IT8347605A0 - SUBSTITUTED UREAS AND THIOUREES HAVING ANTIATEROSCLEROTIC ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM - Google Patents
SUBSTITUTED UREAS AND THIOUREES HAVING ANTIATEROSCLEROTIC ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEMInfo
- Publication number
- IT8347605A0 IT8347605A0 IT8347605A IT4760583A IT8347605A0 IT 8347605 A0 IT8347605 A0 IT 8347605A0 IT 8347605 A IT8347605 A IT 8347605A IT 4760583 A IT4760583 A IT 4760583A IT 8347605 A0 IT8347605 A0 IT 8347605A0
- Authority
- IT
- Italy
- Prior art keywords
- thiourees
- antiaterosclerotic
- activity
- procedure
- contain
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/342,693 US4473579A (en) | 1982-01-26 | 1982-01-26 | Antiatherosclerotic tetrasubstituted ureas and thioureas |
US06/342,698 US4387105A (en) | 1982-01-26 | 1982-01-26 | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8347605A0 true IT8347605A0 (en) | 1983-01-25 |
IT1203647B IT1203647B (en) | 1989-02-15 |
Family
ID=26993144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT47605/83A IT1203647B (en) | 1982-01-26 | 1983-01-25 | REPLACED UREAS AND THIOURAS HAVING ANTI-THEROSCLEROTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (20)
Country | Link |
---|---|
KR (1) | KR890001808B1 (en) |
AT (1) | AT391313B (en) |
AU (1) | AU562699B2 (en) |
CH (1) | CH654571A5 (en) |
DE (1) | DE3247581A1 (en) |
DK (1) | DK160869C (en) |
ES (2) | ES8406422A1 (en) |
FI (1) | FI85013C (en) |
FR (1) | FR2521134B1 (en) |
GB (1) | GB2113684B (en) |
GR (1) | GR77186B (en) |
HU (1) | HU200746B (en) |
IE (1) | IE54683B1 (en) |
IL (1) | IL67417A (en) |
IT (1) | IT1203647B (en) |
NL (1) | NL8300269A (en) |
NO (1) | NO158417C (en) |
PL (1) | PL143836B1 (en) |
PT (1) | PT76138A (en) |
SE (1) | SE462653B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2138804A (en) * | 1983-04-27 | 1984-10-31 | Sumitomo Chemical Co | Fungicidal N-phenylcarbamates |
GB2149394B (en) * | 1983-07-19 | 1986-09-24 | American Cyanamid Co | Ureas |
US4818899A (en) * | 1986-12-03 | 1989-04-04 | Minnesota Mining And Manufacturing Company | Second harmonic generation by carbamic acid derivatives |
US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
DE68911203T2 (en) * | 1988-03-30 | 1994-04-14 | Warner Lambert Co | N - [[(2,6-disubstituted) phenyl] N'-arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents. |
AU7317391A (en) * | 1990-02-14 | 1991-09-03 | Chugai Seiyaku Kabushiki Kaisha | Inhibitor of denatured ldl formation |
US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
DE69314929T2 (en) * | 1992-07-20 | 1998-03-19 | Eisai Co Ltd | BENZENE DERIVATIVES |
JP2003524574A (en) * | 1997-08-05 | 2003-08-19 | ノボ ノルディスク アクティーゼルスカブ | 2,5- and 3,5-disubstituted aniline derivatives, their preparation and use |
TW415942B (en) * | 1997-09-03 | 2000-12-21 | American Home Prod | Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents |
US6455566B1 (en) | 1997-09-03 | 2002-09-24 | Wyeth | Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents |
US6221913B1 (en) * | 1998-01-21 | 2001-04-24 | Zymogenetics, Inc. | Dialkyl ureas as calcitonin mimetics |
CA2692598A1 (en) * | 2007-07-10 | 2009-01-15 | Amgen Inc. | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL212631A (en) * | 1949-12-06 | |||
US2688039A (en) * | 1952-02-08 | 1954-08-31 | Ciba Pharm Prod Inc | Halogen-containing di-(substituted phenyl)-thioureas |
US3326663A (en) * | 1964-09-25 | 1967-06-20 | Shell Oil Co | Herbicidal phenylureas |
US3335142A (en) * | 1965-07-07 | 1967-08-08 | American Cyanamid Co | Process for the preparation of n, n'-disubstituted ureas |
US3659012A (en) * | 1969-05-26 | 1972-04-25 | Lilly Co Eli | Methods of treating helminth infections with thiourea derivatives |
US3728386A (en) * | 1970-07-27 | 1973-04-17 | Exxon Research Engineering Co | N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides |
US3928437A (en) * | 1970-09-02 | 1975-12-23 | Ciba Geigy Corp | Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas |
US3856952A (en) * | 1973-03-01 | 1974-12-24 | Pennwalt Corp | Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides |
US3903130A (en) * | 1974-05-03 | 1975-09-02 | Stauffer Chemical Co | 1-Trifluormethylphenyl-3-dicyanophenyl urea |
DE2928485A1 (en) * | 1979-07-14 | 1981-01-29 | Bayer Ag | USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS |
-
1982
- 1982-12-05 IL IL67417A patent/IL67417A/en not_active IP Right Cessation
- 1982-12-22 DE DE19823247581 patent/DE3247581A1/en not_active Withdrawn
- 1982-12-28 KR KR8205843A patent/KR890001808B1/en active
-
1983
- 1983-01-14 GR GR70261A patent/GR77186B/el unknown
- 1983-01-21 AU AU10681/83A patent/AU562699B2/en not_active Ceased
- 1983-01-24 GB GB08301863A patent/GB2113684B/en not_active Expired
- 1983-01-25 CH CH404/83A patent/CH654571A5/en not_active IP Right Cessation
- 1983-01-25 DK DK028683A patent/DK160869C/en not_active IP Right Cessation
- 1983-01-25 PT PT76138A patent/PT76138A/en not_active IP Right Cessation
- 1983-01-25 HU HU83227A patent/HU200746B/en not_active IP Right Cessation
- 1983-01-25 ES ES519246A patent/ES8406422A1/en not_active Expired
- 1983-01-25 FR FR8301082A patent/FR2521134B1/en not_active Expired
- 1983-01-25 IT IT47605/83A patent/IT1203647B/en active
- 1983-01-25 SE SE8300370A patent/SE462653B/en not_active IP Right Cessation
- 1983-01-25 FI FI830247A patent/FI85013C/en not_active IP Right Cessation
- 1983-01-25 NO NO830238A patent/NO158417C/en unknown
- 1983-01-25 IE IE146/83A patent/IE54683B1/en not_active IP Right Cessation
- 1983-01-25 AT AT0023983A patent/AT391313B/en not_active IP Right Cessation
- 1983-01-25 PL PL1983240284A patent/PL143836B1/en unknown
- 1983-01-25 NL NL8300269A patent/NL8300269A/en not_active Application Discontinuation
-
1984
- 1984-04-11 ES ES531508A patent/ES531508A0/en active Granted
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Legal Events
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TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950131 |