ES531508A0 - PROCEDURE TO PREPARE SUBSTITUTED UREAS AND THIOUREAS. - Google Patents
PROCEDURE TO PREPARE SUBSTITUTED UREAS AND THIOUREAS.Info
- Publication number
- ES531508A0 ES531508A0 ES531508A ES531508A ES531508A0 ES 531508 A0 ES531508 A0 ES 531508A0 ES 531508 A ES531508 A ES 531508A ES 531508 A ES531508 A ES 531508A ES 531508 A0 ES531508 A0 ES 531508A0
- Authority
- ES
- Spain
- Prior art keywords
- thioureas
- procedure
- substituted ureas
- prepare substituted
- prepare
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/342,693 US4473579A (en) | 1982-01-26 | 1982-01-26 | Antiatherosclerotic tetrasubstituted ureas and thioureas |
US06/342,698 US4387105A (en) | 1982-01-26 | 1982-01-26 | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
Publications (2)
Publication Number | Publication Date |
---|---|
ES531508A0 true ES531508A0 (en) | 1985-07-01 |
ES8505943A1 ES8505943A1 (en) | 1985-07-01 |
Family
ID=26993144
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519246A Granted ES519246A0 (en) | 1982-01-26 | 1983-01-25 | PROCEDURE FOR PREPARING SUBSTITUTED UREAS AND THIOUREAS |
ES531508A Expired ES8505943A1 (en) | 1982-01-26 | 1984-04-11 | Antiatherosclerotic substituted ureas and thioureas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519246A Granted ES519246A0 (en) | 1982-01-26 | 1983-01-25 | PROCEDURE FOR PREPARING SUBSTITUTED UREAS AND THIOUREAS |
Country Status (20)
Country | Link |
---|---|
KR (1) | KR890001808B1 (en) |
AT (1) | AT391313B (en) |
AU (1) | AU562699B2 (en) |
CH (1) | CH654571A5 (en) |
DE (1) | DE3247581A1 (en) |
DK (1) | DK160869C (en) |
ES (2) | ES519246A0 (en) |
FI (1) | FI85013C (en) |
FR (1) | FR2521134B1 (en) |
GB (1) | GB2113684B (en) |
GR (1) | GR77186B (en) |
HU (1) | HU200746B (en) |
IE (1) | IE54683B1 (en) |
IL (1) | IL67417A (en) |
IT (1) | IT1203647B (en) |
NL (1) | NL8300269A (en) |
NO (1) | NO158417C (en) |
PL (1) | PL143836B1 (en) |
PT (1) | PT76138A (en) |
SE (1) | SE462653B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2138804A (en) * | 1983-04-27 | 1984-10-31 | Sumitomo Chemical Co | Fungicidal N-phenylcarbamates |
GB2149394B (en) * | 1983-07-19 | 1986-09-24 | American Cyanamid Co | Ureas |
US4818899A (en) * | 1986-12-03 | 1989-04-04 | Minnesota Mining And Manufacturing Company | Second harmonic generation by carbamic acid derivatives |
US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
JPH0678298B2 (en) * | 1988-03-30 | 1994-10-05 | ワーナー‐ランバート・コンパニー | N-[[(2,6-disubstituted) phenyl] -N'-arylalkyl] ureas |
CA2076012A1 (en) * | 1990-02-14 | 1991-08-15 | Yasuyuki Kato | Agent for inhibiting the formation of denatured ldl |
US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
US5462958A (en) * | 1992-07-20 | 1995-10-31 | Eisai Co., Ltd. | Benzene derivatives and method of treating arteriosclerosis with benzene derivatives |
JP2003524574A (en) * | 1997-08-05 | 2003-08-19 | ノボ ノルディスク アクティーゼルスカブ | 2,5- and 3,5-disubstituted aniline derivatives, their preparation and use |
TW415942B (en) * | 1997-09-03 | 2000-12-21 | American Home Prod | Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents |
US6455566B1 (en) | 1997-09-03 | 2002-09-24 | Wyeth | Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents |
US6221913B1 (en) * | 1998-01-21 | 2001-04-24 | Zymogenetics, Inc. | Dialkyl ureas as calcitonin mimetics |
JP5504484B2 (en) * | 2007-07-10 | 2014-05-28 | アムジエン・インコーポレーテツド | Urea derivatives and related diamines, methods for their production and use |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL92838C (en) * | 1949-12-06 | |||
US2688039A (en) * | 1952-02-08 | 1954-08-31 | Ciba Pharm Prod Inc | Halogen-containing di-(substituted phenyl)-thioureas |
US3326663A (en) * | 1964-09-25 | 1967-06-20 | Shell Oil Co | Herbicidal phenylureas |
US3335142A (en) * | 1965-07-07 | 1967-08-08 | American Cyanamid Co | Process for the preparation of n, n'-disubstituted ureas |
US3659012A (en) * | 1969-05-26 | 1972-04-25 | Lilly Co Eli | Methods of treating helminth infections with thiourea derivatives |
US3728386A (en) * | 1970-07-27 | 1973-04-17 | Exxon Research Engineering Co | N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides |
US3928437A (en) * | 1970-09-02 | 1975-12-23 | Ciba Geigy Corp | Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas |
US3856952A (en) * | 1973-03-01 | 1974-12-24 | Pennwalt Corp | Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides |
US3903130A (en) * | 1974-05-03 | 1975-09-02 | Stauffer Chemical Co | 1-Trifluormethylphenyl-3-dicyanophenyl urea |
DE2928485A1 (en) * | 1979-07-14 | 1981-01-29 | Bayer Ag | USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS |
-
1982
- 1982-12-05 IL IL67417A patent/IL67417A/en not_active IP Right Cessation
- 1982-12-22 DE DE19823247581 patent/DE3247581A1/en not_active Withdrawn
- 1982-12-28 KR KR8205843A patent/KR890001808B1/en active
-
1983
- 1983-01-14 GR GR70261A patent/GR77186B/el unknown
- 1983-01-21 AU AU10681/83A patent/AU562699B2/en not_active Ceased
- 1983-01-24 GB GB08301863A patent/GB2113684B/en not_active Expired
- 1983-01-25 PL PL1983240284A patent/PL143836B1/en unknown
- 1983-01-25 NL NL8300269A patent/NL8300269A/en not_active Application Discontinuation
- 1983-01-25 FR FR8301082A patent/FR2521134B1/en not_active Expired
- 1983-01-25 NO NO830238A patent/NO158417C/en unknown
- 1983-01-25 IT IT47605/83A patent/IT1203647B/en active
- 1983-01-25 ES ES519246A patent/ES519246A0/en active Granted
- 1983-01-25 CH CH404/83A patent/CH654571A5/en not_active IP Right Cessation
- 1983-01-25 PT PT76138A patent/PT76138A/en not_active IP Right Cessation
- 1983-01-25 AT AT0023983A patent/AT391313B/en not_active IP Right Cessation
- 1983-01-25 FI FI830247A patent/FI85013C/en not_active IP Right Cessation
- 1983-01-25 SE SE8300370A patent/SE462653B/en not_active IP Right Cessation
- 1983-01-25 HU HU83227A patent/HU200746B/en not_active IP Right Cessation
- 1983-01-25 DK DK028683A patent/DK160869C/en not_active IP Right Cessation
- 1983-01-25 IE IE146/83A patent/IE54683B1/en not_active IP Right Cessation
-
1984
- 1984-04-11 ES ES531508A patent/ES8505943A1/en not_active Expired
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990405 |