BE896572A - BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS - Google Patents

BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

Info

Publication number
BE896572A
BE896572A BE0/210633A BE210633A BE896572A BE 896572 A BE896572 A BE 896572A BE 0/210633 A BE0/210633 A BE 0/210633A BE 210633 A BE210633 A BE 210633A BE 896572 A BE896572 A BE 896572A
Authority
BE
Belgium
Prior art keywords
benzoazacycloalkyl
imidazolidines
spiro
therapeutics
preparation
Prior art date
Application number
BE0/210633A
Other languages
French (fr)
Inventor
C Malen
J-L Peglion
J Duhault
M Boulanger
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BE896572A publication Critical patent/BE896572A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE0/210633A 1982-04-27 1983-04-26 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS BE896572A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (en) 1982-04-27 1982-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
BE896572A true BE896572A (en) 1983-10-26

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/210633A BE896572A (en) 1982-04-27 1983-04-26 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

Country Status (22)

Country Link
JP (1) JPS5910584A (en)
KR (1) KR840004428A (en)
AT (1) ATA125383A (en)
AU (1) AU1395383A (en)
BE (1) BE896572A (en)
DD (1) DD209833A5 (en)
DE (1) DE3315106A1 (en)
DK (1) DK183583A (en)
ES (1) ES8405796A1 (en)
FR (1) FR2525603A1 (en)
GB (1) GB2133401B (en)
GR (1) GR78481B (en)
IL (1) IL68497A0 (en)
IT (1) IT1167123B (en)
LU (1) LU84770A1 (en)
MA (1) MA19783A1 (en)
NL (1) NL8301476A (en)
NO (1) NO831473L (en)
OA (1) OA07412A (en)
PT (1) PT76595B (en)
SE (1) SE8302347L (en)
ZA (1) ZA832927B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
MXPA05013366A (en) 2003-06-17 2006-04-05 Arena Pharm Inc Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases.
EP2332919A3 (en) 2003-06-17 2011-10-19 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
PT1838677E (en) 2004-12-21 2009-11-16 Arena Pharm Inc Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
PT1833473E (en) 2004-12-23 2009-12-17 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
EP2518053A1 (en) 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
WO2008070111A2 (en) 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
EP2288585A1 (en) 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
EP2611782A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
KR20180118801A (en) 2010-09-01 2018-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 Modified-release dosage forms of 5-ht2c agonists useful for weight management
NZ630494A (en) 2010-09-01 2016-05-27 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
KR20130101524A (en) 2010-09-01 2013-09-13 아레나 파마슈티칼스, 인크. Non-hygroscopic Salts of 5-HT2C Agonists
MX2015004532A (en) 2012-10-09 2016-01-20 Arena Pharm Inc Method of weight management.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
FR2525603A1 (en) 1983-10-28
GR78481B (en) 1984-09-27
ZA832927B (en) 1984-06-27
OA07412A (en) 1984-11-30
SE8302347L (en) 1983-10-28
PT76595A (en) 1983-05-01
SE8302347D0 (en) 1983-04-26
JPS5910584A (en) 1984-01-20
GB8311508D0 (en) 1983-06-02
NO831473L (en) 1983-10-28
DE3315106A1 (en) 1983-11-03
LU84770A1 (en) 1984-11-28
IL68497A0 (en) 1983-07-31
DK183583A (en) 1983-10-28
NL8301476A (en) 1983-11-16
IT1167123B (en) 1987-05-13
PT76595B (en) 1986-01-21
DK183583D0 (en) 1983-04-26
GB2133401B (en) 1985-10-23
ATA125383A (en) 1986-05-15
FR2525603B1 (en) 1984-09-14
AU1395383A (en) 1983-11-03
ES521895A0 (en) 1984-06-16
IT8348155A0 (en) 1983-04-26
MA19783A1 (en) 1983-12-31
DD209833A5 (en) 1984-05-23
ES8405796A1 (en) 1984-06-16
GB2133401A (en) 1984-07-25
KR840004428A (en) 1984-10-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ADIR

Effective date: 19860430