FR2525603B1 - - Google Patents

Info

Publication number
FR2525603B1
FR2525603B1 FR8207203A FR8207203A FR2525603B1 FR 2525603 B1 FR2525603 B1 FR 2525603B1 FR 8207203 A FR8207203 A FR 8207203A FR 8207203 A FR8207203 A FR 8207203A FR 2525603 B1 FR2525603 B1 FR 2525603B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8207203A
Other languages
French (fr)
Other versions
FR2525603A1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR8207203A priority Critical patent/FR2525603A1/en
Priority to AT0125383A priority patent/ATA125383A/en
Priority to LU84770A priority patent/LU84770A1/en
Priority to DD83250187A priority patent/DD209833A5/en
Priority to DK183583A priority patent/DK183583A/en
Priority to AU13953/83A priority patent/AU1395383A/en
Priority to SE8302347A priority patent/SE8302347L/en
Priority to JP58073687A priority patent/JPS5910584A/en
Priority to ZA832927A priority patent/ZA832927B/en
Priority to BE0/210633A priority patent/BE896572A/en
Priority to IT48155/83A priority patent/IT1167123B/en
Priority to PT76595A priority patent/PT76595B/en
Priority to GR71214A priority patent/GR78481B/el
Priority to IL68497A priority patent/IL68497A0/en
Priority to KR1019830001753A priority patent/KR840004428A/en
Priority to NO831473A priority patent/NO831473L/en
Priority to NL8301476A priority patent/NL8301476A/en
Priority to ES521895A priority patent/ES521895A0/en
Priority to DE19833315106 priority patent/DE3315106A1/en
Priority to OA57984A priority patent/OA07412A/en
Priority to MA20003A priority patent/MA19783A1/en
Priority to GB08311508A priority patent/GB2133401B/en
Publication of FR2525603A1 publication Critical patent/FR2525603A1/en
Application granted granted Critical
Publication of FR2525603B1 publication Critical patent/FR2525603B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR8207203A 1982-04-27 1982-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION Granted FR2525603A1 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (en) 1982-04-27 1982-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
AT0125383A ATA125383A (en) 1982-04-27 1983-04-08 METHOD FOR PRODUCING NEW BENZOAZACYCLOALKYL SPIRO-IMIDAZOLIDINES
DD83250187A DD209833A5 (en) 1982-04-27 1983-04-25 METHOD OF PREPARING BENZOAZACYCLOALKYL SPIRO-IMIDAZOLIDINES
LU84770A LU84770A1 (en) 1982-04-27 1983-04-25 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
NO831473A NO831473L (en) 1982-04-27 1983-04-26 PROCEDURE FOR THE PREPARATION OF BENZOAZACYCLYLKYL-SPIRO-IMIDAZOLIDINES
SE8302347A SE8302347L (en) 1982-04-27 1983-04-26 BENSOAZACYCLOYLKYL-SPIRO-IMIDAZOLIDINES, PREPARING THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP58073687A JPS5910584A (en) 1982-04-27 1983-04-26 Imidazolidine derivative
ZA832927A ZA832927B (en) 1982-04-27 1983-04-26 Benzoazacycloalkyl-spiro-imidazolidines,their preparation and compositions containing them
BE0/210633A BE896572A (en) 1982-04-27 1983-04-26 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
IT48155/83A IT1167123B (en) 1982-04-27 1983-04-26 BENZOAZACYCLOALKYLSPYRO-IMIDAZOLIDINE, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DK183583A DK183583A (en) 1982-04-27 1983-04-26 PROCEDURE FOR PREPARING BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES
GR71214A GR78481B (en) 1982-04-27 1983-04-26
IL68497A IL68497A0 (en) 1982-04-27 1983-04-26 Benzoazacycloalkyl-spiro-imidazolidines,their preparation and pharmaceutical compositions containing them
KR1019830001753A KR840004428A (en) 1982-04-27 1983-04-26 Method for preparing benzo azacyclo alkyl-spiro-imidazolidine
AU13953/83A AU1395383A (en) 1982-04-27 1983-04-26 Benzoazacycloalkyl-spiro-imidazolidines
NL8301476A NL8301476A (en) 1982-04-27 1983-04-26 BENZOAZACYCLOALKYLSPIROIMIDAZOLIDINES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE.
PT76595A PT76595B (en) 1982-04-27 1983-04-26 PROCESS FOR THE PREPARATION OF BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES
ES521895A ES521895A0 (en) 1982-04-27 1983-04-27 PREPARATION PROCEDURE OF BENZOAZACICLOALQUIL-ESPIROIMIDAZOLIDINA, AS WELL AS ITS SALTS OBTAINED FROM PHARMACEUTICALLY ORGANICALLY BASED MINERAL OR ORGANIC BASES.
DE19833315106 DE3315106A1 (en) 1982-04-27 1983-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME
OA57984A OA07412A (en) 1982-04-27 1983-04-27 Benzoazacycloalhyl-spiro-imidazolidines their preparation and their application in therapy.
MA20003A MA19783A1 (en) 1982-04-27 1983-04-27 PROCESS FOR THE PREPARATION OF BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES.
GB08311508A GB2133401B (en) 1982-04-27 1983-04-27 Benzoazacycloalkyl-spiro-imidazolidines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (en) 1982-04-27 1982-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
FR2525603A1 FR2525603A1 (en) 1983-10-28
FR2525603B1 true FR2525603B1 (en) 1984-09-14

