ES8505943A1 - Antiatherosclerotic substituted ureas and thioureas - Google Patents
Antiatherosclerotic substituted ureas and thioureasInfo
- Publication number
- ES8505943A1 ES8505943A1 ES531508A ES531508A ES8505943A1 ES 8505943 A1 ES8505943 A1 ES 8505943A1 ES 531508 A ES531508 A ES 531508A ES 531508 A ES531508 A ES 531508A ES 8505943 A1 ES8505943 A1 ES 8505943A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- phenyl
- substituent
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
Abstract
Substituted ureas and thioureas of the formula below are disclosed which are useful as antiatherosclerotic agents < IMAGE > wherein X represents at least one substituent selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 alkynyl, hydroxy, C1-C4 alkoxy, phenoxy, mercapto, C1-C4 alkylthio, amino, C1-C4 alkylamino, di-(C1-C4 alkyl)amino, halo, trihalomethyl, C1-C4 alkanoyl, benzoyl, C1-C4 alkanamido, C1-C4 alkanesulfonyl, C1-C4 alkanesulfinyl, benzenesulfonyl, toluenesulfonyl, nitro, cyano, carboxy, C1-C4 carboalkoxy, carbamoyl, sulfamyl, methylenedioxy, phenyl, ortho-phenylene, tolyl, benzyl, halobenzyl, methylbenzyl, and the group: < IMAGE > wherein Y is selected from the group consisting of oxygen and sulfur R1 and R2 are the same or different and are independently selected from the group consisting of C4-C12 alkyl, C4-C12 alkenyl, C4-C12 alkynyl, C4-C12 cycloalkyl, C4-C12 cycloalkylalkyl, C7-C14 aralkyl, furyl and C7-C14 aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of C1-C10 alkyl, C1-C10 alkoxy, phenoxy, benzyloxy, methylenedioxy, C1- C4 alkylthio, phenyl, halo, trihalomethyl, adamantyl, C1-C4 carboalkoxy, and nitro and R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 alkynyl, benzyl, benzyl bearing at least one substituent Z, naphthyl, phenyl, and phenyl bearing at least one substituent Z, Z being selected independently of X from the group consisting of those from which X is selected.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/342,693 US4473579A (en) | 1982-01-26 | 1982-01-26 | Antiatherosclerotic tetrasubstituted ureas and thioureas |
| US06/342,698 US4387105A (en) | 1982-01-26 | 1982-01-26 | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES531508A0 ES531508A0 (en) | 1985-07-01 |
| ES8505943A1 true ES8505943A1 (en) | 1985-07-01 |
Family
ID=26993144
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519246A Expired ES8406422A1 (en) | 1982-01-26 | 1983-01-25 | Antiatherosclerotic substituted ureas and thioureas |
| ES531508A Expired ES8505943A1 (en) | 1982-01-26 | 1984-04-11 | Antiatherosclerotic substituted ureas and thioureas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519246A Expired ES8406422A1 (en) | 1982-01-26 | 1983-01-25 | Antiatherosclerotic substituted ureas and thioureas |
Country Status (20)
| Country | Link |
|---|---|
| KR (1) | KR890001808B1 (en) |
| AT (1) | AT391313B (en) |
| AU (1) | AU562699B2 (en) |
| CH (1) | CH654571A5 (en) |
| DE (1) | DE3247581A1 (en) |
| DK (1) | DK160869C (en) |
| ES (2) | ES8406422A1 (en) |
| FI (1) | FI85013C (en) |
| FR (1) | FR2521134B1 (en) |
| GB (1) | GB2113684B (en) |
| GR (1) | GR77186B (en) |
| HU (1) | HU200746B (en) |
| IE (1) | IE54683B1 (en) |
| IL (1) | IL67417A (en) |
| IT (1) | IT1203647B (en) |
| NL (1) | NL8300269A (en) |
| NO (1) | NO158417C (en) |
| PL (1) | PL143836B1 (en) |
| PT (1) | PT76138A (en) |
| SE (1) | SE462653B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2138804A (en) * | 1983-04-27 | 1984-10-31 | Sumitomo Chemical Co | Fungicidal N-phenylcarbamates |
| GB2149394B (en) * | 1983-07-19 | 1986-09-24 | American Cyanamid Co | Ureas |
| US4818899A (en) * | 1986-12-03 | 1989-04-04 | Minnesota Mining And Manufacturing Company | Second harmonic generation by carbamic acid derivatives |
