GB8301863D0 - Antiatherosclerotic substituted ureas and thioureas - Google Patents
Antiatherosclerotic substituted ureas and thioureasInfo
- Publication number
- GB8301863D0 GB8301863D0 GB838301863A GB8301863A GB8301863D0 GB 8301863 D0 GB8301863 D0 GB 8301863D0 GB 838301863 A GB838301863 A GB 838301863A GB 8301863 A GB8301863 A GB 8301863A GB 8301863 D0 GB8301863 D0 GB 8301863D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- antiatherosclerotic
- thioureas
- substituted ureas
- ureas
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/342,693 US4473579A (en) | 1982-01-26 | 1982-01-26 | Antiatherosclerotic tetrasubstituted ureas and thioureas |
| US06/342,698 US4387105A (en) | 1982-01-26 | 1982-01-26 | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8301863D0 true GB8301863D0 (en) | 1983-02-23 |
| GB2113684A GB2113684A (en) | 1983-08-10 |
| GB2113684B GB2113684B (en) | 1985-12-18 |
Family
ID=26993144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08301863A Expired GB2113684B (en) | 1982-01-26 | 1983-01-24 | Antiatherosclerotic substituted ureas and thioureas |
Country Status (20)
| Country | Link |
|---|---|
| KR (1) | KR890001808B1 (en) |
| AT (1) | AT391313B (en) |
| AU (1) | AU562699B2 (en) |
| CH (1) | CH654571A5 (en) |
| DE (1) | DE3247581A1 (en) |
| DK (1) | DK160869C (en) |
| ES (2) | ES8406422A1 (en) |
| FI (1) | FI85013C (en) |
| FR (1) | FR2521134B1 (en) |
| GB (1) | GB2113684B (en) |
| GR (1) | GR77186B (en) |
| HU (1) | HU200746B (en) |
| IE (1) | IE54683B1 (en) |
| IL (1) | IL67417A (en) |
| IT (1) | IT1203647B (en) |
| NL (1) | NL8300269A (en) |
| NO (1) | NO158417C (en) |
| PL (1) | PL143836B1 (en) |
| PT (1) | PT76138A (en) |
| SE (1) | SE462653B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2138804A (en) * | 1983-04-27 | 1984-10-31 | Sumitomo Chemical Co | Fungicidal N-phenylcarbamates |
| GB2149394B (en) * | 1983-07-19 | 1986-09-24 | American Cyanamid Co | Ureas |
| US4818899A (en) * | 1986-12-03 | 1989-04-04 | Minnesota Mining And Manufacturing Company | Second harmonic generation by carbamic acid derivatives |
| US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
| EP0344425B1 (en) * | 1988-03-30 | 1993-12-08 | Warner-Lambert Company | N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents |
| WO1991011994A1 (en) * | 1990-02-14 | 1991-08-22 | Chugai Seiyaku Kabushiki Kaisha | Inhibitor of denatured ldl formation |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
| HUT67475A (en) * | 1992-07-20 | 1995-04-28 | Eisai Co Ltd | Benzene derivatives and pharmaceutical compositions containing them as active components |
| WO1999007672A1 (en) * | 1997-08-05 | 1999-02-18 | Novo Nordisk A/S | Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use |
| US6455566B1 (en) | 1997-09-03 | 2002-09-24 | Wyeth | Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents |
| TW415942B (en) * | 1997-09-03 | 2000-12-21 | American Home Prod | Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents |
| CA2284864A1 (en) * | 1998-01-21 | 1999-07-29 | Zymogenetics, Inc. | Dialkyl ureas as calcitonin mimetics |
| JP5504484B2 (en) * | 2007-07-10 | 2014-05-28 | アムジエン・インコーポレーテツド | Urea derivatives and related diamines, methods for their production and use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL212631A (en) * | 1949-12-06 | |||
| US2688039A (en) * | 1952-02-08 | 1954-08-31 | Ciba Pharm Prod Inc | Halogen-containing di-(substituted phenyl)-thioureas |
| US3326663A (en) * | 1964-09-25 | 1967-06-20 | Shell Oil Co | Herbicidal phenylureas |
| US3335142A (en) * | 1965-07-07 | 1967-08-08 | American Cyanamid Co | Process for the preparation of n, n'-disubstituted ureas |
| US3659012A (en) * | 1969-05-26 | 1972-04-25 | Lilly Co Eli | Methods of treating helminth infections with thiourea derivatives |
| US3728386A (en) * | 1970-07-27 | 1973-04-17 | Exxon Research Engineering Co | N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides |
| US3928437A (en) * | 1970-09-02 | 1975-12-23 | Ciba Geigy Corp | Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas |
| US3856952A (en) * | 1973-03-01 | 1974-12-24 | Pennwalt Corp | Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides |
| US3903130A (en) * | 1974-05-03 | 1975-09-02 | Stauffer Chemical Co | 1-Trifluormethylphenyl-3-dicyanophenyl urea |
| DE2928485A1 (en) * | 1979-07-14 | 1981-01-29 | Bayer Ag | USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS |
-
1982
- 1982-12-05 IL IL67417A patent/IL67417A/en not_active IP Right Cessation
- 1982-12-22 DE DE19823247581 patent/DE3247581A1/en not_active Withdrawn
- 1982-12-28 KR KR8205843A patent/KR890001808B1/en active
-
1983
- 1983-01-14 GR GR70261A patent/GR77186B/el unknown
- 1983-01-21 AU AU10681/83A patent/AU562699B2/en not_active Ceased
- 1983-01-24 GB GB08301863A patent/GB2113684B/en not_active Expired
- 1983-01-25 NL NL8300269A patent/NL8300269A/en not_active Application Discontinuation
- 1983-01-25 NO NO830238A patent/NO158417C/en unknown
- 1983-01-25 SE SE8300370A patent/SE462653B/en not_active IP Right Cessation
- 1983-01-25 PL PL1983240284A patent/PL143836B1/en unknown
- 1983-01-25 DK DK028683A patent/DK160869C/en not_active IP Right Cessation
- 1983-01-25 FR FR8301082A patent/FR2521134B1/en not_active Expired
- 1983-01-25 CH CH404/83A patent/CH654571A5/en not_active IP Right Cessation
- 1983-01-25 IT IT47605/83A patent/IT1203647B/en active
- 1983-01-25 PT PT76138A patent/PT76138A/en not_active IP Right Cessation
- 1983-01-25 AT AT0023983A patent/AT391313B/en not_active IP Right Cessation
- 1983-01-25 ES ES519246A patent/ES8406422A1/en not_active Expired
- 1983-01-25 HU HU83227A patent/HU200746B/en not_active IP Right Cessation
- 1983-01-25 IE IE146/83A patent/IE54683B1/en not_active IP Right Cessation
- 1983-01-25 FI FI830247A patent/FI85013C/en not_active IP Right Cessation
-
1984
- 1984-04-11 ES ES531508A patent/ES531508A0/en active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19960124 |