艾尼纳制药公司 Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
SI2332921T1 (en) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride
EP1838677B1 (en) 2004-12-21 2009-09-09 Arena Pharmaceuticals, Inc. Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
EP2322162A1 (en) 2004-12-23 2011-05-18 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
JP5199997B2 (en) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド Process for preparing 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and related intermediates
EP2099743B1 (en) 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (en) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. Processes for the preparation of 5-ht2c receptor agonists
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
EP2611449A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG188364A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Salts of lorcaserin with optically active acids
RU2674670C1 (en) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Method of correction of body mass

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
NL8301476A (en) 1983-11-16
OA07412A (en) 1984-11-30
PT76595B (en) 1986-01-21
IT8348155A0 (en) 1983-04-26
LU84770A1 (en) 1984-11-28
DD209833A5 (en) 1984-05-23
BE896572A (en) 1983-10-26
GB2133401A (en) 1984-07-25
ATA125383A (en) 1986-05-15
GB2133401B (en) 1985-10-23
SE8302347L (en) 1983-10-28
FR2525603A1 (en) 1983-10-28
MA19783A1 (en) 1983-12-31
IT1167123B (en) 1987-05-13
JPS5910584A (en) 1984-01-20
IL68497A0 (en) 1983-07-31
GR78481B (en) 1984-09-27
DK183583A (en) 1983-10-28
DK183583D0 (en) 1983-04-26
ES521895A0 (en) 1984-06-16
AU1395383A (en) 1983-11-03
GB8311508D0 (en) 1983-06-02
ZA832927B (en) 1984-06-27
PT76595A (en) 1983-05-01
SE8302347D0 (en) 1983-04-26
KR840004428A (en) 1984-10-15
NO831473L (en) 1983-10-28
DE3315106A1 (en) 1983-11-03
FR2525603B1 (en) 1984-09-14

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