| US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
| DE68911203T2 (en) * | 1988-03-30 | 1994-04-14 | Warner Lambert Co | N - [[(2,6-disubstituted) phenyl] N'-arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents. |
| AU7317391A (en) * | 1990-02-14 | 1991-09-03 | Chugai Seiyaku Kabushiki Kaisha | Inhibitor of denatured ldl formation |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
| DE69314929T2 (en) * | 1992-07-20 | 1998-03-19 | Eisai Co Ltd | BENZENE DERIVATIVES |
| EP1019367A1 (en) * | 1997-08-05 | 2000-07-19 | Novo Nordisk A/S | Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use |
| TW415942B (en) * | 1997-09-03 | 2000-12-21 | American Home Prod | Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents |
| US6455566B1 (en) | 1997-09-03 | 2002-09-24 | Wyeth | Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents |
| JP2001501979A (en) * | 1998-01-21 | 2001-02-13 | ザイモジェネティクス，インコーポレイティド | Dialkyl ureas as mimetics of calcitonin. |
| AU2008275595B2 (en) * | 2007-07-10 | 2013-11-14 | Amgen Inc. | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL212631A (en) * | 1949-12-06 | |||
| US2688039A (en) * | 1952-02-08 | 1954-08-31 | Ciba Pharm Prod Inc | Halogen-containing di-(substituted phenyl)-thioureas |
| US3326663A (en) * | 1964-09-25 | 1967-06-20 | Shell Oil Co | Herbicidal phenylureas |
| US3335142A (en) * | 1965-07-07 | 1967-08-08 | American Cyanamid Co | Process for the preparation of n, n'-disubstituted ureas |
| US3659012A (en) * | 1969-05-26 | 1972-04-25 | Lilly Co Eli | Methods of treating helminth infections with thiourea derivatives |
| US3728386A (en) * | 1970-07-27 | 1973-04-17 | Exxon Research Engineering Co | N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides |
| US3928437A (en) * | 1970-09-02 | 1975-12-23 | Ciba Geigy Corp | Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas |
| US3856952A (en) * | 1973-03-01 | 1974-12-24 | Pennwalt Corp | Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides |
| US3903130A (en) * | 1974-05-03 | 1975-09-02 | Stauffer Chemical Co | 1-Trifluormethylphenyl-3-dicyanophenyl urea |
| DE2928485A1 (en) * | 1979-07-14 | 1981-01-29 | Bayer Ag | USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS |
-
1982
- 1982-12-05 IL IL67417A patent/IL67417A/en not_active IP Right Cessation
- 1982-12-22 DE DE19823247581 patent/DE3247581A1/en not_active Withdrawn
- 1982-12-28 KR KR8205843A patent/KR890001808B1/en active
-
1983
- 1983-01-14 GR GR70261A patent/GR77186B/el unknown
- 1983-01-21 AU AU10681/83A patent/AU562699B2/en not_active Ceased
- 1983-01-24 GB GB08301863A patent/GB2113684B/en not_active Expired
- 1983-01-25 DK DK028683A patent/DK160869C/en not_active IP Right Cessation
- 1983-01-25 IE IE146/83A patent/IE54683B1/en not_active IP Right Cessation
- 1983-01-25 PL PL1983240284A patent/PL143836B1/en unknown
- 1983-01-25 SE SE8300370A patent/SE462653B/en not_active IP Right Cessation
- 1983-01-25 AT AT0023983A patent/AT391313B/en not_active IP Right Cessation
- 1983-01-25 IT IT47605/83A patent/IT1203647B/en active
- 1983-01-25 CH CH404/83A patent/CH654571A5/en not_active IP Right Cessation
- 1983-01-25 FR FR8301082A patent/FR2521134B1/en not_active Expired
- 1983-01-25 ES ES519246A patent/ES8406422A1/en not_active Expired
- 1983-01-25 PT PT76138A patent/PT76138A/en not_active IP Right Cessation
- 1983-01-25 FI FI830247A patent/FI85013C/en not_active IP Right Cessation
- 1983-01-25 NL NL8300269A patent/NL8300269A/en not_active Application Discontinuation
- 1983-01-25 NO NO830238A patent/NO158417C/en unknown
- 1983-01-25 HU HU83227A patent/HU200746B/en not_active IP Right Cessation
-
1984
- 1984-04-11 ES ES531508A patent/ES8505943A1/en not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990405 |