SE8302347L - BENSOAZACYCLOYLKYL-SPIRO-IMIDAZOLIDINES, PREPARING THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
BENSOAZACYCLOYLKYL-SPIRO-IMIDAZOLIDINES, PREPARING THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- SE8302347L SE8302347L SE8302347A SE8302347A SE8302347L SE 8302347 L SE8302347 L SE 8302347L SE 8302347 A SE8302347 A SE 8302347A SE 8302347 A SE8302347 A SE 8302347A SE 8302347 L SE8302347 L SE 8302347L
- Authority
- SE
- Sweden
- Prior art keywords
- bensoazacycloylkyl
- imidazolidines
- spiro
- preparing
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention provides a compound of the general formula: <IMAGE> in which - R1 represents a halogen or a hydrogen atom, or a hydroxy or methoxy group, - R2 represents a hydrogen atom, a lower alkyl radical, a phenyl-lower alkyl radical, a lower alkanoyl radical or a p-toluenesulphonyl group, and - n represents 1 or 2, in the racemic form or as an optical isomer, or salts thereof and a process for their preparation. These compounds are useful in the treatment of diabetes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8207203A FR2525603A1 (en) | 1982-04-27 | 1982-04-27 | BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8302347D0 SE8302347D0 (en) | 1983-04-26 |
SE8302347L true SE8302347L (en) | 1983-10-28 |
Family
ID=9273425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8302347A SE8302347L (en) | 1982-04-27 | 1983-04-26 | BENSOAZACYCLOYLKYL-SPIRO-IMIDAZOLIDINES, PREPARING THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPS5910584A (en) |
KR (1) | KR840004428A (en) |
AT (1) | ATA125383A (en) |
AU (1) | AU1395383A (en) |
BE (1) | BE896572A (en) |
DD (1) | DD209833A5 (en) |
DE (1) | DE3315106A1 (en) |
DK (1) | DK183583A (en) |
ES (1) | ES521895A0 (en) |
FR (1) | FR2525603A1 (en) |
GB (1) | GB2133401B (en) |
GR (1) | GR78481B (en) |
IL (1) | IL68497A0 (en) |
IT (1) | IT1167123B (en) |
LU (1) | LU84770A1 (en) |
MA (1) | MA19783A1 (en) |
NL (1) | NL8301476A (en) |
NO (1) | NO831473L (en) |
OA (1) | OA07412A (en) |
PT (1) | PT76595B (en) |
SE (1) | SE8302347L (en) |
ZA (1) | ZA832927B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
EA016558B1 (en) | 2003-06-17 | 2012-05-30 | Арена Фармасьютикалз, Инк. | Benzazepine derivatives useful for the treatment of 5htreceptor associated diseases |
MXPA05013364A (en) | 2003-06-17 | 2006-03-17 | Arena Pharm Inc | Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases. |
JP5270167B2 (en) | 2004-12-21 | 2013-08-21 | アリーナ ファーマシューティカルズ, インコーポレイテッド | Crystalline form of (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
SG158168A1 (en) | 2004-12-23 | 2010-01-29 | Arena Pharm Inc | 5ht2c receptor modulator compositions and methods of use |
WO2007120517A2 (en) | 2006-04-03 | 2007-10-25 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto |
JP5404414B2 (en) | 2006-12-05 | 2014-01-29 | アリーナ ファーマシューティカルズ, インコーポレイテッド | Method for preparing (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its intermediates |
WO2009111004A1 (en) | 2008-03-04 | 2009-09-11 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
US9045431B2 (en) | 2010-06-02 | 2015-06-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
WO2012030938A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
KR101913442B1 (en) | 2010-09-01 | 2018-10-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
WO2012030939A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Administration of lorcaserin to individuals with renal impairment |
MX2013002421A (en) | 2010-09-01 | 2013-05-17 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists. |
AU2012392187B2 (en) | 2012-10-09 | 2018-07-12 | Arena Pharmaceuticals, Inc. | Method of weight management |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/en active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/en not_active IP Right Cessation
- 1983-04-25 DD DD83250187A patent/DD209833A5/en unknown
- 1983-04-25 LU LU84770A patent/LU84770A1/en unknown
- 1983-04-26 IT IT48155/83A patent/IT1167123B/en active
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-26 SE SE8302347A patent/SE8302347L/en not_active Application Discontinuation
- 1983-04-26 BE BE0/210633A patent/BE896572A/en not_active IP Right Cessation
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 PT PT76595A patent/PT76595B/en unknown
- 1983-04-26 DK DK183583A patent/DK183583A/en not_active Application Discontinuation
- 1983-04-26 IL IL68497A patent/IL68497A0/en unknown
- 1983-04-26 JP JP58073687A patent/JPS5910584A/en active Pending
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/en not_active Application Discontinuation
- 1983-04-26 NL NL8301476A patent/NL8301476A/en not_active Application Discontinuation
- 1983-04-26 ZA ZA832927A patent/ZA832927B/en unknown
- 1983-04-26 NO NO831473A patent/NO831473L/en unknown
- 1983-04-27 ES ES521895A patent/ES521895A0/en active Granted
- 1983-04-27 OA OA57984A patent/OA07412A/en unknown
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/en not_active Withdrawn
- 1983-04-27 MA MA20003A patent/MA19783A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPS5910584A (en) | 1984-01-20 |
ATA125383A (en) | 1986-05-15 |
DD209833A5 (en) | 1984-05-23 |
MA19783A1 (en) | 1983-12-31 |
AU1395383A (en) | 1983-11-03 |
DK183583D0 (en) | 1983-04-26 |
DK183583A (en) | 1983-10-28 |
IL68497A0 (en) | 1983-07-31 |
IT1167123B (en) | 1987-05-13 |
FR2525603B1 (en) | 1984-09-14 |
GB2133401B (en) | 1985-10-23 |
ES8405796A1 (en) | 1984-06-16 |
ZA832927B (en) | 1984-06-27 |
KR840004428A (en) | 1984-10-15 |
LU84770A1 (en) | 1984-11-28 |
GB2133401A (en) | 1984-07-25 |
PT76595A (en) | 1983-05-01 |
SE8302347D0 (en) | 1983-04-26 |
GB8311508D0 (en) | 1983-06-02 |
NO831473L (en) | 1983-10-28 |
IT8348155A0 (en) | 1983-04-26 |
NL8301476A (en) | 1983-11-16 |
GR78481B (en) | 1984-09-27 |
ES521895A0 (en) | 1984-06-16 |
BE896572A (en) | 1983-10-26 |
FR2525603A1 (en) | 1983-10-28 |
DE3315106A1 (en) | 1983-11-03 |
OA07412A (en) | 1984-11-30 |
PT76595B (en) | 1986-01-21 |
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Legal Events
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NAV | Patent application has lapsed |
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