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8207203A Granted FR2525603A1 (en) 1982-04-27 1982-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Country Status (22)

Country Link
JP (1) JPS5910584A (en)
KR (1) KR840004428A (en)
AT (1) ATA125383A (en)
AU (1) AU1395383A (en)
BE (1) BE896572A (en)
DD (1) DD209833A5 (en)
DE (1) DE3315106A1 (en)
DK (1) DK183583A (en)
ES (1) ES521895A0 (en)
FR (1) FR2525603A1 (en)
GB (1) GB2133401B (en)
GR (1) GR78481B (en)
IL (1) IL68497A0 (en)
IT (1) IT1167123B (en)
LU (1) LU84770A1 (en)
MA (1) MA19783A1 (en)
NL (1) NL8301476A (en)
NO (1) NO831473L (en)
OA (1) OA07412A (en)
PT (1) PT76595B (en)
SE (1) SE8302347L (en)
ZA (1) ZA832927B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EA016558B1 (en) 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Benzazepine derivatives useful for the treatment of 5htreceptor associated diseases
MXPA05013364A (en) 2003-06-17 2006-03-17 Arena Pharm Inc Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases.
JP5270167B2 (en) 2004-12-21 2013-08-21 アリーナ ファーマシューティカルズ， インコーポレイテッド Crystalline form of (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
SG158168A1 (en) 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
WO2007120517A2 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
JP5404414B2 (en) 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ， インコーポレイテッド Method for preparing (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its intermediates
WO2009111004A1 (en) 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
WO2012030938A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
KR101913442B1 (en) 2010-09-01 2018-10-30 에자이 알앤드디 매니지먼트 가부시키가이샤 Modified-release dosage forms of 5-ht2c agonists useful for weight management
WO2012030939A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
MX2013002421A (en) 2010-09-01 2013-05-17 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists.
AU2012392187B2 (en) 2012-10-09 2018-07-12 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
JPS5910584A (en) 1984-01-20
ATA125383A (en) 1986-05-15
DD209833A5 (en) 1984-05-23
MA19783A1 (en) 1983-12-31
AU1395383A (en) 1983-11-03
DK183583D0 (en) 1983-04-26
DK183583A (en) 1983-10-28
IL68497A0 (en) 1983-07-31
IT1167123B (en) 1987-05-13
GB2133401B (en) 1985-10-23
SE8302347L (en) 1983-10-28
ES8405796A1 (en) 1984-06-16
ZA832927B (en) 1984-06-27
KR840004428A (en) 1984-10-15
LU84770A1 (en) 1984-11-28
GB2133401A (en) 1984-07-25
PT76595A (en) 1983-05-01
SE8302347D0 (en) 1983-04-26
GB8311508D0 (en) 1983-06-02
NO831473L (en) 1983-10-28
IT8348155A0 (en) 1983-04-26
NL8301476A (en) 1983-11-16
GR78481B (en) 1984-09-27
ES521895A0 (en) 1984-06-16
BE896572A (en) 1983-10-26
FR2525603A1 (en) 1983-10-28
DE3315106A1 (en) 1983-11-03
OA07412A (en) 1984-11-30
PT76595B (en) 1986-01-21

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Legal Events

Date Code Title Description
ST Notification of lapse